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Article ; Online: Preoperative urinary function does not predict postoperative acute urinary retention in men after rectal resection.

Zhu, K J / Thanigasalam, R / Solomon, M J

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2020 Volume 22, Issue 12, Page(s) 2260–2269

Abstract: Aim: Acute urinary retention (AUR) is a well-known complication after rectal surgery. It can be associated with additional morbidity. Causes of postoperative AUR are often multifactorial - involving patient-, pathology- and treatment-related factors. A ... ...

Abstract	Aim: Acute urinary retention (AUR) is a well-known complication after rectal surgery. It can be associated with additional morbidity. Causes of postoperative AUR are often multifactorial - involving patient-, pathology- and treatment-related factors. A proportion of men undergoing total mesorectal excision (TME) have preexisting urinary dysfunction and this may predispose to AUR. The aim of this study was to prospectively assess the influence of preoperative urinary function on postoperative AUR in men undergoing TME. Method: A prospective multicentre cohort study was conducted. All adult men undergoing rectal resection between June 2016 and January 2018 were recruited. Combined pelvic resections, inability to void per urethra and emergency surgery were excluded. Preoperative urinary function was assessed with uroflowmetry, prostate ultrasound and the International Prostate Symptom Score (IPSS). The incidence of postoperative AUR, urinary tract infection (UTI) and length of hospital stay (LOS) were measured. Results: Seventy-seven patients (mean age 61 years) were recruited. The overall incidence of AUR was 21%. Preoperative urinary function, IPSS and past urological history were not predictive for postoperative AUR. AUR was not associated with UTI and did not affect LOS. Patients with UTI had a higher intravesical protrusion of the prostate. Conclusion: Preoperative urinary dysfunction in men is not predictive of postoperative AUR after TME. It should not preclude early trial of void after TME. AUR did not predispose to UTI, nor did it prolong LOS.
MeSH term(s)	Adult ; Cohort Studies ; Humans ; Infant, Newborn ; Male ; Prospective Studies ; Prostatic Hyperplasia ; Urinary Retention/epidemiology ; Urinary Retention/etiology ; Urination
Language	English
Publishing date	2020-08-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.15280
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Zs.A 5799: Show issues

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Article: [Effect analysis of the modified wire-loop snare technique in retrieving severely tilted inferior vena cava filters].

Yang, H / Ge, W N / Zhang, J T / Zhu, K J / Niu, L Y / Wang, H F / Wang, Y W

Zhonghua wai ke za zhi [Chinese journal of surgery

2022 Volume 60, Issue 12, Page(s) 1063–1068

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Humans ; Vena Cava Filters ; Retrospective Studies
Language	Chinese
Publishing date	2022-12-08
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	604573-x
ISSN	0529-5815
ISSN	0529-5815
DOI	10.3760/cma.j.cn112139-20220515-00223
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Zs.B 2469: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 218: Show issues

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Article: Primary peritonectomy/HIPEC for disseminated peritoneal adenomucinosis achieves much lower recurrence rates and better survival than secondary procedures.

Zhu, K J / Morris, D L

The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland

2010 Volume 7, Issue 6, Page(s) 345–350

Abstract: Background: Two main treatment options are available for pseudomyxoma peritonei (PMP) and disseminated peritoneal adenomucinosis (DPAM)--incomplete cytoreductive (debulking) surgery and peritonectomy with intraperitoneal chemotherapy. Several studies ... ...

Abstract	Background: Two main treatment options are available for pseudomyxoma peritonei (PMP) and disseminated peritoneal adenomucinosis (DPAM)--incomplete cytoreductive (debulking) surgery and peritonectomy with intraperitoneal chemotherapy. Several studies have demonstrated improved survival with peritonectomy. This study analyses outcome following peritonectomy in patients undergoing a primary procedure compared to those who have had previous debulks. Methods: Between April 1997 and May 2008, 63 patients underwent peritonectomy for DPAM--38 had had previous debulk(s) and 25 underwent primary peritonectomy. Patients were followed-up at three- to six-monthly intervals postoperatively, with a mean follow-up time of 21 and 34 months, respectively. Results: Mean survival for patients undergoing primary peritonectomy was 109.8 months. Mean survival for patients with previous debulks was 49.2 months (p=0.027). Five-year survival was 95.5% in the primary peritonectomy group and 67.5% in the previous debulk group. Conclusion: Disease recurrence after primary peritonectomy for DPAM is significantly less frequent than after secondary peritonectomy.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Digestive System Surgical Procedures/methods ; Female ; Humans ; Male ; Middle Aged ; Peritoneal Cavity/surgery ; Peritoneal Neoplasms/drug therapy ; Peritoneal Neoplasms/mortality ; Peritoneal Neoplasms/pathology ; Peritoneal Neoplasms/surgery ; Pseudomyxoma Peritonei/drug therapy ; Pseudomyxoma Peritonei/mortality ; Pseudomyxoma Peritonei/pathology ; Pseudomyxoma Peritonei/surgery ; Young Adult
Language	English
Publishing date	2010-07-28
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	2102927-1
ISSN	1479-666X
ISSN	1479-666X
DOI	10.1016/s1479-666x(09)80108-x
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Zs.A 5756: Show issues

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Article ; Online: Case report. Novel and recurrent COL7A1 mutations in Chinese patients with dystrophic epidermolysis bullosa pruriginosa.

Zhu, K J / Zhu, C Y / Zhou, Y / Fan, Y M

Genetics and molecular research : GMR

2014 Volume 13, Issue 3, Page(s) 7587–7592

Abstract: Dystrophic epidermolysis bullosa pruriginosa (DEB-Pr) is a rare subtype of dystrophic epidermolysis bullosa (DEB). This disease is characterized by severe itching, lichenoid nodules or prurigo-like lesions, and linear scarring with a predilection for the ...

Abstract	Dystrophic epidermolysis bullosa pruriginosa (DEB-Pr) is a rare subtype of dystrophic epidermolysis bullosa (DEB). This disease is characterized by severe itching, lichenoid nodules or prurigo-like lesions, and linear scarring with a predilection for the extensor limbs. Pathogenic mutations in the type VII collagen alpha 1 (COL7A1) gene have been identified. We analyzed mutations in the COL7A1 gene in a Chinese family including 5 affected individuals with typical DEB-Pr and in a patient previously reported with sporadic DEB-Pr. The entire coding region and exon-intron boundaries of COL7A1 were detected by polymerase chain reaction and direct sequencing. We identified one novel heterozygote mutation (c.6842G>T, p.G2281V) and a second mutation (c.5443G>A, p.G1815R) reported previously in patients with DEB. Our findings contribute to the COL7A1 mutation database and further reveal the genetic and phenotypic heterogeneity of DEB-Pr.
MeSH term(s)	Adolescent ; Adult ; Collagen Type VII/genetics ; DNA Mutational Analysis ; Epidermolysis Bullosa Dystrophica/diagnosis ; Epidermolysis Bullosa Dystrophica/genetics ; Epidermolysis Bullosa Dystrophica/pathology ; Exons ; Female ; Heterozygote ; Humans ; Male ; Mutation ; Pedigree ; Phenotype ; Skin/pathology ; Young Adult
Chemical Substances	COL7A1 protein, human ; Collagen Type VII
Language	English
Publishing date	2014-09-12
Publishing country	Brazil
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2114039-X
ISSN	1676-5680 ; 1676-5680
ISSN (online)	1676-5680
ISSN	1676-5680
DOI	10.4238/2014.September.12.26
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Article ; Online: A novel insertion mutation in the ADAR1 gene of a Chinese family with dyschromatosis symmetrica hereditaria.

Zhu, C Y / Zhu, K J / Zhou, Y / Fan, Y M

Genetics and molecular research : GMR

2013 Volume 12, Issue 3, Page(s) 2858–2862

Abstract: Dyschromatosis symmetrica hereditaria (DSH) is an autosomal dominant pigmentary genodermatosis, characterized by a mixture of hyperpigmented and hypopigmented macules that are mainly present on the dorsal portions of the extremities. The DSH locus was ... ...

Abstract	Dyschromatosis symmetrica hereditaria (DSH) is an autosomal dominant pigmentary genodermatosis, characterized by a mixture of hyperpigmented and hypopigmented macules that are mainly present on the dorsal portions of the extremities. The DSH locus was mapped to chromosome 1q11-q12 and, subsequently, pathogenic mutations in the double-stranded RNA-specific adenosine deaminase (ADAR1) gene were identified. We performed a mutational analysis of the ADAR1 gene in a Chinese family that included three individuals affected with typical DSH phenotypes. Mutations within the entire coding region and the exon-intron boundaries of ADAR1 were detected and confirmed by polymerase chain reaction and direct sequencing, respectively. An insertion mutation within exon 12, c.3035_3036insC (p.P1012fsX1017), was identified in all family members affected by DSH, but not in the healthy members or 100 unrelated controls. This finding improves our understanding of the role of ADAR1 in DSH.
MeSH term(s)	Adenosine Deaminase/genetics ; China ; Exons ; Female ; Genetic Predisposition to Disease ; Humans ; INDEL Mutation/genetics ; Introns ; Male ; Pedigree ; Phenotype ; Pigmentation Disorders/congenital ; Pigmentation Disorders/etiology ; Pigmentation Disorders/genetics ; RNA-Binding Proteins
Chemical Substances	RNA-Binding Proteins ; ADARB1 protein, human (EC 3.5.4.4) ; Adenosine Deaminase (EC 3.5.4.4)
Language	English
Publishing date	2013-08-12
Publishing country	Brazil
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2114039-X
ISSN	1676-5680 ; 1676-5680
ISSN (online)	1676-5680
ISSN	1676-5680
DOI	10.4238/2013.August.12.1
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Article ; Online: Lack of association between CARD10/CARMA3 tag SNPs and psoriasis vulgaris in the southern Chinese population.

Shi, G / Zhang, M F / Liao, P Y / Wang, T T / Li, S J / Fan, Y M / Zhu, K J

Genetics and molecular research : GMR

2017 Volume 16, Issue 1

Abstract: Previously, we determined that the CARD11 rs4722404 single nucleotide polymorphism (SNP) increases risk of early-onset psoriasis vulgaris (PsV). Moreover, the CARD14 gene polymorphism c.C2458T (p.Arg820Trp) is associated with clinical features of this ... ...

Abstract	Previously, we determined that the CARD11 rs4722404 single nucleotide polymorphism (SNP) increases risk of early-onset psoriasis vulgaris (PsV). Moreover, the CARD14 gene polymorphism c.C2458T (p.Arg820Trp) is associated with clinical features of this disease. CARMA1/CARD11, CARMA2/CARD14, and CARMA3/CARD10 are conserved across many species and constitute a family of proteins, all of the members of which contain various functional domains characteristic of this group. The NF-κB signaling pathway, regulated by the CARMA family of scaffold proteins and its eponymous component, is a crucial mediator in the pathogenesis of psoriasis. However, little is known about the association between CARMA3/CARD10 and PsV. The aim of this study was to evaluate the relationship between the gene encoding this protein and risk of PsV in the southern Han Chinese population. Genomic DNA from 568 individuals of southern Chinese origin, including 355 patients with PsV and 213 control subjects, was analyzed. We selected seven tag SNPs in the CARMA3/CARD10 gene and genotyped them by the SNaPshot assay. Our results identified no significant association between these SNPs and PsV in the Chinese population examined. Future studies should focus on the potential function of the CARMA3/CARD10 gene in the pathogenesis of PsV.
MeSH term(s)	Adult ; Asian Continental Ancestry Group/genetics ; CARD Signaling Adaptor Proteins/genetics ; Case-Control Studies ; China ; Female ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Psoriasis ; Risk ; Sequence Analysis, DNA
Chemical Substances	CARD Signaling Adaptor Proteins ; CARD10 protein, human
Language	English
Publishing date	2017-03-15
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2114039-X
ISSN	1676-5680 ; 1676-5680
ISSN (online)	1676-5680
ISSN	1676-5680
DOI	10.4238/gmr16019025
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Article: An improvement of double emulsion technique for preparing bovine serum albumin-loaded PLGA microspheres.

Zhang, J X / Zhu, K J

Journal of microencapsulation

2005 Volume 21, Issue 7, Page(s) 775–785

Abstract: A modified double emulsion technique was adopted to prepare bovine serum albumin (BSA) loaded poly (D,L-lactic-co-glycolic acid) (PLGA) microspheres. In the formulations, polysorbates (Tween) such as Tween20, Tween40 or Tween80, instead of frequently ... ...

Abstract	A modified double emulsion technique was adopted to prepare bovine serum albumin (BSA) loaded poly (D,L-lactic-co-glycolic acid) (PLGA) microspheres. In the formulations, polysorbates (Tween) such as Tween20, Tween40 or Tween80, instead of frequently used poly (vinyl alcohol) (PVA), was used as the emulsifier. Microspheres with porous surface, large particle size, low microsphere yield (approximately 65.4%) and BSA entrapment efficiency (approximately 25.2%) were obtained when Tween80 aqueous solution alone was used as the outer aqueous phase. However, microspheres with smooth surface, high yield and BSA entrapment efficiency could be produced successfully by introducing sodium chloride or glucose into the outer aqueous phase. Adding 5.0%(w/v) sodium chloride into the continuous phase led to increase in microsphere yield and BSA entrapment efficiency from 65.4% and 25.2% to approximately 100% and 76.6%, respectively. Microsphere yield and BSA entrapment efficiency increased from 64.5% and 25.2% to 97.2% and 89.3%, respectively, when 15.0%,(w/v) glucose was added into the continuous phase. In constrast to the microspheres prepared in the presence of additive, a more marked burst release was observed for microspheres prepared without additive in the continuous phase, which may be attributed to the porous morphology of the latter.
MeSH term(s)	Animals ; Biodegradation, Environmental ; Delayed-Action Preparations ; Drug Compounding/methods ; Emulsions ; Glucose ; Lactic Acid ; Microscopy, Electron, Scanning ; Microspheres ; Particle Size ; Polyglycolic Acid ; Polylactic Acid-Polyglycolic Acid Copolymer ; Polymers ; Serum Albumin, Bovine/pharmacokinetics ; Sodium Chloride ; Viscosity
Chemical Substances	Delayed-Action Preparations ; Emulsions ; Polymers ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; Polyglycolic Acid (26009-03-0) ; Serum Albumin, Bovine (27432CM55Q) ; Lactic Acid (33X04XA5AT) ; Sodium Chloride (451W47IQ8X) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2005-03-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	843632-0
ISSN	1464-5246 ; 0265-2048
ISSN (online)	1464-5246
ISSN	0265-2048
DOI	10.1080/02652040400008465
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Zs.A 2267: Show issues

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Article ; Online: Association between hypoxia-inducible factor-1a levels in serum and synovial fluid with the radiographic severity of knee osteoarthritis.

Chu, H / Xu, Z M / Yu, H / Zhu, K J / Huang, H

Genetics and molecular research : GMR

2014 Volume 13, Issue 4, Page(s) 10529–10536

Abstract: Osteoarthritis (OA) is primarily characterized by articular cartilage degradation. Hypoxia-inducible factor-1a (HIF-1a), a subunit of the basic helix-loop-helix-containing PER-ARNT-SIM (PAS) domain transcription factors, plays a vital role in the ... ...

Abstract	Osteoarthritis (OA) is primarily characterized by articular cartilage degradation. Hypoxia-inducible factor-1a (HIF-1a), a subunit of the basic helix-loop-helix-containing PER-ARNT-SIM (PAS) domain transcription factors, plays a vital role in the survival of articular chondrocytes to the hostile hypoxic microenvironment and complicates the progression of OA. In this study, we examined whether HIF-1a levels in the serum and synovial fluid (SF) of patients with knee OA were increased and whether the increase was correlated with the radiographic severity of the disease. A total of 278 knee OA patients and 203 healthy controls were enrolled in this study. Knee OA radiographic grading was performed according to Kellgren-Lawrence (KL) grading system by evaluating X-ray changes observed on anteroposterior knee radiography. HIF-1a levels in the serum and SF were determined using an enzyme-linked immunosorbent assay. Serum HIF-1a levels in patients with knee OA were higher than those in healthy controls. Knee OA patients with KL grade 4 showed significantly elevated HIF-1a levels in the serum and SF compared with those with KL grades 2 and 3. Knee OA patients with KL grade 3 showed significantly higher SF levels of HIF-1a than those with KL grade 2. HIF-1a levels in the serum and SF of knee OA patients were significantly correlated with disease severity according to KL grading criteria. HIF-1a levels in the serum and SF were closely related to the radiographic severity of OA and may serve as an alternative biomarker for the progression and prognosis of knee OA.
MeSH term(s)	Aged ; Biomarkers/blood ; Disease Progression ; Female ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/blood ; Male ; Middle Aged ; Osteoarthritis, Knee/blood ; Osteoarthritis, Knee/diagnostic imaging ; Osteoarthritis, Knee/physiopathology ; Radiography ; Severity of Illness Index ; Synovial Fluid
Chemical Substances	Biomarkers ; HIF1A protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit
Language	English
Publishing date	2014-12-12
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2114039-X
ISSN	1676-5680 ; 1676-5680
ISSN (online)	1676-5680
ISSN	1676-5680
DOI	10.4238/2014.December.12.15
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Article ; Online: Pressure-induced enhancement of thermoelectric power factor in pristine and hole-doped SnSe crystals.

Su, Na / Qin, B C / Zhu, K J / Liu, Z Y / Shahi, P / Sun, J P / Wang, B S / Sui, Y / Shi, Y G / Zhao, L D / Cheng, J-G

RSC advances

2019 Volume 9, Issue 46, Page(s) 26831–26837

Abstract: We evaluate the influence of pressure on the thermoelectric power factors PF ≡ ...

Abstract	We evaluate the influence of pressure on the thermoelectric power factors PF ≡
Language	English
Publishing date	2019-08-28
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/c9ra05134a
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Article: Pressure-induced enhancement of thermoelectric power factor in pristine and hole-doped SnSe crystals

Su, Na / Qin, B. C / Zhu, K. J / Liu, Z. Y / Shahi, P / Sun, J. P / Wang, B. S / Sui, Y / Shi, Y. G / Zhao, L. D / Cheng, J.-G

RSC advances. 2019 Aug. 28, v. 9, no. 46

2019

Abstract: We evaluate the influence of pressure on the thermoelectric power factors PF ≡ S2σ of pristine and Na-doped SnSe crystals by measuring their electrical conductivity σ(T) and Seebeck coefficient S(T) up to ∼22 kbar with a self-clamped piston-cylinder cell. ...

Abstract	We evaluate the influence of pressure on the thermoelectric power factors PF ≡ S2σ of pristine and Na-doped SnSe crystals by measuring their electrical conductivity σ(T) and Seebeck coefficient S(T) up to ∼22 kbar with a self-clamped piston-cylinder cell. For both cases, σ(T) is enhanced while S(T) reduced with increasing pressure as expected, but their imbalanced variations lead to a monotonic enhancement of PF under pressure. For pristine SnSe, σ(290 K) increases by ∼4 times from ∼10.1 to 38 S cm−1, while S(290 K) decreases by only ∼12% from 474 to 415 μV K−1, leading to about three-fold enhancement of PF from 2.24 to 6.61 μW cm−1 K−2, which is very close to the optimal value of SnSe above the structural transition at ∼800 K at ambient pressure. In comparison, the PF of Na-doped SnSe at 290 K is enhanced moderately by ∼30% up to 20 kbar. In contrast, the PF of isostructural black phosphorus with a simple band structure was found to decrease under pressure. The comparison with black phosphorus indicates that the multi-valley valence band structure of SnSe is beneficial for the enhancement of PF by retaining a large Seebeck coefficient under pressure. Our results also provide experimental confirmation on the previous theoretical prediction that high pressure can be used to optimize the thermoelectric efficiency of SnSe.
Keywords	ambient pressure ; crystals ; electrical conductivity ; phosphorus ; prediction
Language	English
Dates of publication	2019-0828
Size	p. 26831-26837.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/c9ra05134a
Database	NAL-Catalogue (AGRICOLA)

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