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  1. Article ; Online: Asperustins A-J: Austocystins with Immunosuppressive and Cytotoxic Activities from

    Chang, Jin-Ling / Gan, Yu-Tian / Zhou, Yin-Hui / Peng, Xiao-Gang / Xie, Zuo-Ye / Meng, Xianggao / Li, Shu-Ming / Ruan, Han-Li

    Journal of natural products

    2024  Volume 87, Issue 4, Page(s) 966–975

    Abstract: Ten new ( ...

    Abstract Ten new (
    MeSH term(s) Aspergillus/chemistry ; Humans ; Immunosuppressive Agents/pharmacology ; Immunosuppressive Agents/chemistry ; Immunosuppressive Agents/isolation & purification ; Molecular Structure ; Crystallography, X-Ray ; Interleukin-6/metabolism ; Anthraquinones/pharmacology ; Anthraquinones/chemistry ; Animals ; Drug Screening Assays, Antitumor ; T-Lymphocytes/drug effects ; Mice ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/isolation & purification ; Cell Proliferation/drug effects
    Chemical Substances Immunosuppressive Agents ; Interleukin-6 ; Anthraquinones ; Antineoplastic Agents
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.3c01243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1144: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Diaporaustalides A-L, Austalide Meroterpenoids from a Plant Endophytic

    Chang, Jin-Ling / Pei, Jiao / Zhou, Yin-Hui / Ouyang, Qian-Xi / Qin, Chun-Lun / Hu, Jia-Yun / Meng, Xiang-Gao / Ruan, Han-Li

    Journal of natural products

    2023  Volume 87, Issue 1, Page(s) 141–151

    Abstract: Twelve new austalide meroterpenoids ( ...

    Abstract Twelve new austalide meroterpenoids (
    MeSH term(s) Molecular Structure ; Lipopolysaccharides/pharmacology ; Fungi ; Crystallography, X-Ray ; Circular Dichroism
    Chemical Substances Lipopolysaccharides
    Language English
    Publishing date 2023-12-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.3c00986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1144: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Effect of ABCB1 rs12720464 and rs1055302 polymorphisms in Chinese patients on the time course of action of rocuronium administered as a single dose.

    Qi, Tian-long / Zhou, Yin-hui / Yuan, Jing-jing / Li, Zhi-song / Wang, Zhong-yu / Chang, Yan-zi / Zhao, Er-xian / Cheng, Dan / Hou, Jun-kai / Tian, Yan / Chen, Ge-zi / Mao, Yuan-yuan / Ren, Yang / Zhang, Li-rong / Kan, Quan-cheng / Zhang, Wei

    International journal of clinical pharmacology and therapeutics

    2016  Volume 54, Issue 6, Page(s) 462–470

    Abstract: Objective: To determine whether ABCB1 gene polymorphisms affect the time course of action of rocuronium in Chinese patients.: Methods: This study included 105 unrelated Chinese patients undergoing general anesthesia with propofol, fentanyl, and ... ...

    Abstract Objective: To determine whether ABCB1 gene polymorphisms affect the time course of action of rocuronium in Chinese patients.
    Methods: This study included 105 unrelated Chinese patients undergoing general anesthesia with propofol, fentanyl, and rocuronium. Neuromuscular monitoring was performed with calibrated acceleromyography. Patients were allowed to recover spontaneously from the neuromuscular block. The time interval between the first maximum depression of the train of four (TOF) and spontaneous recovery TOF ratio of 0.25/0.7/0.8/0.9 was recorded. The Sequenom MassArray® single-nucleotide polymorphism (SNP) detection technology was used to detect the genotypes of the ABCB1 rs12720464, rs1055302. Demographic and non-genetic clinical data were also collected.
    Results: In the present study, the mean time to spontaneous recovery of TOF ratio 0.8/0.9 in ABCB1 rs12720464 GG genotype was longer compared to that observed in ABCB1 rs12720464 AG genotype (56.77 ± 14.23 minutes vs. 49.50 ± 10.49 minutes, and 62.58 ± 18.16 minutes vs. 53.20 ± 12.56 minutes, respectively, p < 0.05). Further, the time to spontaneous recovery of TOF 0.7/0.8/0.9 in ABCB1 rs1055302 GG genotype was longer than that in ABCB1 rs1055302 AG genotype (52.00 ± 12.10 minutes vs. 44.83 ± 7.38 minutes, 55.96 ± 13.92 minutes vs. 46.83 ± 7.67 minutes, 61.66 ± 17.70 minutes vs. 49.50 ± 8.44 minutes, respectively, p < 0.05).
    Conclusion: In Chinese patients who were administered a single dose of rocuronium, the genetic variants ABCB1 rs12720464, and rs1055302 contribute to the individual< variability of time course of action.
    MeSH term(s) ATP Binding Cassette Transporter, Sub-Family B/genetics ; Adult ; Androstanols/pharmacology ; Asian Continental Ancestry Group/genetics ; Female ; Genotype ; Humans ; Male ; Middle Aged ; Neuromuscular Nondepolarizing Agents/pharmacology ; Polymorphism, Single Nucleotide
    Chemical Substances ABCB1 protein, human ; ATP Binding Cassette Transporter, Sub-Family B ; Androstanols ; Neuromuscular Nondepolarizing Agents ; rocuronium (WRE554RFEZ)
    Language English
    Publishing date 2016-06
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 124384-6
    ISSN 0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
    ISSN 0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
    DOI 10.5414/CP202547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 467: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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