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  1. Article ; Online: A Binocular Stereo-Imaging-Perception System with a Wide Field-of-View and Infrared- and Visible Light-Dual-Band Fusion.

    Zhu, Youpan / Zhang, Dan / Zhou, Yongkang / Jin, Weiqi / Zhou, Lingling / Wu, Guanlin / Li, Yong

    Sensors (Basel, Switzerland)

    2024  Volume 24, Issue 2

    Abstract: With the continuous evolution of autonomous driving and unmanned driving systems, traditional limitations such as a limited field-of-view, poor ranging accuracy, and real-time display are becoming inadequate to satisfy the requirements of binocular ... ...

    Abstract With the continuous evolution of autonomous driving and unmanned driving systems, traditional limitations such as a limited field-of-view, poor ranging accuracy, and real-time display are becoming inadequate to satisfy the requirements of binocular stereo-perception systems. Firstly, we designed a binocular stereo-imaging-perception system with a wide-field-of-view and infrared- and visible light-dual-band fusion. Secondly we proposed a binocular stereo-perception optical imaging system with a wide field-of-view of 120.3°, which solves the small field-of-view of current binocular stereo-perception systems. Thirdly, For image aberration caused by the wide-field-of-view system design, we propose an ellipsoidal-image-aberration algorithm with a low consumption of memory resources and no loss of field-of-view. This algorithm simultaneously solves visible light and infrared images with an aberration rate of 45% and 47%, respectively. Fourthly, a multi-scale infrared- and visible light-image-fusion algorithm is used, which improves the situational-awareness capabilities of a binocular stereo-sensing system in a scene and enhances image details to improve ranging accuracy. Furthermore, this paper is based on the Taylor model-calibration binocular stereo-sensing system of internal and external parameters for limit correction; the implemented algorithms are integrated into an NVIDIA Jetson TX2 + FPGA hardware framework, enabling near-distance ranging experiments. The fusion-ranging accuracy within 20 m achieved an error of 0.02 m, outperforming both visible light- and infrared-ranging methods. It generates the fusion-ranging-image output with a minimal delay of only 22.31 ms at a frame rate of 50 Hz.
    Language English
    Publishing date 2024-01-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s24020676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Global scientific trends in continuous renal replacement therapy from 2000 to 2023: A bibliometric and visual analysis.

    Tao, ZhongBin / Feng, YanDong / Wang, Jie / Zhou, YongKang / Yang, JunQiang

    Blood purification

    2024  

    Abstract: Introduction: Continuous renal replacement therapy (CRRT) is one of the most widely used blood purification and organ support methods in the ICU. However, the development process, the current status, hotspots, and future trends of CRRT remain unclear.!## ...

    Abstract Introduction: Continuous renal replacement therapy (CRRT) is one of the most widely used blood purification and organ support methods in the ICU. However, the development process, the current status, hotspots, and future trends of CRRT remain unclear.
    Method: The WoSCC database was used to analyze CRRT research evolution and theme trends. VOSviewer was used to construct co-authorship, co-occurrence, co-citation, and network visualizations. Citespace is used to detect bursts for co-occurrence items. Several important subtopics were reviewed and discussed in more detail.
    Results: Global publications increased from 56 in 2000 to 398 in 2023, a 710.71% increase. Blood Purification published the most manuscripts, followed by International Journal of Artificial Organs. The United States, the San Bortolo Hospital, and Bellomo, R were the most productive and impactful institution, country, and author respectively. Based on co-occurrence cluster analysis, five clusters emerged: (1) Clinical applications and management of CRRT; (2) Sepsis and CRRT; (3) CRRT anticoagulant management; (4) CRRT and antibiotic pharmacokinetics and pharmacodynamics; and (5) Comparison of CRRT and intermittent hemodialysis. COVID-19, initiation, ECOMO, cefepime, guidelines, cardiogenic shock, biomarker and outcome were the latest high-frequency keywords or strongest bursts, indicating the emerging frontiers of CRRT.
    Conclusions: There has been widespread publication and citation of CRRT research in the past two decades. We provide an overview of current trends, global collaboration patterns, basic knowledge, research hotspots, and emerging frontiers.
    Language English
    Publishing date 2024-02-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 605548-5
    ISSN 1421-9735 ; 0253-5068
    ISSN (online) 1421-9735
    ISSN 0253-5068
    DOI 10.1159/000536312
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Low-Delay Dynamic Range Compression and Contrast Enhancement Algorithm Based on an Uncooled Infrared Sensor with Local Optimal Contrast.

    Zhu, Youpan / Zhou, Yongkang / Jin, Weiqi / Zhang, Li / Wu, Guanlin / Shao, Yiping

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 21

    Abstract: Real-time compression of images with a high dynamic range into those with a low dynamic range while preserving the maximum amount of detail is still a critical technology in infrared image processing. We propose a dynamic range compression and ... ...

    Abstract Real-time compression of images with a high dynamic range into those with a low dynamic range while preserving the maximum amount of detail is still a critical technology in infrared image processing. We propose a dynamic range compression and enhancement algorithm for infrared images with local optimal contrast (DRCE-LOC). The algorithm has four steps. The first involves blocking the original image to determine the optimal stretching coefficient by using the information of the local block. In the second, the algorithm combines the original image with a low-pass filter to create the background and detailed layers, compressing the background layer with a dynamic range of adaptive gain, and enhancing the detailed layer for the visual characteristics of the human eye. Third, the original image was used as input, the compressed background layer was used as a brightness-guided image, and the local optimal stretching coefficient was used for dynamic range compression. Fourth, an 8-bit image was created (from typical 14-bit input) by merging the enhanced details and the compressed background. Implemented on FPGA, it used 2.2554 Mb of Block RAM, five dividers, and a root calculator with a total image delay of 0.018 s. The study analyzed mainstream algorithms in various scenarios (rich scenes, small targets, and indoor scenes), confirming the proposed algorithm's superiority in real-time processing, resource utilization, preservation of the image's details, and visual effects.
    Language English
    Publishing date 2023-10-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23218860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Effects of altered excitation-inhibition imbalance by repetitive transcranial magnetic stimulation for self-limited epilepsy with centrotemporal spikes.

    Yang, Yujiao / Han, Yixian / Wang, Jing / Zhou, Yongkang / Chen, Dong / Wang, Mengyang / Li, Tianfu

    Frontiers in neurology

    2023  Volume 14, Page(s) 1164082

    Abstract: Objectives: Patients with self-limited epilepsy with centrotemporal spikes (SeLECTS) with electrical status epilepticus in sleep (ESES) have generalized cognitive impairment, yet treatment options are limited. Our study aimed to examine the therapeutic ... ...

    Abstract Objectives: Patients with self-limited epilepsy with centrotemporal spikes (SeLECTS) with electrical status epilepticus in sleep (ESES) have generalized cognitive impairment, yet treatment options are limited. Our study aimed to examine the therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) on SeLECTS with ESES. In addition, we applied electroencephalography (EEG) aperiodic components (offset and slope) to investigate the improvement of rTMS on the excitation-inhibition imbalance (E-I imbalance) in the brain of this group of children.
    Methods: Eight SeLECTS patients with ESES were included in this study. Low-frequency rTMS (≤1 Hz) was applied for 10 weekdays in each patient. To assess the clinical efficacy and changes in E-I imbalance, EEG recordings were performed both before and after rTMS. Seizure-reduction rate and spike-wave index (SWI) were measured to investigate the clinical effects of rTMS. The aperiodic offset and slope were calculated to explore the effect of rTMS on E-I imbalance.
    Results: Five of the eight patients (62.5%) were seizure-free within 3 months after stimulation, with treatment effects decreasing with longer follow-ups. The SWI decreased significantly at 3 and 6 months after rTMS compared with the baseline (
    Conclusion: Patients achieved favorable outcomes in the first 3 months after rTMS. The ameliorative effect of rTMS on SWI may last up to 6 months. Low-frequency rTMS could reduce firing rates in neuronal populations throughout the brain, which was most pronounced at the site of stimulation. A significant reduction in the slope after rTMS treatment suggested an improvement in the E-I imbalance in the SeLECTS.
    Language English
    Publishing date 2023-05-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1164082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Long-term clinical outcomes and prognosis after definitive radiotherapy for patients with cervical esophageal squamous cell carcinoma: a single-institution retrospective study.

    Zhang, Shumin / Sun, Jing / Pan, Xiangou / Kim, Jae Y / Zhu, Wenchao / Zhou, Yongkang

    Journal of thoracic disease

    2023  Volume 15, Issue 12, Page(s) 6976–6987

    Abstract: Background: Definitive radiotherapy has become a more common treatment for cervical esophageal squamous cell carcinoma (CESCC), but data about long-term clinical outcomes is still relatively sparse. The purpose of this study was to describe long-term ... ...

    Abstract Background: Definitive radiotherapy has become a more common treatment for cervical esophageal squamous cell carcinoma (CESCC), but data about long-term clinical outcomes is still relatively sparse. The purpose of this study was to describe long-term clinical outcomes after definitive radiotherapy for CESCC, and identify the prognostic factors influencing these outcomes.
    Methods: We retrospectively analyzed all patients who received definitive radiotherapy for CESCC at our institution between 2006 and 2014. The overall survival (OS) rate, locoregional failure-free survival (LRFFS) rate, and toxicities were retrospectively evaluated during long-term follow-up. Univariate and multivariate analyses were performed to identify prognostic factors.
    Results: A total of 120 patients were included for analysis. The median prescribed radiation dose for the gross tumor and metastatic lymph nodes was 60 Gy. Elective nodal irradiation (ENI) was performed on 99 patients (83%); 90 patients (75%) received concurrent chemotherapy. The OS rates were 22.7% at 5 years and 14.9% at 8 years. The LRFFS rates at 3, 5, and 8 years were 27.5%, 21.7%, and 15.0%, respectively. The univariate analysis suggested that N classification and non-regional lymph node metastasis (M1Lym) status were independent risk factors for overall survival (P<0.01). A dose of more than 60 Gy didn't have a statistically significant influence in the multivariate analysis, although a total dose of more than 60 Gy was associated with improved survival in the univariate analysis. Concurrent chemotherapy was not associated with OS or LRFFS time in the univariate or multivariate analysis. A total of 74 patients (61.7%) experienced locoregional treatment failure. The most commonly documented acute toxicities were grade 1 and grade 2 toxicities in 61 patients (50.8%). There were 2 patients diagnosed with hypothyroidism as a late toxicity event.
    Conclusions: Definitive radiotherapy is a reasonable curative treatment option with laryngopharyngeal preservation for CESCC patients. Radical treatments for lymph node metastases may improve the OS and LRFFS times. Monitoring for thyroid function may be warranted during long-term follow-up.
    Language English
    Publishing date 2023-12-22
    Publishing country China
    Document type Journal Article
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd-23-1789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Role of

    Cai, Pengfei / Zhang, Wenyi / Jiang, Sufei / Xiong, Yiwei / Qiao, Hui / Yuan, Huwei / Gao, Zijian / Zhou, Yongkang / Jin, Shubo / Fu, Hongtuo

    International journal of molecular sciences

    2024  Volume 25, Issue 3

    Abstract: This study investigates the role of lysosomal acid ... ...

    Abstract This study investigates the role of lysosomal acid lipase
    MeSH term(s) Animals ; Male ; Palaemonidae/metabolism ; Semen/metabolism ; Gonadal Steroid Hormones/metabolism ; Cholesterol/metabolism ; Triglycerides/metabolism ; Arthropod Proteins/genetics ; Arthropod Proteins/metabolism
    Chemical Substances Gonadal Steroid Hormones ; Cholesterol (97C5T2UQ7J) ; Triglycerides ; Arthropod Proteins
    Language English
    Publishing date 2024-01-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25031399
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [Manufacturing classification system for oral solid dosage forms of traditional Chinese medicines(Ⅲ): classification of granule dissolving behaviors].

    Qi, Fei-Yu / Yu, Jia-Qi / Li, Wen-Jing / Zhou, Yong-Kang / Zhang, Zhi-Qiang / Qiao, Yan-Jiang / Xu, Bing

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2023  Volume 48, Issue 15, Page(s) 3988–3996

    Abstract: Solubility is an important sensory quality attribute of traditional Chinese medicine(TCM) granules. In this paper, 90 batches of granules(30 batches of TCM formula granules, 30 batches of Chinese patent medicine granules and 30 batches of Japanese Kampo ... ...

    Abstract Solubility is an important sensory quality attribute of traditional Chinese medicine(TCM) granules. In this paper, 90 batches of granules(30 batches of TCM formula granules, 30 batches of Chinese patent medicine granules and 30 batches of Japanese Kampo granules) were used as the research objects. The turbidity sensor was used to characterize the turbidity curve of the granule dissolution process. The classification system of granule dissolution behaviors was constructed from three dimensions: dissolution degree, equilibrium time, and dissolution mechanism. According to the equilibrium time, the granule dissolution rates were divided into three categories : faster(<100 s), general(101-300 s) and slow(>301 s). According to the turbidity curve profile, the granule dissolution mechanisms were classified into dissolution-controlled type(α-type), dispersion-controlled type(β-type), and dispersion-controlled type followed by dissolution-controlled type(γ-type). The proportion of TCM formula granules, Chinese patent medicine granules and Japanese Kampo granules with complete dissolution or slight turbidity at the end of dissolution was 46.7%, 96.7%, and 10.0%. The proportion of TCM formula granules, Chinese patent medicine granules, and Japanese Kampo granules with faster dissolution rates(<100 s) was 23.3%, 26.7%, and 40.0%. The average dissolution rate of Japanese Kampo granules was faster than that of TCM formula granules, and it was slightly faster than the average dissolution rate of Chinese patent medicine granules. The dissolution mechanism of Chinese patent medicine granules was mainly α-type, while that of Japanese Kampo granules was mainly β-type, and the three types of dissolution mechanisms of TCM formula granules accounted for a relatively average. The purpose of improving the solubility and dispersion of granules can be achieved by combining the comprehensive application of various functional excipients with the small dosage of Japanese Kampo granules and the wide addition scope of excipients. In the process of transforming TCM compound prescriptions into formulas, there is still much room for innovation in formula excipients and process optimization.
    MeSH term(s) Medicine, Chinese Traditional ; Drugs, Chinese Herbal ; Excipients ; Solubility ; Nonprescription Drugs ; Biological Products
    Chemical Substances Drugs, Chinese Herbal ; Excipients ; Nonprescription Drugs ; Biological Products
    Language Chinese
    Publishing date 2023-10-06
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.20230629.301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The effects of endogenous FSH and its receptor on oogenesis and folliculogenesis in female Alligator sinensis.

    Nie, Haitao / Xu, Yunlu / Zhang, Yuqian / Wen, Yue / Zhan, Jixiang / Xia, Yong / Zhou, Yongkang / Wang, Renping / Wu, Xiaobing

    BMC zoology

    2023  Volume 8, Issue 1, Page(s) 8

    Abstract: Background: The precise mechanisms of hormone action responsible for the full course of events modulating folliculogenesis in crocodilian have not been determined, although histological features have been identified.: Results: The Alligator sinensis ... ...

    Abstract Background: The precise mechanisms of hormone action responsible for the full course of events modulating folliculogenesis in crocodilian have not been determined, although histological features have been identified.
    Results: The Alligator sinensis ovarian morphological characteristics observed at 1, 15, 30, 60, 90, and 300 days post hatching(dph) revealed that the dynamic changes in germ cells varied in different meiotic and developmental stages, confirming that the processes of folliculogenesis were protracted and asynchronous. The presence of endogenous follicle-stimulating hormone(FSH) mRNA and protein expression within the cerebrum at 1 dph, in parallel with the increase in germ cells within the germ cell nests(Nest) from 1 dph to 15 dph, suggested that endocrine regulation of the pituitary-gonad axis is an early event in oogonia division. Furthermore, the endogenous expression of FSH showed a trend of negative feedback augmentation accompanied by the exhaustion of maternal yolk E
    Conclusion: The corresponding results contribute an expansion of the understanding of physiological processes and shed some light on the specific factors responsible for gonadotropin function in the early folliculogenesis of crocodilians.
    Language English
    Publishing date 2023-07-04
    Publishing country England
    Document type Journal Article
    ISSN 2056-3132
    ISSN (online) 2056-3132
    DOI 10.1186/s40850-023-00170-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: An improved 3D KiU-Net for segmentation of liver tumor.

    Chen, Guodong / Li, Zheng / Wang, Jian / Wang, Jun / Du, Shisuo / Zhou, Jinghao / Shi, Jun / Zhou, Yongkang

    Computers in biology and medicine

    2023  Volume 160, Page(s) 107006

    Abstract: It is a challenging task to accurately segment liver tumors from Computed Tomography (CT) images. The widely used U-Net and its variants generally suffer from the issue to accurately segment the detailed edges of small tumors, because the progressive ... ...

    Abstract It is a challenging task to accurately segment liver tumors from Computed Tomography (CT) images. The widely used U-Net and its variants generally suffer from the issue to accurately segment the detailed edges of small tumors, because the progressive down sampling operations in the encoder module will gradually increase the receptive fields. These enlarged receptive filed have limited ability to learn the information about tiny structures. KiU-Net is a newly proposed dual-branch model that can effectively perform image segmentation for small targets. However, the 3D version of KiU-Net has high computational complexity, which limits its application. In this work, an improved 3D KiU-Net (named TKiU-NeXt) is proposed for liver tumor segmentation from CT images. In TKiU-NeXt, a Transformer-based Kite-Net (TK-Net) branch is proposed to build the over-complete architecture to learn more detailed features for small structures, and an extended 3D version of UNeXt is developed to replace the original U-Net branch, which can effectively reduce computational complexity but still with superior segmentation performance. Moreover, a Mutual Guided Fusion Block (MGFB) is designed to effectively learn more features from two branches and then fuse the complementary features for image segmentation. The experimental results on two public CT datasets and a private dataset demonstrate that the proposed TKiU-NeXt outperforms all the compared algorithms, and it also has less computational complexity. It suggests the effectiveness and efficiency of TKiU-NeXt.
    MeSH term(s) Humans ; Algorithms ; Learning ; Liver Neoplasms/diagnostic imaging ; Tomography, X-Ray Computed ; Image Processing, Computer-Assisted
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2023.107006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Chemical synthesis of a 28 kDa full-length PET degrading enzyme ICCG by the removable backbone modification strategy.

    Gao, Yun-Pu / Sun, Peng-Fei / Guo, Wu-Chen / Zhou, Yong-Kang / Zheng, Ji-Shen / Tang, Shan

    Bioorganic chemistry

    2023  Volume 143, Page(s) 107047

    Abstract: Chemical protein synthesis offers a powerful way to access otherwise-difficult-to-obtain proteins such as mirror-image proteins. Although a large number of proteins have been chemically synthesized to date, the acquisition to proteins containing ... ...

    Abstract Chemical protein synthesis offers a powerful way to access otherwise-difficult-to-obtain proteins such as mirror-image proteins. Although a large number of proteins have been chemically synthesized to date, the acquisition to proteins containing hydrophobic peptide fragments has proven challenging. Here, we describe an approach that combines the removable backbone modification strategy and the peptide hydrazide-based native chemical ligation for the chemical synthesis of a 28 kDa full-length PET degrading enzyme IGGC (a higher depolymerization efficiency of variant leaf-branch compost cutinase (LCC)) containing hydrophobic peptide segments. The synthetic ICCG exhibits the enzymatic activity and will be useful in establishing the corresponding mirror-image version of ICCG.
    MeSH term(s) Hydrolases/chemistry ; Peptide Fragments ; Peptides/chemistry ; Polyethylene Terephthalates/chemistry
    Chemical Substances Hydrolases (EC 3.-) ; Peptide Fragments ; Peptides ; Polyethylene Terephthalates ; cutinase (EC 3.1.1.-)
    Language English
    Publishing date 2023-12-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2023.107047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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