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Article ; Online: Inactivation of microglia dampens blood-brain barrier permeability and loss of dopaminergic neurons in paraquat-lesioned mice.

Zhou, Yu-Ting / Xu, Ya-Ning / Ren, Xi-Yun / Zhang, Xiao-Feng

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2023 Volume 174, Page(s) 113692

Abstract: Prior studies indicated the involvement of neuroinflammation in the dopaminergic neurodegeneration in mice of paraquat (PQ)-induced Parkinson's disease (PD), but the underlying mechanisms remain to be elucidated. The present study explored whether ... ...

Abstract	Prior studies indicated the involvement of neuroinflammation in the dopaminergic neurodegeneration in mice of paraquat (PQ)-induced Parkinson's disease (PD), but the underlying mechanisms remain to be elucidated. The present study explored whether microglia-mediated inflammation disrupted blood-brain barrier (BBB) and its related mechanism. C57BL/6 mice were injected intraperitoneally with PQ, twice a week for six weeks, following with or without minocycline (intraperitoneal injection, once every two days). The microglial activation, BBB permeability, expression of tight junctions (TJs) proteins and matrix metalloproteinase (MMP), as well as the loss of dopaminergic neurons and neurological deficits assessment, were evaluated. Minocycline efficiently restrained nigral microglial activation induced by PQ in mice. PQ-induced increase of EB content in the brain and excessive expression of zonula occludin-1 (ZO-1), claudin-5 and occludin were significantly dampened by minocycline treatment. Inhibition of microglial activation by minocycline greatly ameliorated the loss of dopaminergic neurons and neurological dysfunctions in PQ-exposed mice. Also, microglial inactivation downregulated the expression of MMP-2/9 in PQ-lesioned mice. These findings suggested the potential protection of suppressing microglia-mediated neuroinflammation against dopaminergic neurodegeneration through attenuating BBB disruption in a mouse of PQ-induced PD, and MMP-2/9 might involve in the contribution, which needs to be verified in future study.
MeSH term(s)	Mice ; Animals ; Paraquat ; Dopaminergic Neurons/metabolism ; Microglia/metabolism ; Matrix Metalloproteinase 2/metabolism ; Blood-Brain Barrier/metabolism ; Occludin/metabolism ; Neuroinflammatory Diseases ; Minocycline/metabolism ; Mice, Inbred C57BL ; Parkinson Disease/metabolism ; Permeability
Chemical Substances	Paraquat (PLG39H7695) ; Matrix Metalloproteinase 2 (EC 3.4.24.24) ; Occludin ; Minocycline (FYY3R43WGO)
Language	English
Publishing date	2023-02-24
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2023.113692
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Article ; Online: Inactivation of microglia dampens blood-brain barrier permeability and loss of dopaminergic neurons in paraquat-lesioned mice

Zhou, Yu-Ting / Xu, Ya-Ning / Ren, Xi-Yun / Zhang, Xiao-Feng

Food and Chemical Toxicology. 2023 Apr., v. 174 p.113692-

2023

Abstract	Prior studies indicated the involvement of neuroinflammation in the dopaminergic neurodegeneration in mice of paraquat (PQ)-induced Parkinson's disease (PD), but the underlying mechanisms remain to be elucidated. The present study explored whether microglia-mediated inflammation disrupted blood-brain barrier (BBB) and its related mechanism. C57BL/6 mice were injected intraperitoneally with PQ, twice a week for six weeks, following with or without minocycline (intraperitoneal injection, once every two days). The microglial activation, BBB permeability, expression of tight junctions (TJs) proteins and matrix metalloproteinase (MMP), as well as the loss of dopaminergic neurons and neurological deficits assessment, were evaluated. Minocycline efficiently restrained nigral microglial activation induced by PQ in mice. PQ-induced increase of EB content in the brain and excessive expression of zonula occludin-1 (ZO-1), claudin-5 and occludin were significantly dampened by minocycline treatment. Inhibition of microglial activation by minocycline greatly ameliorated the loss of dopaminergic neurons and neurological dysfunctions in PQ-exposed mice. Also, microglial inactivation downregulated the expression of MMP-2/9 in PQ-lesioned mice. These findings suggested the potential protection of suppressing microglia-mediated neuroinflammation against dopaminergic neurodegeneration through attenuating BBB disruption in a mouse of PQ-induced PD, and MMP-2/9 might involve in the contribution, which needs to be verified in future study.
Keywords	Parkinson disease ; blood-brain barrier ; brain ; inflammation ; intraperitoneal injection ; metalloproteinases ; mice ; minocycline ; neuroglia ; occludins ; paraquat ; permeability ; toxicology ; Microglial inactivation ; Tight junctions ; Matrix metalloproteinases ; Dopaminergic neurons
Language	English
Dates of publication	2023-04
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2023.113692
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Article ; Online: Effect of ultrasound-guided continuous erector spinae plane block on postoperative pain and inflammatory response in patients undergoing modified radical mastectomy for breast cancer: study protocol for a randomised controlled trial.

Yu, Liang / Shen, Xiao-Juan / Liu, He / Zhou, Yu-Ting / Zhang, Qin / Zhang, Zhen-Duo / Shen, Shu-Min

Trials

2024 Volume 25, Issue 1, Page(s) 51

Abstract: Background: A single injection of local anaesthetic (LA) in the erector spinae plane block (ESPB) can reduce pain after modified radical mastectomy (MRM) surgery, but the duration of analgesia is affected by the duration of the LA. The aim of this study ...

Abstract	Background: A single injection of local anaesthetic (LA) in the erector spinae plane block (ESPB) can reduce pain after modified radical mastectomy (MRM) surgery, but the duration of analgesia is affected by the duration of the LA. The aim of this study is to investigate the effect of continuous ESPB on acute and chronic pain and inflammatory response after MRM surgery. Methods: In this prospective, randomised, controlled trial, we will recruit 160 patients, aged 18-80 years, scheduled for elective MRM surgery under general anaesthesia. They will be randomly assigned to two groups: a continuous ESPB group (group E) and a sham block group (group C). Both groups of patients will have a nerve block (group C pretended to puncture) and an indwelling catheter fixed prior to surgery. Electronic pumps containing LA are shielded. The primary outcome is the total consumption of analgesic agents. The secondary outcomes include the levels of inflammation-related cytokines; the occurrence of chronic pain (post-mastectomy pain syndrome, PMPS); static and dynamic pain scores at 2, 6, 12, 24 and 48 h postoperatively; and post-operative and post-puncture adverse reactions. Discussion: Analgesia after MRM surgery is important and chronic pain can develop when acute pain is prolonged, but the analgesic effect of a nerve block with a single injection of LA is limited by the duration of drug action. The aim of this trial is to investigate whether continuous ESPB can reduce acute pain after MRM surgery and reduce the incidence of chronic pain (PMPS), with fewer postoperative analgesic drug-related complications and less inflammatory response. Continuous ESPB and up to 12 months of follow-up are two innovations of this trial. Trial registration: Chinese Clinical Trial Registry ( https://www.chictr.org.cn/ ) ChiCTR2200061935. Registered on 11 July 2022. This trial is a prospective registry with the following registry names: Effect of ultrasound-guided continuous erector spinae plane block on postoperative pain and inflammatory response in patients undergoing modified radical mastectomy for breast cancer.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/surgery ; Chronic Pain/diagnosis ; Chronic Pain/etiology ; Chronic Pain/prevention & control ; Acute Pain ; Mastectomy, Modified Radical/adverse effects ; Mastectomy/adverse effects ; Pain, Postoperative/diagnosis ; Pain, Postoperative/etiology ; Pain, Postoperative/prevention & control ; Anesthetics, Local/adverse effects ; Nerve Block/adverse effects ; Postoperative Complications ; Analgesics ; Ultrasonography, Interventional ; Analgesics, Opioid ; Randomized Controlled Trials as Topic
Chemical Substances	Anesthetics, Local ; Analgesics ; Analgesics, Opioid
Language	English
Publishing date	2024-01-15
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-023-07777-0
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Article ; Online: The multifaceted role of macrophage mitophagy in SiO

Zhou, Yu-Ting / Li, Shuang / Du, Shu-Ling / Zhao, Jia-Hui / Cai, Ya-Qiong / Zhang, Zhao-Qiang

Journal of applied toxicology : JAT

2024

Abstract: Prolonged exposure to environments with high concentrations of crystalline silica (CS) can lead to silicosis. Macrophages play a crucial role in the pathogenesis of silicosis. In the process of silicosis, silica ( ... ...

Abstract	Prolonged exposure to environments with high concentrations of crystalline silica (CS) can lead to silicosis. Macrophages play a crucial role in the pathogenesis of silicosis. In the process of silicosis, silica (SiO
Language	English
Publishing date	2024-04-22
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	604625-3
ISSN	1099-1263 ; 0260-437X
ISSN (online)	1099-1263
ISSN	0260-437X
DOI	10.1002/jat.4612
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Article ; Online: A time-course study of microglial activation and dopaminergic neuron loss in the substantia nigra of mice with paraquat-induced Parkinson's disease.

Yang, Hui-Ming / Wang, Yong-Ling / Liu, Chong-Yue / Zhou, Yu-Ting / Zhang, Xiao-Feng

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2022 Volume 164, Page(s) 113018

Abstract: Activated microglia play an active role in the pathogenesis of PD and paraquat (PQ) induces PD. The study was to understand the time relationship between microglial activation and dopaminergic neuron loss in the substantia nigra (SN) of PQ-induced PD ... ...

Abstract	Activated microglia play an active role in the pathogenesis of PD and paraquat (PQ) induces PD. The study was to understand the time relationship between microglial activation and dopaminergic neuron loss in the substantia nigra (SN) of PQ-induced PD mice. Male C57BL/6 mice were injected intraperitoneally with PQ, twice a week for six weeks. Some mice underwent behavioral assessments each week and were sacrificed for SN tissues, in which histopathological analysis, dopaminergic neuron loss, microglial activation and phenotypic characteristics were evaluated. The results showed that motor retardation, coordination disorders and limb stiffness occurred four weeks after PQ exposure, as well as the degeneration and loss of dopaminergic neurons in the SN. Activated microglia and increased CD68 expression appeared two weeks after PQ exposure in time-dependent manners. Increased CD86 and decreased CD206 expression were observed four weeks after PQ exposure, accompanied by increased TNF-α and IL-6 levels and decreased IL-10 and TGF-β levels. These results indicate that PQ can activate microglia in vivo, and microglial activation precedes neuronal loss in the SN. Activated microglia are characterized by mixed M1/M2 polarization in the early stage and M1 polarization in the late stage of PQ-induced PD development.
MeSH term(s)	Animals ; Dopamine/metabolism ; Dopaminergic Neurons/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Microglia/metabolism ; Nerve Degeneration/chemically induced ; Nerve Degeneration/metabolism ; Nerve Degeneration/pathology ; Paraquat/toxicity ; Parkinson Disease/metabolism ; Substantia Nigra/metabolism
Chemical Substances	Paraquat (PLG39H7695) ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2022-04-14
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2022.113018
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Zs.A 529: Show issues

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Article ; Online: Syntheses, Structures, and Magnetic Properties of Three Cyano-Bridged Fe

Xu, Fang-Xue / Zhou, Yu-Ting / Zhang, Cheng-Cheng / Zhang, Xin-Yu / Wei, Hai-Yan / Wang, Xin-Yi

Inorganic chemistry

2023 Volume 62, Issue 38, Page(s) 15465–15478

Abstract: Three new cyano-bridged ... ...

Abstract	Three new cyano-bridged Fe
Language	English
Publishing date	2023-09-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.3c01803
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Article ; Online: Zinc deficiency compromises the maturational competence of porcine oocyte by inducing mitophagy and apoptosis.

Lai, Xin-Le / Xiong, Wen-Jie / Li, Li-Shu / Lan, Meng-Fan / Zhang, Jin-Xin / Zhou, Yu-Ting / Niu, Dong / Duan, Xing

Ecotoxicology and environmental safety

2023 Volume 252, Page(s) 114593

Abstract: Zinc, an essential trace mineral, plays a pivotal role in cell proliferation, maintenance of redox homeostasis, apoptosis, and aging. Serum zinc concentrations are reduced in patients with polycystic ovary syndrome (PCOS). However, the underlying ... ...

Abstract	Zinc, an essential trace mineral, plays a pivotal role in cell proliferation, maintenance of redox homeostasis, apoptosis, and aging. Serum zinc concentrations are reduced in patients with polycystic ovary syndrome (PCOS). However, the underlying mechanism of the effects of zinc deficiency on the female reproductive system, especially oocyte quality, has not been fully elucidated. Thus, we established an in vitro experimental model by adding N,N,N',N'-Tetrakis(2-pyridylmethyl) ethylenediamine (TPEN) into the culture medium, and to determine the potential regulatory function of zinc during porcine oocytes maturation. In the present study, we found that zinc deficiency caused aberrant meiotic progress, accompanied by the disrupted cytoskeleton structure in porcine oocytes. Zinc deficiency impaired mitochondrial function and dynamics, leading to the increase of reactive oxygen species (ROS) and acetylation level of the antioxidative enzyme superoxide dismutase 2 (SOD2), eventually induced the occurrence of oxidative stress and early apoptosis. Moreover, zinc deficiency perturbed cytosolic Ca
MeSH term(s)	Swine ; Female ; Animals ; Trace Elements/metabolism ; Mitophagy ; Oocytes/metabolism ; Zinc/toxicity ; Zinc/metabolism ; Reactive Oxygen Species/metabolism ; Apoptosis
Chemical Substances	Trace Elements ; Zinc (J41CSQ7QDS) ; Reactive Oxygen Species
Language	English
Publishing date	2023-01-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2023.114593
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Article ; Online: Comprehensive treatment strategy for diesel truck exhaust.

Li, Tian / Yang, Hai-Li / Xu, Le-Tian / Zhou, Yu-Ting / Min, Yong-Jun / Yan, Shi-Cheng / Zhang, Yong-Hui / Wang, Xiao-Ming

Environmental science and pollution research international

2023 Volume 30, Issue 19, Page(s) 54324–54332

Abstract: At present, diesel vehicles still play an irreplaceable role in the traditional energy field in China. Diesel vehicle exhaust contains hydrocarbons, carbon monoxide, nitrogen oxides, and particulate matter, which can lead to haze weather, photochemical ... ...

Abstract	At present, diesel vehicles still play an irreplaceable role in the traditional energy field in China. Diesel vehicle exhaust contains hydrocarbons, carbon monoxide, nitrogen oxides, and particulate matter, which can lead to haze weather, photochemical smog, and the greenhouse effect; endanger human health; and damage the ecological environment. In 2020, the number of motor vehicles in China reached 372 million, and the number of automobiles reached 281 million, of which 20.92 million are diesel vehicles, accounting for only 5.6% of the number of motor vehicles and 7.4% of the number of automobiles. Nevertheless, diesel vehicles emitted 88.8% of nitrogen oxides and 99% of particulate matter in total vehicle emissions. Diesel vehicles, especially diesel trucks, have become the top priority of motor vehicle pollution control. However, there are few reviews on the comprehensive treatment of diesel vehicle exhaust. This review provides an overview of exhaust gas composition, hazards, and treatment techniques. Phytoremediation, three-way catalytic conversion, rare earth catalytic degradation, and nanoscale TiO
MeSH term(s)	Humans ; Vehicle Emissions/analysis ; Air Pollutants/analysis ; Gasoline/analysis ; Environmental Monitoring ; Particulate Matter/analysis ; Motor Vehicles ; Nitrogen Oxides/analysis
Chemical Substances	Vehicle Emissions ; Air Pollutants ; Gasoline ; Particulate Matter ; Nitrogen Oxides
Language	English
Publishing date	2023-03-20
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-26506-3
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Article ; Online: Perfluorooctanoic acid (PFOA) exposure affects early embryonic development and offspring oocyte quality via inducing mitochondrial dysfunction

Zhou, Yu-Ting / Li, Rui / Li, Si-Hong / Ma, Xiang / Liu, Lu / Niu, Dong / Duan, Xing

Environment International. 2022 Sept., v. 167 p.107413-

2022

Abstract: Perfluorooctanoic acid (PFOA) is a synthetic perfluorinated compound that is extensively used as an integral surfactant in commercial production. Owing to its hydrophilicity and persistence, PFOA can accumulate in living organisms and induce severe ... ...

Abstract	Perfluorooctanoic acid (PFOA) is a synthetic perfluorinated compound that is extensively used as an integral surfactant in commercial production. Owing to its hydrophilicity and persistence, PFOA can accumulate in living organisms and induce severe disease in animals and humans. It has been reported that PFOA exposure can affect ovarian function and induce reproductive toxicity; however, the effects and potential mechanism of PFOA exposure during gestation on early embryonic development and offspring remain unclear. This study found that PFOA exposure in vitro disrupted spindle assembly and chromosome alignment during the first cleavage of early mouse embryos, which impacted early embryonic cleavage and blastocyst formation. Moreover, PFOA exposure caused mitochondrial dysfunction and oxidative stress by inducing aberrant Ca²⁺ levels, liquid drops(LDs), and mitochondrial membrane potential in the 2-cell stage. Furthermore, we found that PFOA exposure resulted in DNA damage, autophagy, and apoptosis in 2-cell stage by inhibiting SOD2 function. Gestational exposure to PFOA significantly increased ovarian apoptosis and disrupted follicle development in F1 offspring. In addition, oocyte maturation competence was decreased in F1 offspring. Finally, single-cell transcriptome analysis revealed that PFOA-induced oocyte deterioration was caused by mitochondrial dysfunction and apoptosis in the F1 offspring. In summary, our results indicated that gestational exposure to PFOA had potential toxic effects on ovarian function and led to a higher incidence of meiotic defects in F1 female offspring.
Keywords	DNA damage ; apoptosis ; autophagy ; blastocyst ; calcium ; chromosomes ; disease severity ; embryogenesis ; environment ; females ; hydrophilicity ; liquids ; maternal exposure ; meiosis ; membrane potential ; mice ; mitochondria ; mitochondrial membrane ; oocytes ; oxidative stress ; perfluorocarbons ; perfluorooctanoic acid ; pregnancy ; progeny ; reproductive toxicology ; surfactants ; toxicity ; transcriptomics ; PFOA ; Early embryonic development
Language	English
Dates of publication	2022-09
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2022.107413
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Article: A time-course study of microglial activation and dopaminergic neuron loss in the substantia nigra of mice with paraquat-induced Parkinson's disease

Yang, Hui-Ming / Wang, Yong-Ling / Liu, Chong-Yue / Zhou, Yu-Ting / Zhang, Xiao-Feng

Food and chemical toxicology. 2022 June, v. 164

2022

Abstract	Activated microglia play an active role in the pathogenesis of PD and paraquat (PQ) induces PD. The study was to understand the time relationship between microglial activation and dopaminergic neuron loss in the substantia nigra (SN) of PQ-induced PD mice. Male C57BL/6 mice were injected intraperitoneally with PQ, twice a week for six weeks. Some mice underwent behavioral assessments each week and were sacrificed for SN tissues, in which histopathological analysis, dopaminergic neuron loss, microglial activation and phenotypic characteristics were evaluated. The results showed that motor retardation, coordination disorders and limb stiffness occurred four weeks after PQ exposure, as well as the degeneration and loss of dopaminergic neurons in the SN. Activated microglia and increased CD68 expression appeared two weeks after PQ exposure in time-dependent manners. Increased CD86 and decreased CD206 expression were observed four weeks after PQ exposure, accompanied by increased TNF-α and IL-6 levels and decreased IL-10 and TGF-β levels. These results indicate that PQ can activate microglia in vivo, and microglial activation precedes neuronal loss in the SN. Activated microglia are characterized by mixed M1/M2 polarization in the early stage and M1 polarization in the late stage of PQ-induced PD development.
Keywords	Parkinson disease ; histopathology ; interleukin-10 ; interleukin-6 ; males ; neuroglia ; neurons ; paraquat ; pathogenesis ; phenotype ; toxicology
Language	English
Dates of publication	2022-06
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2022.113018
Database	NAL-Catalogue (AGRICOLA)

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