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Article ; Online: Relapse of lupus nephritis induced by nivolumab in an 84-year-old patient with oral cancer

Zhou Zhou / Qiankun Zhang / Xinbin Wang

Journal of International Medical Research, Vol

a case report

2023 Volume 51

Abstract: Various immunity-related adverse events have been reported to be associated with the inhibition of programmed cell death receptor 1. We report a rare case of a relapse of lupus nephritis (LN), involving rapidly progressive glomerulonephritis, which was ... ...

Abstract	Various immunity-related adverse events have been reported to be associated with the inhibition of programmed cell death receptor 1. We report a rare case of a relapse of lupus nephritis (LN), involving rapidly progressive glomerulonephritis, which was induced by nivolumab treatment in a patient with oral cancer. The patient had a history of systemic lupus erythematosus and underwent treatment with steroids, rituximab, and plasmapheresis. However, her renal function did not improve, and she died of multiple organ failure. To our knowledge, this is the first description of severe LN induced by nivolumab.
Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Thesis ; Online: Situación económico-financiera y estrategia de desarrollo empresarial en china ante la pandemia covid-19

Zhou, Zhou

2020

Abstract: Treball de Final de Màster Universitari en Gestió Financera i Comptabilitat Avançada (Pla de 2013). Codi: SRL031. Curs acadèmic 2019/2020 ... Este trabajo tiene como objetivo analizar la situación económico-financiera y la estrategia de desarrollo ... ...

Abstract	Treball de Final de Màster Universitari en Gestió Financera i Comptabilitat Avançada (Pla de 2013). Codi: SRL031. Curs acadèmic 2019/2020 Este trabajo tiene como objetivo analizar la situación económico-financiera y la estrategia de desarrollo empresarial en China ante la pandemia Covid-19. Se analiza desde un punto de vista muy completo, desde las presiones que ya existían y las que provocó el virus, así como una visión a nivel de China y a nivel internacional del suceso. Ante la pandemia, entre las industrias favorables y desfavorables se observa que la más afectada es la industria terciaria. La parte positiva es que ha impulsado muchas innovaciones futuras, hacía una sociedad más tecnológica, con tratamientos médicos más optimizados y con más producción a nivel nacional en China. Seguidamente se detallan los problemas a los que se enfrentan las empresas y los problemas a los que se enfrentarán en el futuro. Entre las políticas adoptadas por el estado para las empresas, generalmente hay una reducción de los costes operativos, promueven políticas para reanudar el trabajo y reanudar la producción, así como proyectos especiales para industrias turísticas. El efecto de la política de apoyo es notable. En este desastre, las empresas pueden descubrir problemas potenciales y tendencias futuras. El país también ha trazado tendencias como una nueva infraestructura para este propósito. En el presente trabajo también se observará que el mercado financiero mundial experimentó fluctuaciones particularmente grandes en marzo, que tuvieron un gran impacto en el mercado de divisas y, especialmente, en el mercado del petróleo. También se analiza la suspensión de la cotización. Somos testigos de este momento histórico. Esta es la segunda vez que esto sucede desde el 1997. Haremos una comparación de esta crisis con la crisis financiera de 2008, ya que existen similitudes y diferencias: es muy probable que la economía mundial caiga en recesión en el 2020, y la duración de esta recesión aún es muy incierta. Para el mercado chino, el impacto es mayor en el comercio internacional, la importación y exportación, así como en el mercado de divisas. Este trabajo pretende proporcionar una referencia para que las empresas encuentren avances, ayudar a las empresas a salir a flote o convertir la "crisis" en "oportunidad" y realizar el desarrollo empresarial. Con el objetivo de que otros países que están sufriendo el Coronavirus puedan prevenir los problemas que este conllevará.
Keywords	Màster Universitari en Gestió Financera i Comptabilitat Avançada ; Máster Universitario en Gestión Financiera y Contabilidad Avanzada ; Master's Degree in Financial Management and Advanced Accounting ; economía china ; China ; pandemia ; COVID-19 ; estrategia empresarial ; epidemia ; covid19
Language	Spanish
Publishing date	2020-07-01T11:51:40Z
Publisher	Universitat Jaume I
Publishing country	es
Document type	Thesis ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Diagnostic value of angiography-derived index of microcirculatory resistance (AMR) for coronary microcirculatory dysfunction (CMD) and its prognostic significance in patients with chronic coronary syndromes in the smoking population.

Qiu, Zhongjue / Wang, Yong / Liu, Yang / Zhou, Zhou / Wang, Zhen

Medicine

2024 Volume 103, Issue 6, Page(s) e37022

Abstract: This study aims to analyze the prognostic significance of angiographic microvascular resistance (AMR) derived from functional coronary angiography in diagnosing coronary microvascular dysfunction (CMD) among patients with chronic coronary syndrome (CCS), ...

Abstract	This study aims to analyze the prognostic significance of angiographic microvascular resistance (AMR) derived from functional coronary angiography in diagnosing coronary microvascular dysfunction (CMD) among patients with chronic coronary syndrome (CCS), particularly focusing on the prognostic significance of CMD in smokers. Additionally, this study assesses the prognostic significance of the diagnostic accuracy of the AMR index for CMD in CCS patients within the smoking population. Seventy-five CCS patients were studied for IMR measurement between June 2018 and December 2020, classified into CMD and non-CMD groups. Pearson correlation analyzed AMR and IMR relationship, while ROC curves determined AMR's predictive value for CMD with optimal cutoff value. An additional 223 CCS patients were included for AMR measurements. The study's primary endpoint was MACE occurrence, followed up through telephone calls. COX one-way analysis and Kaplan-Meier analysis evaluated the association between AMR and MACE risk. In the study, 52% of patients were diagnosed with CMD, and the AUC under the AMR curve for predicted IMR ≥ 25 was 0.90 (95% CI: 0.79-0.95). The CMD group had a higher proportion of female patients, smokers, and those with hypertension and diabetes mellitus compared to the non-CMD group (all P < .05). The CMD group exhibited higher AMR values than the non-CMD group (3.20 ± 0.5 vs 1.95 ± 0.45, P < .01), with a significant correlation between AMR and IMR (R2 = 0.81, P < .001). The ROC curve illustrated AMR's effectiveness in diagnosing CMD in CCS patients, using IMR as the gold standard, with the optimal cutoff value of AMR = 2.6mmHgs/cm (sensitivity: 90.5%, specificity: 81.5%). Patients with AMR ≥ 2.6mmHgs/cm had a higher risk of MACE events (HR = 6.00; 95% CI: 1.59-22.67). AMR in patients with CCS was significantly correlated with IMR and demonstrated good diagnostic accuracy. AMR ≥ 2.6 mm Hg*s/cm was associated with an increased risk of MACE occurrence and served as a valuable prognostic factor. In patients with CCS, AMR has a high diagnostic performance, In patients with CCS who smoke, impaired coronary microvascular function as assessed by AMR is significant and is an independent predictor of MACE.
MeSH term(s)	Humans ; Female ; Prognosis ; Microcirculation ; Myocardial Ischemia ; Coronary Angiography ; Syndrome ; Smoking/adverse effects ; Coronary Artery Disease
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000037022
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Article ; Online: Editorial:

Zhou, Zhou / Liu, Yuanjun / Yang, Chunfu / Saka, Hector Alex

Frontiers in cellular and infection microbiology

2024 Volume 14, Page(s) 1372714

MeSH term(s)	Humans ; Chlamydia/genetics ; Chlamydia Infections/pathology
Language	English
Publishing date	2024-02-06
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2024.1372714
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Article ; Online: Fascia lata autografts achieve interface healing with the supraspinatus muscle histologically and mechanically in a rat supraspinatus tendon reconstruction model for massive irreparable rotator cuff tears.

Liao, Yatao / Zhou, Zhou / Wang, Jun / Li, Huaisheng / Zhou, Binghua

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

2024

Abstract: Purpose: To evaluate the histologic healing process and mechanical characteristics of the interface between a fascia lata autograft and supraspinatus muscle by establishing a supraspinatus tendon reconstruction model for chronic massive, irreparable ... ...

Abstract	Purpose: To evaluate the histologic healing process and mechanical characteristics of the interface between a fascia lata autograft and supraspinatus muscle by establishing a supraspinatus tendon reconstruction model for chronic massive, irreparable rotator cuff tears (MIRCTs). Methods: A total of 40 rats were studied. Eight rats were sacrificed to establish an intact control group, and the other rats were first established as the chronic MIRCTs model and then developed as the supraspinatus tendon reconstruction model. Histology, fatty infiltration, mechanics and the open field test for the interface between the fascia lata autograft and muscle were assessed at 2, 4, 8 and 16 weeks postoperatively. Results: Histologically, the interface between the fascia lata autograft and muscle gradually regenerated structural similarities to the normal muscle-tendon interface by 16 weeks postoperatively. The amounts of collagen I and III were both increased significantly during the healing time and stabilized at 8 weeks postoperatively. Fatty infiltration was obvious in the supraspinatus muscle 4 weeks after the MIRCTs model. However, the degree of fatty infiltration in the supraspinatus muscle gradually decreased after supraspinatus tendon reconstruction and stabilized at 8 weeks postoperatively. The ultimate failure force and the ultimate stress gradually increased from 2 to 16 weeks and reached the level of the intact control tendon at 16 weeks postoperatively (P=0.086). The movability of the forepaw returned to normal in the open field test (P=0.907). Conclusions: In this rat supraspinatus tendon reconstruction model, fascia lata autografts showed good interface healing with the supraspinatus muscle, and fatty infiltration in the supraspinatus muscle was histologically decreased. The interface between the fascia lata autograft and muscle can sustain mechanical strength similar to the anatomical muscle-tendon interface. Clinical relevance: The supraspinatus tendon reconstruction technique using fascia lata autografts might be a good histological and biomechanical option for treating MIRCTs.
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	632528-2
ISSN	1526-3231 ; 0749-8063
ISSN (online)	1526-3231
ISSN	0749-8063
DOI	10.1016/j.arthro.2024.02.048
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Article ; Online: A method for generating case-specific vehicle models from a single-view vehicle image for accurate pedestrian injury reconstructions.

Huang, Qi / Lindgren, Natalia / Zhou, Zhou / Li, Xiaogai / Kleiven, Svein

Accident; analysis and prevention

2024 Volume 200, Page(s) 107555

Abstract: Developing vehicle finite element (FE) models that match real accident-involved vehicles is challenging. This is related to the intricate variety of geometric features and components. The current study proposes a novel method to efficiently and ... ...

Abstract	Developing vehicle finite element (FE) models that match real accident-involved vehicles is challenging. This is related to the intricate variety of geometric features and components. The current study proposes a novel method to efficiently and accurately generate case-specific buck models for car-to-pedestrian simulations. To achieve this, we implemented the vehicle side-view images to detect the horizontal position and roundness of two wheels to rectify distortions and deviations and then extracted the mid-section profiles for comparative calculations against baseline vehicle models to obtain the transformation matrices. Based on the generic buck model which consists of six key components and corresponding matrices, the case-specific buck model was generated semi-automatically based on the transformation metrics. Utilizing this image-based method, a total of 12 vehicle models representing four vehicle categories including family car (FCR), Roadster (RDS), small Sport Utility Vehicle (SUV), and large SUV were generated for car-to-pedestrian collision FE simulations in this study. The pedestrian head trajectories, total contact forces, head injury criterion (HIC), and brain injury criterion (BrIC) were analyzed comparatively. We found that, even within the same vehicle category and initial conditions, the variation in wrap around distance (WAD) spans 84-165 mm, in HIC ranges from 98 to 336, and in BrIC fluctuates between 1.25 and 1.46. These findings highlight the significant influence of vehicle frontal shape and underscore the necessity of using case-specific vehicle models in crash simulations. The proposed method provides a new approach for further vehicle structure optimization aiming at reducing pedestrian head injury and increasing traffic safety.
MeSH term(s)	Humans ; Accidents, Traffic/prevention & control ; Pedestrians ; Motor Vehicles ; Craniocerebral Trauma/prevention & control ; Brain Injuries ; Biomechanical Phenomena ; Walking/injuries
Language	English
Publishing date	2024-03-25
Publishing country	England
Document type	Journal Article
ZDB-ID	210223-7
ISSN	1879-2057 ; 0001-4575
ISSN (online)	1879-2057
ISSN	0001-4575
DOI	10.1016/j.aap.2024.107555
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Article ; Online: Universal Definition and Classification of Heart Failure Triggers the Standardization of Diagnosis and Treatment of Heart Failure

XU Fen / ZHOU Zhou

Xiehe Yixue Zazhi, Vol 12, Iss 5, Pp 621-

2021 Volume 623

Abstract: Recently, the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology and Japanese Heart Failure Society jointly issued a consensus statement on Universal Definition and Classification of Heart Failure. ... ...

Abstract	Recently, the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology and Japanese Heart Failure Society jointly issued a consensus statement on Universal Definition and Classification of Heart Failure. Natriuretic peptides were written into the universal definition of heart failure and became the second cardiac marker written into the definition of disease after troponin.The consensus proposed new four classes of heart failure according to ejection fraction(EF), including heart failure with reduced EF(HFrEF), heart failure with mildly reduced EF(HFmrEF), heart failure with preserved EF(HFpEF)and heart failure with improved EF(HFimpEF). Universal Definition and Classification of Heart Failure has wide applicability, which is helpful for clinicians, researchers and patients to understand and adopt.It is an important first step forward to the standardization of diagnosis and treatment of heart failure. While using the universal definition and classification of heart failure, clinical staff should actively conduct scientific research to promote the standardization of diagnosis and treatment of heart failure.
Keywords	heart failure ; natriuretic peptide ; definition ; classification ; standardization ; Medicine ; R
Subject code	610
Language	Chinese
Publishing date	2021-09-01T00:00:00Z
Publisher	Editorial Office of Medical Journal of Peking Union Medical College Hospital
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Spectral Inference under Complex Temporal Dynamics

Yang, Jun / Zhou, Zhou

Journal of the American Statistical Association. 2022 Jan. 2, v. 117, no. 537

2022

Abstract: We develop a unified theory and methodology for the inference of evolutionary Fourier power spectra for a general class of locally stationary and possibly nonlinear processes. In particular, simultaneous confidence regions (SCR) with asymptotically ... ...

Abstract	We develop a unified theory and methodology for the inference of evolutionary Fourier power spectra for a general class of locally stationary and possibly nonlinear processes. In particular, simultaneous confidence regions (SCR) with asymptotically correct coverage rates are constructed for the evolutionary spectral densities on a nearly optimally dense grid of the joint time-frequency domain. A simulation based bootstrap method is proposed to implement the SCR. The SCR enables researchers and practitioners to visually evaluate the magnitude and pattern of the evolutionary power spectra with asymptotically accurate statistical guarantee. The SCR also serves as a unified tool for a wide range of statistical inference problems in time-frequency analysis ranging from tests for white noise, stationarity and time-frequency separability to the validation for non-stationary linear models.
Keywords	Americans ; Whites ; density ; journals ; linear models ; methodology ; researchers ; statistical inference ; temporal variation ; whiting
Language	English
Dates of publication	2022-0102
Size	p. 133-155.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	2064981-2
ISSN	1537-274X
ISSN	1537-274X
DOI	10.1080/01621459.2020.1764365
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Finite-time terminal sliding mode attitude control for tailless full-wing configuration UAVs based on extended state observers and auxiliary compensators.

Sun, Ruijie / Zhou, Zhou / Zhu, Xiaoping

ISA transactions

2023 Volume 144, Page(s) 282–307

Abstract: Considering the sensitivity of the tailless full-wing configuration unmanned aerial vehicle to disturbance and the strong nonlinearity and coupling caused by the manipulation combining the propeller and rudder, a finite-time terminal sliding mode ... ...

Abstract	Considering the sensitivity of the tailless full-wing configuration unmanned aerial vehicle to disturbance and the strong nonlinearity and coupling caused by the manipulation combining the propeller and rudder, a finite-time terminal sliding mode controller with compound compensation is proposed in this paper to ensure stable attitude control. Based on singular perturbation theory, the inner loop sliding mode controller is designed so that the supremum of the convergence time of the rotational angular velocity tracking error in the sliding phase can be directly determined by the control parameters without requiring the initial state, and the outer loop sliding mode controller is designed so that the sliding surface function of the attitude angle tracking error has a fast convergence speed when it is far from and close to the origin. The compound compensation design further addresses the manipulation nonlinearity and disturbance sensitivity of the research object. Based on the minimum Euclidean norm optimization, the designed control allocator achieves command decoupling and reduces the desired control command. Through comprehensive verification, the proposed controller shows superior control performance and low energy consumption and exhibits strong robustness in the cruising flight envelope.
Language	English
Publishing date	2023-10-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2012746-7
ISSN	1879-2022 ; 0019-0578
ISSN (online)	1879-2022
ISSN	0019-0578
DOI	10.1016/j.isatra.2023.10.024
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Advances in drug resistance of triple negative breast cancer caused by pregnane X receptor.

Rao, Zhou-Zhou / Tang, Zhong-Wen / Wen, Jie

World journal of clinical oncology

2023 Volume 14, Issue 9, Page(s) 335–342

Abstract: Breast cancer is the most common malignancy in women worldwide. Triple-negative breast cancer (TNBC), refers breast cancer negative for estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2, characterized by high drug ... ...

Abstract	Breast cancer is the most common malignancy in women worldwide. Triple-negative breast cancer (TNBC), refers breast cancer negative for estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2, characterized by high drug resistance, high metastasis and high recurrence, treatment of which is a difficult problem in the clinical treatment of breast cancer. In order to better treat TNBC clinically, it is a very urgent task to explore the mechanism of TNBC resistance in basic breast cancer research. Pregnane X receptor (PXR) is a nuclear receptor whose main biological function is to participate in the metabolism, transport and clearance of allobiological agents in PXR. PXR plays an important role in drug metabolism and clearance, and PXR is highly expressed in tumor tissues of TNBC patients, which is related to the prognosis of breast cancer patients. This reviews synthesized the important role of PXR in the process of high drug resistance to TNBC chemotherapeutic drugs and related research progress.
Language	English
Publishing date	2023-09-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2587357-X
ISSN	2218-4333
ISSN	2218-4333
DOI	10.5306/wjco.v14.i9.335
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