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  1. Article: Effect of Inter-Fragmentary Gap Size on Neovascularization During Bone Healing: A Micro-CT Imaging Study.

    Zhou, Zhilun / Yan, Yang / Yu, Hao / Yang, Guanzhong / Su, Hao / Zhang, Tao / Fan, Yubo / Zhao, Feng

    Frontiers in bioengineering and biotechnology

    2022  Volume 10, Page(s) 808182

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2022-02-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2022.808182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Large Language Models Empowered Agent-based Modeling and Simulation

    Gao, Chen / Lan, Xiaochong / Li, Nian / Yuan, Yuan / Ding, Jingtao / Zhou, Zhilun / Xu, Fengli / Li, Yong

    A Survey and Perspectives

    2023  

    Abstract: Agent-based modeling and simulation has evolved as a powerful tool for modeling complex systems, offering insights into emergent behaviors and interactions among diverse agents. Integrating large language models into agent-based modeling and simulation ... ...

    Abstract Agent-based modeling and simulation has evolved as a powerful tool for modeling complex systems, offering insights into emergent behaviors and interactions among diverse agents. Integrating large language models into agent-based modeling and simulation presents a promising avenue for enhancing simulation capabilities. This paper surveys the landscape of utilizing large language models in agent-based modeling and simulation, examining their challenges and promising future directions. In this survey, since this is an interdisciplinary field, we first introduce the background of agent-based modeling and simulation and large language model-empowered agents. We then discuss the motivation for applying large language models to agent-based simulation and systematically analyze the challenges in environment perception, human alignment, action generation, and evaluation. Most importantly, we provide a comprehensive overview of the recent works of large language model-empowered agent-based modeling and simulation in multiple scenarios, which can be divided into four domains: cyber, physical, social, and hybrid, covering simulation of both real-world and virtual environments. Finally, since this area is new and quickly evolving, we discuss the open problems and promising future directions.

    Comment: 37 pages
    Keywords Computer Science - Artificial Intelligence ; Computer Science - Computation and Language ; Computer Science - Computers and Society ; Computer Science - Multiagent Systems
    Subject code 004
    Publishing date 2023-12-19
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Disruption in the Chinese E-Commerce During COVID-19

    Yuan, Yuan / Guan, Muzhi / Zhou, Zhilun / Kim, Sundong / Cha, Meeyoung / Jin, Depeng / Li, Yong

    Abstract: The recent outbreak of the novel coronavirus (COVID-19) has infected millions of citizens worldwide and claimed many lives. This paper examines its impact on the Chinese e-commerce market by analyzing behavioral changes seen from a large online shopping ... ...

    Abstract The recent outbreak of the novel coronavirus (COVID-19) has infected millions of citizens worldwide and claimed many lives. This paper examines its impact on the Chinese e-commerce market by analyzing behavioral changes seen from a large online shopping platform. We first conduct a time series analysis to identify product categories that faced the most extensive disruptions. The time-lagged analysis shows that behavioral patterns seen in shopping actions are highly responsive to epidemic development. Based on these findings, we present a consumer demand prediction method by encompassing the epidemic statistics and behavioral features for COVID-19 related products. Experiment results demonstrate that our predictions outperform existing baselines and further extend to the long-term and province-level forecasts. We discuss how our market analysis and prediction can help better prepare for future pandemics by gaining an extra time to launch preventive steps.
    Keywords covid19
    Publisher ArXiv
    Document type Article
    Database COVID19

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  4. Book ; Online: Disruption in the Chinese E-Commerce During COVID-19

    Yuan, Yuan / Guan, Muzhi / Zhou, Zhilun / Kim, Sundong / Cha, Meeyoung / Jin, Depeng / Li, Yong

    2020  

    Abstract: The recent outbreak of the novel coronavirus (COVID-19) has infected millions of citizens worldwide and claimed many lives. This paper examines its impact on the Chinese e-commerce market by analyzing behavioral changes seen from a large online shopping ... ...

    Abstract The recent outbreak of the novel coronavirus (COVID-19) has infected millions of citizens worldwide and claimed many lives. This paper examines its impact on the Chinese e-commerce market by analyzing behavioral changes seen from a large online shopping platform. We first conduct a time series analysis to identify product categories that faced the most extensive disruptions. The time-lagged analysis shows that behavioral patterns seen in shopping actions are highly responsive to epidemic development. Based on these findings, we present a consumer demand prediction method by encompassing the epidemic statistics and behavioral features for COVID-19 related products. Experiment results demonstrate that our predictions outperform existing baselines and further extend to the long-term and province-level forecasts. We discuss how our market analysis and prediction can help better prepare for future pandemics by gaining an extra time to launch preventive steps.

    Comment: 10 pages, 7 figures, 6 tables
    Keywords Physics - Physics and Society ; Computer Science - Computers and Society ; 68T07 ; J.4 ; covid19
    Publishing date 2020-07-22
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Mitigation of Articular Cartilage Degeneration and Subchondral Bone Sclerosis in Osteoarthritis Progression Using Low-Intensity Ultrasound Stimulation.

    Li, Xiaofei / Sun, Yueli / Zhou, Zhilun / Zhang, Dongye / Jiao, Jian / Hu, Minyi / Hassan, Chaudhry Raza / Qin, Yi-Xian

    Ultrasound in medicine & biology

    2018  Volume 45, Issue 1, Page(s) 148–159

    Abstract: The purpose of this study was to evaluate the effect of low-intensity ultrasound on articular cartilage and subchondral bone alterations in joints under normal and functional disuse conditions during osteoarthritis (OA) progression. Total of thirty 5-mo- ... ...

    Abstract The purpose of this study was to evaluate the effect of low-intensity ultrasound on articular cartilage and subchondral bone alterations in joints under normal and functional disuse conditions during osteoarthritis (OA) progression. Total of thirty 5-mo-old female Sprague-Dawley rats were randomly assigned to six groups (n = 5/group): age-matched group, OA group, OA + ultrasound (US) group, hindlimb suspension (HLS) group, HLS + OA group and HLS + OA + US group. The surgical anterior cruciate ligament was used to induce OA in the right knee joints. After 2 wk of OA induction, low-intensity ultrasound generated with a 3-MHz transducer with 20% pulse duty cycle and 30 mW/cm
    MeSH term(s) Animals ; Cartilage Diseases/complications ; Cartilage Diseases/diagnostic imaging ; Cartilage Diseases/pathology ; Cartilage, Articular/diagnostic imaging ; Cartilage, Articular/pathology ; Disease Models, Animal ; Female ; Osteoarthritis/complications ; Osteoarthritis/diagnostic imaging ; Osteoarthritis/pathology ; Rats ; Rats, Sprague-Dawley ; Sclerosis ; Tibia/diagnostic imaging ; Tibia/pathology ; Ultrasonic Waves ; X-Ray Microtomography
    Language English
    Publishing date 2018-10-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 186150-5
    ISSN 1879-291X ; 0301-5629
    ISSN (online) 1879-291X
    ISSN 0301-5629
    DOI 10.1016/j.ultrasmedbio.2018.08.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Pressure Drop in Tortuosity/Kinking of the Internal Carotid Artery: Simulation and Clinical Investigation.

    Wang, Lijun / Zhao, Feng / Wang, Daming / Hu, Shen / Liu, Jiachun / Zhou, Zhilun / Lu, Jun / Qi, Peng / Song, Shiying

    BioMed research international

    2016  Volume 2016, Page(s) 2428970

    Abstract: Background. Whether carotid tortuosity/kinking of the internal carotid artery leads to cerebral ischemia remains unclear. There is very little research about the hemodynamic variation induced by carotid tortuosity/kinking in the literature. The objective ...

    Abstract Background. Whether carotid tortuosity/kinking of the internal carotid artery leads to cerebral ischemia remains unclear. There is very little research about the hemodynamic variation induced by carotid tortuosity/kinking in the literature. The objective of this study was to research the blood pressure changes induced by carotid tortuosity/kinking. Methods. We first created a geometric model of carotid tortuosity/kinking. Based on hemodynamic boundary conditions, the hemodynamics of carotid tortuosity and kinking were studied via a finite element simulation. Then, an in vitro system was built to validate the numerical simulation results. The mean arterial pressure changes before and after carotid kinking were measured using pressure sensors in 12 patients with carotid kinking. Results. Numerical simulation revealed that the pressure drops increased with increases in the kinking angles. Clinical tests and in vitro experiments confirmed the numerical simulation results. Conclusions. Carotid kinking leads to blood pressure reduction. In certain conditions, kinking may affect the cerebral blood supply and be associated with cerebral ischemia.
    MeSH term(s) Adult ; Aged ; Blood Pressure ; Carotid Artery, Internal/physiopathology ; Computer Simulation ; Coronary Disease/physiopathology ; Diabetes Mellitus/physiopathology ; Humans ; Hyperlipidemias/physiopathology ; Hypertension/physiopathology ; Middle Aged ; Models, Cardiovascular
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2016/2428970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Effect of fixation on neovascularization during bone healing.

    Zhao, Feng / Zhou, Zhilun / Yan, Yang / Yuan, Zhen / Yang, Guanzhong / Yu, Hao / Su, Hao / Zhang, Tao / Fan, Yubo

    Medical engineering & physics

    2014  Volume 36, Issue 11, Page(s) 1436–1442

    Abstract: Fixation and vascularity after bone fracture are two critical factors for successful healing, and their influences on bone healing have been studied by many researchers. This research aims to obtain three-dimensional (3D) reconstruction images of ... ...

    Abstract Fixation and vascularity after bone fracture are two critical factors for successful healing, and their influences on bone healing have been studied by many researchers. This research aims to obtain three-dimensional (3D) reconstruction images of neovascularization of the soft tissues surrounding the fracture with vascular perfusion and micro-computer tomography (micro-CT) imaging, and to investigate the effect of stable fixation on neovascularization and the pattern of vascularity during the process of bone healing. To accomplish this, 36 Sprague-Dawley (SD) rats underwent mid-shaft transverse osteotomy of the right tibia. Half of them received stable fixation with a newly custom-designed external fixator (FSF, the group of fracture with stable fixation), while the rest received no fixation (FNF, the group of fracture with no fixation). The results indicated that FNF samples had more transversal vascular distribution than FSF samples; FSF samples had more longitudinal vascular distribution than FNF samples; and the spatio-temporal pattern of vascularity in FSF samples was more similar to that in the control group (CON, the group without fracture) than that in FNF samples. At the time of 2 and 4 weeks postoperatively, FNF samples had significantly higher vessel volume ratio (VV/TV), larger vessel number (VN) and higher vessel surface density (VS/TV) than CON samples. At all sacrifice times, FSF samples contained significantly higher VV/TV, VN and VS/TV values compared with FNF samples. In summary, neovascularization and its pattern are obviously influenced by the mechanical fixation. Stable fixation can promote longitudinal vascularity pattern formation, which tends to be similar to the natural vascularity pattern, and this benefits the inter-fragmentary blood fluid connectivity during bone healing process.
    MeSH term(s) Animals ; Blood Vessels/physiology ; Fracture Fixation ; Fracture Healing ; Imaging, Three-Dimensional ; Neovascularization, Physiologic ; Rats ; Rats, Sprague-Dawley ; Tibia/blood supply ; Tibia/diagnostic imaging ; Tibia/physiology ; Tibia/surgery ; X-Ray Microtomography
    Language English
    Publishing date 2014-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1181080-4
    ISSN 1873-4030 ; 1350-4533
    ISSN (online) 1873-4030
    ISSN 1350-4533
    DOI 10.1016/j.medengphy.2014.07.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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