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  1. Article ; Online: Comparison of endoscopic resection therapies for rectal neuroendocrine tumors.

    Lu, Meijiao / Cui, Hongxia / Qian, Mingjie / Shen, Yating / Zhu, Jianhong

    Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy

    2024  , Page(s) 1–8

    Abstract: Aims: This study was to evaluate and compare the efficacy and safety of endoscopic mucosal resection (EMR), clip-and-snare assisted endoscopic mucosal resection (CS-EMR), and endoscopic submucosal dissection (ESD) for the endoscopic resection of rectal ... ...

    Abstract Aims: This study was to evaluate and compare the efficacy and safety of endoscopic mucosal resection (EMR), clip-and-snare assisted endoscopic mucosal resection (CS-EMR), and endoscopic submucosal dissection (ESD) for the endoscopic resection of rectal NETs.
    Material and methods: A retrospective analysis was performed on 47 patients with rectal NETs who underwent endoscopic treatment in The Second Affiliated Hospital of Soochow University. Manifestations of clinic pathological characteristics, complications, procedure time and hospitalization costs were studied.
    Results: The complete resection rates with CS-EMR and ESD were significantly higher than those with EMR (CS-EMR vs. EMR,
    Conclusions: The CS-EMR technique is more effective and efficient than EMR for small rectal NETs. In addition, CS-EMR reduces procedure time, duration of post-procedure hospitalization and decreases patients' cost compared to ESD while ensuring sufficient vertical margin distances.
    Language English
    Publishing date 2024-05-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1317160-4
    ISSN 1365-2931 ; 1364-5706
    ISSN (online) 1365-2931
    ISSN 1364-5706
    DOI 10.1080/13645706.2024.2330580
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3467: Show issues Location:
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  2. Article: Gene Therapy Strategies Targeting Aging-Related Diseases.

    Yu, Jingyu / Li, Tianwen / Zhu, Jianhong

    Aging and disease

    2023  Volume 14, Issue 2, Page(s) 398–417

    Abstract: Rapid advancements have taken place in gene therapy technology. However, effective methods for treating aging- or age-related chronic diseases, which are often closely related to genes or even multiple genes, are still lacking. The path to developing ... ...

    Abstract Rapid advancements have taken place in gene therapy technology. However, effective methods for treating aging- or age-related chronic diseases, which are often closely related to genes or even multiple genes, are still lacking. The path to developing cures is winding, while gene therapy that targets genes related to aging represents an exciting research direction with tremendous potential. Among aging-related genes, some candidates have been studied at different levels, from cell to organismal levels (e.g., mammalian models) with different methods, from overexpression to gene editing. The
    Language English
    Publishing date 2023-04-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2625789-0
    ISSN 2152-5250
    ISSN 2152-5250
    DOI 10.14336/AD.2022.00725
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  3. Article: Comparison of Dosage of Glucocorticoid in Idiopathic Membranous Nephropathy: A Systematic Review and Network Meta-Analysis.

    Li, Yanhua / Gao, Ziqing / Zhu, Jianhong / Su, Jianan / Chen, Pengwei / Li, Jiande / Feng, Min

    Cureus

    2024  Volume 16, Issue 1, Page(s) e51936

    Abstract: Purpose: Idiopathic membranous nephropathy (IMN) with moderate risk or above was recommended to receive immunosuppressive therapy. We attempted to evaluate the optimal dose of glucocorticoid when combined with evidence-proven effective ... ...

    Abstract Purpose: Idiopathic membranous nephropathy (IMN) with moderate risk or above was recommended to receive immunosuppressive therapy. We attempted to evaluate the optimal dose of glucocorticoid when combined with evidence-proven effective immunosuppressants by network meta-analysis.
    Methods: A systematic review of the literature was conducted in PubMed, Embase, Cochrane Library, and ClinicalTrials.gov from inception until January 2022. Randomized controlled trials (RCTs) in IMN limited to supportive care, glucocorticoids, cyclophosphamide, chlorambucil, calcineurin inhibitors (CNIs), and rituximab were screened.
    Results: Twenty-eight RCTs of 1,830 patients were included. Therapeutic regimens were divided as follows: moderate- to high-dose glucocorticoids plus CNIs (HMSCn), moderate- to high-dose glucocorticoids plus cyclophosphamide (HMSCt), moderate- to high-dose glucocorticoids plus chlorambucil (HMSCh), zero- to low-dose glucocorticoids plus CNIs (LNSCn), zero- to low-dose glucocorticoids plus cyclophosphamide (LNSCt), rituximab alone (R), glucocorticoids alone (SE), and supportive care alone (SP). Compared with SP, HMSCh (risk ratio [RR]: 1.77, 95% confidence interval [CI]: 1, 3.18), HMSCn (RR: 2.5, 95%CI: 1.25, 5.11), HMSCt (RR: 2.15, 95%CI: 1.29, 3.64), LNSCn (RR: 2.16, 95%CI: 1.25, 3.95), and R (RR: 2.07, 95%CI: 1, 4.39) had a higher probability of total remission rate, while HMSCn represented the highest probability depending on the surface under the cumulative ranking area (SUCRA) ranking values. Regarding infection, no significant difference was found between different doses of glucocorticoids plus the same immunosuppressant. HMSCn and HMSCt showed superiority in reducing 24-hour urine total protein compared with HMSCh, LNSCn, SE, and SP, while HMSCn seemed to be the most effective regimen through the ranking of SUCRA value.
    Conclusion: Moderate- to high-dose glucocorticoids showed superiority in proteinuria remission when combined with CNIs in IMN, with no increasing risk of infection.
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.51936
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  4. Article ; Online: Internal hernia after endoscopic retrograde cholangiopancreatography.

    Chen, Tianbao / Ma, Yimin / Qiao, Zhenguo / Zhu, Jianhong

    Asian journal of surgery

    2022  Volume 45, Issue 12, Page(s) 2740–2741

    MeSH term(s) Humans ; Cholangiopancreatography, Endoscopic Retrograde/adverse effects ; Pancreatic Diseases ; Internal Hernia
    Language English
    Publishing date 2022-06-18
    Publishing country China
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2022.06.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Magnifying endoscopic findings of early-stage poorly differentiated colorectal adenocarcinoma: a case report.

    Li, Haiyan / Liu, Yao / Zhu, Jianhong

    BMC gastroenterology

    2022  Volume 22, Issue 1, Page(s) 148

    Abstract: Background: Colorectal poorly differentiated adenocarcinoma is rarely founded, especially in early-stage. Endoscopic features of early poorly differentiated colorectal cancer in magnifying endoscopy and chromoendoscopy haven't been clarified.: Case ... ...

    Abstract Background: Colorectal poorly differentiated adenocarcinoma is rarely founded, especially in early-stage. Endoscopic features of early poorly differentiated colorectal cancer in magnifying endoscopy and chromoendoscopy haven't been clarified.
    Case presentation: A 49-year-old man was referred to our hospital for endoscopic treatment of a lateral spread tumor located in the rectum. We performed pre-resection endoscopic examination for the patient. In magnifying endoscopy with crystal violet staining, the lesion showed irregular microvessels and turned out to be poorly stained with predominantly non-structural pit pattern and a few roundish pits scattered on the surface. The histology revealed a poorly differentiated adenocarcinoma of the rectum invading the deep submucosal layer with negative lymphovascular invasion.
    Conclusions: In this case report, we presented a case of poorly differentiated colorectal adenocarcinoma detected at an early stage, showing interesting endoscopic findings in magnifying endoscopy with crystal violet staining.
    MeSH term(s) Adenocarcinoma/diagnostic imaging ; Adenocarcinoma/surgery ; Colorectal Neoplasms/pathology ; Endoscopy, Gastrointestinal ; Gentian Violet ; Humans ; Male ; Middle Aged ; Staining and Labeling
    Chemical Substances Gentian Violet (J4Z741D6O5)
    Language English
    Publishing date 2022-03-28
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2041351-8
    ISSN 1471-230X ; 1471-230X
    ISSN (online) 1471-230X
    ISSN 1471-230X
    DOI 10.1186/s12876-022-02209-w
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  6. Article ; Online: Ultrasound guidance for the removal of guide-wire sliding into abdominal cavity.

    Zhu, Zhiyong / Zhu, Jianhong / Qiao, Zhenguo

    Asian journal of surgery

    2022  Volume 45, Issue 7, Page(s) 1484–1486

    MeSH term(s) Abdominal Cavity/diagnostic imaging ; Abdominal Cavity/surgery ; Humans ; Ultrasonography
    Language English
    Publishing date 2022-03-10
    Publishing country China
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2022.02.059
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  7. Article ; Online: Euclidean Distance Transform on the Sea Based on Cellular Automata Modeling

    Jiasheng WANG,Kun YANG,Yanhui ZHU, Jianhong XIONG

    Journal of Geodesy and Geoinformation Science, Vol 3, Iss 2, Pp 71-

    2020  Volume 80

    Abstract: To explore the problem of distance transformations while obstacles existing, this paper presents an obstacle-avoiding Euclidean distance transform method based on cellular automata. This research took the South China Sea and its adjacent sea areas as an ... ...

    Abstract To explore the problem of distance transformations while obstacles existing, this paper presents an obstacle-avoiding Euclidean distance transform method based on cellular automata. This research took the South China Sea and its adjacent sea areas as an example, imported the data of land-sea distribution and target points, took the length of the shortest obstacle-avoiding path from current cell to the target cells as the state of a cellular, designed the state transform rule of each cellular that considering a distance operator, then simulated the propagation of obstacle-avoiding distance, and got the result raster of obstacle-avoiding distance transform. After analyzing the effect and precision of obstacle avoiding, we reached the following conclusions: first, the presented method can visually and dynamically show the process of obstacle-avoiding distance transform, and automatically calculate the shortest distance bypass the land; second, the method has auto-update mechanism and each cellular can rectify distance value according to its neighbor cellular during the simulation process; at last, it provides an approximate solution for exact obstacle-avoiding Euclidean distance transform and the proportional error is less than 1.96%. The proposed method can apply to the fields of shipping routes design, maritime search and rescue, etc.
    Keywords |distance transform|cellular automata|obstacles avoiding|south china sea ; Science ; Q ; Geodesy ; QB275-343
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Surveying and Mapping Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Stereopure AIMer: A Promising RNA Base-editing Tool for Monogenic Neurological Diseases.

    Yu, Jingyu / Li, Tianwen / Chen, Kezhu / Tang, Qisheng / Zhu, Jianhong

    Neuroscience bulletin

    2022  Volume 39, Issue 2, Page(s) 353–355

    MeSH term(s) RNA ; CRISPR-Cas Systems
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2022-08-22
    Publishing country Singapore
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2419741-5
    ISSN 1995-8218 ; 1673-7067
    ISSN (online) 1995-8218
    ISSN 1673-7067
    DOI 10.1007/s12264-022-00935-5
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  9. Article: Entanglement of CCR5 and Alzheimer's Disease.

    Li, Tianwen / Zhu, Jianhong

    Frontiers in aging neuroscience

    2019  Volume 11, Page(s) 209

    Abstract: Although the mechanisms of Alzheimer's disease are diverse and unclear, the past 20 years have witnessed the unprecedented development of the AD inflammation theory. As a key inflammatory receptor family, the C-C chemokine receptor family is a remarkable ...

    Abstract Although the mechanisms of Alzheimer's disease are diverse and unclear, the past 20 years have witnessed the unprecedented development of the AD inflammation theory. As a key inflammatory receptor family, the C-C chemokine receptor family is a remarkable participant in the cause of Alzheimer's disease; of this family, CCR5 is the most widely studied. CCR5 is an essential entrance when HIV infects immune cells and is also involved in other inflammatory and immune activities. New evidence on the inevitably intertwined link between Alzheimer's disease and CCR5 indicates that CCR5 accelerates the development of Alzheimer's disease, and few studies disputed it. The role of CCR5 in Alzheimer's disease remains elusive. However, as the research progresses, this intricate relationship will gradually be uncovered.
    Language English
    Publishing date 2019-08-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2019.00209
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  10. Article ; Online: A binary composite La(OH)

    Zheng, Dianyuan / Sun, Chengxiang / Yao, Rongbin / Li, Jinli / Zheng, Yuhang / Zhu, Jianhong / Liu, Cheng

    RSC advances

    2023  Volume 13, Issue 31, Page(s) 21643–21654

    Abstract: In this work, we present a binary composite of La(OH) ...

    Abstract In this work, we present a binary composite of La(OH)
    Language English
    Publishing date 2023-07-19
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra03151a
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