LIVIVO - Search results -

Search results

Result 1 - 10 of total 117

Search options

Article ; Online: Analysis of clinicopathologic and imaging features of dual-phenotype hepatocellular carcinoma.

Huang, Ketuan / He, Yongfei / Liang, Tianyi / Mo, Shutian / Liao, Yuan / Gao, Qiang / Liao, Xiwen / Han, Chuangye / Zhu, Guangzhi / Peng, Tao

Scientific reports

2024 Volume 14, Issue 1, Page(s) 3314

Abstract: Dual-phenotype hepatocellular carcinoma (DPHCC) is a new subtype of hepatocellular carcinoma (HCC). This study aimed to investigate the relationship between the computerized tomography scan (CT) imaging and clinicopathologic features of DPHCC. The CT ... ...

Abstract	Dual-phenotype hepatocellular carcinoma (DPHCC) is a new subtype of hepatocellular carcinoma (HCC). This study aimed to investigate the relationship between the computerized tomography scan (CT) imaging and clinicopathologic features of DPHCC. The CT imaging and clinicopathologic data of 97 HCC cases who underwent radical resection were collected retrospectively. The CT imaging feature was evaluated by the ratio of the average CT value of tumor to liver (TLR) in the plain scan, arterial, portal vein and delayed phases. The association between CT imaging and clinicopathologic features was analyzed using the t-test or chi-square test. Univariate and multivariate recurrence-free survival (RFS) analysis and overall survival (OS) were performed. The positive rates of cytokeratin 7 (CK7) and CK19 were 35.1% and 20.6% respectively. The positive rate of CK19 was significantly higher in cases with age < 47 years (P = 0.005), tumor diameter > 4 cm (P = 0.016) or AFP ≥ 400 ng/ml (P = 0.007). The TLR in the portal vein phase was significantly lower in CK19 positive group (P = 0.024). The recurrence risk was significantly higher in cases with CK19 positive (HR: 2.17, 95% CI 1.16 to 4.04, P = 0.013), tumor diameter > 4 cm (HR: 2.05, 95% CI 1.11 to 3.78, P = 0.019), AFP ≥ 400 ng/ml (HR: 2.50, 95% CI 1.37 to 4.54, P = 0.002) or CA199 ≥ 37 U/ml (HR: 2.23, 95% CI 1.12 to 4.42, P = 0.020). However, imaging features, pathological subtype, CK7 or CK19 expression were not significantly related to HCC OS in the univariate and multivariate analysis (all P > 0.05). The expression of CK19 may be associated with the enhancement feature of the portal vein phase CT image, and CK19 positive may suggest a worse RFS.
MeSH term(s)	Humans ; Middle Aged ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; alpha-Fetoproteins/metabolism ; Retrospective Studies ; Phenotype ; Intermediate Filament Proteins ; Keratin-7 ; Prognosis
Chemical Substances	alpha-Fetoproteins ; Intermediate Filament Proteins ; Keratin-7
Language	English
Publishing date	2024-02-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-53831-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Influence of ambient temperature on an Yb:YAG disk laser with anti-Stokes fluorescence cooling.

Wu, Minglang / Zeng, Yuanhang / Zhu, Guangzhi / He, Zijian / Ma, Xiangyu / Zhu, Xiao

Optics letters

2023 Volume 48, Issue 17, Page(s) 4488–4491

Abstract: In general, the operating characteristics of solid-state lasers are significantly impacted by the ambient temperature, especially for Yb:YAG crystal with an anti-Stokes fluorescence cooling effect. In this Letter, the influence of the ambient temperature ...

Abstract	In general, the operating characteristics of solid-state lasers are significantly impacted by the ambient temperature, especially for Yb:YAG crystal with an anti-Stokes fluorescence cooling effect. In this Letter, the influence of the ambient temperature on the operating characteristics at the zero thermal load (ZTL) state is studied for an Yb:YAG disk crystal with a 1030 nm intra-cavity-pumped scheme. Theoretical analysis indicates that the output power of the laser at the ZTL state is significantly enhanced as the ambient temperature increases. Experimental results show that when the ambient temperature increases to 40°C, the output power of the laser at the ZTL state can reach 1.11 W, which is more than twice than that achieved at an ambient temperature of 25.5°C. This Letter provides a technical pathway for achieving a higher-power radiation-balanced laser (RBL).
Language	English
Publishing date	2023-09-01
Publishing country	United States
Document type	Journal Article
ISSN	1539-4794
ISSN (online)	1539-4794
DOI	10.1364/OL.495992
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book ; Online: Efficient Task Offloading Algorithm for Digital Twin in Edge/Cloud Computing Environment

Zhang, Ziru / Zhang, Xuling / Zhu, Guangzhi / Wang, Yuyang / Hui, Pan

2023

Abstract: In the era of Internet of Things (IoT), Digital Twin (DT) is envisioned to empower various areas as a bridge between physical objects and the digital world. Through virtualization and simulation techniques, multiple functions can be achieved by ... ...

Abstract	In the era of Internet of Things (IoT), Digital Twin (DT) is envisioned to empower various areas as a bridge between physical objects and the digital world. Through virtualization and simulation techniques, multiple functions can be achieved by leveraging computing resources. In this process, Mobile Cloud Computing (MCC) and Mobile Edge Computing (MEC) have become two of the key factors to achieve real-time feedback. However, current works only considered edge servers or cloud servers in the DT system models. Besides, The models ignore the DT with not only one data resource. In this paper, we propose a new DT system model considering a heterogeneous MEC/MCC environment. Each DT in the model is maintained in one of the servers via multiple data collection devices. The offloading decision-making problem is also considered and a new offloading scheme is proposed based on Distributed Deep Learning (DDL). Simulation results demonstrate that our proposed algorithm can effectively and efficiently decrease the system's average latency and energy consumption. Significant improvement is achieved compared with the baselines under the dynamic environment of DTs.
Keywords	Computer Science - Machine Learning ; Computer Science - Distributed ; Parallel ; and Cluster Computing ; Computer Science - Networking and Internet Architecture
Subject code	006
Publishing date	2023-07-11
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: RAD51AP1

Wei, Yongguang / Lan, Chenlu / Wang, Xiangkun / Zhou, Xin / Liao, Xiwen / Huang, Huasheng / Wei, Zhongliu / Li, Tianman / Peng, Tao / Zhu, Guangzhi

International journal of general medicine

2023 Volume 16, Page(s) 4377–4392

Abstract: Background: RAD51: Methods: In this study, comprehensive bioinformatic analysis of : Results: RAD51AP1: Conclusion: Taken together, ...

Abstract	Background: RAD51 Methods: In this study, comprehensive bioinformatic analysis of Results: RAD51AP1 Conclusion: Taken together,
Language	English
Publishing date	2023-09-26
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S431206
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Parallel beam splitting and controlling system based on cascaded acousto-optic modulators.

Cheng, Wenhao / Zhu, Guangzhi / Tang, Haogang / Xu, Puchang / Li, Zhuoyun / Wu, Minglang / Aleksei, Kozlov / Zhu, Xiao

Applied optics

2023 Volume 62, Issue 11, Page(s) 2740–2747

Abstract: In recent years, ultrashort pulse lasers (lasers) have been already widely used for providing excellent laser machining quality for the electronics industry, replication tools, and other applications. However, the major drawback of this processing is low ...

Abstract	In recent years, ultrashort pulse lasers (lasers) have been already widely used for providing excellent laser machining quality for the electronics industry, replication tools, and other applications. However, the major drawback of this processing is low efficiency, especially for a large number of laser ablation demands. In this paper, a beam-splitting approach based on cascaded acousto-optic modulators (AOMs) is proposed and analyzed in detail. The cascaded AOMs can split a laser beam into several beamlets with the same propagation direction. These beamlets can be switched on and off individually, and the beam pitch can be changed independently. At the same time, the experimental setup of three cascaded AOM beam splittings is built up to verify the capability of the high-speed control (switching rate:1 MHz), high-energy utilization rate (>96
Language	English
Publishing date	2023-05-03
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.483680
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: PUS1

Lan, Chenlu / Huang, Xinlei / Liao, Xiwen / Zhou, Xin / Peng, Kai / Wei, Yongguang / Han, Chuangye / Peng, Tao / Wang, Jianyao / Zhu, Guangzhi

Pharmacogenomics and personalized medicine

2023 Volume 16, Page(s) 337–355

Abstract: Objective: The mechanisms of pseudouridine synthase (PUS) are not definite in hepatocellular carcinoma (HCC), the objective of this study is to investigate the effect of PUS genes in HCC.: Materials and methods: Differentially expressed and ... ...

Abstract	Objective: The mechanisms of pseudouridine synthase (PUS) are not definite in hepatocellular carcinoma (HCC), the objective of this study is to investigate the effect of PUS genes in HCC. Materials and methods: Differentially expressed and prognostic gene of PUS enzymes was identified based on The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC) and Gene Expression Profiling Interactive Analysis (GEPIA) databases. For the identified gene, pseudouridine synthase 1 ( Results: PUS1 Conclusion: PUS1
Language	English
Publishing date	2023-04-15
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2508173-1
ISSN	1178-7066
ISSN	1178-7066
DOI	10.2147/PGPM.S405621
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Robust analysis of a novel PANoptosis-related prognostic gene signature model for hepatocellular carcinoma immune infiltration and therapeutic response.

Wei, Yongguang / Lan, Chenlu / Yang, Chengkun / Liao, Xiwen / Zhou, Xin / Huang, Xinlei / Xie, Haixiang / Zhu, Guangzhi / Peng, Tao

Scientific reports

2023 Volume 13, Issue 1, Page(s) 14519

Abstract: PANoptosis, an interplay between pyroptosis, apoptosis, and necroptosis, is deeply involved in cancer development and immunity. However, the influence of PANoptosis in hepatocellular carcinoma (HCC) remains to be further investigated. The differentially ... ...

Abstract	PANoptosis, an interplay between pyroptosis, apoptosis, and necroptosis, is deeply involved in cancer development and immunity. However, the influence of PANoptosis in hepatocellular carcinoma (HCC) remains to be further investigated. The differentially expressed PANoptosis-related genes (PANRGs) was screened in The Cancer Genome Atlas (TCGA) database. Accordingly, mutation, bioinformatics, and consensus clustering analyses were performed. Then, a prognostic risk model was developed by least absolute shrinkage and selection operator (LASSO) Cox regression. Furthermore, the prognostic value, immunity correlation and therapeutic response prediction ability of risk model were explored. A total of 18 PANRGs were differently expressed in the TCGA-HCC cohort and were mainly involved in cancer- and cell death-related signal pathways. Using unsupervised clustering method, we identified two PANRGs-mediated clustering patterns. The remarkable differences between the two clusters on overall survival (OS) and clinical features were demonstrated respectively. Based on the five-gene prognostic risk model, the calculated PANRG-scores were used to categorize the subgroups as high- and low-risk. Notably, the high-risk subgroup had a dismal prognosis and exhibited much lower immune infiltration levels of mast cells, nature killer cells and pDCs, but higher levels of aDCs, iDCs and Treg cells than those in the low-risk subgroup. Furthermore, we constructed a reliable nomogram combining clinical traits and PANRG-score to predict the OS of HCC patients. The significantly negative correlation between PANoptosis and tumor mutation burden (TMB), ferroptosis were revealed. In drug sensitivity analysis, the high-risk subgroup had a considerably lower TIDE score, suggesting a preferable response to immunotherapy, and may be more sensitive to Tipifarnib, Imatinib, Doxorubicin, and Gemcitabine. The upregulated mRNA expressions of FADD were validated in 16 paired HCC tissues of Guangxi cohort. Based on PANoptosis-related genes, an integrated risk signature was constructed to provide a roadmap for patient stratification and predict HCC patient's prognosis. The patients with the higher PANRG-score may carry a dismal survival and relatively low immune infiltration, but a potential better immunotherapy response. Therefore, future HCC therapy perspectives should emphasize the setting of PANoptosis to achieve a personalized, practicable and effective therapeutic regimen.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/therapy ; Prognosis ; Liver Neoplasms/genetics ; Liver Neoplasms/therapy ; China ; Nomograms
Language	English
Publishing date	2023-09-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-41670-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Case report: hepatic arterial infusion chemotherapy combined with sintilimab and lenvatinib for conversion therapy of colorectal cancer liver metastases.

Peng, Kai / Li, Yuhua / Su, Hao / Lan, Chenlu / Huang, Zaida / Wei, Yongguang / Liao, Xiwen / Peng, Minhao / Peng, Tao / Zhu, Guangzhi

Frontiers in immunology

2023 Volume 14, Page(s) 1325445

Abstract: Background: Liver metastasis is one of the most common causes of death in patients with colorectal cancer. Therefore, improving the treatment effect of liver metastatic carcinoma of colorectal cancer is also one of the effective ways to improve the ... ...

Abstract	Background: Liver metastasis is one of the most common causes of death in patients with colorectal cancer. Therefore, improving the treatment effect of liver metastatic carcinoma of colorectal cancer is also one of the effective ways to improve the survival time of patients with colorectal cancer. The main treatment method for liver metastasis of colorectal cancer is preoperative neoadjuvant chemotherapy through intravenous administration. However, no one has reported a conversion therapy approach for the treatment of colorectal cancer liver metastases patients through arterial infusion chemotherapy combined with targeted agents and PD-1 monoclonal antibody. This case reports a conversion therapy method of liver metastases of colorectal cancer by hepatic arterial infusion chemotherapy (HAIC), sintilimab injection combined with lenvatinib to achieve radical resection of liver metastatic carcinoma after treatment. Case presentation: The patient was a 69-year-old man who had previously undergone laparoscopic left hemicolectomy for descending colorectal cancer and multiple interventional and surgical treatments for hepatocellular carcinoma. During this treatment, the patient underwent radiological and serological tests, and primary liver cancer was considered at the initial diagnosis stage. Therefore, this liver malignant tumor lesion was treated according to the primary liver cancer treatment protocol before surgical resection. Therefore, the patient received HAIC combined with sintilimab injection and lenvatinib. After three treatment cycles, radiological examination showed no obvious tumor activity, alpha-fetoprotein (AFP) decreased to normal, protein induced by vitamin K absence or antagonist II (PIVKA II) decreased significantly, and the curative effect was evaluated as complete remission. Subsequently, we performed surgical resection of this liver lesion. The pathological response of left lobe tumor was partial remission (PR). Most of the tumors were necrotic and the necrosis rate was greater than 95%. A small amount of live tumor tissue remains (<5%). The pathological classification of this tumor was confirmed as moderately differentiated adenocarcinoma by immunohistochemical staining of multiple tumor indicators in the pathology department. No significant adverse drug events were observed in this patient during treatment. Conclusion: Hepatic arterial infusion chemotherapy combined with sintilimab injection and lenvatinib conversion therapy provides the opportunity for radical surgical resection of colorectal cancer liver metastases.
MeSH term(s)	Male ; Humans ; Aged ; Fluorouracil ; Hepatic Artery/pathology ; Liver Neoplasms/pathology ; Carcinoma, Hepatocellular/pathology ; Colorectal Neoplasms/pathology
Chemical Substances	sintilimab (8FU7FQ8UPK) ; lenvatinib (EE083865G2) ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2023-12-15
Publishing country	Switzerland
Document type	Case Reports ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1325445
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Dual transformation therapy for giant hepatocellular carcinoma: Two case reports and review of literature.

Gao, Qiang / Zhu, Guang-Zhi / Han, Chuang-Ye / Ye, Xin-Ping / Huang, Hua-Sheng / Mo, Shu-Tian / Peng, Tao

World journal of gastrointestinal surgery

2023 Volume 15, Issue 9, Page(s) 2089–2097

Abstract: Background: In the translational therapy of giant hepatocellular carcinoma (HCC), hepatic arterial infusion chemotherapy (HAIC) combined with anti-PD-1 immunotherapy and tyrosine kinase inhibitors (TKI) after laparoscopic portal vein ligation (PVL) is ... ...

Abstract	Background: In the translational therapy of giant hepatocellular carcinoma (HCC), hepatic arterial infusion chemotherapy (HAIC) combined with anti-PD-1 immunotherapy and tyrosine kinase inhibitors (TKI) after laparoscopic portal vein ligation (PVL) is extremely rare. This is a dual conversion therapy that combines surgery and oncology. Here, we report two cases of successful surgical completion after dual conversion therapy. Case summary: We report that a 54-year-old man and a 69-year-old woman were diagnosed with primary HCC combined with hepatitis B cirrhosis (case 2 also combined with fatty liver) on physical examination. Due to the insufficient residual liver volume assessed before surgery, laparoscopic right PVL was performed, followed by HAIC combined with anti-PD-1 immunotherapy and TKI. Finally, surgical resection was successfully completed, and pathology confirmed that the tumor was mostly necrotic (90%) in one case, and no live tumor tissue was found in the other case. Conclusion: In the process of surgical transformation, our treatment plan takes into account the control and transformation of oncology at the same time, which is expected to provide more opportunities for radical hepatectomy and improve the prognosis of patients with large liver cancer.
Language	English
Publishing date	2023-07-13
Publishing country	United States
Document type	Case Reports
ZDB-ID	2573700-4
ISSN	1948-9366
ISSN	1948-9366
DOI	10.4240/wjgs.v15.i9.2089
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Sarcosine dehydrogenase as an immune infiltration-associated biomarker for the prognosis of hepatocellular carcinoma.

Xie, Haixiang / Yang, Kejian / Qin, Chongjiu / Zhou, Xin / Liu, Junqi / Nong, Jusen / Luo, Jianzhu / Wei, Yongguang / Hua, Huasheng / Han, Chuangye / Liao, Xiwen / Yang, Chengkun / Su, Hao / Zhu, Guangzhi / Ye, Xinping / Peng, Tao

Journal of Cancer

2024 Volume 15, Issue 1, Page(s) 149–165

Abstract: This study was aimed to investigate the prognostic value and clinical significance of sarcosine dehydrogenase (SARDH) in hepatocellular carcinoma (HCC) and to explore the underlying mechanisms. The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) ...

Abstract	This study was aimed to investigate the prognostic value and clinical significance of sarcosine dehydrogenase (SARDH) in hepatocellular carcinoma (HCC) and to explore the underlying mechanisms. The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), HPA and CPTAC databases were adopted to analyze the expression of SARDH mRNA and protein between normal liver tissue and HCC, and examine their relationship with clinicopathological features. Kaplan-Meier analysis, Cox regression, as well as nomogram were adopted to explore the prognostic value of SARDH in HCC. Gene Ontology (GO), Kyoto Gene and Genome Encyclopedia (KEGG) together with Gene Set Enrichment Analysis (GSEA) were adopted to analyze the molecular mechanisms and biological functions of SARDH in HCC; while MethSurv, STRING, GeneMANIA, TIMER database data and single-sample gene set enrichment analysis (ssGSEA) algorithm were used for other bioinformatic analysis. Furthermore, immunohistochemistry was used to verify the expression of SARDH. Compared to normal liver tissue, SARDH expression was markedly lower in HCC. A lower SARDH expression was linked with Pathologic T stage (T3&T4), pathologic stage (Stage III&IV), and histologic grade (G3&4), which further indicates worse prognosis. Besides, results of bioinformatic analysis proved that SARDH expression was correlated with immune infiltration. In addition, SARDH hypermethylation was related to a poorer prognosis. SARDH expression was related to several key genes in the Ferroptosis pathway.
Language	English
Publishing date	2024-01-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2573318-7
ISSN	1837-9664
ISSN	1837-9664
DOI	10.7150/jca.89616
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito