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Article: Cerebral aspergillosis after heart-lung transplantation in a child: Case report with 3-year follow-up and literature review.

Zhuang, Huanwei / Xiang, Kun / Gong, Shuji / Zhou, Yangang / Chen, Jinlan

2023 Volume 9, Page(s) 1042631

Abstract: There are limited cases of heart-lung transplantation (HLT) in children worldwide owing to lack of donors, demanding surgical teamwork, and arduous post-operative management. Post-transplant management difficulties stem from the possible development of ... ...

Abstract	There are limited cases of heart-lung transplantation (HLT) in children worldwide owing to lack of donors, demanding surgical teamwork, and arduous post-operative management. Post-transplant management difficulties stem from the possible development of several post-operative complications, with infection being a common complication. Intracranial fungal infections are difficult to diagnose and prone to treatment delays because of their relatively insidious onset and atypical clinical presentation. Here, we present a case of a cerebral infection developed 3 months after HLT in a 10-year-old child, showing no positive results on conventional imaging or cerebrospinal fluid (CSF) examination and culture. On metagenomic next-generation sequencing of the cerebrospinal fluid, the causative organism was finally determined as
Language	English
Publishing date	2023-01-06
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.1042631
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Article ; Online: Insight into autophagy in platinum resistance of cancer.

Yang, Fang / Xu, Ke / Zhou, Yan-Gang / Ren, Tao

International journal of clinical oncology

2023 Volume 28, Issue 3, Page(s) 354–362

Abstract: Platinum drugs, as a class of widely used chemotherapy agents, frequently appear in the treatment of cancer at different phrases. However, platinum resistance is the major bottleneck of platinum drugs for exerting anti-tumor effect. At present, the ... ...

Abstract	Platinum drugs, as a class of widely used chemotherapy agents, frequently appear in the treatment of cancer at different phrases. However, platinum resistance is the major bottleneck of platinum drugs for exerting anti-tumor effect. At present, the mechanism of platinum resistance has been thoroughly explored in terms of drug delivery methods, DNA damage repair function, etc., but it has not yet been translated into an effective weapon for reversing platinum resistance. Recently, autophagy has been proved to be closely related to platinum resistance, and the involved molecular mechanism may provide a new perspective on platinum resistance. The aim of this review is to sort out the studies related to autophagy and platinum resistance, and to focus on summarizing the relevant molecular mechanisms, so as to provide clues for future studies related to autophagy and platinum resistance.
MeSH term(s)	Humans ; Platinum/therapeutic use ; Platinum/pharmacology ; Drug Resistance, Neoplasm ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/pharmacology ; Neoplasms/drug therapy ; Neoplasms/genetics ; Autophagy
Chemical Substances	Platinum (49DFR088MY) ; Antineoplastic Agents
Language	English
Publishing date	2023-01-27
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	1400227-9
ISSN	1437-7772 ; 1341-9625
ISSN (online)	1437-7772
ISSN	1341-9625
DOI	10.1007/s10147-023-02301-5
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Article ; Online: Analysis of the clinical application of ceftazidime-avibactam in China.

Wang, Qing / Xu, Ping / Zhou, Yangang

Journal of infection and public health

2022 Volume 15, Issue 4, Page(s) 455–459

Abstract: Background: The efficacy and safety of ceftazidime-avibactam were mainly reported in phase II and phase III clinical trials, rarely in the real-world study. The limited real-world study which evaluated the clinical response of this drug shown ... ...

Abstract	Background: The efficacy and safety of ceftazidime-avibactam were mainly reported in phase II and phase III clinical trials, rarely in the real-world study. The limited real-world study which evaluated the clinical response of this drug shown inconsistent results. This study aimed to investigate the rationality of the clinical use of ceftazidime-avibactam and to evaluate its clinical response in the treatment of multidrug-resistant gram-negative bacteria (MDR-GNB) infections in China. Methods: This retrospective study evaluated the outcomes of adult patients with MDR-GNB infections treated with ceftazidime-avibactam during September 2018 to August 2020. Patients' characteristics, comorbidities, microbes, laboratory indicators and medication information were collected. The rationality of ceftazidime-avibactam clinical use, and its clinical response in the treatment of MDR-GNB infections were analyzed. Results: A total of 30 patients were included in this study, of which, 66.6% received target treatment, 26.7% received empirical treatment, and 6.7% received treatment with no indication. Only 50.0% (11/22) of patients were administrated the recommended dose according to the drug instruction or guidelines, at a median treatment duration of 10 days (range: 2-74 days). The most common source of infection was pneumonia (53.6%, 15/28). Carbapenem-resistant Klebsiella pneumoniae was the predominant pathogen (65%, 13/20). A total of 16 patients (61.5%) achieved clinical response. Patients received target treatment had higher clinical response rate than that of patients received empirical treatment (77.8% vs 25.0%, P = 0.026). A total of 11 patients (61.1%) achieved microbiological response. One patient occurred gastrointestinal adverse reactions. Conclusions: It is necessary to strengthen the monitor of the clinical application of ceftazidime-avibactam, such as the appropriate indication, reasonable dosage and duration, to improve its clinical outcome. Our results showed that ceftazidime-avibactam might be a potencial choice for the MDR-GNB infections. However, further research are still needed to identify its efficacy and safety in the real world.
MeSH term(s)	Adult ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Azabicyclo Compounds/adverse effects ; Ceftazidime/adverse effects ; Drug Combinations ; Drug Resistance, Multiple, Bacterial ; Gram-Negative Bacterial Infections/microbiology ; Humans ; Microbial Sensitivity Tests ; Retrospective Studies ; beta-Lactamase Inhibitors/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Azabicyclo Compounds ; Drug Combinations ; avibactam, ceftazidime drug combination ; beta-Lactamase Inhibitors ; Ceftazidime (9M416Z9QNR)
Language	English
Publishing date	2022-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2467587-8
ISSN	1876-035X ; 1876-0341
ISSN (online)	1876-035X
ISSN	1876-0341
DOI	10.1016/j.jiph.2022.02.003
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Article ; Online: Fan beam CT-guided online adaptive external radiotherapy of uterine cervical cancer: a dosimetric evaluation.

Peng, Haibo / Zhang, Jie / Xu, Ningyue / Zhou, Yangang / Tan, Huigang / Ren, Tao

BMC cancer

2023 Volume 23, Issue 1, Page(s) 588

Abstract: Purpose: To discuss the dosimetric advantages and reliability of the accurate delivery of online adaptive radiotherapy(online ART) for uterine cervical cancer(UCC).: Methods and materials: Six UCC patients were enrolled in this study. 95% of the ... ...

Abstract	Purpose: To discuss the dosimetric advantages and reliability of the accurate delivery of online adaptive radiotherapy(online ART) for uterine cervical cancer(UCC). Methods and materials: Six UCC patients were enrolled in this study. 95% of the planning target volume (PTV) reached 100% of the prescription dose (50.4 Gy/28fractions/6weeks) was required. The patients were scanned with uRT-Linac 506c KV-FBCT then the target volume (TV) and organs at risk (OARs) were delineated by doctors. The dosimeters designed and obtained a routine plan (Plan0). KV-FBCT was used for image guidance before subsequent fractional treatment. The online ART was processed after registration, which acquired a virtual nonadaptive radiotherapy plan (VPlan) and an adaptive plan (APlan). VPlan was the direct calculation of Plan0 on the fractional image, while APlan required adaptive optimization and calculation. In vivo dose monitoring and three-dimensional dose reconstruction were required during the implementation of APlan. Results: The inter-fractional volumes of the bladder and rectum changed greatly among the treatments. These changes influenced the primary gross tumor volume (GTVp) and the position deviation of GTVp and PTV and positively affected the prescription dose coverage of TV. GTVp decreased gradually along with dose accumulation. The Dmax, D98, D95, D50, and D2 of APlan were superior to those of VPlan in target dose distribution. APlan had good conformal index, homogeneity index and target coverage. The rectum V40 and Dmax, bladder V40, the small bowel V40 and Dmax of APlan were better than that of VPlan. The APlan's fractional mean γ passing rate was significantly higher than the international standard and the mean γ passing rate of all cases after the three-dimensional reconstruction was higher than 97.0%. Conclusion: Online ART in external radiotherapy of UCC significantly improved the dose distribution and can become an ideal technology to achieve individualized precise radiotherapy.
MeSH term(s)	Female ; Humans ; Radiotherapy Planning, Computer-Assisted/methods ; Uterine Cervical Neoplasms/diagnostic imaging ; Uterine Cervical Neoplasms/radiotherapy ; Reproducibility of Results ; Organs at Risk ; Radiotherapy, Intensity-Modulated/methods ; Radiotherapy, Image-Guided/methods ; Radiotherapy Dosage ; Tomography, X-Ray Computed
Language	English
Publishing date	2023-06-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-023-11089-6
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Article: Analysis of patient medication compliance and quality of life of physician-pharmacist collaborative clinics for T2DM management in primary healthcare in China: A mixed-methods study.

Xiao, Jie / Wang, Qing / Tan, Shenglan / Chen, Lei / Tang, Bingjie / Huang, Shuting / Zhou, Yangang / Xu, Ping

Frontiers in pharmacology

2023 Volume 14, Page(s) 1098207

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-03-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1098207
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Article ; Online: Abnormalities of the Serum proteomic in thrombosis after CVC catheterization in patients with end-stage renal disease.

Wang, Li / Mei, Xi / Zhou, Yangang / Zeng, Jun / Yang, Ting / Liao, Lumiu / Xiong, Man / Zhao, Xiaoshan / He, Rui

Iranian journal of kidney diseases

2023 Volume 17, Issue 6, Page(s) 335–347

Abstract: Introduction: This study utilized serum proteomics with tandem mass tags (TMT) to investigate potential biomarkers associated with femoral central venous catheter (CVC) thrombosis in endstage kidney disease (ESKD) patients. TMT proteomics analysis on ... ...

Abstract	Introduction: This study utilized serum proteomics with tandem mass tags (TMT) to investigate potential biomarkers associated with femoral central venous catheter (CVC) thrombosis in endstage kidney disease (ESKD) patients. TMT proteomics analysis on serum samples was conducted to identify proteins with distinct expression levels that may be linked to thrombosis. The findings have important implications for enhancing anticoagulant procedures, catheter closure techniques, and determining optimal intervention timing for post-catheterization dialysis. Methods: Thirty ESKD patients with CVC receiving hemodialysis between May 2021 and October 2022 at the First Affiliated Hospital of Chengdu Medical College were included in the study, and grouped according to vascular color Doppler ultrasound results, including 23 patients in the thrombo-positive group and 7 patients in the thrombo-negative group. Selection criteria were: 1) Patients with ESKD candidate for hemodialysis initiation; 2) no dialysis access has been placed previously, and CVC needs to be inserted as a temporary access; 3) patients volunteered to participate in this clinical study. Clinical data, blood tests, coagulation function, and biochemical parameters were collected and analyzed on the 14th day after catheterization. Color ultrasonography was conducted on the same day to categorize patients into two groups: those with thrombus-positive results and those with thrombus-negative results. Results: TMT proteomics analysis identified twenty-eight differently expressed proteins, including 16 upregulated and 12 downregulated proteins. Enrichment analysis demonstrated nine proteins that were significantly enriched in four pathways within the thrombus-positive group after CVC insertion. Enzyme-linked immunosorbent assay (ELISA) test confirmed the TMT proteomics findings, specifically highlighting significant differences in human plasma kallikrein B1 (KLKB1) and angiopoietin-like protein 3 (ANGPTL3) levels on the 14th day after CVC insertion. Additionally, KLKB1, fibrinogen (FIB), D-dimer, and fibrinogen degradation products (FDP) levels were significantly elevated, while ANGPTL3 levels were decreased on the 14th day after CVC insertion in the thrombus-positive ESKD patient group. Conclusion: Monitoring coagulation status post-CVC catheterization and evaluating potential biomarkers like KLKB1 and ANGPTL3 can contribute to the development of personalized treatment plans, improving the quality of hemodialysis and the overall quality of life for ESKD patients. DOI: 10.52547/ijkd.7671.
MeSH term(s)	Humans ; Catheterization, Central Venous/methods ; Proteomics ; Quality of Life ; Thrombosis/diagnostic imaging ; Thrombosis/etiology ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Renal Dialysis/adverse effects ; Renal Dialysis/methods ; Biomarkers ; Fibrinogen ; Angiopoietin-Like Protein 3
Chemical Substances	Biomarkers ; Fibrinogen (9001-32-5) ; ANGPTL3 protein, human ; Angiopoietin-Like Protein 3
Language	English
Publishing date	2023-11-28
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2388271-2
ISSN	1735-8604 ; 1735-8582
ISSN (online)	1735-8604
ISSN	1735-8582
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Article ; Online: Optimization of polymyxin B regimens for the treatment of carbapenem-resistant organism nosocomial pneumonia: a real-world prospective study.

Tang, Tiantian / Li, Ying / Xu, Ping / Zhong, Yanjun / Yang, Min / Ma, Wanjun / Xiang, Daxiong / Zhang, Bikui / Zhou, Yangang

Critical care (London, England)

2023 Volume 27, Issue 1, Page(s) 164

Abstract: Background: Polymyxin B is the first-line therapy for Carbapenem-resistant organism (CRO) nosocomial pneumonia. However, clinical data for its pharmacokinetic/pharmacodynamic (PK/PD) relationship are limited. This study aimed to investigate the ... ...

Abstract	Background: Polymyxin B is the first-line therapy for Carbapenem-resistant organism (CRO) nosocomial pneumonia. However, clinical data for its pharmacokinetic/pharmacodynamic (PK/PD) relationship are limited. This study aimed to investigate the relationship between polymyxin B exposure and efficacy for the treatment of CRO pneumonia in critically ill patients, and to optimize the individual dosing regimens. Methods: Patients treated with polymyxin B for CRO pneumonia were enrolled. Blood samples were assayed using a validated high-performance liquid chromatography-tandem mass spectrometry method. Population PK analysis and Monte Carlo simulation were performed using Phoenix NLME software. Logistic regression analyses and receiver operating characteristic (ROC) curve were employed to identify the significant predictors and PK/PD indices of polymyxin B efficacy. Results: A total of 105 patients were included, and the population PK model was developed based on 295 plasma concentrations. AUC Conclusions: For CRO pneumonia, daily dose of 75 and 100 mg Q12 h was recommended for clinical efficacy. Inhalation of polymyxin B is beneficial for patients who cannot achieve the target concentration by intravenous administration.
MeSH term(s)	Humans ; Polymyxin B/therapeutic use ; Polymyxin B/pharmacology ; Anti-Bacterial Agents ; Carbapenems/therapeutic use ; Prospective Studies ; Cross Infection/drug therapy ; Healthcare-Associated Pneumonia/drug therapy ; Pneumonia/drug therapy ; Microbial Sensitivity Tests
Chemical Substances	Polymyxin B (J2VZ07J96K) ; Anti-Bacterial Agents ; Carbapenems
Language	English
Publishing date	2023-04-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2041406-7
ISSN	1466-609X ; 1364-8535
ISSN (online)	1466-609X
ISSN	1364-8535
DOI	10.1186/s13054-023-04448-z
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Article ; Online: Higher incidence of neurotoxicity and skin hyperpigmentation in renal transplant patients treated with polymyxin B.

Zhou, Yangang / Li, Ying / Xie, Xubiao / Song, Lei / Lan, Gongbin / Sun, Bao / Tang, Tiantian / Yan, Han / Zhang, Bikui / Xu, Ping

British journal of clinical pharmacology

2022 Volume 88, Issue 11, Page(s) 4742–4750

Abstract: Background: Toxicity is a major concern related to the clinical use of polymyxin B, and available safety data for renal transplant patients are limited.: Aims: We investigated the safety of polymyxin B and toxicity risk factors in renal transplant ... ...

Abstract	Background: Toxicity is a major concern related to the clinical use of polymyxin B, and available safety data for renal transplant patients are limited. Aims: We investigated the safety of polymyxin B and toxicity risk factors in renal transplant patients. Methods: A prospective study was performed on a group of renal transplant patients who received intravenous polymyxin B between January 2018 and August 2021. Polymyxin B treatment was monitored to evaluate toxicity and risk factors. Results: A total of 235 courses of polymyxin B were administered to 213 patients. Of these, 121 (51.5%) developed skin hyperpigmentation (SH), 149 (63.4%) developed neurotoxicity and 10 (5.5%) developed acute kidney injury of which 80% was reversible. Risk factors for developing SH included a high total dose by weight (odds ration [OR] 1.31, 95% confidence interval [CI] 1.08-1.60, P = .008) and the presence of neurotoxicity (OR 2.86, 95% CI 1.56-5.26, P = .001). Neurotoxicity manifested during the first 2 days of treatment. Neurotoxicity occurred most commonly in women (OR 3.84, 95% CI 1.82-8.10, P < .0001), and the presence of SH (OR 1.98, 95% CI 1.13-3.46, P = .016) was also an independent risk factor. Conclusions: Neurotoxicity and SH are the two major adverse effects of polymyxin B in renal transplant patients, which may limit its clinical use.
MeSH term(s)	Anti-Bacterial Agents/adverse effects ; Female ; Humans ; Hyperpigmentation/chemically induced ; Hyperpigmentation/epidemiology ; Incidence ; Kidney Transplantation/adverse effects ; Neurotoxicity Syndromes/epidemiology ; Neurotoxicity Syndromes/etiology ; Polymyxin B/adverse effects ; Prospective Studies
Chemical Substances	Anti-Bacterial Agents ; Polymyxin B (J2VZ07J96K)
Language	English
Publishing date	2022-05-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	188974-6
ISSN	1365-2125 ; 0306-5251 ; 0264-3774
ISSN (online)	1365-2125
ISSN	0306-5251 ; 0264-3774
DOI	10.1111/bcp.15384
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Article ; Online: Exploring the anti-ferroptosis mechanism of Kai-Xin-San against Alzheimer's disease through integrating network pharmacology, bioinformatics, and experimental validation strategy in vivo and in vitro.

Yan, Chenchen / Yang, Song / Shao, Simai / Zu, Runru / Lu, Hao / Chen, Yuanzhao / Zhou, Yangang / Ying, Xiran / Xiang, Shixie / Zhang, Peixu / Li, Zhonghua / Yuan, Ye / Zhang, Zhenqiang / Wang, Pan / Xie, Zhishen / Wang, Wang / Ma, Huifen / Sun, Yiran

Journal of ethnopharmacology

2024 Volume 326, Page(s) 117915

Abstract: Ethnopharmacological relevance: Kai Xin San (KXS), first proposed by Sun Simiao during the Tang Dynasty, has been utilized to treat dementia by tonifying qi and dispersing phlegm.: Aim of the study: This study aimed to elucidate the mechanism by ... ...

Abstract	Ethnopharmacological relevance: Kai Xin San (KXS), first proposed by Sun Simiao during the Tang Dynasty, has been utilized to treat dementia by tonifying qi and dispersing phlegm. Aim of the study: This study aimed to elucidate the mechanism by which KXS exerts its therapeutic effects on Alzheimer's disease (AD) by targeting ferroptosis, using a combination of network pharmacology, bioinformatics, and experimental validation strategies. Materials and methods: The active target sites and the further potential mechanisms of KXS in protecting against AD were investigated through molecular docking, molecular dynamics simulation, and network pharmacology, and combined with the validation of animal experiments. Results: Computational and experimental findings provide the first indication that KXS significantly improves learning and memory defects and inhibits neuronal ferroptosis by repairing mitochondria damage and upregulating the protein expression of ferroptosis suppressor protein 1 (FSP1) in vivo APP/PS1 mice AD model. According to bioinformatics analysis, the mechanism by which KXS inhibits ferroptosis may involve SIRT1. KXS notably upregulated the mRNA and protein expression of SIRT1 in both vivo APP/PS1 mice and in vitro APP-overexpressed HT22 cells. Additionally, KXS inhibited ferroptosis induced by APP-overexpression in HT22 cells through activating the SIRT1-FSP1 signal pathway. Conclusions: Collectively, our findings suggest that KXS may inhibit neuronal ferroptosis through activating the SIRT1/FSP1 signaling pathway. This study reveals the scientific basis and underlying modern theory of replenishing qi and eliminating phlegm, which involves the inhibition of ferroptosis. Moreover, it highlights the potential application of SIRT1 or FSP1 activators in the treatment of AD and other ferroptosis-related diseases.
MeSH term(s)	Mice ; Animals ; Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Sirtuin 1/genetics ; Ferroptosis ; Molecular Docking Simulation ; Network Pharmacology ; Computational Biology ; Drugs, Chinese Herbal
Chemical Substances	Kai-Xin-San ; Sirtuin 1 (EC 3.5.1.-) ; Drugs, Chinese Herbal
Language	English
Publishing date	2024-02-13
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.117915
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Article ; Online: The efficacy and toxicity of metronomic oral vinorelbine monotherapy in patients with non-small cell lung cancer: a meta-analysis.

Xu, Ke / Liu, Tao / Zhang, Jie / Zhou, Yangang / Yang, Fang / Ren, Tao

International journal of clinical oncology

2020 Volume 25, Issue 9, Page(s) 1624–1634

Abstract: Purpose: To evaluate the efficacy and toxicity of metronomic oral vinorelbine monotherapy in patients with stage IIIB/IV and advanced non-small cell lung cancer (NSCLC).: Methods: The PubMed, Embase, Cochrane library, Wanfang, and CNKI databases were ...

Abstract	Purpose: To evaluate the efficacy and toxicity of metronomic oral vinorelbine monotherapy in patients with stage IIIB/IV and advanced non-small cell lung cancer (NSCLC). Methods: The PubMed, Embase, Cochrane library, Wanfang, and CNKI databases were searched for relevant studies. The overall response rate (ORR), disease control rate (DCR), progression-free survival (PFS), overall survival (OS), and incidence of severe adverse events (grade ≥ 3 adverse events; grade 3/4 AEs) were calculated using the methods of merging ratios and means. Merged ratios and means and their 95% confidence intervals (CIs) were used to descriptively analyze the efficacy and toxicity of metronomic oral vinorelbine monotherapy in patients with stage IIIB/IV and advanced NSCLC. Results: The ORR and DCR achieved with metronomic oral vinorelbine monotherapy were 12% (95% CI 5-20) and 48% (95% CI 38-59), respectively. Median PFS and OS were 3.46 months (95% CI 2.49-4.43) and 8.22 months (95% CI 7.21-9.24), respectively. The incidence of grade 3/4 AEs was 16% (95% CI 10-22). The more common grade 3/4 AEs were neutropenia 9% (95% CI 2-20) and leukopenia 8% (95% CI 1-19). Conclusion: Metronomic oral vinorelbine monotherapy has a certain effect on patients with stage IIIB/IV and advanced NSCLC, especially for untreated elderly patients. It offers the advantages of convenience, lower cost and acceptable incidence of severe adverse events.
MeSH term(s)	Administration, Metronomic ; Antineoplastic Agents, Phytogenic/administration & dosage ; Antineoplastic Agents, Phytogenic/adverse effects ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/pathology ; Clinical Trials as Topic ; Humans ; Leukopenia/chemically induced ; Lung Neoplasms/drug therapy ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Neutropenia/chemically induced ; Progression-Free Survival ; Treatment Outcome ; Vinorelbine/administration & dosage ; Vinorelbine/adverse effects
Chemical Substances	Antineoplastic Agents, Phytogenic ; Vinorelbine (Q6C979R91Y)
Language	English
Publishing date	2020-05-29
Publishing country	Japan
Document type	Journal Article ; Meta-Analysis
ZDB-ID	1400227-9
ISSN	1437-7772 ; 1341-9625
ISSN (online)	1437-7772
ISSN	1341-9625
DOI	10.1007/s10147-020-01707-9
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