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  1. Book ; Thesis: Glucose substitution rescues lifespan of aging telomere dysfunctional mice by elevating glycolysis and IGF-1/mTOR dependent mitochondrial biogenesis

    Zhou, Yuan

    2014  

    Author's details by Yuan Zhou
    Language English
    Size II, 70 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Ulm, Univ., Diss., 2014
    HBZ-ID HT018809362
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Recent advances in wearable actuated ankle-foot orthoses: Medical effects, design, and control.

    Zhou, Yuan

    Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine

    2022  Volume 237, Issue 2, Page(s) 163–178

    Abstract: This paper presents a survey on recent advances of wearable actuated ankle-foot orthoses (AAFOs). First of all, their medical functions are investigated. From the short-term aspect, they lead to rectification of pathological gaits, reduction of metabolic ...

    Abstract This paper presents a survey on recent advances of wearable actuated ankle-foot orthoses (AAFOs). First of all, their medical functions are investigated. From the short-term aspect, they lead to rectification of pathological gaits, reduction of metabolic cost, and improvement of gait performance. After AAFO-based walking training with sufficient time, free walking performance can be enhanced. Then, key design factors are studied. First, primary design parameters are investigated. Second, common actuators are analysed. Third, human-robot interaction (HRI), ergonomics, safety, and application places, are considered. In the following section, control technologies are reviewed from the aspects of rehabilitation stages, gait feature quantities, and controller characteristics. Finally, existing problems are discussed; development trends are prospected.
    MeSH term(s) Humans ; Ankle ; Foot Orthoses ; Equipment Design ; Gait ; Walking ; Wearable Electronic Devices ; Biomechanical Phenomena
    Language English
    Publishing date 2022-12-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1065942-0
    ISSN 2041-3033 ; 0046-2039 ; 0954-4119
    ISSN (online) 2041-3033
    ISSN 0046-2039 ; 0954-4119
    DOI 10.1177/09544119221142335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: MRM-BERT: a novel deep neural network predictor of multiple RNA modifications by fusing BERT representation and sequence features.

    Wang, Linshu / Zhou, Yuan

    RNA biology

    2024  Volume 21, Issue 1, Page(s) 1–10

    Abstract: RNA modifications play crucial roles in various biological processes and diseases. Accurate prediction of RNA modification sites is essential for understanding their functions. In this study, we propose a hybrid approach that fuses a pre-trained sequence ...

    Abstract RNA modifications play crucial roles in various biological processes and diseases. Accurate prediction of RNA modification sites is essential for understanding their functions. In this study, we propose a hybrid approach that fuses a pre-trained sequence representation with various sequence features to predict multiple types of RNA modifications in one combined prediction framework. We developed MRM-BERT, a deep learning method that combined the pre-trained DNABERT deep sequence representation module and the convolutional neural network (CNN) exploiting four traditional sequence feature encodings to improve the prediction performance. MRM-BERT was evaluated on multiple datasets of 12 commonly occurring RNA modifications, including m
    MeSH term(s) Neural Networks, Computer ; RNA/genetics ; ROC Curve ; Software
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2159587-2
    ISSN 1555-8584 ; 1555-8584
    ISSN (online) 1555-8584
    ISSN 1555-8584
    DOI 10.1080/15476286.2024.2315384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Research on the prognostic value of adjusting intraperitoneal three-dimensional quality evaluation mode in laparoscopic cholecystectomy patients.

    Zhou, Yuan / Chen, Zhan-Qing

    World journal of gastrointestinal surgery

    2024  Volume 16, Issue 4, Page(s) 1078–1086

    Abstract: Background: Benign gallbladder diseases have become a high-prevalence condition not only in China but also worldwide. The main types of benign gallbladder diseases include gallbladder polyps, acute and chronic cholecystitis, and gallstones, with ... ...

    Abstract Background: Benign gallbladder diseases have become a high-prevalence condition not only in China but also worldwide. The main types of benign gallbladder diseases include gallbladder polyps, acute and chronic cholecystitis, and gallstones, with gallstones being the most common, accounting for over 70% of cases. Although the mortality rate of benign gallbladder diseases is low, they carry obvious potential risks. Studies have shown that an increased incidence of benign gallbladder diseases can increase the risk of cardiovascular diseases and gallbladder cancer, resulting in a substantial disease burden on patients and their families.
    Aim: To assess the medical utility of the Configuration-Procedure-Consequence (CPC) three-dimensional quality evaluation model in modulating the prognosis of laparoscopic cholecystectomy patients.
    Methods: A total of 98 patients who underwent laparoscopic cholecystectomy in our hospital from February 2020 to January 2022 were selected as the subjects. According to the random number table method, they were divided into a study group and a control group, with 49 patients in each group. The control group received routine perioperative care, while the study group had the addition of the CPC three-dimensional quality evaluation. The postoperative recovery-related indicators (time to first flatus, time to oral intake, time to ambulation, hospital stay), stress indicators (cortisol and adrenaline levels), distinctions in anxiety and depression status, and the incidence of perioperative complications were compared.
    Results: The time to first flatus, time to oral intake, time to ambulation, and hospital stay of the study group patients were obviously lower than those of the control group patients, with statistical significance (
    Conclusion: Implementing the CPC three-dimensional quality evaluation model for patients undergoing laparoscopic cholecystectomy can help accelerate their perioperative recovery process, alleviate perioperative stress symptoms, mitigate anxiety, depression, and other adverse emotions, and to some extent, reduce the incidence of perioperative complications.
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573700-4
    ISSN 1948-9366
    ISSN 1948-9366
    DOI 10.4240/wjgs.v16.i4.1078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Putting the brakes on pollen wall development: A conserved negative feedback loop regulates pollen exine formation in flowering plants.

    Zhou, Yuan / Dobritsa, Anna A

    Molecular plant

    2023  Volume 16, Issue 9, Page(s) 1376–1378

    MeSH term(s) Magnoliopsida/genetics ; Feedback ; Morphogenesis ; Pollen
    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2393618-6
    ISSN 1752-9867 ; 1674-2052
    ISSN (online) 1752-9867
    ISSN 1674-2052
    DOI 10.1016/j.molp.2023.08.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Innovation network, knowledge absorption ability, and technology innovation performance--An empirical analysis of China's intelligent manufacturing industry.

    Wang, Yawei / Zhou, Yuan

    PloS one

    2023  Volume 18, Issue 11, Page(s) e0293429

    Abstract: Based on the social network theory, this study utilizes knowledge absorption capacity as the mediating variable and technology turbulence as the moderating variable; furthermore, it focuses on China's intelligent manufacturing industry data to explore ... ...

    Abstract Based on the social network theory, this study utilizes knowledge absorption capacity as the mediating variable and technology turbulence as the moderating variable; furthermore, it focuses on China's intelligent manufacturing industry data to explore the effect of the intelligent manufacturing enterprise innovation network on technology innovation performance and the regulating mechanism of technology turbulence. Based on the patent data obtained from Derwent Database (survey period: 2016-2020), the empirical analysis indicates the following: (1) Network relationship, network location, and network density are significantly and positively correlated with technology innovation performance; however, network size exerts no significant effect on technology innovation performance. (2) Network relationship strength, network location, and network density exert significantly positive effects on the two dimensions of knowledge absorption capacity, namely the In-degree and the Out-degree. Network size exerts no significant effect on knowledge absorption capacity. (3) Knowledge absorption capacity exerts a partial mediating effect on the relationship between innovation network and technology innovation performance. (4) The three dimensions of innovation network that exert a significant effect on technology innovation performance are positively correlated with the interaction terms of technology turbulence, which indicates that the interaction terms, namely innovation network and technology turbulence, exert a positive impact on technology innovation performance through knowledge absorption capacity, and that the moderating effect of technology turbulence exerts a role through knowledge absorption capacity. Finally, this study postulates implementations and policy proposals for enhancing the innovation performance of intelligent manufacturing enterprises.
    MeSH term(s) Manufacturing Industry ; Inventions ; Technology ; Commerce ; China
    Language English
    Publishing date 2023-11-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0293429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Development and Validation of a New Nomogram Model for Predicting Acute Ischemic Stroke in Elderly Patients with Non-Valvular Atrial Fibrillation: A Single-Center Cross-Sectional Study.

    Guo, Jiongchao / Zhou, Yuan / Zhou, Bingfeng

    Clinical interventions in aging

    2024  Volume 19, Page(s) 67–79

    Abstract: Background and aims: Non-valvular atrial fibrillation (NVAF) patients face a 3-5 times greater risk of acute ischemic stroke (AIS) compared to those without NVAF. This study aims to establish a novel clinical prediction model for AIS in elderly patients ...

    Abstract Background and aims: Non-valvular atrial fibrillation (NVAF) patients face a 3-5 times greater risk of acute ischemic stroke (AIS) compared to those without NVAF. This study aims to establish a novel clinical prediction model for AIS in elderly patients with NVAF by incorporating relevant biomarker indicators.
    Methods: A total of 301 individuals diagnosed with NVAF were selected for this investigation at the Third Affiliated Hospital of Anhui Medical University. Based on the presence of AIS, patients were categorized into two groups: the Stroke Cohort and the Non-Stroke Cohort. Predictor screening was performed using the least absolute shrinkage and selection operation (LASSO) regression algorithm. The binary logistic regression equation was applied to fit the model, followed by internal validation using the bootstrap resampling method (1000 times). Receiver operating characteristic (ROC) curve, calibration degree curve plots, and clinical decision curve analysis (DCA) were generated, respectively. Finally, a nomogram was constructed to present the prediction model.
    Results: The final results of this study revealed that neutrophil-to-lymphocyte ratio (NLR), red cell distribution width (RDW), lipoprotein(a) (Lp(a)), systolic pressure, history of stroke, hyperlipidemia were independent risk factors for AIS in elderly patients with NVAF (
    Conclusion: NLR, RDW, Lp(a), SP, history of stroke, hyperlipidemia, and HDL-C emerge as independent prognostic factors for acute ischemic stroke in elderly patients with non-valvular atrial fibrillation. The predictive utility of the nomogram model may potentially surpass that of the CHA2DS2-VASc scoring system.
    MeSH term(s) Humans ; Aged ; Ischemic Stroke/complications ; Atrial Fibrillation/diagnosis ; Cross-Sectional Studies ; Nomograms ; Models, Statistical ; Prognosis ; Stroke/epidemiology ; Stroke/etiology ; Risk Factors ; Hyperlipidemias
    Language English
    Publishing date 2024-01-10
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2364924-0
    ISSN 1178-1998 ; 1176-9092
    ISSN (online) 1178-1998
    ISSN 1176-9092
    DOI 10.2147/CIA.S437065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Embryonal Tumor with Multilayered Rosettes, NOS of Cervical Spinal Cord.

    Zhou, Yuan / Zhu, Lin / Tu, Pin

    Neurology India

    2024  Volume 71, Issue 6, Page(s) 1266–1267

    MeSH term(s) Humans ; Cervical Cord/diagnostic imaging ; Cervical Cord/pathology ; Neoplasms, Germ Cell and Embryonal ; Brain Neoplasms/pathology ; Spinal Cord/pathology ; Neck/pathology ; Neuroectodermal Tumors, Primitive/pathology
    Language English
    Publishing date 2024-01-04
    Publishing country India
    Document type Letter
    ZDB-ID 415522-1
    ISSN 1998-4022 ; 0028-3886
    ISSN (online) 1998-4022
    ISSN 0028-3886
    DOI 10.4103/0028-3886.391338
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: SpatialcoGCN: deconvolution and spatial information-aware simulation of spatial transcriptomics data via deep graph co-embedding.

    Yin, Wang / Wan, You / Zhou, Yuan

    Briefings in bioinformatics

    2024  Volume 25, Issue 3

    Abstract: Spatial transcriptomics (ST) data have emerged as a pivotal approach to comprehending the function and interplay of cells within intricate tissues. Nonetheless, analyses of ST data are restricted by the low spatial resolution and limited number of ... ...

    Abstract Spatial transcriptomics (ST) data have emerged as a pivotal approach to comprehending the function and interplay of cells within intricate tissues. Nonetheless, analyses of ST data are restricted by the low spatial resolution and limited number of ribonucleic acid transcripts that can be detected with several popular ST techniques. In this study, we propose that both of the above issues can be significantly improved by introducing a deep graph co-embedding framework. First, we establish a self-supervised, co-graph convolution network-based deep learning model termed SpatialcoGCN, which leverages single-cell data to deconvolve the cell mixtures in spatial data. Evaluations of SpatialcoGCN on a series of simulated ST data and real ST datasets from human ductal carcinoma in situ, developing human heart and mouse brain suggest that SpatialcoGCN could outperform other state-of-the-art cell type deconvolution methods in estimating per-spot cell composition. Moreover, with competitive accuracy, SpatialcoGCN could also recover the spatial distribution of transcripts that are not detected by raw ST data. With a similar co-embedding framework, we further established a spatial information-aware ST data simulation method, SpatialcoGCN-Sim. SpatialcoGCN-Sim could generate simulated ST data with high similarity to real datasets. Together, our approaches provide efficient tools for studying the spatial organization of heterogeneous cells within complex tissues.
    MeSH term(s) Humans ; Animals ; Mice ; Gene Expression Profiling ; Computer Simulation ; RNA ; Transcriptome
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2024-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2068142-2
    ISSN 1477-4054 ; 1467-5463
    ISSN (online) 1477-4054
    ISSN 1467-5463
    DOI 10.1093/bib/bbae130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Effects of urban green space landscape pattern on flood retention efficiency from "urban-block" scale perspective.

    Li, Bei / Jiao, Sheng / Zhou, Min / Zhou, Yuan

    Ying yong sheng tai xue bao = The journal of applied ecology

    2024  Volume 35, Issue 2, Page(s) 533–542

    Abstract: Under the background of frequent flood disasters and stock planning challenges, clarifying the relationship and mechanism of urban green space landscape patterns and flood retention efficiency at multiple spatial scales has become a critical scientific ... ...

    Title translation “城市-街区”尺度下绿地景观格局对雨洪滞蓄效能的影响研究进展.
    Abstract Under the background of frequent flood disasters and stock planning challenges, clarifying the relationship and mechanism of urban green space landscape patterns and flood retention efficiency at multiple spatial scales has become a critical scientific issue in realizing the maximum flood retention efficiency of limited urban green spaces and improving the capabilities of urban flood control. We reviewed and summarized the factors, mechanisms, and scale differences in the influence of green space landscape patterns on flood retention efficacy at the urban and block scales. Based on the causes for differences in conclusions and research deficiencies, we suggested that future studies should focus on watershed-scale research and expand the investigation into three-dimensional green space landscape patterns. Additionally, attention should be paid to urban and suburban areas separately, and a set of research indices with indicative significance for the flooding process should be established for different flood-sensitive areas and block structures. These measures will help quantitatively reveal how green space landscape patterns of urban and block scales affect flooding process, providing theoretical guidance for urban planning and establishing urban flood safety patterns.
    MeSH term(s) Cities ; City Planning ; Disasters ; Floods ; Parks, Recreational
    Language English
    Publishing date 2024-03-24
    Publishing country China
    Document type Review ; Journal Article
    ZDB-ID 2881809-X
    ISSN 1001-9332
    ISSN 1001-9332
    DOI 10.13287/j.1001-9332.202402.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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