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Article: Preoperative cognitive training improves postoperative cognitive function: a meta-analysis and systematic review of randomized controlled trials.

Zhao, Li / Guo, Yiping / Zhou, Xuelei / Mao, Wei / Li, Linji

2024 Volume 14, Page(s) 1293153

Abstract: Background: Postoperative cognitive dysfunction (POCD) and postoperative delirium (POD) are common post-surgical complications that often lead to prolonged hospitalization, reduced quality of life, increased healthcare costs, and increased patient ... ...

Abstract	Background: Postoperative cognitive dysfunction (POCD) and postoperative delirium (POD) are common post-surgical complications that often lead to prolonged hospitalization, reduced quality of life, increased healthcare costs, and increased patient mortality. We conducted a meta-analysis to evaluate the effects of preoperative cognitive function training on postoperative cognitive function. Methods: PubMed, Cochrane Library, Embase, Web of Science, ClinicalTrials, China National Knowledge Infrastructure, Wanfang Database, VIP Database, and Chinese Biomedical Literature Database were searched for randomized controlled trials comparing the effects of preoperative cognitive function training and conventional preoperative measures on postoperative cognitive function. The search period spanned from the establishment of the databases to March 31, 2023. The primary outcomes were the incidence of POCD and POD. Results: Eleven randomized controlled trials involving 1,045 patients were included. The results of the meta-analysis showed that, compared to the control group, preoperative cognitive function training significantly reduced the incidence of POCD (RR = 0.38, Conclusion: Cognitive function training significantly reduced the incidence of POCD; however, there was no significant difference in the incidence of POD. Preoperative cognitive function training should be promoted and emphasized as a simple, economical, and practical method of improving postoperative cognitive function. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=396154.
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1293153
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effect of thoracic paravertebral nerve block on delirium in patients after video-assisted thoracoscopic surgery: a systematic review and meta-analysis of randomized controlled trials.

Zhou, Xuelei / Mao, Wei / Zhao, Li / Zhu, Hongyu / Chen, Linlin / Xie, Ying / Li, Linji

Frontiers in neurology

2024 Volume 15, Page(s) 1347991

Abstract: Background: Nerve blocks are widely used in various surgeries to alleviate postoperative pain and promote recovery. However, the impact of nerve block on delirium remains contentious. This study aims to systematically evaluate the influence of Thoracic ... ...

Abstract	Background: Nerve blocks are widely used in various surgeries to alleviate postoperative pain and promote recovery. However, the impact of nerve block on delirium remains contentious. This study aims to systematically evaluate the influence of Thoracic Paravertebral Nerve Block (TPVB) on the incidence of delirium in patients post Video-Assisted Thoracoscopic Surgery (VATS). Methods: We conducted a systematic search of PubMed, Embase, Web of Science, Cochrane Library, and Scopus databases in June 2023. The search strategy combined free-text and Medical Subject Headings (MeSH) terms, including perioperative cognitive dysfunction, delirium, postoperative cognitive dysfunction, paravertebral nerve block, thoracic surgery, lung surgery, pulmonary surgery, and esophageal/esophagus surgery. We utilized a random effects model for the analysis and synthesis of effect sizes. Results: We included a total of 9 RCTs involving 1,123 participants in our study. In VATS, TPVB significantly reduced the incidence of delirium on postoperative day three (log(OR): -0.62, 95% CI [-1.05, -0.18], Conclusion: The comprehensive results suggest that in patients undergoing VATS, TPVB significantly reduces the incidence of delirium and notably diminishes pain scores. Systematic review registration: CRD42023435528. https://www.crd.york.ac.uk/PROSPERO.
Language	English
Publishing date	2024-04-10
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2024.1347991
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Article ; Online: Puerarin prevents cadmium-induced mitochondrial fission in AML-12 cells via Sirt1-dependent pathway.

Wan, Xue-Mei / Zheng, Chuan / Zhou, Xue-Lei

Ecotoxicology and environmental safety

2022 Volume 248, Page(s) 114302

Abstract: Recent investigations have revealed that puerarin (PU) alleviates cadmium (Cd)-caused hepatic damage via inhibiting oxidative stress. Mitochondria are dynamic organelles and play a critical part in regulating the occurrence of oxidative stress, but the ... ...

Abstract	Recent investigations have revealed that puerarin (PU) alleviates cadmium (Cd)-caused hepatic damage via inhibiting oxidative stress. Mitochondria are dynamic organelles and play a critical part in regulating the occurrence of oxidative stress, but the role of mitochondria in the protection of PU against hepatocellular damage caused by Cd exposure remains unknown. Thus, this study was aimed to clarify this issue using mouse hepatocyte AML-12 cell line. Transmission electron microscopy analysis firstly showed that PU prevents Cd-induced mitochondrial ultrastructure damage. Mitochondrial network image analysis by confocal microscopy revealed that PU exerts the protection against Cd-induced cytotoxicity via restoring mitochondrial network fragmentation. Also, mitochondrial dynamic protein expression profiles showed that enhanced fission protein levels and inhibited fusion protein levels in Cd-treated cells were significantly reversed by PU, suggesting the protective effect of PU against Cd-induced mitochondrial fission. Moreover, changes of intracellular ATP level and protein levels of key regulators involving in mitochondrial biogenesis indicated that Sirtuin-1(Sirt1) pathway may be involved in the protection of Cd-impaired mitochondrial function by PU. Next, Sirt1 protein levels in treated cells were effectively regulated by genetic knockdown or chemical agonist SRT1720. Accordingly, alleviation of Cd-induced mitochondrial fission assays and cell viability by PU was markedly regulated by SRT1720 or Sirt1 knockdown, suggesting the indispensable role of Sirt1 in this process. Collectively, these findings highlight that PU prevents Cd-induced mitochondrial fission to alleviate cytotoxicity via Sirt1-dependent pathway, which provide novel evidences to fully understand the hepatoprotective action of PU against heavy metal toxicity.
MeSH term(s)	Animals ; Mice ; Mitochondrial Dynamics ; Cadmium/toxicity ; Sirtuin 1/genetics ; Leukemia, Myeloid, Acute
Chemical Substances	puerarin (Z9W8997416) ; Cadmium (00BH33GNGH) ; Sirtuin 1 (EC 3.5.1.-) ; Sirt1 protein, mouse (EC 3.5.1.-)
Language	English
Publishing date	2022-11-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2022.114302
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Article: Effects of perioperative cognitive function training on postoperative cognitive dysfunction and postoperative delirium: a systematic review and meta-analysis.

Zhao, Li / Zhu, Hongyu / Mao, Wei / Zhou, Xuelei / Xie, Ying / Li, Linji

Frontiers in neurology

2023 Volume 14, Page(s) 1146164

Abstract: Background: Randomized controlled trials (RCTs) have shown conflicting results regarding the effects of perioperative cognitive training (CT) on the incidence of postoperative cognitive dysfunction (POCD) and postoperative delirium (POD). We, therefore, ...

Abstract	Background: Randomized controlled trials (RCTs) have shown conflicting results regarding the effects of perioperative cognitive training (CT) on the incidence of postoperative cognitive dysfunction (POCD) and postoperative delirium (POD). We, therefore, performed a meta-analysis to assess the overall effects of studies on this topic. Methods: We searched PubMed, Embase, the Cochrane Library, and Web of Science for all RCTs and cohort studies that investigated the effects of perioperative CT on the incidence of POCD and POD. Data extraction and quality assessment were conducted independently by two researchers. Results: This study included nine clinical trials with a total of 975 patients. The results showed that perioperative CT significantly reduced the incidence of POCD compared with the control group [risk ratio (RR) = 0.5, 95% CI (confidence interval): 0.28-0.89, Conclusion: Our meta-analysis revealed that perioperative cognitive training is possibly an effective measure to reduce the incidence of POCD, but not for the incidence of POD. Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022371306, identifier: CRD42022371306.
Language	English
Publishing date	2023-06-21
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1146164
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Article ; Online: Successful use of peritoneal dialysis after abdominal surgery in a patient with factor XI deficiency: A case report.

Li, Xueying / Chen, Ming / Wang, Yong / Zhou, Xuelei / Wang, Min / Zou, Lihua

Seminars in dialysis

2023 Volume 36, Issue 2, Page(s) 178–182

Abstract: Factor XI (FXI) deficiency is a rare bleeding disorder of unpredictable severity that correlates poorly with FXI coagulation activity and that poses great challenges for perioperative hemostatic management and the dialysis methods potentially available ... ...

Abstract	Factor XI (FXI) deficiency is a rare bleeding disorder of unpredictable severity that correlates poorly with FXI coagulation activity and that poses great challenges for perioperative hemostatic management and the dialysis methods potentially available to new end-stage renal disease (ESRD) patients. We describe an individual with both ESRD and severe FXI deficiency, who successfully underwent peritoneal dialysis (PD) after emergency abdominal surgery. In the traditional concept, recent abdominal surgery is a contraindication to PD, especially for patients with bleeding risk. However, this case report highlights that PD can still be an possible option for patients with FXI deficiency who have just undergone abdominal surgery; laparoscopic PD catheter placement offers a chance to establish PD access in patients traditionally viewed as noncandidates for this method. Careful perioperative management and fresh frozen plasma transfusion ensure successful surgery. This case should be of help to clinicians and patients considering PD in similar situations.
MeSH term(s)	Humans ; Factor XI Deficiency ; Factor XI ; Blood Component Transfusion ; Renal Dialysis ; Plasma ; Peritoneal Dialysis ; Kidney Failure, Chronic
Chemical Substances	Factor XI (9013-55-2)
Language	English
Publishing date	2023-01-03
Publishing country	United States
Document type	Case Reports ; Research Support, Non-U.S. Gov't
ZDB-ID	1028193-9
ISSN	1525-139X ; 0894-0959
ISSN (online)	1525-139X
ISSN	0894-0959
DOI	10.1111/sdi.13136
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2879: Show issues

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Article: The research progress of perioperative non-pharmacological interventions on postoperative cognitive dysfunction: a narrative review.

Zhao, Li / Guo, Yiping / Zhou, Xuelei / Mao, Wei / Zhu, Hongyu / Chen, Linlin / Liu, Xianchun / Zhang, Longyi / Xie, Ying / Li, Linji

Frontiers in neurology

2024 Volume 15, Page(s) 1369821

Abstract: Postoperative cognitive dysfunction (POCD) is a common neurological complication in elderly patients after surgery and general anesthesia. The occurrence of POCD seriously affects the postoperative recovery of patients, and leads to prolonged hospital ... ...

Abstract	Postoperative cognitive dysfunction (POCD) is a common neurological complication in elderly patients after surgery and general anesthesia. The occurrence of POCD seriously affects the postoperative recovery of patients, and leads to prolonged hospital stay, reduced quality of life, increased medical costs, and even higher mortality. There is no definite and effective drug treatment for POCD. More evidence shows that perioperative non-pharmacological intervention can improve postoperative cognitive function and reduce the incidence of POCD. Therefore, our studies summarize the current non-pharmacological interventions of POCD from the aspects of cognitive training, physical activity, transcutaneous electrical acupoint stimulation, noninvasive brain stimulation, non-pharmacological sleep improvement, music therapy, environment, and multimodal combination Interventions, to provide more data for clinical application and research.
Language	English
Publishing date	2024-05-01
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2024.1369821
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Article: Chitosan-based composite microspheres for treatment of hexavalent chromium and EBBR from aqueous solution

Han, Shiqi / Zhou, Xuelei / Xie, Honghao / Wang, Xiaohong / Yang, Lingze / Wang, Huili / Hao, Chen

Chemosphere. 2022 June 22,

2022

Abstract: Hexavalent chromium is widely used in industrial fields, but its pollution has posed a great threat to the environment due to its high toxicity. We created a chitosan-based microsphere biosorbent (CP) by combining polyethyleneimine with chitosan adopting ...

Abstract	Hexavalent chromium is widely used in industrial fields, but its pollution has posed a great threat to the environment due to its high toxicity. We created a chitosan-based microsphere biosorbent (CP) by combining polyethyleneimine with chitosan adopting inverse emulsion polymerization method. Under the optimal conditions (pH = 3), the maximum adsorption capacity of composite microspheres can reach 299.89 mg g⁻¹, which is much higher than that of chitosan microspheres (168.91 mg g⁻¹). When the amount of CP is 0.25 g L⁻¹, the removal rate of 50 mg L⁻¹ Cr(VI) and 50 mg L⁻¹ Eriochrome blue-black R (EBBR) can reach 95% and 99%, respectively. The time required for CP to reach adsorption equilibrium (180 min) was significantly shorter than that of chitosan microspheres (540 min), and the adsorption rate was significantly improved. Langmuir isotherm model, pseudo-second-order kinetic model and thermodynamic calculation results penetrated an endothermic spontaneous, monolayer, and chemical adsorption process. Biomass composite microspheres CP has obvious selectivity and the adsorption capacity retention rate of CP was still 71.32% after four adsorption cycles. This work proposed an easily prepared and biomass-based microspheres for the effective removal of Cr(VI) in printing and dyeing wastewater pollution through adsorption.
Keywords	adsorption ; aqueous solutions ; biomass ; biosorbents ; chitosan ; chromium ; emulsions ; endothermy ; kinetics ; microparticles ; pH ; polyethyleneimine ; polymerization ; sorption isotherms ; thermodynamics ; toxicity ; water pollution
Language	English
Dates of publication	2022-0622
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2022.135486
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 2540: Show issues

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Article ; Online: Chitosan-based composite microspheres for treatment of hexavalent chromium and EBBR from aqueous solution.

Han, Shiqi / Zhou, Xuelei / Xie, Honghao / Wang, Xiaohong / Yang, Lingze / Wang, Huili / Hao, Chen

Chemosphere

2022 Volume 305, Page(s) 135486

Abstract	Hexavalent chromium is widely used in industrial fields, but its pollution has posed a great threat to the environment due to its high toxicity. We created a chitosan-based microsphere biosorbent (CP) by combining polyethyleneimine with chitosan adopting inverse emulsion polymerization method. Under the optimal conditions (pH = 3), the maximum adsorption capacity of composite microspheres can reach 299.89 mg g
MeSH term(s)	Adsorption ; Chitosan ; Chromium/analysis ; Hydrogen-Ion Concentration ; Kinetics ; Microspheres ; Waste Water ; Water Pollutants, Chemical ; Water Purification/methods
Chemical Substances	Waste Water ; Water Pollutants, Chemical ; Chromium (0R0008Q3JB) ; chromium hexavalent ion (18540-29-9) ; Chitosan (9012-76-4)
Language	English
Publishing date	2022-06-25
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2022.135486
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Study on the performance of novel nanomaterials for detection of biomarkers such as PCT based on immunochromatography sensitivity.

Jiao, Feiyan / Song, Bailing / Wang, Lei / Zhou, Hao / Zhou, Xuelei / Liu, Tingwei / Li, Xinxia / Li, Jiutong

Nanotechnology

2023 Volume 34, Issue 22

Abstract: In this study, by comparing the UV-vis spectral characteristics of colloidal gold and colloidal gold enhancer, and their differences as immunochromatographic tracers in the qualitative detection of PCT, IL-6, Hp and quantitative determination of PCT ... ...

Abstract	In this study, by comparing the UV-vis spectral characteristics of colloidal gold and colloidal gold enhancer, and their differences as immunochromatographic tracers in the qualitative detection of PCT, IL-6, Hp and quantitative determination of PCT performance, the factors that may affect the sensitivity were discussed. The results show that the absorbance at 520 nm of CGE diluted 20-fold and colloidal gold diluted 2-fold were comparable, and the sensitivity of CGE immunoprobe for qualitative detection of PCT, IL-6 and Hp was higher than that of colloidal gold immunoprobe, and the reproducibility and accuracy of both immunoprobes for quantitative detection of PCT were good. Indicating that the high sensitivity of CGE immunoprobe detection is mainly due to the absorption coefficient of CGE at 520 nm is about 10 times that of colloidal gold immunoprobe, CGE has stronger light absorption capacity and stronger quenching effect on rhodamine 6 G on the nitrocellulose membrane surface of the test strip.
MeSH term(s)	Biomarkers ; Chromatography, Affinity/methods ; Gold Colloid/chemistry ; Interleukin-6 ; Reproducibility of Results ; Nanostructures
Chemical Substances	Biomarkers ; Gold Colloid ; Interleukin-6
Language	English
Publishing date	2023-03-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1362365-5
ISSN	1361-6528 ; 0957-4484
ISSN (online)	1361-6528
ISSN	0957-4484
DOI	10.1088/1361-6528/acbf57
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: TASP1 Promotes Proliferation and Migration in Gastric Cancer via EMT and AKT/P-AKT Pathway.

Wan, Xue-Mei / Zhou, Xue-Lei / Du, Yong-Jun / Shen, Hui / Yang, Zhengxia / Ding, Yanhong

Journal of immunology research

2021 Volume 2021, Page(s) 5521325

Abstract: Threonine aspartase 1 (TASP1) was reported to function in the development of cancer. However, the regulatory mechanism of TASP1 in gastric cancer (GC) remains unclear. In this study, we determined the expression of TASP1 in tissues of GC patients, GC ... ...

Abstract	Threonine aspartase 1 (TASP1) was reported to function in the development of cancer. However, the regulatory mechanism of TASP1 in gastric cancer (GC) remains unclear. In this study, we determined the expression of TASP1 in tissues of GC patients, GC cells by qRT-PCR, and western blot and assessed the relationship between TASP1 and GC cell proliferation and migration via CCK-8 and transwell assay. It was found that the expression of TASP1 in GC tissues or GC cell lines was significantly higher than that in normal adjacent tissues or normal cells. The proliferation and migration of GC cells were inhibited upon TASP1 knockdown. Mechanism investigation revealed that TASP1 promoted GC cell proliferation and migration through upregulating the p-AKT/AKT expression. TASP1 induced GC cell migration via the epithelial -mesenchymal transition (EMT) pathway. In conclusion, TASP1 promotes GC progression through the EMT and AKT/p-AKT pathway, and it may serve as a new potential biomarker and therapeutic target for GC.
MeSH term(s)	Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Endopeptidases/genetics ; Endopeptidases/metabolism ; Epithelial-Mesenchymal Transition/genetics ; Gastric Mucosa/pathology ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/genetics ; Stomach Neoplasms/genetics ; Stomach Neoplasms/pathology ; Up-Regulation
Chemical Substances	AKT1 protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Endopeptidases (EC 3.4.-) ; taspase1, human (EC 3.4.22.-)
Language	English
Publishing date	2021-04-29
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2817541-4
ISSN	2314-7156 ; 2314-8861
ISSN (online)	2314-7156
ISSN	2314-8861
DOI	10.1155/2021/5521325
Database	MEDical Literature Analysis and Retrieval System OnLINE

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