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Article ; Online: New applications of clutter simulation in airborne early warning radar

ZHU Huan, ZHANG Liang, WU Tao

Zhihui kongzhi yu fangzhen, Vol 45, Iss 6, Pp 128-

2023 Volume 133

Abstract: The characteristics of airborne early warning radar and the difficulties of clutter suppression are introduced in this paper. The research process of clutter simulation is then reviewed. On the basis of the analysis of the clutter model of airborne early ...

Abstract	The characteristics of airborne early warning radar and the difficulties of clutter suppression are introduced in this paper. The research process of clutter simulation is then reviewed. On the basis of the analysis of the clutter model of airborne early warning radar and the conventional clutter suppression methods, a cognitive clutter suppression method based on high fidelity clutter simulation is proposed. This method uses digital elevation map data, land cover and land use data to carry out signal level airborne radar clutter inversion. It supplements homogeneous clutter samples, improves clutter suppression performance under heterogeneous environment, and points out a new way for the application of clutter simulation in airborne early warning radar. Finally, according to the typical parameters of airborne early warning radar and geographical environment, the effectiveness of this method is verified by simulation.
Keywords	airborne early warning radar\|knowledge-aided\|high fidelity clutter simulation ; Military Science ; U
Subject code	910
Language	Chinese
Publishing date	2023-12-01T00:00:00Z
Publisher	Editorial Office of Command Control and Simulation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Morphology and Molecular Phylogeny of the Genus

Liu, Benwen / Lan, Qiumei / Dai, Qingyu / Zhu, Huan / Liu, Guoxiang

Plants (Basel, Switzerland)

2024 Volume 13, Issue 5

Abstract: ... ...

Abstract	Stigeoclonium
Language	English
Publishing date	2024-03-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants13050748
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Establishment of a Fah-LSL mouse model to study BEC-to-hepatocyte conversion.

Wang, Xingrui / Pu, Wenjuan / Zhu, Huan / Zhang, Mingjun / Zhou, Bin

Biophysics reports

2024 Volume 9, Issue 6, Page(s) 309–324

Abstract: The liver consists predominantly of hepatocytes and biliary epithelial cells (BECs), which serve distinct physiological functions. Although hepatocytes primarily replenish their own population during homeostasis and injury repair, recent findings have ... ...

Abstract	The liver consists predominantly of hepatocytes and biliary epithelial cells (BECs), which serve distinct physiological functions. Although hepatocytes primarily replenish their own population during homeostasis and injury repair, recent findings have suggested that BECs can transdifferentiate into hepatocytes when hepatocyte-mediated liver regeneration is impaired. However, the cellular and molecular mechanisms governing this BEC-to-hepatocyte conversion remain poorly understood largely because of the inefficiency of existing methods for inducing lineage conversion. Therefore, this study introduces a novel mouse model engineered by the Zhou's lab, where hepatocyte senescence is induced by the deletion of the fumarylacetoacetate (
Language	English
Publishing date	2024-03-21
Publishing country	China
Document type	Journal Article
ISSN	2364-3420
ISSN (online)	2364-3420
DOI	10.52601/bpr.2023.230034
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Article ; Online: Twenty-Four week Taichi training improves pulmonary diffusion capacity and glycemic control in patients with Type 2 diabetes mellitus.

Liu, Xiaoli / Zhu, Huan / Peng, Yong / Liu, Yaofeng / Shi, Xiangrong

PloS one

2024 Volume 19, Issue 4, Page(s) e0299495

Abstract: This study evaluated the effect of 24-week Taichi training and Taichi plus resistance band training on pulmonary diffusion capacity and glycemic control in patients with Type 2 diabetes mellitus (T2DM). Forty-eight patients with T2DM were randomly ... ...

Abstract	This study evaluated the effect of 24-week Taichi training and Taichi plus resistance band training on pulmonary diffusion capacity and glycemic control in patients with Type 2 diabetes mellitus (T2DM). Forty-eight patients with T2DM were randomly divided into three groups: Group A-Taichi training: practiced Taichi 60 min/day, 6 days/week for 24 weeks; Group B-Taichi plus resistance band training: practiced 60-min Taichi 4 days/week plus 60-min resistance band training 2 days/week for 24 weeks; and Group C-controls: maintaining their daily lifestyles. Stepwise multiple regression analysis was applied to predict diffusion capacity of the lungs for carbon monoxide (DLCO) by fasting blood glucose, insulin, glycosylated hemoglobin (HbA1c), tumour necrosis factor alpha (TNF-α), von Willebrand Factor (vWF), interleukin-6 (IL-6), intercellular adhesion molecule 1 (ICAM-1), endothelial nitric oxide synthase (eNOS), nitric oxide (NO), endothelin-1 (ET-1), vascular endothelial growth factor, and prostaglandin I-2. Taichi with or without resistance band training significantly improved DLCO, increased insulin sensitivity, eNOS and NO, and reduced fasting blood glucose, insulin, HbA1c, TNF-α, vWF, IL-6, ICAM-1, and ET-1. There was no change in any of these variables in the control group. DLCO was significantly predicted (R2 = 0.82) by insulin sensitivity (standard-β = 0.415, P<0.001), eNOS (standard-β = 0.128, P = 0.017), TNF-α (standard-β = -0.259, P = 0.001), vWF (standard-β = -0.201, P = 0.007), and IL-6 (standard-β = -0.175, P = 0.032) in patients with T2DM. The impact of insulin sensitivity was the most important predictor for the variation of DLCO based on the multiple regression modeling. This study demonstrates that 24-week Taichi training and Taichi plus resistance band training effectively improve pulmonary diffusion capacity and blood glycemic control in patients with T2DM. Variation of DLCO is explained by improved insulin sensitivity and endothelial function, and reduced inflammatory markers, including TNF-α, vWF, and IL-6.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2 ; Intercellular Adhesion Molecule-1 ; Blood Glucose/metabolism ; Insulin Resistance ; Glycated Hemoglobin ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Glycemic Control ; von Willebrand Factor ; Vascular Endothelial Growth Factor A ; Insulin ; Lung/metabolism
Chemical Substances	Intercellular Adhesion Molecule-1 (126547-89-5) ; Blood Glucose ; Glycated Hemoglobin ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; von Willebrand Factor ; Vascular Endothelial Growth Factor A ; Insulin
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0299495
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Article: The effect of 12 week-maximum fat oxidation intensity (FATmax) exercise on microvascular function in obese patients with nonalcoholic fatty liver disease and its mechanism.

Yang, Ruiqi / Wan, Li / Zhu, Huan / Peng, Yong

General physiology and biophysics

2023 Volume 42, Issue 3, Page(s) 251–262

Abstract: Fifty-four obese patients with non-alcoholic fatty liver disease (NAFLD) were selected for this study were randomly divided into an exercise group (16 men and 11 women, mean age 21.3 ± 1.0) and control group (16 men and 11 women, mean age 21.8 ± 0.8). ... ...

Abstract	Fifty-four obese patients with non-alcoholic fatty liver disease (NAFLD) were selected for this study were randomly divided into an exercise group (16 men and 11 women, mean age 21.3 ± 1.0) and control group (16 men and 11 women, mean age 21.8 ± 0.8). The exercise group underwent a 12-week FATmax exercise intervention, while the control group did not engage in any type of systematic physical activity. The controlled diet was given to both groups. After the test, the microvascular reactivity of the exercise group was significantly higher than that of the control group (p < 0.05). After the experiment, the concentration of malondialdehyde (MDA), the activity of catalase (CAT) and the activity of exercise group were significantly lower than those of the control group (p < 0.05); and in contrast the activities of total superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) were significantly higher than those of the control group (p< 0.05). The change in microcirculation function caused by 12-week FATmax intensity exercise may have an interaction mechanism with oxidative stress and antioxidant system function, and may improve the microvascular reactivity of obese NAFLD patients. In addition, also may improve of oxidative stress and antioxidant system functions.
MeSH term(s)	Female ; Humans ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/metabolism ; Antioxidants/metabolism ; Obesity/complications ; Obesity/metabolism ; Catalase/metabolism ; Oxidative Stress ; Exercise ; Superoxide Dismutase/metabolism ; Glutathione Peroxidase/metabolism ; Malondialdehyde/metabolism ; Liver/metabolism
Chemical Substances	Antioxidants ; Catalase (EC 1.11.1.6) ; Superoxide Dismutase (EC 1.15.1.1) ; Glutathione Peroxidase (EC 1.11.1.9) ; Malondialdehyde (4Y8F71G49Q)
Language	English
Publishing date	2023-03-06
Publishing country	Slovakia
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	791184-1
ISSN	0231-5882
ISSN	0231-5882
DOI	10.4149/gpb_2023004
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Article ; Online: Lakes-scale pattern of eukaryotic phytoplankton diversity and assembly process shaped by electrical conductivity in central Qinghai-Tibet Plateau.

Zhu, Huan / Xiong, Xiong / Liu, Benwen / Liu, Guoxiang

FEMS microbiology ecology

2023 Volume 100, Issue 1

Abstract: Phytoplankton are the main primary producers in aquatic ecosystems and play an important role in food web and geochemical cycles. Its diversity, community structure, and assembly process are influenced by several factors. Alpine lake ecosystems are ... ...

Abstract	Phytoplankton are the main primary producers in aquatic ecosystems and play an important role in food web and geochemical cycles. Its diversity, community structure, and assembly process are influenced by several factors. Alpine lake ecosystems are relatively weak and extremely sensitive to global climate change. However, the impact of climate change on phytoplankton in Qinghai-Tibet Plateau lakes and their responses are still unclear. In this study, we analyzed the diversity, environmental drivers, and assembly process of phytoplankton community in the central QTP lakes. The phytoplankton of these lakes can be primarily distinguished into freshwater and brackish types, with significant differences in species diversity and community dissimilarity. Both shared nearly same key environmental factors that significantly affecting phytoplankton such as EC, and brackish lakes were also positively correlative with TN. Stochastic process was predominant in phytoplankton assembly. Additionally, freshwater and brackish lakes were dominated by dispersal limitation and heterogeneous selection respectively. Alpine lakes had significant EC thresholds, and their diversity and assembly processes changed significantly around the thresholds. The present findings have important implications for understanding and predicting the response of lake phytoplankton communities to climate change and for making decisions to protect the ecological resources of alpine lakes.
MeSH term(s)	Tibet ; Phytoplankton ; Ecosystem ; Lakes ; Electric Conductivity
Language	English
Publishing date	2023-12-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	283722-5
ISSN	1574-6941 ; 0168-6496
ISSN (online)	1574-6941
ISSN	0168-6496
DOI	10.1093/femsec/fiad163
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Article ; Online: Identifying disease-related microbes based on multi-scale variational graph autoencoder embedding Wasserstein distance.

Zhu, Huan / Hao, Hongxia / Yu, Liang

BMC biology

2023 Volume 21, Issue 1, Page(s) 294

Abstract: Background: Enormous clinical and biomedical researches have demonstrated that microbes are crucial to human health. Identifying associations between microbes and diseases can not only reveal potential disease mechanisms, but also facilitate early ... ...

Abstract	Background: Enormous clinical and biomedical researches have demonstrated that microbes are crucial to human health. Identifying associations between microbes and diseases can not only reveal potential disease mechanisms, but also facilitate early diagnosis and promote precision medicine. Due to the data perturbation and unsatisfactory latent representation, there is a significant room for improvement. Results: In this work, we proposed a novel framework, Multi-scale Variational Graph AutoEncoder embedding Wasserstein distance (MVGAEW) to predict disease-related microbes, which had the ability to resist data perturbation and effectively generate latent representations for both microbes and diseases from the perspective of distribution. First, we calculated multiple similarities and integrated them through similarity network confusion. Subsequently, we obtained node latent representations by improved variational graph autoencoder. Ultimately, XGBoost classifier was employed to predict potential disease-related microbes. We also introduced multi-order node embedding reconstruction to enhance the representation capacity. We also performed ablation studies to evaluate the contribution of each section of our model. Moreover, we conducted experiments on common drugs and case studies, including Alzheimer's disease, Crohn's disease, and colorectal neoplasms, to validate the effectiveness of our framework. Conclusions: Significantly, our model exceeded other currently state-of-the-art methods, exhibiting a great improvement on the HMDAD database.
MeSH term(s)	Humans ; Colorectal Neoplasms ; Precision Medicine
Language	English
Publishing date	2023-12-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2133020-7
ISSN	1741-7007 ; 1741-7007
ISSN (online)	1741-7007
ISSN	1741-7007
DOI	10.1186/s12915-023-01796-8
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Article: [Association Between Socioeconomic Status, Productive Aging, and Frailty Index in Urban Elderly Population in China].

Zhu, Huan / Gao, Bo / Peng, Jia-Yi / Li, Xing-Yue

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

2023 Volume 54, Issue 2, Page(s) 386–392

Abstract: Objective: To explore the impact of socioeconomic status and productive aging on the frailty index of urban elderly population in China, and to provide reference for improving their health level.: Methods: We obtained data from the 2018 Chinese ... ...

Abstract	Objective: To explore the impact of socioeconomic status and productive aging on the frailty index of urban elderly population in China, and to provide reference for improving their health level. Methods: We obtained data from the 2018 Chinese Longitudinal Healthy Longevity Survey (CLHLS) and included 1890 urban elderly people aged 60 and over in the study. Multiple linear regression model was used to analyze the influencing factors of the productive aging and the frailty index of the urban elderly population in China. A structural equation model was constructed to explore the relationship between socioeconomic status, productive aging, and frailty index. Results: Elderly people with high socioeconomic status ( Conclusion: The socioeconomic status and productive aging of the elderly people are important predictors of their frailty index. The government should exert its leadership functions to encourage the elderly, especially those with low education and income levels, to actively learn knowledge and skills, and to provide support for the elderly to participate in productive activities.
MeSH term(s)	Humans ; Aged ; Middle Aged ; Frailty ; Aging ; Social Class ; Health Status ; China/epidemiology ; Socioeconomic Factors
Language	Chinese
Publishing date	2023-03-22
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2106840-9
ISSN	1672-173X
ISSN	1672-173X
DOI	10.12182/20230360501
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Article ; Online: Vision-Based Contact Adhesion Measurement Method on Soft Matter Surfaces.

Lu, Siying / Zhu, Huan / Song, Le / Zheng, Yelong / Fang, Fengzhou

Langmuir : the ACS journal of surfaces and colloids

2023 Volume 39, Issue 30, Page(s) 10432–10444

Abstract: Adhesion property measurements contribute to a comprehensive understanding of the mechanical properties of soft matters. Indentation tests are a common method for measuring the adhesion force. However, indenters generally have a large volume and a small ... ...

Abstract	Adhesion property measurements contribute to a comprehensive understanding of the mechanical properties of soft matters. Indentation tests are a common method for measuring the adhesion force. However, indenters generally have a large volume and a small sensing angle and, thus, are not conducive to local detection in high-precision environments. Here, we propose a vision-based contact adhesion measurement (VisCAM) method to achieve the contact image and adhesion force on soft matter surfaces from the perspective of indentation direction. The coupling of the 7.6 mm diameter probe and a flexible fiber makes the system similar to a miniaturized endoscope. Classical contact theories and finite element models are used for the contact mechanics analysis of silicone rubber. The image grayscale-load mathematical model is constructed based on the change in contact light spot. Finally, the uncertainty of the system is less than 4%, and the measurement error is 0.04 N. In-vitro kidney indentation experiments showed that the local adhesion force measurement of soft tissues can be completed. Our method provides better solutions for understanding the adhesion properties of soft matters.
Language	English
Publishing date	2023-07-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.3c00796
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Article ; Online: Phylotranscriptomic and Evolutionary Analyses of the Green Algal Order Chaetophorales (Chlorophyceae, Chlorophyta).

Liu, Benwen / Chen, Yangliang / Zhu, Huan / Liu, Guoxiang

Genes

2022 Volume 13, Issue 8

Abstract: Considering the phylogenetic differences in the taxonomic framework of the Chaetophorales as determined by the use of nuclear molecular markers or chloroplast genes, the current study was the first to use phylotranscriptomic analyses comparing the ... ...

Abstract	Considering the phylogenetic differences in the taxonomic framework of the Chaetophorales as determined by the use of nuclear molecular markers or chloroplast genes, the current study was the first to use phylotranscriptomic analyses comparing the transcriptomes of 12 Chaetophorales algal species. The results showed that a total of 240,133 gene families and 143 single-copy orthogroups were identified. Based on the single-copy orthogroups, supergene analysis and the coalescent-based approach were adopted to perform phylotranscriptomic analysis of the Chaetophorales. The phylogenetic relationships of most species were consistent with those of phylogenetic analyses based on the chloroplast genome data rather than nuclear molecular markers. The Schizomeriaceae and the Aphanochaetaceae clustered into a well-resolved basal clade in the Chaetophorales by either strategy. Evolutionary analyses of divergence time and substitution rate also revealed that the closest relationships existed between the Schizomeriaceae and Aphanochaetaceae. All species in the Chaetophorales exhibited a large number of expanded and contracted gene families, in particular the common ancestor of the Schizomeriaceae and Aphanochaetaceae. The only terrestrial alga,
MeSH term(s)	Base Sequence ; Chlorophyceae/genetics ; Chlorophyta/genetics ; DNA, Chloroplast/genetics ; Evolution, Molecular ; Phylogeny
Chemical Substances	DNA, Chloroplast
Language	English
Publishing date	2022-08-04
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes13081389
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