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Article ; Online: Risk factors of acute respiratory distress syndrome in sepsis caused by intra-abdominal infections: A retrospective study.

Ma, Yuteng / Zhu, Chengrui / Ma, Xiaochun / Zhou, Baosen / Dong, Ming

2024 Volume 175, Issue 5, Page(s) 1432–1438

Abstract: Background: Intra-abdominal infections are frequently associated with acute respiratory distress syndrome, which significantly affects patient prognosis. However, little is known about the specific risk factors of acute respiratory distress syndrome in ... ...

Abstract	Background: Intra-abdominal infections are frequently associated with acute respiratory distress syndrome, which significantly affects patient prognosis. However, little is known about the specific risk factors of acute respiratory distress syndrome in sepsis caused by intra-abdominal infections. Methods: This retrospective study included adult patients with intra-abdominal sepsis admitted to the intensive care unit of a tertiary teaching hospital in China between June 2017 and June 2022. Patients were categorized based on the presence or absence of acute respiratory distress syndrome. Data, including vital signs, laboratory values, and severity scores collected within 24 hours of sepsis diagnosis, as well as outcomes within 90 days, were analyzed. Multivariable logistic regression was used to identify independent risk factors associated with acute respiratory distress syndrome. Results: A total of 738 patients were included, of whom 218 (29.5%) developed acute respiratory distress syndrome. Patients with acute respiratory distress syndrome were younger, had a higher body mass index and disease severity scores, and exhibited higher proportions of septic shock and hospital-acquired intra-abdominal infections. The mortalities in the intensive care unit and at 28 and 90 days were higher in the acute respiratory distress syndrome group. In the multivariate logistic regression model, age under 65 years (odds ratio [95% confidence interval]: 1.571 [1.093-2.259]), elevated body mass index (2.070 [1.382-3.101] for overweight, 6.994 [3.207-15.255]) for obesity, septic shock (2.043 [1.400-2.980]), procalcitonin (1.009 [1.004-1.015]), hospital-acquired intra-abdominal infections (2.528[1.373-4.657]), and source of intra-abdominal infections (2.170 [1.140-4.128] for biliary tract infection, 0.443 [0.217-0.904] for gastroduodenal perforation) were independently associated with acute respiratory distress syndrome. Conclusion: In patients with intra-abdominal sepsis, age under 65 years, higher body mass index and procalcitonin, septic shock, hospital-acquired intra-abdominal infections, and biliary tract infection were risk factors for acute respiratory distress syndrome.
MeSH term(s)	Adult ; Humans ; Aged ; Shock, Septic/complications ; Retrospective Studies ; Procalcitonin ; Sepsis/complications ; Risk Factors ; Prognosis ; Respiratory Distress Syndrome/etiology ; Intensive Care Units ; Hospitals, Teaching ; Intraabdominal Infections/complications ; Intraabdominal Infections/diagnosis
Chemical Substances	Procalcitonin
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	202467-6
ISSN	1532-7361 ; 0039-6060
ISSN (online)	1532-7361
ISSN	0039-6060
DOI	10.1016/j.surg.2024.01.020
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Article ; Online: Role of pyroptosis in hemostasis activation in sepsis.

Zhu, Chengrui / Liang, Yingjian / Luo, Yangtuo / Ma, Xiaochun

Frontiers in immunology

2023 Volume 14, Page(s) 1114917

Abstract: Sepsis is frequently associated with hemostasis activation and thrombus formation, and systematic hemostatic changes are associated with a higher risk of mortality. The key events underlying hemostasis activation during sepsis are the strong activation ... ...

Abstract	Sepsis is frequently associated with hemostasis activation and thrombus formation, and systematic hemostatic changes are associated with a higher risk of mortality. The key events underlying hemostasis activation during sepsis are the strong activation of innate immune pathways and the excessive inflammatory response triggered by invading pathogens. Pyroptosis is a proinflammatory form of programmed cell death, that defends against pathogens during sepsis. However, excessive pyroptosis can lead to a dysregulation of host immune responses and organ dysfunction. Recently, pyroptosis has been demonstrated to play a prominent role in hemostasis activation in sepsis. Several studies have demonstrated that pyroptosis participates in the release and coagulation activity of tissue factors. In addition, pyroptosis activates leukocytes, endothelial cells, platelets, which cooperate with the coagulation cascade, leading to hemostasis activation in sepsis. This review article attempts to interpret the molecular and cellular mechanisms of the hemostatic imbalance induced by pyroptosis during sepsis and discusses potential therapeutic strategies.
MeSH term(s)	Humans ; Endothelial Cells/metabolism ; Pyroptosis ; Sepsis ; Hemostasis ; Hemostatics
Chemical Substances	Hemostatics
Language	English
Publishing date	2023-01-23
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1114917
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Article ; Online: MCMC: Multi-Constrained Model Compression via One-Stage Envelope Reinforcement Learning.

Li, Siqi / Chen, Jun / Liu, Shanqi / Zhu, Chengrui / Tian, Guanzhong / Liu, Yong

IEEE transactions on neural networks and learning systems

2024 Volume PP

Abstract: Model compression methods are being developed to bridge the gap between the massive scale of neural networks and the limited hardware resources on edge devices. Since most real-world applications deployed on resource-limited hardware platforms typically ... ...

Abstract	Model compression methods are being developed to bridge the gap between the massive scale of neural networks and the limited hardware resources on edge devices. Since most real-world applications deployed on resource-limited hardware platforms typically have multiple hardware constraints simultaneously, most existing model compression approaches that only consider optimizing one single hardware objective are ineffective. In this article, we propose an automated pruning method called multi-constrained model compression (MCMC) that allows for the optimization of multiple hardware targets, such as latency, floating point operations (FLOPs), and memory usage, while minimizing the impact on accuracy. Specifically, we propose an improved multi-objective reinforcement learning (MORL) algorithm, the one-stage envelope deep deterministic policy gradient (DDPG) algorithm, to determine the pruning strategy for neural networks. Our improved one-stage envelope DDPG algorithm reduces exploration time and offers greater flexibility in adjusting target priorities, enhancing its suitability for pruning tasks. For instance, on the visual geometry group (VGG)-16 network, our method achieved an 80% reduction in FLOPs, a 2.31× reduction in memory usage, and a 1.92× acceleration, with an accuracy improvement of 0.09% compared with the baseline. For larger datasets, such as ImageNet, we reduced FLOPs by 50% for MobileNet-V1, resulting in a 4.7× faster speed and 1.48× memory compression, while maintaining the same accuracy. When applied to edge devices, such as JETSON XAVIER NX, our method resulted in a 71% reduction in FLOPs for MobileNet-V1, leading to a 1.63× faster speed, 1.64× memory compression, and an accuracy improvement.
Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Journal Article
ISSN	2162-2388
ISSN (online)	2162-2388
DOI	10.1109/TNNLS.2024.3353763
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Article: A Case Report of

Zhu, Chengrui / Hu, Bo / Li, Xiaotong / Han, Weiying / Liang, Yingjian / Ma, Xiaochun

Frontiers in cardiovascular medicine

2024 Volume 11, Page(s) 1347885

Abstract: Mycoplasma pneumoniae (M. pneumoniae) ...

Abstract	Mycoplasma pneumoniae (M. pneumoniae)
Language	English
Publishing date	2024-04-16
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2024.1347885
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Article ; Online: The Landscape of Global Ocean Microbiome: From Bacterioplankton to Biofilms.

Lu, Jie / Shu, Yi / Zhang, Heng / Zhang, Shangxian / Zhu, Chengrui / Ding, Wei / Zhang, Weipeng

International journal of molecular sciences

2023 Volume 24, Issue 7

Abstract: The development of metagenomics has opened up a new era in the study of marine microbiota, which play important roles in biogeochemical cycles. In recent years, the global ocean sampling expeditions have spurred this research field toward a deeper ... ...

Abstract	The development of metagenomics has opened up a new era in the study of marine microbiota, which play important roles in biogeochemical cycles. In recent years, the global ocean sampling expeditions have spurred this research field toward a deeper understanding of the microbial diversities and functions spanning various lifestyles, planktonic (free-living) or sessile (biofilm-associated). In this review, we deliver a comprehensive summary of marine microbiome datasets generated in global ocean expeditions conducted over the last 20 years, including the Sorcerer II GOS Expedition, the
MeSH term(s)	Aquatic Organisms ; Oceans and Seas ; Microbiota ; Plankton ; Metagenomics ; Biofilms
Language	English
Publishing date	2023-03-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24076491
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Article ; Online: Drug therapies for treatment of idiopathic pulmonary fibrosis: a systematic review, Bayesian network meta-analysis, and cost-effectiveness analysis.

Zhao, Chunyang / Yin, Yan / Zhu, Chengrui / Zhu, Min / Ji, Tianlong / Li, Zhonghao / Cai, Jiayi

EClinicalMedicine

2023 Volume 61, Page(s) 102071

Abstract: Background: Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with poor prognosis and a high economic burden for individuals and healthcare resources. Studies of the costs associated with the efficiency of IPF medications ... ...

Abstract	Background: Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with poor prognosis and a high economic burden for individuals and healthcare resources. Studies of the costs associated with the efficiency of IPF medications are scarce. We aimed to conduct a network meta-analysis (NMA) and cost-effectiveness analysis to identify the optimum pharmacological strategy among all currently available IPF regimens. Methods: We first performed a systematic review and network meta-analysis. We searched eight databases for eligible randomised controlled trials (RCTs) published, in any language, between January 1, 1992 and July 31, 2022, that investigated the efficacy or tolerability (or both) of drug therapies for the treatment of IPF. The search was updated on February 1, 2023. Eligible RCTs were enrolled, with no restriction on dose, duration, or length of follow-up, if they included at least one of: all-cause mortality, acute exacerbation rate, disease progression rate, serious adverse events, and any adverse events under investigation. A subsequent Bayesian NMA within random-effects models was performed, followed by a cost-effectiveness analysis using the data obtained from our NMA, by developing a Markov model from the US payer's perspective. Assumptions were checked by deterministic and probabilistic sensitivity approaches to identify sensitive factors. We prospectively registered the protocol (CRD42022340590) in PROSPERO. Findings: 51 publications comprising 12,551 participants with IPF were analysed for the NMA, and the findings indicated that pirfenidone and Interpretation: This NMA and cost-effectiveness analysis suggests that NAC + pirfenidone is the most cost-effective option for treatment of IPF at WTP thresholds of $150,000 and $200,000. However, given that clinical practice guidelines have not addressed the application of this therapy, large well-designed and multicentre trials are warranted to provide a better picture of IPF management. Funding: None.
Language	English
Publishing date	2023-06-29
Publishing country	England
Document type	Journal Article
ISSN	2589-5370
ISSN (online)	2589-5370
DOI	10.1016/j.eclinm.2023.102071
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Article ; Online: Diagnostic and therapeutic strategies of acute invasive fungal rhinosinusitis.

Luo, Yang-Tuo / Zhu, Cheng-Rui / He, Bing / Yan, Ai-Hui / Wei, Hong-Quan

Asian journal of surgery

2022

Abstract: Acute invasive fungal rhinosinusitis (AIFR) is a rare disease, but the prognosis is by no means ideal. Pathologically, fungal infection is not only located in the sinus cavity, but also invades the sinus mucosa and bone wall, the surrounding structures ... ...

Abstract	Acute invasive fungal rhinosinusitis (AIFR) is a rare disease, but the prognosis is by no means ideal. Pathologically, fungal infection is not only located in the sinus cavity, but also invades the sinus mucosa and bone wall, the surrounding structures and tissues such as the orbit and anterior skull base are often compromised and are accompanied with intracranial and extracranial complications. Despite decades of efforts, acute invasive fungal rhinosinusitis remains a devastating disease, the mortality of the disease continues to hover around 50%. The main impediments to improving the prognosis of acute invasive fungal rhinosinusitis are the difficulties of early diagnosis and the rapid reversal of immune insufficiency. Moreover, aggressive surgery combined with systemic antifungal therapy are significant positive prognostic factors as well. Progress and standardization of AIFR treatment protocols have been limited by the scarcity of the disease and the absence of published randomized studies. Therewith, how to improve the therapeutic outcome and reduce the mortality rate has always been a challenging clinical discussion. We have summarized the relevant case series and literature from the recent years, management with optimal diagnostic and curative strategies are reviewed.
Language	English
Publishing date	2022-05-17
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2022.05.006
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Article ; Online: Unfractionated Heparin Protects Microcirculation in Endotoxemic Rats by Antagonizing Histones.

Zhu, Chengrui / Liang, Yingjian / Liu, Yina / Shu, Wenqi / Luan, Zhenggang / Ma, Xiaochun

The Journal of surgical research

2022 Volume 282, Page(s) 84–92

Abstract: Introduction: Levels of extracellular histones are highly increased in sepsis and may facilitate microcirculatory dysfunction. Unfractionated heparin (UFH) binds histones and neutralizes their cytotoxicity. We investigated the effect of UFH on ... ...

Abstract	Introduction: Levels of extracellular histones are highly increased in sepsis and may facilitate microcirculatory dysfunction. Unfractionated heparin (UFH) binds histones and neutralizes their cytotoxicity. We investigated the effect of UFH on microcirculatory dysfunction by interacting with extracellular histones in endotoxemic rats. Methods: Twenty-four Wistar rats were randomly divided into three groups: control, lipopolysaccharide (LPS) group, and LPS + UFH group. In the LPS and LPS + UFH groups, 10 mg/kg LPS was injected to induce endotoxemia, and 100 IU/kg/h UFH was administered intravenously in the LPS + UFH group. The rats underwent midline laparotomy, and then intestinal microcirculation was evaluated using an incident dark field microscope. Circulating histones and microstructures of the rat intestinal microvascular endothelium were also detected. Additionally, the antagonistic effect of UFH on histone-induced cytotoxicity was investigated in human intestinal microvascular endothelial cells. Results: UFH protected the microcirculation of the intestinal serosa and mucosa in endotoxemic rats, as evidenced by increased total vessel density, perfused vessel density, and proportion of perfused vessels of both the serosa and mucosa, and increased microcirculatory flow index of the mucosa in the LPS + UFH group. UFH treatment decreased the levels of circulating histones and alleviated intestinal microvascular endothelial injuries in endotoxemic rats. Furthermore, UFH inhibited histone cytotoxicity in vitro. Conclusions: UFH attenuated microcirculatory dysfunction in endotoxemic rats by antagonizing extracellular histones, thereby providing a potential therapeutic strategy for sepsis.
MeSH term(s)	Rats ; Humans ; Animals ; Heparin/pharmacology ; Heparin/therapeutic use ; Endotoxemia/metabolism ; Microcirculation ; Histones ; Lipopolysaccharides/pharmacology ; Endothelial Cells ; Rats, Wistar ; Sepsis/drug therapy
Chemical Substances	Heparin (9005-49-6) ; Histones ; Lipopolysaccharides
Language	English
Publishing date	2022-10-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80170-7
ISSN	1095-8673 ; 0022-4804
ISSN (online)	1095-8673
ISSN	0022-4804
DOI	10.1016/j.jss.2022.09.019
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Article ; Online: Ginger (Zingiber officinale Roscoe) preparations for prophylaxis of postoperative nausea and vomiting: A Bayesian network meta-analysis.

Zhao, Chunyang / Chen, Weiyuan / Wang, Daqiu / Cong, Xiufeng / Zhu, Min / Zhu, Chengrui / Xu, Jiayao / Cai, Jiayi

Journal of ethnopharmacology

2023 Volume 317, Page(s) 116791

Abstract: Ethnopharmacological relevance: Ginger has been proposed for prevention of postoperative nausea and vomiting (PONV), however it remains equivocal whether ginger can be an alternative option and which certain preparation is optimal for PONV prophylaxis.!# ...

Abstract	Ethnopharmacological relevance: Ginger has been proposed for prevention of postoperative nausea and vomiting (PONV), however it remains equivocal whether ginger can be an alternative option and which certain preparation is optimal for PONV prophylaxis. Aim of the study: We conducted a network meta-analysis (NMA) to compare and rank relative efficacy for PONV control among all available ginger preparations collected in the databases. Methods: Eligible records were identified by retrieving Medline (via Pubmed), Embase, Web of Science, CENTRAL, CNKI, WHO ICTRP and ClinicalTrials.gov for randomized controlled trials that investigated the efficacy of ginger therapies for the prophylaxis of PONV. A bayesian NMA within random-effects models was implemented. Certainty of evidence for estimates was investigated following GRADE framework. We prospectively registered the protocol (CRD 42021246073) in PROSPERO. Results: Eighteen publications comprising 2199 participants with PONV were identified. Ginger oil (RR [95%CI], 0.39 [0.16, 0.96]) appeared to have the highest probability of being ranked best to decrease the incidence of postoperative vomiting (POV), with statistical significance compared with placebo, based on high to moderate confidence in estimates. With regard to reducing postoperative nausea (PON), statistically superiority was not observed in ginger regimens compared with placebo based on moderate to low certainty of evidence. Reduction in antemetic use and nausea intensity were noticed in ginger powder and oil. Ginger was significantly associated with better efficacy for Asian, older age, higher dosage, preoperative administration, hepatobiliary and gastrointestinal surgery. Conclusions: Ginger oil appeared to be superior to other ginger treatments for the prophylaxis of POV. With regard to reducing PON, ginger preparations indicated no obvious advantages.
MeSH term(s)	Humans ; Postoperative Nausea and Vomiting/prevention & control ; Postoperative Nausea and Vomiting/drug therapy ; Zingiber officinale ; Network Meta-Analysis ; Bayes Theorem ; Antiemetics/therapeutic use ; Vomiting/drug therapy
Chemical Substances	Antiemetics
Language	English
Publishing date	2023-06-26
Publishing country	Ireland
Document type	Meta-Analysis ; Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116791
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Article ; Online: A biosensor encompassing fusarinine C-magnetic nanoparticles and aptamer-red/green carbon dots for dual-channel fluorescent and RGB discrimination of Campylobacter and Aliarcobacter.

Liu, Weixing / Zhu, Chengrui / Gao, Shaoqian / Ma, Keran / Zhang, Shangxian / Du, Qingbao / Sui, Kangmin / Liu, Chenguang / Chi, Zhe

Talanta

2023 Volume 266, Issue Pt 2, Page(s) 125085

Abstract: The diarrhea pathogens Campylobacter and Aliarcobacter are similar in morphology and their leading symptoms, making them difficult to be differentially diagnosed. Herein, we report a biosensor with two modules to differentiate the genera-representative ... ...

Abstract	The diarrhea pathogens Campylobacter and Aliarcobacter are similar in morphology and their leading symptoms, making them difficult to be differentially diagnosed. Herein, we report a biosensor with two modules to differentiate the genera-representative species of C. jejuni and A. butzleri. Module 1 was fusarinine C-decorated magnetic nanoparticles; module 2 consisted of C. jejuni-specific aptamer modified with red-emitting carbon dots (CDs) and A. butzleri-specific aptamer-modified green-emitting CDs, consisting non-interfering dual-fluorescence detection channels. Module 1 was used to selectively capture C. jejuni and A. butzleri from an un-cultured sample, and the specific CDs in module 2 would then recognize and bind to their counterpart bacteria when subjected to the collected module 1-bacteria complex. By measuring the fluorescence intensities from the CDs-bound bacteria, the abundance of each bacterium could be differentially indicated. This biosensor exhibited a wide detection range of up to 1 × 10
MeSH term(s)	Humans ; Animals ; Campylobacter ; Chickens ; Magnetite Nanoparticles ; Carbon ; Coloring Agents
Chemical Substances	fusigen (19624-79-4) ; Magnetite Nanoparticles ; Carbon (7440-44-0) ; Coloring Agents
Language	English
Publishing date	2023-08-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2023.125085
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