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Article ; Online: Low osteotomy cut of Dega procedure for older children with developmental dysplasia of the hip.

Du, Ming-Hua / Xu, Rui-Jiang / Li, Wen-Chao / Zhu, Hai-Yan

Journal of pediatric orthopedics. Part B

2024

Abstract: The effect on acetabular management in developmental dysplasia of the hip (DDH) patients aged 7 or older with modified low Dega osteotomy procedure was evaluated. Patients between 7 and 14 years old were managed with modified low Dega osteotomy and open ... ...

Abstract	The effect on acetabular management in developmental dysplasia of the hip (DDH) patients aged 7 or older with modified low Dega osteotomy procedure was evaluated. Patients between 7 and 14 years old were managed with modified low Dega osteotomy and open reduction and concomitant procedures to evaluate whether low level osteotomy improved the clinical and radiologic outcomes after treatment. Clinical status was assessed using the modified McKay's criteria; radiologic evaluations were assessed for the modified Severin classification, the mean acetabular index (AI), Sharp angle and center-edge (CE) angle. And occurrence of triradiate cartilage injury and complications was recorded. Forty-two DDH patients (57 hips) between 7 and 14 years old were managed with modified low Dega osteotomy. The results demonstrated the latest follow-up 43 hips (75.4%) were rated excellent and 10 hips (17.5%) rated good according to the modified McKay criteria and 41 hips (71.9%) were rated excellent and 11 hips (19.3%) rated good according to Modified Severin classification, respectively. The mean Hip Score improved from 69.53 ± 7.14 before the operation to 93.17 ± 8.43 at the final follow-up. The mean AI changed from 31.9° to 20.2°, mean Sharp angle decreased from 59.3° to 38.8° and mean CE angle increased from -10.9° to 35.2°, preoperatively and at latest follow-up, respectively. The modified low Dega osteotomy combined with open reduction and concomitant procedures were found to be adequate in improving instant and sustained clinical and radiographic outcomes for the late detected pediatric walking DDH patients.
Language	English
Publishing date	2024-02-27
Publishing country	United States
Document type	Journal Article
ISSN	1473-5865
ISSN (online)	1473-5865
DOI	10.1097/BPB.0000000000001163
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Article: [Research Status of TPO/c-MPL Signaling Pathway in Acute Myeloid Leukemia--Review].

Wang, Nan / Zhu, Hai-Yan

Zhongguo shi yan xue ye xue za zhi

2021 Volume 29, Issue 4, Page(s) 1351–1354

Abstract: Thrombopoietin (TPO) can activate hematopoietic cell proliferation by its receptor c-MPL mediated downstream pathways and induce the generation of megakaryocyte. In recent years, domestic and foreign researches have confirmed that TPO/ c-MPL pathway also ...

Abstract	Thrombopoietin (TPO) can activate hematopoietic cell proliferation by its receptor c-MPL mediated downstream pathways and induce the generation of megakaryocyte. In recent years, domestic and foreign researches have confirmed that TPO/ c-MPL pathway also plays an important role in the self-renewal and quiescence of leukemia stem cell, and its expression in acute myeloid leukemia (AML) also indicates the chemotherapy resistance and poor prognosis. In this article, the research progress of the roles of TPO/c-MPL pathway in chemotherapy resistance, prognosis of AML patients, and the application of TPO/ c-MPL receptor agonists in AML were summarized briefly.
MeSH term(s)	Humans ; Leukemia, Myeloid, Acute ; Neoplasm Proteins ; Proto-Oncogene Proteins/metabolism ; Receptors, Cytokine ; Receptors, Thrombopoietin ; Signal Transduction ; Thrombopoietin
Chemical Substances	Neoplasm Proteins ; Proto-Oncogene Proteins ; Receptors, Cytokine ; Receptors, Thrombopoietin ; MPL protein, human (143641-95-6) ; Thrombopoietin (9014-42-0)
Language	Chinese
Publishing date	2021-08-06
Publishing country	China
Document type	Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2021.04.054
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Article ; Online: Cystofilobasidium josepaulonis

Zhu, Hai-Yan / Wei, Xu-Yang / Liu, Xin-Zhan / Bai, Feng-Yan

International journal of systematic and evolutionary microbiology

2023 Volume 73, Issue 5

Abstract: A yeast strain belonging to the basidiomycetous yeast ... ...

Abstract	A yeast strain belonging to the basidiomycetous yeast genus
MeSH term(s)	DNA, Fungal/genetics ; Phylogeny ; Agar ; DNA, Ribosomal Spacer/genetics ; Sequence Analysis, DNA ; Mycological Typing Techniques ; RNA, Ribosomal, 16S/genetics ; DNA, Bacterial/genetics ; Bacterial Typing Techniques ; Base Composition ; Fatty Acids/chemistry ; Basidiomycota ; RNA, Ribosomal/genetics
Chemical Substances	DNA, Fungal ; Agar (9002-18-0) ; DNA, Ribosomal Spacer ; RNA, Ribosomal, 16S ; DNA, Bacterial ; Fatty Acids ; RNA, Ribosomal
Language	English
Publishing date	2023-05-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2002336-4
ISSN	1466-5034 ; 1466-5026
ISSN (online)	1466-5034
ISSN	1466-5026
DOI	10.1099/ijsem.0.005865
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Article ; Online: Pichia kurtzmaniana

Zhu, Hai-Yan / Guo, Liang-Chen / Hu, Shuang / Wei, Yu-Hua / Hui, Feng-Li / Liu, Xin-Zhan / Bai, Feng-Yan

International journal of systematic and evolutionary microbiology

2024 Volume 74, Issue 3

Abstract: Three yeast strains belonging to the ascomycetous yeast ... ...

Abstract	Three yeast strains belonging to the ascomycetous yeast genus
MeSH term(s)	Bacterial Typing Techniques ; Base Composition ; Candida ; China ; DNA, Bacterial/genetics ; Fatty Acids/chemistry ; Phylogeny ; Pichia ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA
Chemical Substances	DNA, Bacterial ; Fatty Acids ; RNA, Ribosomal, 16S
Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2002336-4
ISSN	1466-5034 ; 1466-5026
ISSN (online)	1466-5034
ISSN	1466-5026
DOI	10.1099/ijsem.0.006306
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Article: Clinical effects and mechanisms of a Chinese patent medicine, Tongxinluo capsule, as an adjuvant treatment in coronary heart disease.

Wang, Jing / Li, Tian Li / Chang, Pei Fen / Gao, Yu Qian / Fan, Jia Sai / Zhang, Chen Hao / Zhu, Hai Yan

Heliyon

2024 Volume 10, Issue 6, Page(s) e27460

Abstract: Coronary heart disease (CHD) is the leading cause of death globally, posing a serious threat to human health. However, the current treatment approaches available for CHD fall short of the ideal results. Tongxinluo (TXL) is a traditional Chinese medicine ( ...

Abstract	Coronary heart disease (CHD) is the leading cause of death globally, posing a serious threat to human health. However, the current treatment approaches available for CHD fall short of the ideal results. Tongxinluo (TXL) is a traditional Chinese medicine (TCM) that has been employed in the clinical treatment of cardiovascular and cerebrovascular diseases (such as angina pectoris, stroke, etc.) in China for many years and holds great potential as a prospective treatment. TXL either as a standalone treatment or in combination with interventions recommended in CHD guidelines has been shown to be effective and well tolerated in clinical trials for CHD. Drawing on the evidence from clinical trials and experimental studies, this review will focus on the cardiovascular protective properties and related mechanisms of TXL. By searching 8 Chinese and English databases, more than 4000 articles were retrieved. These articles were categorized, then read, and finally written into this review. In this review, the pharmacological properties of TXL include regulation of blood lipids, improvement of endothelial function, anti-inflammatory, antioxidant, inhibition of apoptosis and regulation of autophagy, anti-fibrosis, promotion of angiogenesis, and modulation of exosome communication. The information provided in this review will help the reader to comprehend better the insights that TCM has developed over time in practice and provide new perspectives for the treatment of CHD.
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e27460
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Article: Exploration of potential biomarkers and therapeutic targets for trauma-related acute kidney injury.

Qi, Peng / Huang, Meng-Jie / Wu, Wei / Ren, Xue-Wen / Zhai, Yong-Zhi / Qiu, Chen / Zhu, Hai-Yan

Chinese journal of traumatology = Zhonghua chuang shang za zhi

2024 Volume 27, Issue 2, Page(s) 97–106

Abstract: Purpose: Acute kidney injury (AKI) is one of the most common functional injuries observed in trauma patients. However, certain trauma medications may exacerbate renal injury. Therefore, the early detection of trauma-related AKI holds paramount ... ...

Abstract	Purpose: Acute kidney injury (AKI) is one of the most common functional injuries observed in trauma patients. However, certain trauma medications may exacerbate renal injury. Therefore, the early detection of trauma-related AKI holds paramount importance in improving trauma prognosis. Methods: Qualified datasets were selected from public databases, and common differentially expressed genes related to trauma-induced AKI and hub genes were identified through enrichment analysis and the establishment of protein-protein interaction (PPI) networks. Additionally, the specificity of these hub genes was investigated using the sepsis dataset and conducted a comprehensive literature review to assess their plausibility. The raw data from both datasets were downloaded using R software (version 4.2.1) and processed with the "affy" package19 for correction and normalization. Results: Our analysis revealed 585 upregulated and 629 downregulated differentially expressed genes in the AKI dataset, along with 586 upregulated and 948 downregulated differentially expressed genes in the trauma dataset. Concurrently, the establishment of the PPI network and subsequent topological analysis highlighted key hub genes, including CD44, CD163, TIMP metallopeptidase inhibitor 1, cytochrome b-245 beta chain, versican, membrane spanning 4-domains A4A, mitogen-activated protein kinase 14, and early growth response 1. Notably, their receiver operating characteristic curves displayed areas exceeding 75%, indicating good diagnostic performance. Moreover, our findings postulated a unique molecular mechanism underlying trauma-related AKI. Conclusion: This study presents an alternative strategy for the early diagnosis and treatment of trauma-related AKI, based on the identification of potential biomarkers and therapeutic targets. Additionally, this study provides theoretical references for elucidating the mechanisms of trauma-related AKI.
MeSH term(s)	Humans ; Biomarkers ; Protein Interaction Maps/genetics ; Prognosis ; Gene Expression Profiling ; Acute Kidney Injury/genetics ; Acute Kidney Injury/therapy ; Computational Biology
Chemical Substances	Biomarkers
Language	English
Publishing date	2024-01-16
Publishing country	China
Document type	Review ; Journal Article
ZDB-ID	2276839-7
ISSN	1008-1275
ISSN	1008-1275
DOI	10.1016/j.cjtee.2024.01.002
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Article ; Online: Evaluating hs-cTnI serum levels and cTnI gene expression compared with cardiac nuclear scan in patients with angina pectoris.

Zhang, Guifang / Zhan, Jiang / Lei, Hong / Zhu, HaiYan / He, Xiaowei

Cellular and molecular biology (Noisy-le-Grand, France)

2023 Volume 69, Issue 7, Page(s) 98–103

Abstract: Exercise stress can cause reversible myocardial ischemia in people with coronary artery disease (CAD). On the other hand, the new troponin biomarker with high sensitivity can detect faster and small amounts of troponin in blood circulation. The present ... ...

Abstract	Exercise stress can cause reversible myocardial ischemia in people with coronary artery disease (CAD). On the other hand, the new troponin biomarker with high sensitivity can detect faster and small amounts of troponin in blood circulation. The present study aimed to investigate the serum troponin level following exercise stress and the result of nuclear heart scans as the gold standard. For this purpose, 93 patients with stable angina and no history of known CAD and organic disease were included in this cross-sectional study. The serum level of the highly sensitive cardiac troponin I (hs-cTnI) was measured 75 minutes after the peak of the exercise test and reached at least 85% of the maximum heart rate. It was compared with the rate of reversible myocardial ischemia based on the nuclear heart scan, the three-month prognosis and the persistence of chest pain were investigated. Also, the expression level of the cTnI gene was evaluated by real-time PCR technique. The results showed that the average age of the patients was 58.9+12.4 years, and 62 (66.66%) patients were female. Reversible myocardial ischemia was observed in 31 patients. The relationship between hs-cTI level and the rate of reversible ischemia cases was significant (p = 0.0041). Also, the cTnI gene expression showed the same results as the serum level. According to the heart nuclear scan report, the hs-cTnI value above 1.6ng/dl had a specificity of 72% and sensitivity of 66%, a positive predictive value of 53%, and a negative predictive value of 78%. There was no significant relationship between hs-cTnI level and prognosis and the continuation of chest pain in patients after three months. Generally, the serum level of high-sensitivity cardiac troponin was higher after exercise in the group with reversible myocardial ischemia.
MeSH term(s)	Humans ; Female ; Middle Aged ; Aged ; Male ; Troponin I/genetics ; Cross-Sectional Studies ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/genetics ; Myocardial Ischemia/diagnostic imaging ; Myocardial Ischemia/genetics ; Chest Pain ; Angina, Stable/diagnostic imaging ; Angina, Stable/genetics ; Gene Expression
Chemical Substances	Troponin I
Language	English
Publishing date	2023-07-31
Publishing country	France
Document type	Journal Article
ZDB-ID	1161779-2
ISSN	1165-158X ; 0145-5680
ISSN (online)	1165-158X
ISSN	0145-5680
DOI	10.14715/cmb/2023.69.7.16
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Article: [Safety and Effectiveness of Ruxolitinib for Treatment of Myeloproliferative Neoplasm: A Meta-Analysis].

Yang, Zhi-Rui / Zhu, Hai-Yan

Zhongguo shi yan xue ye xue za zhi

2018 Volume 26, Issue 2, Page(s) 493–501

Abstract: Objective: To evaluate the efficacy and safety of ruxolitinib in treatment of myeloproliferative neoplasm.: Methods: Random clinical trials (~September 30, 2017) were identified from PubMed, Embase, Cochrane Library, Clinical Trials, CBM and Chinese ... ...

Abstract	Objective: To evaluate the efficacy and safety of ruxolitinib in treatment of myeloproliferative neoplasm. Methods: Random clinical trials (~September 30, 2017) were identified from PubMed, Embase, Cochrane Library, Clinical Trials, CBM and Chinese Journal Full-text Database. The quality of RCT was assessed by Cochrane risk bias. Meta analysis was performed with Revman 5.3. Results: Ruxolitinib was efficacious in relieving splenomegaly (RR 49.12, 95% CI [15.81-152.59], P<0.001). The incidence of anemia significantly increased after ruxolitinib treatment (RR 1.71, 95% CI [1.05-2.77], P=0.16), while the thrombocytopenia (RR 1.04, 95% CI [0.50-2.16], P=0.92) and neutropenia (RR 2.46, 95% CI [0.91-6.61], P=0.07) had no statistical difference as compared with that in control group. Ischemia events had no significant difference as compared with control (RR 0.57, 95% CI [0.33-1.00], P=0.05). Infection events had no significant difference as compared with the control group (RR 1.18, 95% CI [0.79-1.78], P=0.24). Conclusion: Ruxolitinib is an efficacious therapeutic strategy on MPD with controlling splenomegaly. However,anemia events and bleeding events may threat its clinical safety, so more high quality RCT are needed.
MeSH term(s)	Humans ; Myeloproliferative Disorders ; Neoplasms ; Pyrazoles ; Thrombocytopenia
Chemical Substances	Pyrazoles ; ruxolitinib (82S8X8XX8H)
Language	Chinese
Publishing date	2018-04-13
Publishing country	China
Document type	Journal Article ; Meta-Analysis
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.7534/j.issn.1009-2137.2018.02.032
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Article ; Online: LncRNA XIST promotes mitochondrial dysfunction of hepatocytes to aggravate hepatic fibrogenesis via miR-539-3p/ADAMTS5 axis.

Wu, Xiong-Jian / Xie, Yuan / Gu, Xiao-Xiang / Zhu, Hai-Yan / Huang, Li-Xing

Molecular and cellular biochemistry

2022 Volume 478, Issue 2, Page(s) 291–303

Abstract: A previous study indicated that long non-coding RNA X-inactive-specific transcript (XIST) promoted ethanol-induced HSCs autophagy and activation. Considering the critical role of HSC activation in hepatic fibrosis, the aim of the present study was to ... ...

Abstract	A previous study indicated that long non-coding RNA X-inactive-specific transcript (XIST) promoted ethanol-induced HSCs autophagy and activation. Considering the critical role of HSC activation in hepatic fibrosis, the aim of the present study was to reveal the exact role of XIST in liver fibrosis and its underlying mechanism. The expression of XIST in the liver from CCL
MeSH term(s)	Humans ; Animals ; Mice ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Hepatocytes/metabolism ; Liver Cirrhosis/genetics ; Cell Proliferation/genetics ; ADAMTS5 Protein
Chemical Substances	MicroRNAs ; RNA, Long Noncoding ; ADAMTS5 protein, human (EC 3.4.24.-) ; ADAMTS5 Protein (EC 3.4.24.-) ; MIRN539 microRNA, human ; Adamts5 protein, mouse (EC 3.4.24.-)
Language	English
Publishing date	2022-07-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	184833-1
ISSN	1573-4919 ; 0300-8177
ISSN (online)	1573-4919
ISSN	0300-8177
DOI	10.1007/s11010-022-04506-0
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Article ; Online: Vishniacozyma pseudocarnescens

Zhu, Hai-Yan / Wei, Yu-Hua / Guo, Liang-Chen / Wei, Xu-Yang / Li, Jun-Ning / Zhang, Ri-Peng / Liu, Xin-Zhan / Bai, Feng-Yan

International journal of systematic and evolutionary microbiology

2023 Volume 73, Issue 10

Abstract: Three strains belonging to the basidiomycetous yeast ... ...

Abstract	Three strains belonging to the basidiomycetous yeast genus
MeSH term(s)	Phylogeny ; DNA, Ribosomal Spacer/genetics ; Mycological Typing Techniques ; DNA, Fungal/genetics ; Sequence Analysis, DNA ; RNA, Ribosomal, 16S/genetics ; DNA, Bacterial/genetics ; Bacterial Typing Techniques ; Base Composition ; Fatty Acids/chemistry ; Basidiomycota ; DNA, Ribosomal
Chemical Substances	DNA, Ribosomal Spacer ; DNA, Fungal ; RNA, Ribosomal, 16S ; DNA, Bacterial ; Fatty Acids ; DNA, Ribosomal
Language	English
Publishing date	2023-10-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2002336-4
ISSN	1466-5034 ; 1466-5026
ISSN (online)	1466-5034
ISSN	1466-5026
DOI	10.1099/ijsem.0.006076
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