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  1. AU="Zhou, Xunjian"
  2. AU="Montero-Vergara, Jetsy"
  3. AU="Pryce, David"
  4. AU="Stabel, Judith R"
  5. AU=Badgley C E AU=Badgley C E
  6. AU=Riback Joshua A.
  7. AU="Sethi, Ansh"
  8. AU="Tibbo, Meagan E"
  9. AU="Prechtl, Stefan"
  10. AU="Kuanyshbek, Alibek"
  11. AU="Annukka Pasanen"
  12. AU="Yi, Ling Ka"
  13. AU="Kong, Hyejin"
  14. AU="Bilio, João"
  15. AU=Hill Stephen J
  16. AU="Hatayama, Sho"
  17. AU="Ruuskanen, Suvi K"
  18. AU="Kim, Song-Rae"
  19. AU="Mizia-Stec, Katarzyna"
  20. AU="Helen V. Firth"
  21. AU=Giroux Leprieur Etienne
  22. AU="Xinhui Gao"
  23. AU="Christoph Schlapbach"
  24. AU="Akbar, Shayista"
  25. AU="Butler, Eboneé N"
  26. AU="Moura-Alves, Márcio"
  27. AU="Marcet, Ismael"
  28. AU=Eichfelder Sebastian
  29. AU=Timins M E
  30. AU="Weber, Stephan"
  31. AU=Galuska David
  32. AU="Carrieri, Mariella"
  33. AU="Hafkamp, Frederique J"
  34. AU="Jessica M. Perkins"
  35. AU="Tariq, Syeda Sumayya"
  36. AU="Meehan, Rebecca"

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  1. Artikel: Prognostic value and therapeutic potential of NEK family in stomach adenocarcinoma.

    Zhou, Xunjian / Nie, Hui / Wang, Chunrong / Yu, Xiaoqian / Yang, Xuejie / He, Xiaoyun / Ou, Chunlin

    Journal of Cancer

    2024  Band 15, Heft 10, Seite(n) 3154–3172

    Abstract: Never in mitosis gene A-related kinase (NEK) is an 11-membered family of serine/threonine kinases (NEK1-NEK11), which are known to play important roles in the formation and development of cancer. However, few studies have examined the roles of these ... ...

    Abstract Never in mitosis gene A-related kinase (NEK) is an 11-membered family of serine/threonine kinases (NEK1-NEK11), which are known to play important roles in the formation and development of cancer. However, few studies have examined the roles of these kinases in the development of stomach adenocarcinoma (STAD). In this study, we conducted a comprehensive analysis of the relationships between the NEKs family members and STAD. The differential expression of the
    Sprache Englisch
    Erscheinungsdatum 2024-04-15
    Erscheinungsland Australia
    Dokumenttyp Journal Article
    ZDB-ID 2573318-7
    ISSN 1837-9664
    ISSN 1837-9664
    DOI 10.7150/jca.90197
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: NKX2-1-AS1 promotes the lymphangiogenesis of lung adenocarcinoma through regulation of ERG-mediated FABP4.

    Tao, Ting / Chen, Hui / Xu, Qimei / Li, Zhen / Chen, Xuelian / Zhou, Xunjian / Luo, Wu

    Tissue & cell

    2024  Band 87, Seite(n) 102314

    Abstract: Lymphatic metastasis is a common metastasis of lung adenocarcinoma (LUAD). The current study illustrated the action of lncRNA NKX2-1-AS1 in lymphangiogenesis in LUAD and the underlying mechanisms. Clinical tissue samples were collected for determining ... ...

    Abstract Lymphatic metastasis is a common metastasis of lung adenocarcinoma (LUAD). The current study illustrated the action of lncRNA NKX2-1-AS1 in lymphangiogenesis in LUAD and the underlying mechanisms. Clinical tissue samples were collected for determining NKX2-1-AS1 expression. Then, H441 and H661 cells were selected to perform gain- and loss-of-function assays for dissecting the roles of NKX2-1-AS1 in LUAD cell proliferation and migration. Besides, H441 and H661 cell supernatant was harvested to stimulate HLECs for assessing tube formation ability. Interaction among NKX2-1-AS1, ERG, and fatty acid binding protein 4 (FABP4) was validated through luciferase and RIP assays. NKX2-1-AS1 was highly-expressed in LUAD tissues. Silencing NKX2-1-AS1 suppressed H441 and H661 cell proliferation and migration, reduced expression levels of lymphangiogenesis-related factors (LYVE-1, VEGF-C, VEGFR3, VEGF-A, VEGFR2, and CCR7), and inhibited HLEC tube formation. Interaction validation demonstrated that NKX2-1-AS1 regulated FABP4 transcription by binding to ERG. Overexpression of FABP4 could effectively block the inhibition role of NKX2-1-AS1 silencing in lymphangiogenesis in H441 and H661 cells. This study provided evidence that NKX2-1-AS1 regulated FABP4 transcription by binding to ERG to facilitate the proliferation and migration of LUAD cells and tube formation of HLECs, thus participating in lymphangiogenesis.
    Mesh-Begriff(e) Humans ; Adenocarcinoma/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Fatty Acid-Binding Proteins/genetics ; Fatty Acid-Binding Proteins/metabolism ; Gene Expression Regulation, Neoplastic ; Lung/pathology ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Lymphangiogenesis/genetics ; MicroRNAs/genetics ; RNA, Long Noncoding/genetics ; Transcriptional Regulator ERG/genetics ; Transcriptional Regulator ERG/metabolism
    Chemische Substanzen ERG protein, human ; FABP4 protein, human ; Fatty Acid-Binding Proteins ; MicroRNAs ; RNA, Long Noncoding ; Transcriptional Regulator ERG ; NKX2-1 protein, human
    Sprache Englisch
    Erscheinungsdatum 2024-01-29
    Erscheinungsland Scotland
    Dokumenttyp Journal Article
    ZDB-ID 204424-9
    ISSN 1532-3072 ; 0040-8166
    ISSN (online) 1532-3072
    ISSN 0040-8166
    DOI 10.1016/j.tice.2024.102314
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Artikel: Malignant rhabdoid tumor of the omentum in an adult male: a case report and literature review.

    Zhou, Xunjian / Duan, Zhi / Tao, Ting / Li, Zhen / Wang, Ning / Xu, Qimei / Wei, Meiyan / Zhong, Zheng / Liu, Ran / Yin, Qinghua / Xiong, Lixin / Chen, Hui

    Frontiers in oncology

    2023  Band 13, Seite(n) 1230021

    Abstract: Malignant rhabdoid tumors (MRTs) are rare tumors with high mortality rates and poor prognoses. MRTs occur mainly in the central nervous system, kidneys, and soft tissues, but rarely in the omentum. MRTs occur more commonly in infants and children and ... ...

    Abstract Malignant rhabdoid tumors (MRTs) are rare tumors with high mortality rates and poor prognoses. MRTs occur mainly in the central nervous system, kidneys, and soft tissues, but rarely in the omentum. MRTs occur more commonly in infants and children and less frequently in adults. Here, we report the first observed case of MRT in an adult omentum. A 35-year-old man with abdominal distension and pain was admitted to the emergency department. Previously, several hospitals considered patients with cirrhosis who had not received active treatment. Computed tomography and magnetic resonance imaging revealed diffuse omental thickening and massive ascites. The surgery was performed at our hospital, and the pathological diagnosis was MRT with a SMARCB1(INI-1) deletion. Postoperatively, his symptoms improved, and he underwent five cycles of chemotherapy. However, 6 months after surgery, the tumor developed liver metastases, and the patient subsequently died. Primary MRT of the greater omentum is rare, and its pathological diagnosis usually requires extensive clinicopathological evaluation of various differential diagnoses and an appropriate work-up to exclude other malignancies associated with SMARCB1 deletion. At the same time, the lack of specific signs of omental MRT and its rapid progression should alert clinicians.
    Sprache Englisch
    Erscheinungsdatum 2023-08-18
    Erscheinungsland Switzerland
    Dokumenttyp Case Reports
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1230021
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Purified Vitexin Compound 1 Serves as a Promising Antineoplastic Agent in Ovarian Cancer.

    Ma, Kewen / Wang, Kuansong / Zhou, Yingjun / Liu, Nian / Guo, Wei / Qi, Jialin / Hu, Zhenmin / Su, Shitong / Tang, Ping / Zhou, Xunjian

    Frontiers in oncology

    2021  Band 11, Seite(n) 734708

    Abstract: Ovarian cancer is a common gynecologic aggressive neoplasm. The mortality of ovarian cancer is top among gynecologic malignancies due to the insidious onset, atypical early symptoms, and chemoresistance. Therefore, it is urgent to seek another promising ... ...

    Abstract Ovarian cancer is a common gynecologic aggressive neoplasm. The mortality of ovarian cancer is top among gynecologic malignancies due to the insidious onset, atypical early symptoms, and chemoresistance. Therefore, it is urgent to seek another promising treatment for ovarian cancer. Purified vitexin compound 1 (VB1) is a kind of neolignan from the seed of traditional Chinese herb vitex negundo that possessed diverse pharmacological effects. VB1 can exhibit anti-neoplastic activities against various cancers. However, the role of VB1 in ovarian cancer treatment has not been elaborated, and the mechanism is unknown. The aim of this study was to investigate the therapeutic effects of VB1 in ovarian cancer cells both
    Sprache Englisch
    Erscheinungsdatum 2021-09-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.734708
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: SOX10 - A Novel Marker for the Differential Diagnosis of Breast Metaplastic Squamous Cell Carcinoma.

    Qi, Jialin / Hu, Zhenmin / Xiao, Heng / Liu, Ruijie / Guo, Wei / Yang, Zhichun / Ma, Kewen / Su, Shitong / Tang, Ping / Zhou, Xunjian / Zhou, Jianhua / Wang, Kuansong

    Cancer management and research

    2020  Band 12, Seite(n) 4039–4044

    Abstract: Introduction: Differential diagnosis of metaplastic squamous cell carcinoma of breast (MSCCB) is difficult. In particular, in terms of metastatic MSCCB, because of the low speciality of traditional markers such as mammaglobin, gross cystic disease fluid ...

    Abstract Introduction: Differential diagnosis of metaplastic squamous cell carcinoma of breast (MSCCB) is difficult. In particular, in terms of metastatic MSCCB, because of the low speciality of traditional markers such as mammaglobin, gross cystic disease fluid protein-15 (GCDFP-15) and GATA binding protein 3 (GATA3), the most common problem is differentiating the spread of MSCCB to the lung from a primary lung squamous cell carcinoma. It is urgently required to explore a novel marker to aid in differential diagnosis.
    Aim: The aim of this study is to explore a novel marker to aid in the differential diagnosis of MSCCB from other squamous cell carcinomas (SCC) in other organs.
    Methods: We tested the expression of SOX10 in 375 human SCC specimens with immunohistochemistry (IHC).
    Results: In a series of 20 MSCCB, 9 (45%) were positive for SOX10. All of them were triple-negative MSCCB. Conversely, SOX10 was totally negative in another 205 SCC originating from lung, skin, cervix, oral mucosa, and esophagus. In a series of 150 triple-negative breast cancer and their metastatic foci, SOX10 labeling in the primary tumor and metastasis was 78% and 79.3%, respectively, and the agreement rate was 97.3% (
    Conclusion: Our findings demonstrate that SOX10 was recommended for differentiating MSCCB from non-mammary metastasis to the breast, as well as for distinguishing primary SCC from metastatic MSCCB, and SOX10 may be valuable in the pathological diagnosis of breast-derived metaplastic squamous cell carcinoma.
    Sprache Englisch
    Erscheinungsdatum 2020-05-28
    Erscheinungsland New Zealand
    Dokumenttyp Journal Article
    ZDB-ID 2508013-1
    ISSN 1179-1322
    ISSN 1179-1322
    DOI 10.2147/CMAR.S250867
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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