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  1. Book ; Online ; E-Book: Design and analysis of pragmatic trials

    Zhang, Song / Ahn, Chul / Zhu, Hong

    (Chapman and Hall/CRC biostatistics series)

    2023  

    Author's details Song Zhang, Chul Ahn, and Hong Zhu
    Series title Chapman and Hall/CRC biostatistics series
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (vii, 206 Seiten)
    Publisher CRC Press
    Publishing place Boca Raton
    Publishing country United States
    Document type Book ; Online ; E-Book
    Note Description based on publisher supplied metadata and other sources
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021878809
    ISBN 978-1-00-087355-9 ; 9780367627355 ; 1-00-087355-2 ; 0367627353
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: A comment on 'Preoperative dexamethasone administration in hepatectomy of 25-minute intermittent Pringle's maneuver for hepatocellular carcinoma: a randomized controlled trial'.

    Zhu, Hong / Wei, Xiaoping

    International journal of surgery (London, England)

    2024  Volume 110, Issue 1, Page(s) 586–588

    MeSH term(s) Humans ; Hepatectomy ; Carcinoma, Hepatocellular/surgery ; Liver Neoplasms/surgery ; Liver/surgery ; Dexamethasone/therapeutic use
    Chemical Substances Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2024-01-01
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000000761
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Optimal Timing of Cholecystectomy for Severe Acute Pancreatitis and Understanding Complications and Comorbidities.

    Zhu, Hong / Wei, Xiaoping

    JAMA surgery

    2024  Volume 159, Issue 4, Page(s) 465–466

    MeSH term(s) Humans ; Pancreatitis/surgery ; Pancreatitis/etiology ; Acute Disease ; Cholecystectomy/adverse effects ; Cholecystectomy, Laparoscopic/adverse effects ; Comorbidity ; Retrospective Studies
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2023.6929
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.72: Show issues Location:
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  4. Article ; Online: Chemo-free treatment of adult patients with Ph-positive acute lymphoblastic leukemia: latest updates from the 2023 ASH annual meeting.

    Shi, Ting / Zhu, Hong-Hu

    Journal of hematology & oncology

    2024  Volume 17, Issue 1, Page(s) 18

    Abstract: The chemo-free concept represents a new direction for managing adult patients with Ph-positive acute lymphoblastic leukemia (Ph + ALL). The tyrosine kinase inhibitors (TKIs), blinatumomab and venetoclax serve as the backbone of chemo-free regimens; ... ...

    Abstract The chemo-free concept represents a new direction for managing adult patients with Ph-positive acute lymphoblastic leukemia (Ph + ALL). The tyrosine kinase inhibitors (TKIs), blinatumomab and venetoclax serve as the backbone of chemo-free regimens; several prospective studies involving these drugs have demonstrated high remission rates and promising, albeit short, survival outcomes. This review summarizes the latest updates on chemo-free regimens in the treatment of adult patients with Ph + ALL, presented at the 2023 ASH annual meeting.
    MeSH term(s) Adult ; Humans ; Prospective Studies ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Protein Kinase Inhibitors/therapeutic use ; Philadelphia Chromosome
    Chemical Substances Protein Kinase Inhibitors
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Review ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2429631-4
    ISSN 1756-8722 ; 1756-8722
    ISSN (online) 1756-8722
    ISSN 1756-8722
    DOI 10.1186/s13045-024-01539-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Immunotherapy for advanced or recurrent hepatocellular carcinoma.

    Luo, Ying-Zhe / Zhu, Hong

    World journal of gastrointestinal oncology

    2023  Volume 15, Issue 3, Page(s) 405–424

    Abstract: Hepatocellular carcinoma (HCC) is associated with high morbidity and mortality, and is prone to intra- and extrahepatic metastasis due to the anatomical and functional characteristics of the liver. Due to the complexity and high relapse rate associated ... ...

    Abstract Hepatocellular carcinoma (HCC) is associated with high morbidity and mortality, and is prone to intra- and extrahepatic metastasis due to the anatomical and functional characteristics of the liver. Due to the complexity and high relapse rate associated with radical surgery or radiofrequency ablation, immune checkpoint inhibitors (ICIs) are increasingly being used to treat HCC. Several immunotherapeutic agents, along with their combinations, have been clinically approved to treat advanced or recurrent HCC. This review discusses the leading ICIs in practice and those currently undergoing randomized phase 1-3 trials as monotherapy or combination therapy. Furthermore, we summarize the rapidly developing alternative strategies such as chimeric antigen receptor-engineered T cell therapy and tumor vaccines. Combination therapy is a promising potential treatment option. These immunotherapies are also summarized in this review, which provides insights into the advantages, limitations, and novel angles for future research in establishing viable and alternative therapies against HCC.
    Language English
    Publishing date 2023-03-29
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2573696-6
    ISSN 1948-5204
    ISSN 1948-5204
    DOI 10.4251/wjgo.v15.i3.405
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Regorafenib combined with sintilimab as second-line treatment for advanced HCC patient: a case report.

    Wan, Yanzhi / Zhu, Hong

    Frontiers in oncology

    2023  Volume 13, Page(s) 1256137

    Abstract: Hepatocellular carcinoma (HCC) is a tumor with a high degree of malignancy. Patients have poor outcomes and short survival times, especially after progression to first-line systemic therapy. Regorafenib is the standard second-line treatment for HCC, but ... ...

    Abstract Hepatocellular carcinoma (HCC) is a tumor with a high degree of malignancy. Patients have poor outcomes and short survival times, especially after progression to first-line systemic therapy. Regorafenib is the standard second-line treatment for HCC, but there is no conclusive evidence that regorafenib combined with immunotherapy can be used as a second-line treatment. We present the case of a 50-year-old man with a chronic hepatitis B (CHB) infection for more than 30 years who was diagnosed with stage Barcelona Clinic Liver Cancer (BCLC)-B hepatocellular carcinoma. Unfortunately, recurrence and metastasis occurred soon after radical surgery and standard first-line treatment with lenvatinib. The patient was then treated with regorafenib plus sintilimab as second-line treatment. Surprisingly, soon after treatment, the patient reached a state of partial response (PR) that lasted for more than one year, which is currently close to that of complete response (CR). Regorafenib combined with sintilimab as second-line treatment showed an excellent curative effect in this patient, who had HCC with multiple metastases to the liver and lungs. This treatment, which has tolerable side effects, enabled the patient to reach a state of PR that lasted over one year, which is currently close to CR. Therefore, it may be a potential second-line treatment strategy.
    Language English
    Publishing date 2023-10-10
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1256137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Endoscopic mucosal electrodes: New directions for recording and regulating gastric myoelectric activity.

    Han, Xu / Zhu, Hong

    Frontiers in surgery

    2023  Volume 9, Page(s) 1035723

    Abstract: With the gradual deepening of the study of gastric motility disorders, people increasingly realize that gastric myoelectric activity plays an important role in coordinating gastric function. This article introduces the advantages of endoscopic mucosal ... ...

    Abstract With the gradual deepening of the study of gastric motility disorders, people increasingly realize that gastric myoelectric activity plays an important role in coordinating gastric function. This article introduces the advantages of endoscopic mucosal electrodes compared with traditional electrodes. Several different types of mucosal electrodes and how to fix the electrodes by endoscope are introduced. Endoscopic mucosal electrodes can record and regulate gastric myoelectric activity, which has great value in the study of gastric motility. Endoscopic mucosal electrode technique refers to the fixation of the electrode in the designated part of the gastric mucosa by endoscope. Through endoscopic mucosal electrodes, on the one hand, we can record gastric myoelectric activity, on the other hand, we can carry out gastric electrical stimulation to interfere with gastric rhythm. Endoscopic mucosal electrodes have higher accuracy than traditional cutaneous electrodes, less trauma and lower cost than serosal electrodes. Endoscopic mucosal electrodes have a good application prospect for diseases such as gastroparesis and obesity.
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2022.1035723
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: An 'Easter egg' in coronary heart disease: chronic atrial thrombosis.

    Zhu, Hong / Xie, Zhongshang

    European heart journal. Case reports

    2023  Volume 7, Issue 8, Page(s) ytad364

    Language English
    Publishing date 2023-08-01
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytad364
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Targeted treatment of T-cell acute lymphoblastic leukemia: latest updates from the 2022 ASH Annual Meeting.

    Xu, Jieyu / Zhu, Hong-Hu

    Experimental hematology & oncology

    2023  Volume 12, Issue 1, Page(s) 30

    Abstract: T-cell acute lymphoblastic leukemia (T-ALL) occurs in approximately 25-30% of adult ALL. Currently, treatment approaches for adult patients with T-ALL remain quite limited, with intensive multiagent chemotherapy serving as the backbone; however, the cure ...

    Abstract T-cell acute lymphoblastic leukemia (T-ALL) occurs in approximately 25-30% of adult ALL. Currently, treatment approaches for adult patients with T-ALL remain quite limited, with intensive multiagent chemotherapy serving as the backbone; however, the cure rate remains unsatisfactory. Thus, the discovery of novel therapeutic strategies, especially targeted therapies, is crucial. Clinical research efforts are now focused on adding targeted therapy that has selective activity for T-ALL to the backbone chemotherapy regimen. To date, nelarabine remains the only targeted agent specifically approved for relapsed T-ALL, and the use of nelarabine in the first-line regimen is still being studied. Meanwhile, a number of novel targeted therapies with low toxicity, such as immunotherapies, are being actively investigated. Chimeric antigen receptor (CAR) T-cell therapy for the treatment of T-cell malignancies has not been as successful as in treating B-ALL due to fratricide. Numerous approaches are now being designed to address this challenge. Novel therapies targeting molecular aberrations in T-ALL are also actively investigated. T-ALL lymphoblasts overexpress BCL2 protein, which makes it an intriguing therapeutic target. This review summarizes the latest updates on targeted treatment of T-ALL from the 2022 ASH annual meeting.
    Language English
    Publishing date 2023-03-11
    Publishing country England
    Document type Letter
    ZDB-ID 2669066-4
    ISSN 2162-3619
    ISSN 2162-3619
    DOI 10.1186/s40164-023-00384-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A rare case of mitral regurgitation caused by primary aldosteronism.

    Xie, Zhongshang / Zhu, Hong

    European heart journal

    2023  Volume 44, Issue 21, Page(s) 1960

    MeSH term(s) Humans ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/etiology ; Mitral Valve Insufficiency/surgery ; Mitral Valve/surgery ; Heart Valve Prosthesis Implantation/adverse effects ; Hyperaldosteronism/complications
    Language English
    Publishing date 2023-05-03
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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