LIVIVO - Search results -

Search results

Result 1 - 10 of total 165

Search options

Article ; Online: A wavelet based data coupling method for spatial damage detection in beam-type structures.

Zhao, Jianwei / Zhou, Zhuo / Guan, Deqing / Guo, Jia

2023 Volume 18, Issue 8, Page(s) e0290265

Abstract: Spatial damage identification is of great significance in mechanical, aerospace, and civil engineering. In this study, a data coupling method based on continuous wavelet transform (CWT) is proposed to identify the spatial damage location of beam-type ... ...

Abstract	Spatial damage identification is of great significance in mechanical, aerospace, and civil engineering. In this study, a data coupling method based on continuous wavelet transform (CWT) is proposed to identify the spatial damage location of beam-type structures. The singularity of the wavelet coefficient can be used to identify the signal singularity, and data coupling method calculates the spatial location of the damage. Numerical simulations and experimental analyses of different type of beams with transfixion damage are carried out to evaluate the accuracy of the method. The results show that the wavelet based data coupling method (W-DCM) can identify the minimum 4.9% damage severity of fixed beam and continuous beam, and can also identify the damage of non-free end of cantilever beam. However, the 9.7% damage severity of the free end of the cantilever beam cannot be identified. It is also found that the W-DCM can effectively circumvent the problem of wavelet coefficients edge effect. This method and wavelet singularity are used to provide a solution to the problem of structural edge damage identification.
Language	English
Publishing date	2023-08-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0290265
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: [Clinical analysis and genetic diagnosis of three children with Isoleucine metabolic disorders due to variants of HSD17B10 and ACAT1 genes].

Ji, Wei / Tian, Guoli / Zhang, Xiaofen / Wang, Yanmin / Yang, Yongchen / Zhou, Zhuo / Guo, Jing

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

2024 Volume 41, Issue 5, Page(s) 540–545

Abstract: Objective: To explore the clinical, biochemical and genetic characteristics of three children with Isoleucine metabolic disorders due to variants of HSD17B10 and ACAT1 genes.: Methods: Two children with 17β hydroxysteroid dehydrogenase 10 (HSD17B10) ... ...

Abstract	Objective: To explore the clinical, biochemical and genetic characteristics of three children with Isoleucine metabolic disorders due to variants of HSD17B10 and ACAT1 genes. Methods: Two children with 17β hydroxysteroid dehydrogenase 10 (HSD17B10) deficiency and a child with β-ketothiolase deficiency (BKD) diagnosed at Shanghai Children's Hospital between 2014 and 2021 were selected as the study subjects. Clinical data of the children were collected. The children were subjected to blood acylcarnitine, urinary organic acid and genetic testing, and candidate variants were analyzed with bioinformatic tools. Results: The main symptoms of the three children had included epilepsy, developmental delay, hypotonia and acidosis. Their blood acylcarnitine methylcrotonyl carnitine (C5:1), 3-hydroxyisovalerylcarnitine (C5-OH) and 3-hydroxybutylcarnitine (C4OH) were increased to various extents, and urine organic acids including methyl crotonylglycine and 2-methyl-3-hydroxybutyric acid were significantly increased. Child 1 and child 2 were respectively found to harbor a c.347G>A (p.R116Q) variant and a c.274G>A (p.A92T) variant of the HSD17B10 gene, and child 3 was found to harbor compound heterozygous variants of the ACAT1 gene, namely c.547G>A (p.G183R) and a c.331G>C (p.A111P). Among these, the c.274G>A (p.A92T) and c.331G>C (p.A111P) variants were unreported previously. Based on the guidelines from the American College of Medical Genetics and Genomics (ACMG), they were respectively classified as variant of unknown significance (PP3_Strong+PM2_supporting) and likely pathogenic (PM3+PM2_Supporting+PP3_Moderate+PP4). Conclusion: Both the HSD17B10 deficiency and BKD can lead to Isoleucine metabolism disorders, which may be difficult to distinguish clinically. Genetic testing can further confirm the diagnosis. Discoveries of the HSD17B10: c.274G>A (p.A92T) variant and the ACAT1: c.331G>C (p.A111P) variant have enriched the mutational spectrum of the two diseases.
MeSH term(s)	Humans ; Male ; Female ; Acetyl-CoA C-Acetyltransferase/genetics ; Isoleucine/genetics ; Infant ; Child, Preschool ; Amino Acid Metabolism, Inborn Errors/genetics ; Amino Acid Metabolism, Inborn Errors/diagnosis ; Child ; Mutation ; Carnitine/analogs & derivatives ; Carnitine/blood ; Carnitine/urine ; Acetyl-CoA C-Acyltransferase/deficiency ; 3-Hydroxyacyl CoA Dehydrogenases
Chemical Substances	ACAT1 protein, human (EC 2.3.1.9) ; Acetyl-CoA C-Acetyltransferase (EC 2.3.1.9) ; Isoleucine (04Y7590D77) ; HSD17B10 protein, human (EC 1.1.1.35) ; Carnitine (S7UI8SM58A) ; Acetyl-CoA C-Acyltransferase (EC 2.3.1.16) ; 3-Hydroxyacyl CoA Dehydrogenases (EC 1.1.1.-)
Language	Chinese
Publishing date	2024-04-29
Publishing country	China
Document type	Journal Article ; Case Reports ; English Abstract
ISSN	1003-9406
ISSN	1003-9406
DOI	10.3760/cma.j.cn511374-20230518-00300
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Extramed: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Comparative analysis of inherited metabolic diseases in normal newborns and high-risk children: Insights from a 10-year study in Shanghai.

Zhang, Xiaofen / Ji, Wei / Wang, Yanmin / Zhou, Zhuo / Guo, Jing / Tian, Guoli

Clinica chimica acta; international journal of clinical chemistry

2024 Volume 558, Page(s) 117893

Abstract: Background: Compare the differences between normal newborns and high-risk children with inherited metabolic diseases. The disease profile includes amino acidemias, fatty acid oxidation disorders, and organic acidemias.: Methods: Data was collected on ...

Abstract	Background: Compare the differences between normal newborns and high-risk children with inherited metabolic diseases. The disease profile includes amino acidemias, fatty acid oxidation disorders, and organic acidemias. Methods: Data was collected on newborns and children from high-risk populations in Shanghai from December 2010 to December 2020. Results: 232,561 newborns were screened for disorders of organic, amino acid, and fatty acid metabolism. The initial positive rate was 0.66 % (1,526/232,561) and the positive recall rate was 77.85 %. The positive predictive value is 4.71 %. Among them, 56 cases were diagnosed as metabolic abnormalities. The total incidence rate is 1:4153. Hyperphenylalaninemia and short-chain acyl-CoA dehydrogenase are the most common diseases in newborns. In addition, in 56 children, 39 (69.42 %) were diagnosed by genetic sequencing. Some hotspot mutations in 14 IEMs have been observed, including PAH gene c.728G > A, c.611A > G, and ACADS gene c. 1031A > G, c.164C > T. A total of 49,860 symptomatic patients were screened, of which 185 were diagnosed with IEM, with a detection rate of 0.37 %. The most commonly diagnosed diseases in high-risk infants aremethylmalonic acidemia and hyperphenylalaninemia. Conclusion: There are more clinical cases of congenital metabolic errors diagnosed by tandem mass spectrometry than newborn screening. The spectrum of diseases, prevalence, and genetic characteristics of normal newborns and high-risk children are quite different.
MeSH term(s)	Humans ; Infant, Newborn ; China/epidemiology ; Male ; Female ; Neonatal Screening ; Infant ; Metabolic Diseases/diagnosis ; Metabolic Diseases/genetics ; Metabolic Diseases/epidemiology ; Metabolism, Inborn Errors/diagnosis ; Metabolism, Inborn Errors/epidemiology ; Metabolism, Inborn Errors/genetics ; Child ; Child, Preschool
Language	English
Publishing date	2024-04-04
Publishing country	Netherlands
Document type	Journal Article ; Comparative Study
ZDB-ID	80228-1
ISSN	1873-3492 ; 0009-8981
ISSN (online)	1873-3492
ISSN	0009-8981
DOI	10.1016/j.cca.2024.117893
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ud II Zs.173: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: High-Entropy Photothermal Materials.

He, Cheng-Yu / Li, Yang / Zhou, Zhuo-Hao / Liu, Bao-Hua / Gao, Xiang-Hu

Advanced materials (Deerfield Beach, Fla.)

2024 , Page(s) e2400920

Abstract: High-entropy (HE) materials, celebrated for their extraordinary chemical and physical properties, have garnered increasing attention for their broad applications across diverse disciplines. The expansive compositional range of these materials allows for ... ...

Abstract	High-entropy (HE) materials, celebrated for their extraordinary chemical and physical properties, have garnered increasing attention for their broad applications across diverse disciplines. The expansive compositional range of these materials allows for nuanced tuning of their properties and innovative structural designs. Recent advances have been centered on their versatile photothermal conversion capabilities, effective across the full solar spectrum (300-2500 nm). The HE effect, coupled with hysteresis diffusion, imparts these materials with desirable thermal and chemical stability. These attributes position HE materials as a revolutionary alternative to traditional photothermal materials, signifying a transformative shift in photothermal technology. This review delivers a comprehensive summary of the current state of knowledge regarding HE photothermal materials, emphasizing the intricate relationship between their compositions, structures, light-absorbing mechanisms, and optical properties. Furthermore, the review outlines the notable advances in HE photothermal materials, emphasizing their contributions to areas, such as solar water evaporation, personal thermal management, solar thermoelectric generation, catalysis, and biomedical applications. The review culminates in presenting a roadmap that outlines prospective directions for future research in this burgeoning field, and also outlines fruitful ways to develop advanced HE photothermal materials and to expand their promising applications.
Language	English
Publishing date	2024-03-04
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202400920
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article: Seasonal variation of microbial community and methane metabolism in coalbed water in the Erlian Basin, China.

Fu, Li / Lai, Shouchao / Zhou, Zhuo / Chen, Zhenhong / Cheng, Lei

Frontiers in microbiology

2023 Volume 14, Page(s) 1114201

Abstract: Coalbed water is a semi-open system connecting underground coalbeds with the external environment. Microorganisms in coalbed water play an important role in coal biogasification and the carbon cycle. The community assemblages of microorganisms in such a ... ...

Abstract	Coalbed water is a semi-open system connecting underground coalbeds with the external environment. Microorganisms in coalbed water play an important role in coal biogasification and the carbon cycle. The community assemblages of microorganisms in such a dynamic system are not well understood. Here, we used high-throughput sequencing and metagenomic analysis to investigate microbial community structure and identify the potential functional microorganisms involved in methane metabolism in coalbed water in the Erlian Basin, a preferred low-rank coal bed methane (CBM) exploration and research area in China. The results showed that there were differences in the responses of bacteria and archaea to seasonal variation. Bacterial community structure was affected by seasonal variation but archaea was not. Methane oxidation metabolism dominated by
Language	English
Publishing date	2023-02-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1114201
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: A real-time green construction optimization strategy for engineering vessels considering fuel consumption and productivity: A case study on a cutter suction dredger

Shang, Gang / Xu, Liyun / Tian, Jinzhu / Cai, Dongwei / Xu, Zhun / Zhou, Zhuo

Energy. 2023 July, v. 274 p.127326-

2023

Abstract: Energy saving in the process of engineering construction is an indispensable measure to achieve industrial low carbon emissions. To reduce fuel consumption in the construction process of engineering vessels, a real-time green construction optimization ... ...

Abstract	Energy saving in the process of engineering construction is an indispensable measure to achieve industrial low carbon emissions. To reduce fuel consumption in the construction process of engineering vessels, a real-time green construction optimization strategy for engineering vessels considering fuel consumption and productivity is proposed. A cutter suction dredger (CSD) is taken as a case study. Based on its working principle, a series of potential monitoring features are determined. In addition, details of data collection are presented. Then, the original data obtained are cleaned based on human experience. The Hilbert Schmidt independence criterion least absolute shrinkage and selection operator (HSIC Lasso) was used to filter out irrelevant and redundant factors to achieve feature dimensionality reduction, followed by data standardization based on the robust scaler function. Five machine learning models, including gradient boosting regression tree (GBRT), extreme gradient boosting (XGBoost), random forest regression (RFR), support vector regression (SVR) and super learner based on stacked strategy (SLBSS), are used to train and test offline data on the basis. The Taguchi test method is used to optimize the hyperparameters of these models. In addition, an online data collection, processing and analysis framework is proposed. The online data collected in real time are used to predict the fuel consumption level based on this framework. Finally, feature importance is analyzed. Aiming at the minimum fuel consumption per unit productivity (FCₚᵤₚ), specific and feasible optimization suggestions are made for CSD construction. The results show that machine learning models can predict the fuel consumption level effectively. The first seven important features should be used for prediction. The productivity, lubricating oil pressure of the pump gearbox in the cabin and slurry density are the three most important factors. Improving the parameters related to productivity and reducing the sailing speed, reamer motor voltage and washing pressure of reamer bearings can improve fuel efficiency, which is beneficial to energy savings and emission reduction. Engineering construction shows that this strategy can reduce the fuel consumption of the CSD by approximately 20%.
Keywords	algorithms ; carbon ; case studies ; data collection ; electric potential difference ; energy use and consumption ; fuels ; humans ; oils ; prediction ; regression analysis ; slurries ; transmission systems ; Construction optimization ; Fuel consumption ; Machine learning ; Cutter suction dredger ; Real-time prediction ; Energy efficiency
Language	English
Dates of publication	2023-07
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	2019804-8
ISSN	0360-5442 ; 0360-5442
ISSN (online)	0360-5442
ISSN	0360-5442
DOI	10.1016/j.energy.2023.127326
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: The discovery of an anti-Candida xanthone with selective inhibition of Candida albicans GAPDH.

Chen, Xing-Ru / Zhou, Tao / Zhou, Zhuo-Da / Fang, Zhan-Hong / Wang, Kai-Bo / Zhang, Chao / Kong, Ling-Yi / Yang, Ming-Hua

International journal of antimicrobial agents

2024 Volume 63, Issue 6, Page(s) 107172

Abstract: Objectives: This study aimed to discover novel antifungals targeting Candida albicans glyceraldehyde-3-phosphate dehydrogenase (CaGAPDH), have an insight into inhibitory mode, and provide evidence supporting CaGAPDH as a target for new antifungals.: ... ...

Abstract	Objectives: This study aimed to discover novel antifungals targeting Candida albicans glyceraldehyde-3-phosphate dehydrogenase (CaGAPDH), have an insight into inhibitory mode, and provide evidence supporting CaGAPDH as a target for new antifungals. Methods: Virtual screening was utilized to discover inhibitors of CaGAPDH. The inhibitory effect on cellular GAPDH was evaluated by determining the levels of ATP, NAD, NADH, etc., as well as examining GAPDH mRNA and protein expression. The role of GAPDH inhibition in C. albicans was supported by drug affinity responsive target stability and overexpression experiments. The mechanism of CaGAPDH inhibition was elucidated by Michaelis-Menten enzyme kinetics and site-specific mutagenesis based on docking. Chemical synthesis was used to produce an improved candidate. Different sources of GAPDH were used to evaluate inhibitory selectivity across species. In vitro and in vivo antifungal tests, along with anti-biofilm activity, were carried out to evaluate antifungal potential of GAPDH inhibitors. Results: A natural xanthone was identified as the first competitive inhibitor of CaGAPDH. It demonstrated in vitro anti-C. albicans potential but also caused hemolysis. XP-W, a synthetic side-chain-optimized xanthone, demonstrated a better safety profile, exhibiting a 50-fold selectivity for CaGAPDH over human GAPDH. XP-W also exhibited potent anti-biofilm activity and displayed broad-spectrum anti-Candida activities in vitro and in vivo, including multi-azole-resistant C. albicans. Conclusions: These results demonstrate for the first time that CaGAPDH is a valuable target for antifungal drug discovery, and XP-W provides a promising lead.
Language	English
Publishing date	2024-04-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2024.107172
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 500: Show issues

Order via subito

Details ▾

Article ; Online: Effects of posterior staphyloma on choroidal structure in myopic adults: a retrospective study.

Zhou, Zhuo-Hua / Xiong, Pian-Pian / Sun, Jiao / Wang, Yan-Ling / Wang, Jia-Lin

BMC ophthalmology

2023 Volume 23, Issue 1, Page(s) 406

Abstract: Background: Studies on the choroid of myopic eyes with posterior staphyloma have shown that choroidal thickness decreased. This retrospective study further analysed the effects of posterior scleral staphyloma on choroidal blood vessels and matrix ... ...

Abstract	Background: Studies on the choroid of myopic eyes with posterior staphyloma have shown that choroidal thickness decreased. This retrospective study further analysed the effects of posterior scleral staphyloma on choroidal blood vessels and matrix components compared to non-pathological myopia. Methods: In this cross-sectional study, ninety-one eyes were divided into pathological (posterior staphyloma) and non-pathological myopia. The latter was further divided into three groups (Group 1: 26 mm ≤ axial length; Group 2: 24 mm ≤ axial length < 26 mm; Group 3: 22 mm ≤ axial length < 24 mm). Choroidal thickness, total choroidal area, luminal area, stromal area, and choroidal vascularity index were calculated. Results: The CVI in N1, N2, I1, S2 of the posterior staphyloma group were lower than those of group 1 (both P < 0.05). The mean height of posterior staphyloma was associated with mean CT (Pearson correlation: r = -0.578, P = 0.039) but not with the mean CVI in posterior staphyloma group. In all groups, the mean choroidal thickness, total choroidal area, luminal area, and stromal area were significantly associated with axial length (P < 0.001), and the mean choroidal vascularity index was significantly associated with the mean choroidal thickness (P < 0.001). Conclusion: The choroidal structure of pathological myopia with posterior staphyloma and non-pathological myopia with longer axial length demonstrates alterations in which choroidal vessels are more impaired than the stroma. A lower choroidal vascularity index should be alert to pathological changes for myopia with axial length > 26 mm.
MeSH term(s)	Humans ; Adult ; Retrospective Studies ; Myopia, Degenerative/complications ; Myopia, Degenerative/diagnosis ; Myopia, Degenerative/pathology ; Cross-Sectional Studies ; Tomography, Optical Coherence ; Scleral Diseases/diagnosis ; Scleral Diseases/pathology ; Choroid/pathology
Language	English
Publishing date	2023-10-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2050436-6
ISSN	1471-2415 ; 1471-2415
ISSN (online)	1471-2415
ISSN	1471-2415
DOI	10.1186/s12886-023-03158-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Historical development of karst evergreen broadleaved forests in East Asia has shaped the evolution of a hemiparasitic genus

Chen, Zhe / Zhou, Zhuo / Guo, Ze-Min / Van Do, Truong / Sun, Hang / Niu, Yang

Plant diversity

2023 Volume 45, Issue 5, Page(s) 501–512

Abstract: ... ...

Abstract	Brandisia
Language	English
Publishing date	2023-03-23
Publishing country	China
Document type	Journal Article
ZDB-ID	2873411-7
ISSN	2468-2659 ; 2095-0845
ISSN (online)	2468-2659
ISSN	2095-0845
DOI	10.1016/j.pld.2023.03.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Structurally Diverse Cytotoxic Polyphenols from

Ye, Yan-Song / Duan, Yao-Tao / Zhou, Zhuo / Thepkaysone, Khamphanh / Douangdeuane, Bounleuane / Xu, Gang

Journal of natural products

2023 Volume 86, Issue 9, Page(s) 2206–2215

Abstract: Thirty-five diverse polyphenols, belonging to seven structure classes, were isolated ... ...

Abstract	Thirty-five diverse polyphenols, belonging to seven structure classes, were isolated from
MeSH term(s)	Humans ; Antineoplastic Agents ; Apoptosis ; Cell Line, Tumor ; Garcinia ; Polyphenols/pharmacology
Chemical Substances	Antineoplastic Agents ; Polyphenols
Language	English
Publishing date	2023-08-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.3c00498
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1144: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito