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Article ; Online: Crystal structure of SARS-CoV-2 main protease (M

Jiang, Haihai / Zou, Xiaofang / Zhou, Xuelan / Zhang, Jin / Li, Jian

Biochemical and biophysical research communications

2023 Volume 692, Page(s) 149352

Abstract: SARS-CoV-2 constantly circulates and evolves worldwide, generating many variants and posing a menace to global health. It is urgently needed to discover effective medicines to treat the disease caused by SARS-CoV-2 and its variants. An established target ...

Abstract	SARS-CoV-2 constantly circulates and evolves worldwide, generating many variants and posing a menace to global health. It is urgently needed to discover effective medicines to treat the disease caused by SARS-CoV-2 and its variants. An established target for anti-SARS-CoV-2 drug discovery is the main protease (M
MeSH term(s)	Humans ; SARS-CoV-2/genetics ; SARS-CoV-2/metabolism ; COVID-19 ; Antiviral Agents/pharmacology ; Antiviral Agents/chemistry ; Protease Inhibitors/chemistry ; Viral Nonstructural Proteins/chemistry ; Molecular Docking Simulation
Chemical Substances	2-(benzotriazol-1-yl)-N-((3-chlorophenyl)methyl)-N-(4-(1H-imidazol-4-yl)phenyl)acetamide ; 3C-like proteinase, SARS-CoV-2 (EC 3.4.22.-) ; Antiviral Agents ; Protease Inhibitors ; Viral Nonstructural Proteins
Language	English
Publishing date	2023-12-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2023.149352
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Article ; Online: Structural Basis for the Inhibition of SARS-CoV-2 M

Zhao, Zhenyu / Zhu, Qinyao / Zhou, Xuelan / Li, Wenwen / Yin, Xiushan / Li, Jian

Viruses

2023 Volume 16, Issue 1

Abstract: Preventing the spread of SARS-CoV-2 and its variants is crucial in the fight against COVID-19. Inhibition of the main protease ( ... ...

Abstract	Preventing the spread of SARS-CoV-2 and its variants is crucial in the fight against COVID-19. Inhibition of the main protease (M
MeSH term(s)	Lactams ; Leucine ; Naphthoquinones/pharmacology ; Nitriles ; SARS-CoV-2/drug effects ; SARS-CoV-2/genetics ; Coronavirus 3C Proteases/antagonists & inhibitors
Chemical Substances	Lactams ; Leucine (GMW67QNF9C) ; Naphthoquinones ; Nitriles ; shikonin (3IK6592UBW) ; Coronavirus 3C Proteases (EC 3.4.22.28) ; 3C-like proteinase, SARS-CoV-2 (EC 3.4.22.-)
Language	English
Publishing date	2023-12-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v16010065
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Article ; Online: Structural basis for the inhibition of coronaviral main proteases by ensitrelvir.

Lin, Cheng / Jiang, Haihai / Li, Wenwen / Zeng, Pei / Zhou, Xuelan / Zhang, Jin / Li, Jian

Structure (London, England : 1993)

2023 Volume 31, Issue 9, Page(s) 1016–1024.e3

Abstract: Main protease ( ... ...

Abstract	Main protease (M
MeSH term(s)	Humans ; SARS-CoV-2/metabolism ; COVID-19 ; Protease Inhibitors/chemistry ; Antiviral Agents/chemistry ; Peptide Hydrolases
Chemical Substances	ensitrelvir (PX665RAA3H) ; Protease Inhibitors ; Antiviral Agents ; Peptide Hydrolases (EC 3.4.-)
Language	English
Publishing date	2023-07-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1213087-4
ISSN	1878-4186 ; 0969-2126
ISSN (online)	1878-4186
ISSN	0969-2126
DOI	10.1016/j.str.2023.06.010
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Article: Effects of Stellate Ganglion Block Through Different Approaches Under Guidance of Ultrasound.

Shan, Hai-Hua / Chen, Hong-Fang / Ni, Yong / Yang, Jia-Xuan / Zhou, Xue-Lan

Frontiers in surgery

2022 Volume 8, Page(s) 797793

Abstract: Objective: This study aimed to investigate the effects of stellate ganglion block (SGB) through different approaches under guidance of ultrasound.: Methods: A total of 130 patients undergoing SGB in our hospital between February 2019 and February ... ...

Abstract	Objective: This study aimed to investigate the effects of stellate ganglion block (SGB) through different approaches under guidance of ultrasound. Methods: A total of 130 patients undergoing SGB in our hospital between February 2019 and February 2020 were enrolled as the research subjects. According to the random number table method, these subjects were divided into two groups: a modified 6th cervical vertebra (C6) group ( Results: The modified C6 group showed shorter SGB operation duration and a lower number of puncture angle adjustments than the C7 group, and the differences were statistically significant ( Conclusion: The operation duration for modified SGB guided by ultrasound puncturing at the C6 transverse process is shorter and requires fewer puncture angle adjustments than puncturing at the C7 transverse process; however, there is no significant difference between the incidence of adverse reactions or the blocking effects of the two methods.
Language	English
Publishing date	2022-01-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2021.797793
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Article ; Online: Pupil Diameter Changes after Anesthesia with Different Doses of Sufentanil under Ultrasound Monitoring.

Zhou, Xue-Lan / Xing, Li-Ji / Liu, Hai-Rui / Qian, Yu / Zhu, Jiang / Xie, Hong

International journal of clinical practice

2022 Volume 2022, Page(s) 6320973

Abstract: Objective: This study aims to observe the changes in pupil diameter (PD) after anesthesia with different doses of sufentanil with the ultrasound method and observe whether pupil contraction is correlated with hemodynamic changes and bispectral index ( ... ...

Abstract	Objective: This study aims to observe the changes in pupil diameter (PD) after anesthesia with different doses of sufentanil with the ultrasound method and observe whether pupil contraction is correlated with hemodynamic changes and bispectral index (BIS) values. Methods: A total of 124 patients between the ages of 18-65 with ASA I-II undergoing general anesthesia for surgery were enrolled in the study. According to the sufentanil dose initially injected, they were randomly divided into groups P, S1, S2, and S3, with 31 cases in each group. Group P was injected with normal saline. Group S1 was injected with 0.2 Results: The ultrasonic method was used to observe that different doses of sufentanil could make the patients' pupils contract. During anesthesia induction, the changes in PD have a positive correlation with SBP, DBP, HR, and BIS values. Conclusion: Ultrasound can become a new noninvasive method to monitor pupil changes during general anesthesia, and ultrasonic observation of pupil changes has great potential for individualized analgesia management in the perioperative period.
MeSH term(s)	Adolescent ; Adult ; Aged ; Anesthesia, General/methods ; Blood Pressure ; Hemodynamics ; Humans ; Middle Aged ; Propofol ; Sufentanil/pharmacology ; Young Adult
Chemical Substances	Sufentanil (AFE2YW0IIZ) ; Propofol (YI7VU623SF)
Language	English
Publishing date	2022-07-14
Publishing country	India
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1386246-7
ISSN	1742-1241 ; 1368-5031
ISSN (online)	1742-1241
ISSN	1368-5031
DOI	10.1155/2022/6320973
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Article ; Online: Crystal structures of main protease (M

Jiang, Haihai / Zou, Xiaofang / Zeng, Pei / Zeng, Xiangyi / Zhou, Xuelan / Wang, Jie / Zhang, Jin / Li, Jian

Molecular biomedicine

2023 Volume 4, Issue 1, Page(s) 23

Abstract: There is an urgent need to develop effective antiviral drugs to prevent the viral infection caused by constantly circulating SARS-CoV-2 as well as its variants. The main protease ( ... ...

Abstract	There is an urgent need to develop effective antiviral drugs to prevent the viral infection caused by constantly circulating SARS-CoV-2 as well as its variants. The main protease (M
Language	English
Publishing date	2023-08-03
Publishing country	Singapore
Document type	Journal Article
ISSN	2662-8651
ISSN (online)	2662-8651
DOI	10.1186/s43556-023-00134-2
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Article: Understanding Mammalian Hair Follicle Ecosystems by Single-Cell RNA Sequencing

Zheng, Qingbo / Zhang, Xiaolan / Bao, Pengjia / Zhou, Xuelan / Chu, Min / Guo, Xian / Liang, Chunnian / Pan, Heping / Yan, Ping

Animals. 2022 Sept. 14, v. 12, no. 18

2022

Abstract: Single-cell sequencing technology can fully reflect the heterogeneity of cell populations at the single cell level, making it possible for us to re-recognize various tissues and organs. At present, the sequencing study of hair follicles is transiting ... ...

Abstract	Single-cell sequencing technology can fully reflect the heterogeneity of cell populations at the single cell level, making it possible for us to re-recognize various tissues and organs. At present, the sequencing study of hair follicles is transiting from the traditional ordinary transcriptome level to the single cell level, which will provide diverse insights into the function of hair follicle cells. This review focuses on research advances in the hair follicle microenvironment obtained from scRNA-seq studies of major cell types in hair follicle development, with a special emphasis on the discovery of new subpopulations of hair follicles by single-cell techniques. We also discuss the problems and current solutions in scRNA-seq observation and look forward to its prospects.
Keywords	RNA ; hair follicles ; mammals ; transcriptome
Language	English
Dates of publication	2022-0914
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani12182409
Database	NAL-Catalogue (AGRICOLA)

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Article: MicroRNA transcriptome of skeletal muscle during yak development reveals miR-652 regulates myoblasts differentiation and survival by targeting ISL1

ZHOU, Xue-lan / GUO, Xian / LIANG, Chun-nian / CHU, Min / WU, Xiao-yun / YAN, Ping

CAAS. Publishing services by Elsevier B.V Journal of integrative agriculture. 2022,

2022

Abstract: The growth and development of skeletal muscle also determine the meat production of yak, ultimately affecting the economic benefits. Hence, improving growth performance is a top priority in the yak industry. Skeletal muscle development is a complex ... ...

Abstract	The growth and development of skeletal muscle also determine the meat production of yak, ultimately affecting the economic benefits. Hence, improving growth performance is a top priority in the yak industry. Skeletal muscle development is a complex process involving the regulation of several genes, including microRNAs (miRNAs). However, the transcription of miRNAs in yak skeletal muscle during prenatal to postnatal stages is unknown. We used small RNA sequencing (small RNA-Seq) to determine the global miRNAs of longissimus dorsi muscle from yak (The samples were collected from three fetuses and three adults). Totally 264 differently expressed miRNAs (\|log2(fold change)\|>1 and P-value≤0.05) were detected between the two groups. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that differently expressed miRNAs target genes participated in pathways associated with muscle development, such as MAPK, PI3K-Akt, and Hippo signaling pathways, etc. miR-652, which was upregulated in the fetal group, was transfected into C2C12 myoblasts to examine its role. miR-652 promoted (P≤0.05) proliferation and differentiation, but inhibited (P≤0.001) apoptosis at early period. Furthermore, miR-652 reduced (P≤0.001) the proportion of C2C12 myoblasts in the G1phase while increasing (P≤0.01) the proportion of cells in the S and G2 phases. Dual-Luciferase Reporter assays indicated that ISL1 served as a target of miR-652. In general, these findings expand our understanding of yak skeletal muscle miRNAs, and suggested that miR-652 probably regulated myogenesis by regulating ISL1.
Keywords	agriculture ; apoptosis ; gene ontology ; genome ; growth performance ; industry ; longissimus muscle ; meat production ; microRNA ; muscle development ; myoblasts ; sequence analysis ; skeletal muscle ; transcriptome ; yaks
Language	English
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	2660426-7
ISSN	2095-3119
ISSN	2095-3119
DOI	10.1016/j.jia.2022.08.116
Database	NAL-Catalogue (AGRICOLA)

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Article: Crystal structures of the catalytic domain of human PARP15 in complex with small molecule inhibitors

Zhou, Xuelan / Yang, Yang / Xu, Qin / Zhou, Huan / Zhong, Fanglin / Deng, Jun / Zhang, Jin / Li, Jian

Biochemical and biophysical research communications. 2022 Sept. 24, v. 622

2022

Abstract: PARP15, or ARTD7, is an enzyme carrying out mono-ADP-ribosylation and regulating activities of a range of cellular proteins. This enzyme belongs to the family of the poly(ADP-ribose) polymerases (PARPs), which comprises of proteins with various potential ...

Abstract	PARP15, or ARTD7, is an enzyme carrying out mono-ADP-ribosylation and regulating activities of a range of cellular proteins. This enzyme belongs to the family of the poly(ADP-ribose) polymerases (PARPs), which comprises of proteins with various potential disease indications. Due to their involvement in a number of cellular processes and important role in DNA repair and regulation, PARPs have been considered attractive therapeutic targets over the past few years. The pursuit of small molecule PARP inhibitors has resulted in several FDA approved drugs for multiple cancers so far. As the use of PARP inhibitors as drug scaffolds is actively explored recently, there is increasing interest in the design of selective inhibitors based on the structural features of the PARP proteins. Here, we solved high-resolution crystal structures of the human PARP15 catalytic domain in complex with three marketed drugs of PARP inhibitors, which includes compounds 3-AB, iniparib and niraparib. The structures reported here contribute to our understanding of the ligand binding modes and structural features in the PARP15 catalytic domain, which can be employed to guide the rational design of selective inhibitors of PARPs.
Keywords	DNA repair ; active sites ; drugs ; enzymes ; humans ; ligands ; research ; therapeutics
Language	English
Dates of publication	2022-0924
Size	p. 93-100.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2022.06.070
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Article ; Online: Structural Basis of Main Proteases of Coronavirus Bound to Drug Candidate PF-07304814

Li, Jian / Lin, Zheng / Zhou, Xuelan / Zhong, Fanglin / Zeng, Pei / McCormick, Peter / Jiang, Haihai / Zhang, Jin

Journal of Molecular Biology. 2022 Aug., v. 434, no. 16 p.167706-

2022

Abstract: New variants of the severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) emerged and spread rapidly all over the world, which strongly supports the need for pharmacological options to complement vaccine strategies. Main protease (Mᵖʳᵒ or 3CLᵖʳᵒ) ... ...

Abstract	New variants of the severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) emerged and spread rapidly all over the world, which strongly supports the need for pharmacological options to complement vaccine strategies. Main protease (Mᵖʳᵒ or 3CLᵖʳᵒ) is a critical enzyme in the life cycle of SARS-CoV-2 and appears to be highly conserved among different genera of coronaviruses, making it an ideal target for the development of drugs with broad-spectrum property. PF-07304814 developed by Pfizer is an intravenously administered inhibitor targeting SARS-CoV-2 Mᵖʳᵒ. Here we showed that PF-07304814 displays broad-spectrum inhibitory activity against Mᵖʳᵒs from multiple coronaviruses. Crystal structures of Mᵖʳᵒs of SARS-CoV-2, SARS-CoV, MERS-CoV, and HCoV-NL63 bound to the inhibitor PF-07304814 revealed a conserved ligand-binding site, providing new insights into the mechanism of inhibition of viral replication. A detailed analysis of these crystal structures complemented by comprehensive comparison defined the key structural determinants essential for inhibition and illustrated the binding mode of action of Mᵖʳᵒs from different coronaviruses. In view of the importance of Mᵖʳᵒ for the medications of SARS-CoV-2 infection, insights derived from the present study should accelerate the design of pan-coronaviral main protease inhibitors that are safer and more effective.
Keywords	Coronavirus infections ; Severe acute respiratory syndrome coronavirus 2 ; Severe acute respiratory syndrome-related coronavirus ; intravenous injection ; mechanism of action ; molecular biology ; proteinases ; vaccines ; virus replication ; coronavirus ; main protease ; PF-07304814 ; inhibitor ; structural basis
Language	English
Dates of publication	2022-08
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	80229-3
ISSN	1089-8638 ; 0022-2836
ISSN (online)	1089-8638
ISSN	0022-2836
DOI	10.1016/j.jmb.2022.167706
Database	NAL-Catalogue (AGRICOLA)

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