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  1. Article: Action Speaks Louder: The Role of Proactive Behavior between Creative Leadership and Employees' Creativity.

    Zhou, Xiaozhou / Zhong, Jie / Zhang, Li

    Behavioral sciences (Basel, Switzerland)

    2024  Volume 14, Issue 3

    Abstract: Drawing on social learning theory, this study presents a moderated mediation model to examine the role of proactive behavior and conformity value in the positive relationship between creative leadership and employees' creativity. Two-wave data are ... ...

    Abstract Drawing on social learning theory, this study presents a moderated mediation model to examine the role of proactive behavior and conformity value in the positive relationship between creative leadership and employees' creativity. Two-wave data are collected from 230 employees and their leaders in an automobile manufacturing enterprise in China, in which employees are encouraged to be creative because they need to implement novel designs and proposals to attract consumers. Statistical analysis reveals that proactive behavior partially mediates the influence of creative leadership on employees' creativity. Conformity value moderates not only the relationship between creative leadership and proactive behavior but also the indirect effect of creative leadership on employees' creativity via proactive behavior. The relationship and the mediating mechanism are stronger in the presence of employees' higher conformity value. We discuss the theoretical and practical implications as well as future research directions of the findings.
    Language English
    Publishing date 2024-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651997-5
    ISSN 2076-328X
    ISSN 2076-328X
    DOI 10.3390/bs14030257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Feasibility analysis of arterial CT radiomics model to predict the risk of local and metastatic recurrence after radical cystectomy for bladder cancer.

    Lv, Huawang / Zhou, Xiaozhou / Liu, Yuan / Liu, Yuting / Chen, Zhiwen

    Discover. Oncology

    2024  Volume 15, Issue 1, Page(s) 40

    Abstract: Purpose: To construct a radiomics-clinical nomogram model for predicting the risk of local and metastatic recurrence within 3 years after radical cystectomy (RC) of bladder cancer (BCa) based on the radiomics features and important clinical risk factors ...

    Abstract Purpose: To construct a radiomics-clinical nomogram model for predicting the risk of local and metastatic recurrence within 3 years after radical cystectomy (RC) of bladder cancer (BCa) based on the radiomics features and important clinical risk factors for arterial computed tomography (CT) images and to evaluate its efficacy.
    Methods: Preoperative CT datasets of 134 BCa patients (24 recurrent) who underwent RC were collected and divided into training (n = 93) and validation sets (n = 41). Radiomics features were extracted from a 1.5 mm CT layer thickness image in the arterial phase. A radiomics score (Rad-Score) model was constructed using the feature dimension reduction method and a logistic regression model. Combined with important clinical factors, including gender, age, tumor size, tumor number and grade, pathologic T stage, lymph node stage and histology type of the archived lesion, and CT image signs, a radiomics-clinical nomogram was developed, and its performance was evaluated in the training and validation sets. Decision curve analyses (DCA) the potential clinical usefulness.
    Results: The radiomics model is finally linear combined by 8 features screened by LASSO regression, and after coefficient weighting, achieved good predictive results. The radiomics nomogram developed by combining two independent predictors, Rad-Score and pathologic T stage, was developed in the training set [AUC, 0.840; 95% confidence interval (CI) 0.743-0.937] and validation set (AUC, 0.883; 95% CI 0.777-0.989). The calibration curve showed good agreement between the predicted probability of the radiomics-clinical model and the actual recurrence rate within 3 years after RC for BCa. DCA show the clinical application value of the radiomics-clinical model.
    Conclusion: The radiomics-clinical nomogram model constructed based on the radiomics features of arterial CT images and important clinical risk factors is potentially feasible for predicting the risk of recurrence within 3 years after RC for BCa.
    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Journal Article
    ISSN 2730-6011
    ISSN (online) 2730-6011
    DOI 10.1007/s12672-024-00880-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Residue-Frustration-Based Prediction of Protein-Protein Interactions Using Machine Learning.

    Zhou, Xiaozhou / Song, Haoyu / Li, Jingyuan

    The journal of physical chemistry. B

    2022  Volume 126, Issue 8, Page(s) 1719–1727

    Abstract: The study of protein-protein interactions (PPIs) is important in understanding the function of proteins. However, it is still a challenge to investigate the transient protein-protein interaction by experiments. Hence, the computational prediction for ... ...

    Abstract The study of protein-protein interactions (PPIs) is important in understanding the function of proteins. However, it is still a challenge to investigate the transient protein-protein interaction by experiments. Hence, the computational prediction for protein-protein interactions draws growing attention. Statistics-based features have been widely used in the studies of protein structure prediction and protein folding. Due to the scarcity of experimental data of PPI, it is difficult to construct a conventional statistical feature for PPI prediction, and the application of statistics-based features is very limited in this field. In this paper, we explored the application of frustration, a statistical potential, in PPI prediction. By comparing the energetic contribution of the extra stabilization energy from a given residue pair in the native protein with the statistics of the energies, we obtained the residue pair's frustration index. By calculating the number of residue pairs with a high frustration index, the highly frustrated density, a residue-frustration-based feature, was then obtained to describe the tendency of residues to be involved in PPI. Highly frustrated density, as well as structure-based features, were then used to describe protein residues and combined with the long short-term memory (LSTM) neural network to predict PPI residue pairs. Our model correctly predicted 75% dimers when only the top 2‰ residue pairs were selected in each dimer. Our model, which considers the statistics-based features, is significantly different from the models based on the chemical features of residues. We found that frustration can effectively describe the tendency of residue to be involved in PPI. Frustration-based features can replace chemical features to combine with machine learning and realize the better performance of PPI prediction. It reveals the great potential of statistical potential such as frustration in PPI prediction.
    MeSH term(s) Algorithms ; Computational Biology ; Machine Learning ; Neural Networks, Computer ; Protein Interaction Mapping ; Proteins/chemistry
    Chemical Substances Proteins
    Language English
    Publishing date 2022-02-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.1c10525
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Reply to Shun-Fa Hung, Shyi-Chun Yii, and Shiu-Dong Chung's Letter to the Editor re: Zhiwen Chen, Peng He, Xiaozhou Zhou, et al. Preliminary Functional Outcome Following Robotic Intracorporeal Orthotopic Ileal Neobladder Suspension with Round Ligaments in Women with Bladder Cancer. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2021.11.012.

    He, Peng / Zhou, Xiaozhou / Chen, Zhiwen

    European urology

    2022  Volume 81, Issue 5, Page(s) e119

    Language English
    Publishing date 2022-02-04
    Publishing country Switzerland
    Document type Letter ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2022.01.038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Residue-Frustration-Based Prediction of Protein–Protein Interactions Using Machine Learning

    Zhou, Xiaozhou / Song, Haoyu / Li, Jingyuan

    Journal of physical chemistry. 2022 Feb. 16, v. 126, no. 8

    2022  

    Abstract: The study of protein–protein interactions (PPIs) is important in understanding the function of proteins. However, it is still a challenge to investigate the transient protein–protein interaction by experiments. Hence, the computational prediction for ... ...

    Abstract The study of protein–protein interactions (PPIs) is important in understanding the function of proteins. However, it is still a challenge to investigate the transient protein–protein interaction by experiments. Hence, the computational prediction for protein–protein interactions draws growing attention. Statistics-based features have been widely used in the studies of protein structure prediction and protein folding. Due to the scarcity of experimental data of PPI, it is difficult to construct a conventional statistical feature for PPI prediction, and the application of statistics-based features is very limited in this field. In this paper, we explored the application of frustration, a statistical potential, in PPI prediction. By comparing the energetic contribution of the extra stabilization energy from a given residue pair in the native protein with the statistics of the energies, we obtained the residue pair’s frustration index. By calculating the number of residue pairs with a high frustration index, the highly frustrated density, a residue-frustration-based feature, was then obtained to describe the tendency of residues to be involved in PPI. Highly frustrated density, as well as structure-based features, were then used to describe protein residues and combined with the long short-term memory (LSTM) neural network to predict PPI residue pairs. Our model correctly predicted 75% dimers when only the top 2‰ residue pairs were selected in each dimer. Our model, which considers the statistics-based features, is significantly different from the models based on the chemical features of residues. We found that frustration can effectively describe the tendency of residue to be involved in PPI. Frustration-based features can replace chemical features to combine with machine learning and realize the better performance of PPI prediction. It reveals the great potential of statistical potential such as frustration in PPI prediction.
    Keywords energy ; neural networks ; prediction ; protein-protein interactions ; statistics
    Language English
    Dates of publication 2022-0216
    Size p. 1719-1727.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1520-5207
    DOI 10.1021/acs.jpcb.1c10525
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Impacts of mutations on dynamic allostery of adenylate kinase.

    Song, Haoyu / Wutthinitikornkit, Yanee / Zhou, Xiaozhou / Li, Jingyuan

    The Journal of chemical physics

    2021  Volume 155, Issue 3, Page(s) 35101

    Abstract: Escherichia coli adenylate kinase (AK) is composed of CORE domain and two branch domains: LID and AMP-binding domain (AMPbd). AK exhibits considerable allostery in a reversible phosphoryl transfer reaction, which is largely attributed to the relative ... ...

    Abstract Escherichia coli adenylate kinase (AK) is composed of CORE domain and two branch domains: LID and AMP-binding domain (AMPbd). AK exhibits considerable allostery in a reversible phosphoryl transfer reaction, which is largely attributed to the relative motion of LID and AMPbd with respect to CORE. Such an allosteric conformational change is also evident in the absence of ligands. Recent studies showed that the mutations in branch domains can adjust dynamic allostery and alter the substrate affinity and enzyme activity. In this work, we use all-atom molecular dynamics simulation to study the impacts of mutations in branch domains on AK's dynamic allostery by comparing two double mutants, i.e., LID mutant (Val135Gly, Val142Gly) and AMPbd mutant (Ala37Gly, Ala55Gly), with wild-type. Two mutants undergo considerable conformational fluctuation and exhibit deviation from the initially extended apo state to more compact structures. The LID domain in the LID mutant adjusts its relative position and firmly adheres to CORE. More strikingly, AMPbd mutations affect the relative positions of both the AMPbd domain and remote LID domain. Both domains undergo considerable movement, especially the inherent hinge swing motion of the flexible LID domain. In both mutants, the mutations can enhance the inter-domain interaction. The results about the conformation change of AK in both mutants are in line with the experiment of AK's affinity and activity. As revealed by our findings, the flexibility of branch domains and their inherent motions, especially LID domain, is highly relevant to dynamic allostery in the AK system.
    MeSH term(s) Adenylate Kinase/chemistry ; Adenylate Kinase/genetics ; Adenylate Kinase/metabolism ; Allosteric Regulation ; Escherichia coli/enzymology ; Mutation ; Protein Conformation ; Protein Domains
    Chemical Substances Adenylate Kinase (EC 2.7.4.3)
    Language English
    Publishing date 2021-07-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0053715
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Exosomal ncRNAs: Multifunctional contributors to the immunosuppressive tumor microenvironment of hepatocellular carcinoma.

    Huang, Qi / Zhong, Xin / Li, Jing / Hu, Rui / Yi, Jinyu / Sun, Jialing / Xu, Youhua / Zhou, Xiaozhou

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2024  Volume 173, Page(s) 116409

    Abstract: Hepatocellular carcinoma (HCC) is a malignant liver cancer characterized by aggressive progression, unfavorable prognosis, and an increasing global health burden. Therapies that precisely target immunological checkpoints and immune cells have gained ... ...

    Abstract Hepatocellular carcinoma (HCC) is a malignant liver cancer characterized by aggressive progression, unfavorable prognosis, and an increasing global health burden. Therapies that precisely target immunological checkpoints and immune cells have gained significant attention as possible therapeutics in recent years. In truth, the efficacy of immunotherapy is heavily contingent upon the tumor microenvironment (TME). Recent studies have indicated that exosomes serve as a sophisticated means of communication among biomolecules, executing an essential part in the TME of immune suppression. Exosomal non-coding RNAs (ncRNAs) can induce the activation of tumor cells and immunosuppressive immune cells that suppress the immune system, such as cancer-associated fibroblasts (CAFs), tumor-associated macrophages (TAMs), tumor-associated neutrophils (TANs), CD
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/therapy ; Carcinoma, Hepatocellular/drug therapy ; Liver Neoplasms/pathology ; Tumor Microenvironment ; RNA, Untranslated/genetics ; Exosomes/genetics ; Exosomes/pathology
    Chemical Substances RNA, Untranslated
    Language English
    Publishing date 2024-03-08
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2024.116409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Experimental study on the effect of chrysin on skin injury induced by amiodarone extravasation in rats.

    Liu, Liuhong / Mai, Yongyi / Liang, Yunfang / Zhou, Xiaozhou / Chen, Ken

    Microvascular research

    2021  Volume 139, Page(s) 104257

    Abstract: Objective: Amiodarone is the first choice for the treatment of arrhythmia, but it is easy to cause extravasation during infusion, after extravasation, it often cause skin injury. The healing of skin injury induced by amiodarone is an inflammatory ... ...

    Abstract Objective: Amiodarone is the first choice for the treatment of arrhythmia, but it is easy to cause extravasation during infusion, after extravasation, it often cause skin injury. The healing of skin injury induced by amiodarone is an inflammatory process. Chrysin, a natural flavonoid, has been investigated to have anti-inflammatory and antioxidant effects. It was reported that chrysin can promote wound healing. So this study aims to investigate the effect of chrysin on amiodarone extravasation-induced skin injury model in rats.
    Methods: The rat model of skin extravasation injury was established by subcutaneous injection of 0.5 mL of amiodarone. After successful modeling, the rats were randomly assigned to the five groups: control group, 10% DMSO group, and low-dose, medium-dose, and high-dose chrysin groups (10, 20 and 40 mg/mL). The extravasation injury model was given locally on the same day for seven days. On day 0, 3, 7 and 10 of administration, the lesion's image were taken to calculate the area, and the tissue of the lesion were collected for H&E staining. Then, the level of IL-6 and TNF-α were measured by ELISA, and the protein expression level of bFGF in the wound tissue were detected by immunohistochemical staining.
    Results: It was found that chrysin groups (20 and 40 mg/mL) compared to contronl group and 10% DMSO solvent group significantly decreased area injury, IL-6 and TNF-α(P < 0.05) on day 3, 7, 10. On the other hand, the chrysin group (40 mg/mL) compared to contronl group and 10% DMSO group significantly increase bFGF(P < 0.05) on day 3, 7.
    Conclusion: Chrysin were effective in reducing injury area, reducing inflammation, and promoting the secretion of bFGF, it can promote the healing of skin injury induced by amiodarone extravasation in rats. These findings provide a good theoretical and experimental basis for the prevention and treatment of amiodarone extravasation-induced skin injury, and provide evidence for finding potential healing agents for the prevention and treatment of amiodarone and other corrosive extravasation-induced injuries from the molecular and cytological levels, thus solving the clinical problems.
    MeSH term(s) Amiodarone ; Animals ; Anti-Inflammatory Agents/pharmacology ; Cell Proliferation/drug effects ; Disease Models, Animal ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Fibroblast Growth Factor 2/metabolism ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Flavonoids/pharmacology ; Interleukin-6/metabolism ; Rats, Sprague-Dawley ; Skin/drug effects ; Skin/metabolism ; Skin/pathology ; Skin Diseases/chemically induced ; Skin Diseases/drug therapy ; Skin Diseases/metabolism ; Skin Diseases/pathology ; Tumor Necrosis Factor-alpha/metabolism ; Wound Healing/drug effects ; Rats
    Chemical Substances Anti-Inflammatory Agents ; Flavonoids ; Il6 protein, rat ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Fibroblast Growth Factor 2 (103107-01-3) ; chrysin (3CN01F5ZJ5) ; Amiodarone (N3RQ532IUT)
    Language English
    Publishing date 2021-09-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80307-8
    ISSN 1095-9319 ; 0026-2862
    ISSN (online) 1095-9319
    ISSN 0026-2862
    DOI 10.1016/j.mvr.2021.104257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Expression and clinical significance of SNF5 in bladder cancer

    DING Hua / WANG Liwei / ZHANG Jingqi / ZHOU Xiaozhou / CHEN Zhiwen

    Di-san junyi daxue xuebao, Vol 42, Iss 24, Pp 2408-

    2020  Volume 2412

    Abstract: Objective To explore the expression and clinical significance of SNF5 in bladder cancer. Methods Based on the data from the Cancer Genome Atlas (TCGA) database, SNF5 mRNA level from 408 cases of bladder cancer tissues and 19 cases of normal bladder ... ...

    Abstract Objective To explore the expression and clinical significance of SNF5 in bladder cancer. Methods Based on the data from the Cancer Genome Atlas (TCGA) database, SNF5 mRNA level from 408 cases of bladder cancer tissues and 19 cases of normal bladder tissues were retrieved and analyzed with clinical data. Kaplan-Meier analysis was employed to study the relationship between SNF5 level and survival rate in these bladder cancer patients. qPCR was performed to determine the expression level of SNF5 in different bladder cancer cell lines (5637, T24, RT4, UM-UC-3, TCCSUP, J82) and normal human urothelial cell line SV-HUC-1. What's more, the protein expression of SNF5 in clinically collected bladder cancer samples (from 157 patients admitted in our hospital from January 2012 to December 2018) was detected by immunohistochemical (IHC) assay, and its association with clinicopathological features was analyzed with Cox regression analysis. Results The mRNA expression of SNF5 was higher in both bladder cancer tissues and cell lines than normal bladder tissues and cells, and the expression variations were significant among different subtypes of bladder cancer and cancer cell lines. The results of Kaplan-Meier analysis indicated that the patients with lower SNF5 mRNA level had worse prognosis than those with higher expression (P < 0.01). Cox regression analysis showed SNF5 was an independent prognostic factor for bladder cancer. The protein level of SNF5 was significantly correlated with myometrial infiltration (P < 0.01) and lymph node metastasis (P < 0.01). Conclusion SNF5 is upregulated in bladder cancer, and closely associated with its incidence, progression and prognosis. It may be used as a promising therapeutic target in treatment for bladder cancer.
    Keywords snf5 ; bladder cancer ; survival analysis ; Medicine (General) ; R5-920
    Subject code 616 ; 610
    Language Chinese
    Publishing date 2020-12-01T00:00:00Z
    Publisher Editorial Office of Journal of Third Military Medical University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Transurethral ureteral orifice resection versus open resection after retroperitoneal laparoscopic nephroureterectomy for upper urinary urothelial carcinoma

    LIAO Deyang / ZHOU Xiaozhou / FU Jian / LIU Yang / LI Zhenyan / WANG Yongquan / ZHOU Zhansong

    Di-san junyi daxue xuebao, Vol 43, Iss 8, Pp 761-

    a clinical control study of 59 cases

    2021  Volume 765

    Abstract: Objective To evaluate the safety and effectiveness of retroperitoneal laparoscopic nephroureterectomy combined with transurethral resection of the ureteral orifice for the treatment of upper urinary urothelial carcinoma (UTUC). Methods We retrospectively ...

    Abstract Objective To evaluate the safety and effectiveness of retroperitoneal laparoscopic nephroureterectomy combined with transurethral resection of the ureteral orifice for the treatment of upper urinary urothelial carcinoma (UTUC). Methods We retrospectively analyzed the clinical data of 59 UTUC cases treated in our hospital from July 2013 to July 2019, who underwent retroperitoneal laparoscopic nephroureterectomy combined with transurethral resection of the ureteral orifice (n=20) or abdominal incision(n=39). Blood loss volume, time of incision drainage, recovery time of postoperative intestinal function, postoperative hospitalization time, postoperative complications and local recurrence, and distant metastasis were compared between the 2 groups. Results The transurethral resection group had significantly longer operative time (219.1±54.2 vs 178.7±60.8 min, P < 0.05), but shorter time of incision drainage, recovery time of postoperative intestinal function and postoperative hospitalization time (P < 0.05) when compared with the abdominal incision group. There were 4 cases having operative complications in the abdominal incision group, including 2 cases of pulmonary infection, 1 case of retroperitoneal effusion, and 1 case of lymphorrhagia. In the transurethral resection group, there was 1 case of postoperative bladder bleeding, and cystoscopic electrocision was performed for hemostasis. No significant differences were found in other evaluated indicators between the 2 groups. Conclusion Retroperitoneal laparoscopic nephroureterectomy combined with resection of the ureteral orifice is safe and effective for the treatment of UTUC. Compared with abdominal incision, transurethral approach has the advantage of less trauma and rapider recovery.
    Keywords retroperitoneal laparoscopy ; transurethral resection of the ureteral orifice ; renal pelvis carcinoma ; ureteral carcinoma ; Medicine (General) ; R5-920
    Subject code 610
    Language Chinese
    Publishing date 2021-04-01T00:00:00Z
    Publisher Editorial Office of Journal of Third Military Medical University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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