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Article ; Online: Correction to: The effect of self-limiting on the prevention and control of the diffuse COVID-19 epidemic with delayed and temporal-spatial heterogeneous.

Zhu, Cheng-Cheng / Zhu, Jiang

BMC infectious diseases

2022 Volume 22, Issue 1, Page(s) 32

Language	English
Publishing date	2022-01-05
Publishing country	England
Document type	Published Erratum
ISSN	1471-2334
ISSN (online)	1471-2334
DOI	10.1186/s12879-021-06875-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Case Report of Three Patients Who Underwent Temporary Peripheral Nerve Stimulation for Treatment of Knee Pain Secondary to Osteoarthritis.

Zhu, Cheng-Cheng / Gargya, Akshat / Haider, Naeem

Cureus

2023 Volume 15, Issue 6, Page(s) e40473

Abstract: Knee osteoarthritis affects millions of people worldwide. There remains a role for novel therapies to manage pain for patients who are unable or unwilling to undergo knee arthroplasty. A peripheral nerve stimulator (PNS) may be beneficial in this ... ...

Abstract	Knee osteoarthritis affects millions of people worldwide. There remains a role for novel therapies to manage pain for patients who are unable or unwilling to undergo knee arthroplasty. A peripheral nerve stimulator (PNS) may be beneficial in this population. We present a case report of three patients who received temporary femoral or saphenous PNS and were either unwilling or unable to undergo knee arthroplasty. Two of the three patients reported significantly reduced pain and improved functioning. Our case report demonstrates that temporary PNS may offer a safe and effective treatment for chronic knee pain secondary to knee osteoarthritis.
Language	English
Publishing date	2023-06-15
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.40473
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Article ; Online: The effect of self-limiting on the prevention and control of the diffuse COVID-19 epidemic with delayed and temporal-spatial heterogeneous.

Zhu, Cheng-Cheng / Zhu, Jiang

BMC infectious diseases

2021 Volume 21, Issue 1, Page(s) 1145

Abstract: Background: The global spread of the novel coronavirus pneumonia is still continuing, and a new round of more serious outbreaks has even begun in some countries. In this context, this paper studies the dynamics of a type of delayed reaction-diffusion ... ...

Abstract	Background: The global spread of the novel coronavirus pneumonia is still continuing, and a new round of more serious outbreaks has even begun in some countries. In this context, this paper studies the dynamics of a type of delayed reaction-diffusion novel coronavirus pneumonia model with relapse and self-limiting treatment in a temporal-spatial heterogeneous environment. Methods: First, focus on the self-limiting characteristics of COVID-19, incorporate the relapse and self-limiting treatment factors into the diffusion model, and study the influence of self-limiting treatment on the diffusion of the epidemic. Second, because the traditional Lyapunov stability method is difficult to determine the spread of the epidemic with relapse and self-limiting treatment, we introduce a completely different method, relying on the existence conditions of the exponential attractor of our newly established in the infinite-dimensional dynamic system to determine the diffusion of novel coronavirus pneumonia. Third, relapse and self-limiting treatment have led to a change in the structure of the delayed diffusion COVID-19 model, and the traditional basic reproduction number [Formula: see text] no longer has threshold characteristics. With the help of the Krein-Rutman theorem and the eigenvalue method, we studied the threshold characteristics of the principal eigenvalue and found that it can be used as a new threshold to describe the diffusion of the epidemic. Results: Our results prove that the principal eigenvalue [Formula: see text] of the delayed reaction-diffusion COVID-19 system with relapse and self-limiting treatment can replace the basic reproduction number [Formula: see text] to describe the threshold effect of disease transmission. Combine with the latest official data and the prevention and control strategies, some numerical simulations on the stability and global exponential attractiveness of the diffusion of the COVID-19 epidemic in China and the USA are given. Conclusions: Through the comparison of numerical simulations, we find that self-limiting treatment can significantly promote the prevention and control of the epidemic. And if the free activities of asymptomatic infected persons are not restricted, it will seriously hinder the progress of epidemic prevention and control.
MeSH term(s)	Basic Reproduction Number ; COVID-19 ; Epidemics ; Humans ; Models, Biological ; SARS-CoV-2
Language	English
Publishing date	2021-11-09
Publishing country	England
Document type	Journal Article
ISSN	1471-2334
ISSN (online)	1471-2334
DOI	10.1186/s12879-021-06670-y
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Article ; Online: Spread trend of COVID-19 epidemic outbreak in China: using exponential attractor method in a spatial heterogeneous SEIQR model.

Zhu, Cheng-Cheng / Zhu, Jiang

Mathematical biosciences and engineering : MBE

2020 Volume 17, Issue 4, Page(s) 3062–3087

Abstract: In this paper we introduce a method of global exponential attractor in the reaction-diffusion epidemic model in spatial heterogeneous environment to study the spread trend and long-term dynamic behavior of the COVID-19 epidemic. First, we prove the ... ...

Abstract	In this paper we introduce a method of global exponential attractor in the reaction-diffusion epidemic model in spatial heterogeneous environment to study the spread trend and long-term dynamic behavior of the COVID-19 epidemic. First, we prove the existence of the global exponential attractor of general dissipative evolution systems. Then, by using the existence theorem, the global asymptotic stability and the persistence of epidemic are discussed. Finally, combine with the official data of the COVID-19 and the national control strategy, some numerical simulations on the stability and global exponential attractiveness of the COVID-19 epidemic are given. Simulations show that the spread trend of the epidemic is in line with our theoretical results, and the preventive measures taken by the Chinese government are effective.
MeSH term(s)	Betacoronavirus ; COVID-19 ; China/epidemiology ; Computer Simulation ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Epidemics/prevention & control ; Epidemics/statistics & numerical data ; Humans ; Mathematical Concepts ; Models, Biological ; Pandemics/prevention & control ; Pandemics/statistics & numerical data ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Quarantine/statistics & numerical data ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-09-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2265126-3
ISSN	1551-0018 ; 1547-1063
ISSN (online)	1551-0018
ISSN	1547-1063
DOI	10.3934/mbe.2020174
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Article: Dynamic analysis of a delayed COVID-19 epidemic with home quarantine in temporal-spatial heterogeneous via global exponential attractor method.

Zhu, Cheng-Cheng / Zhu, Jiang

Chaos, solitons, and fractals

2020 Volume 143, Page(s) 110546

Abstract: As the COVID-19 epidemic has entered the normalization stage, the task of prevention and control remains very arduous. This paper constructs a time delay reaction-diffusion model that is closer to the actual spread of the COVID-19 epidemic, including ... ...

Abstract	As the COVID-19 epidemic has entered the normalization stage, the task of prevention and control remains very arduous. This paper constructs a time delay reaction-diffusion model that is closer to the actual spread of the COVID-19 epidemic, including relapse, time delay, home quarantine and temporal-spatial heterogeneous environment that affect the spread of COVID-19. These factors increase the number of equations and the coupling between equations in the system, making it difficult to apply the methods commonly used to discuss global dynamics, such as the Lyapunov function method. Therefore, we use the global exponential attractor theory in the infinite-dimensional dynamic system to study the spreading trend of the COVID-9 epidemic with relapse, time delay, home quarantine in a temporal-spatial heterogeneous environment. Using our latest results of global exponential attractor theory, the global asymptotic stability and the persistence of the COVID-19 epidemic are discussed. We find that due to the influence of relapse in the in temporal-spatial heterogeneity environment, the principal eigenvalue
Language	English
Publishing date	2020-12-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2003919-0
ISSN	1873-2887 ; 0960-0779
ISSN (online)	1873-2887
ISSN	0960-0779
DOI	10.1016/j.chaos.2020.110546
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Article ; Online: ZNF554 Inhibits Endometrial Cancer Progression via Regulating RBM5 and Inactivating WNT/β-Catenin Signaling Pathway.

Zhu, Cheng-Cheng / Sun, Heng-Liang / Long, Teng-Fei / Lyu, Yuan-Yuan / Liu, Jiang-Li / Ni, Guan-Tai

Current medical science

2024 Volume 44, Issue 2, Page(s) 406–418

Abstract: Objective: Uterine corpus endometrial carcinoma (UCEC), a kind of gynecologic malignancy, poses a significant risk to women's health. The precise mechanism underlying the development of UCEC remains elusive. Zinc finger protein 554 (ZNF554), a member of ...

Abstract	Objective: Uterine corpus endometrial carcinoma (UCEC), a kind of gynecologic malignancy, poses a significant risk to women's health. The precise mechanism underlying the development of UCEC remains elusive. Zinc finger protein 554 (ZNF554), a member of the Krüppel-associated box domain zinc finger protein superfamily, was reported to be dysregulated in various illnesses, including malignant tumors. This study aimed to examine the involvement of ZNF554 in the development of UCEC. Methods: The expression of ZNF554 in UCEC tissues and cell lines were examined by qRT-PCR and Western blot assay. Cells with stably overexpressed or knocked-down ZNF554 were established through lentivirus infection. CCK-8, wound healing, and Transwell invasion assays were employed to assess cell proliferation, migration, and invasion. Propidium iodide (PI) staining combined with fluorescence-activated cell sorting (FACS) flow cytometer was utilized to detect cell cycle distribution. qRT-PCR and Western blotting were conducted to examine relative mRNA and protein levels. Chromatin immunoprecipitation assay and luciferase reporter assay were used to explore the regulatory role of ZNF554 in RNA binding motif 5 (RBM5). Results: The expression of ZNF554 was found to be reduced in both UCEC samples and cell lines. Decreased expression of ZNF554 was associated with higher tumor stage, decreased overall survival, and reduced disease-free survival in UCEC. ZNF554 overexpression suppressed cell proliferation, migration, and invasion, while also inducing cell cycle arrest. In contrast, a decrease in ZNF554 expression resulted in the opposite effect. Mechanistically, ZNF554 transcriptionally regulated RBM5, leading to the deactivation of the Wingless (WNT)/β-catenin signaling pathway. Moreover, the findings from rescue studies demonstrated that the inhibition of RBM5 negated the impact of ZNF554 overexpression on β-catenin and p-glycogen synthase kinase-3β (p-GSK-3β). Similarly, the deliberate activation of RBM5 reduced the increase in β-catenin and p-GSK-3β caused by the suppression of ZNF554. In vitro experiments showed that ZNF554 overexpression-induced decreases in cell proliferation and migration were counteracted by RBM5 knockdown. Additionally, when RBM5 was overexpressed, it hindered the improvements in cell proliferation and migration caused by reducing the ZNF554 levels. Conclusion: ZNF554 functions as a tumor suppressor in UCEC. Furthermore, ZNF554 regulates UCEC progression through the RBM5/WNT/β-catenin signaling pathway. ZNF554 shows a promise as both a prognostic biomarker and a therapeutic target for UCEC.
MeSH term(s)	Humans ; Female ; Wnt Signaling Pathway/genetics ; beta Catenin/genetics ; beta Catenin/metabolism ; Glycogen Synthase Kinase 3 beta/metabolism ; Cell Line, Tumor ; Endometrial Neoplasms/genetics ; DNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Cell Cycle Proteins/genetics ; Tumor Suppressor Proteins/genetics
Chemical Substances	beta Catenin ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; RBM5 protein, human ; DNA-Binding Proteins ; RNA-Binding Proteins ; Cell Cycle Proteins ; Tumor Suppressor Proteins
Language	English
Publishing date	2024-04-15
Publishing country	China
Document type	Journal Article
ZDB-ID	2931065-9
ISSN	2523-899X ; 2096-5230
ISSN (online)	2523-899X
ISSN	2096-5230
DOI	10.1007/s11596-024-2845-7
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Article ; Online: Ultrasound-guided Visualization of Subglottic Secretions in Intubated Patients.

Tao, Kun-Ming / Zhu, Cheng-Cheng / Lu, Zhi-Jie

Anesthesiology

2020 Volume 133, Issue 6, Page(s) 1260

MeSH term(s)	Body Fluids/diagnostic imaging ; Glottis/diagnostic imaging ; Humans ; Intubation, Intratracheal ; Suction/methods ; Ultrasonography, Interventional/methods
Language	English
Publishing date	2020-09-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	269-0
ISSN	1528-1175 ; 0003-3022
ISSN (online)	1528-1175
ISSN	0003-3022
DOI	10.1097/ALN.0000000000003528
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Article: Spread trend of COVID-19 epidemic outbreak in China: using exponential attractor method in a spatial heterogeneous SEIQR model

Zhu, Cheng-Cheng / Zhu, Jiang

Math Biosci Eng

Abstract	In this paper we introduce a method of global exponential attractor in the reaction-diffusion epidemic model in spatial heterogeneous environment to study the spread trend and long-term dynamic behavior of the COVID-19 epidemic. First, we prove the existence of the global exponential attractor of general dissipative evolution systems. Then, by using the existence theorem, the global asymptotic stability and the persistence of epidemic are discussed. Finally, combine with the official data of the COVID-19 and the national control strategy, some numerical simulations on the stability and global exponential attractiveness of the COVID-19 epidemic are given. Simulations show that the spread trend of the epidemic is in line with our theoretical results, and the preventive measures taken by the Chinese government are effective.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #806651
Database	COVID19

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Article ; Online: Influence of spatial heterogeneous environment on long-term dynamics of a reaction-diffusion SVIR epidemic model with relaps.

Zhu, Cheng-Cheng / Zhu, Jiang / Liu, Xiao-Lan

Mathematical biosciences and engineering : MBE

2019 Volume 16, Issue 5, Page(s) 5897–5922

Abstract: In this paper by adding the factors of disease relapse and vaccination in the space hetero-geneous environment, we establish and discuss a class of reaction-diffusion SVIR model with relapse and a varying external source in spatial heterogeneous ... ...

Abstract	In this paper by adding the factors of disease relapse and vaccination in the space hetero-geneous environment, we establish and discuss a class of reaction-diffusion SVIR model with relapse and a varying external source in spatial heterogeneous environment. By applying a different method than the Lyapunov function, we study the long-term dynamic behavior of this model by means of global exponential attractor theory and gradient flow method. The global asymptotic stability and the persistence of epidemic are proved. To test the validity of our theoretical results, we choose some specific epidemic disease with some more practical and more definitive official data to simulate the global stability and exponential attraction of the model. The simulation results showed that the factors of disease relapse, vaccination and spatial heterogeneity had a great influence on the persists uniformly of the disease.
Language	English
Publishing date	2019-09-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1551-0018
ISSN (online)	1551-0018
DOI	10.3934/mbe.2019295
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Article ; Online: Effects of obesity and diabetes on the epigenetic modification of mammalian gametes.

Ou, Xiang-Hong / Zhu, Cheng-Cheng / Sun, Shao-Chen

Journal of cellular physiology

2018 Volume 234, Issue 6, Page(s) 7847–7855

Abstract: Obesity and diabetes are closely associated with numerous reproductive disorders, including termination of ovulation, irregular menstruation, low fertility, abortion, and risky pregnancy, which are now regarded as global health problems. Paternal/ ... ...

Abstract	Obesity and diabetes are closely associated with numerous reproductive disorders, including termination of ovulation, irregular menstruation, low fertility, abortion, and risky pregnancy, which are now regarded as global health problems. Paternal/maternal obesity and diabetes can also be transmitted to the subsequent generation via gametes, suggesting the association of epigenetic inheritance with obesity and diabetes, particularly for its effects on offspring. Recent studies indicate that both obesity and diabetes change DNA and histone methylation levels, histone acetylation, and noncoding RNAs such as microRNAs (miRNAs) in oocytes and sperm. Several important genes, such as PPAR-α, Igf2, H19, Fyn, Stella, Sirt3, Sirt6, and Peg3 as well as miRNAs, such as let-7c, reportedly participate in the regulation of epigenetic modifications in mammalian gametes. This review summarizes the recent progress that links obesity/diabetes and reproductive disorders from the perspective of gamete epigenetic modifications.
MeSH term(s)	Animals ; DNA Methylation/genetics ; Diabetes Mellitus/genetics ; Diabetes Mellitus/pathology ; Epigenesis, Genetic/genetics ; Female ; Germ Cells/growth & development ; Germ Cells/metabolism ; Histone Code/genetics ; Humans ; Male ; Obesity/genetics ; Obesity/pathology ; Oocytes/growth & development ; Oocytes/metabolism ; Spermatozoa/growth & development ; Spermatozoa/metabolism
Language	English
Publishing date	2018-12-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	3116-1
ISSN	1097-4652 ; 0021-9541
ISSN (online)	1097-4652
ISSN	0021-9541
DOI	10.1002/jcp.27847
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