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  1. Article: Comment on: "

    Liu, Xiangyu / Zhu, Meilin

    Hepatobiliary surgery and nutrition

    2022  Volume 11, Issue 4, Page(s) 647–648

    Language English
    Publishing date 2022-08-04
    Publishing country China (Republic : 1949- )
    Document type Journal Article ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn-22-99
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comment on: Acute pancreatitis in pregnancy: meta-analysis of maternal and fetal outcomes.

    Liu, Xiangyu / Zhu, Meilin

    The British journal of surgery

    2022  Volume 109, Issue 12, Page(s) e125

    Language English
    Publishing date 2022-08-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znac259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.66: Show issues Location:
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  3. Article ; Online: Spatial impacts of the intercity flow of long stay international visitors based on mobile phone data in Yangtze River Delta, China.

    Wang, Yao / Zhu, Meilin / Meng, Xiaodong

    PloS one

    2023  Volume 18, Issue 9, Page(s) e0290758

    Abstract: The intercity daily flow of long stay international visitors (LSIV) reflects the economic globalisation and regional integration of a region. We made the first attempt to use mobile phone data to identify international visitors who stayed longer than one ...

    Abstract The intercity daily flow of long stay international visitors (LSIV) reflects the economic globalisation and regional integration of a region. We made the first attempt to use mobile phone data to identify international visitors who stayed longer than one month in the Yangtze River Delta (YRD) region in 2019, analysed the spatial patterns of LSIV, and revealed the impact factors associated with the daily intercity flow of LSIV. We discussed spatial dependence using multiscale geographically weighted regression (MGWR), and performed cluster analysis to understand the combination effects. The results show that enterprises have the largest effect, AQI and administrative hierarchy have relatively low effects, and income, imports and exports do not have any significant effect. Overall, the economically developed eastern regions of the YRD region are more attractive for daily travel by LSIV, with the Shanghai metropolitan area being the most attractive. Our findings provide new insights into the relationship between the intercity daily flow of LSIV and the urban economy and society in the delta region to help suggest planning recommendations to enhance the globalisation development strategy and provide a better environment for international visitors in the delta region.
    MeSH term(s) China ; Rivers ; Cell Phone ; Cluster Analysis ; Income
    Language English
    Publishing date 2023-09-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0290758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Gastric adenocarcinoma combined with mucosa-associated lymphoma.

    Zhu, Mei-Lin / Bai, Xue-Qin / Liu, Xiang-Yu

    Asian journal of surgery

    2023  Volume 47, Issue 2, Page(s) 1236–1238

    MeSH term(s) Humans ; Lymphoma, B-Cell, Marginal Zone/pathology ; Stomach Neoplasms/pathology ; Adenocarcinoma/pathology ; Mucous Membrane/pathology ; Gastric Mucosa/pathology
    Language English
    Publishing date 2023-11-22
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.11.045
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2831: Show issues Location:
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  5. Article ; Online: Antidepressant effects of esketamine via the BDNF/AKT/mTOR pathway in mice with postpartum depression and their offspring.

    Qin, Han / Yu, Miao / Han, Nianjiao / Zhu, Meilin / Li, Xia / Zhou, Jing

    Progress in neuro-psychopharmacology & biological psychiatry

    2024  Volume 132, Page(s) 110992

    Abstract: Postpartum depression (PPD) is a serious mental health problem that can negatively affect future generations. BDNF/AKT/mTOR signaling in the frontal lobe and hippocampus in mice is associated with depression, but its role in mice with PPD and their ... ...

    Abstract Postpartum depression (PPD) is a serious mental health problem that can negatively affect future generations. BDNF/AKT/mTOR signaling in the frontal lobe and hippocampus in mice is associated with depression, but its role in mice with PPD and their offspring is unknown. This study was aimed at investigating the effects of esketamine (ESK), a drug approved for treatment of refractory depression, on the BDNF/AKT/mTOR pathway in mice with PPD and their offspring. A model of chronic unpredictable mild stress with pregnancy was used. ESK was injected into postpartum mice, and behavioral tests were conducted to predict the severity of symptoms at the end of lactation and in the offspring after adulthood. Both mice with PPD and their offspring showed significant anxiety- and depression-like behaviors that were ameliorated with the ESK intervention. ESK enhanced exploratory behavior in unfamiliar environments, increased the preference for sucrose, and ameliorated the impaired BDNF/AKT/mTOR signaling in the frontal and hippocampal regions in mice. Thus, ESK may have great potential in treating PPD and decreasing the incidence of depression in offspring.
    MeSH term(s) Animals ; Female ; Mice ; Pregnancy ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Antidepressive Agents/metabolism ; Brain-Derived Neurotrophic Factor/metabolism ; Depression/psychology ; Depression, Postpartum/drug therapy ; Depression, Postpartum/metabolism ; Disease Models, Animal ; Hippocampus/metabolism ; Ketamine ; Proto-Oncogene Proteins c-akt/metabolism ; Stress, Psychological/drug therapy ; TOR Serine-Threonine Kinases/metabolism
    Chemical Substances Antidepressive Agents ; Brain-Derived Neurotrophic Factor ; Esketamine (50LFG02TXD) ; Ketamine (690G0D6V8H) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 781181-0
    ISSN 1878-4216 ; 0278-5846
    ISSN (online) 1878-4216
    ISSN 0278-5846
    DOI 10.1016/j.pnpbp.2024.110992
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1342: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: Practice and Exploration of Laboratory Animal and Laboratory Safety Training for Medical Freshmen

    SONG Guoying / XU Yan / ZHU Meilin / ZHANG Hongwei / LI Pei

    Shiyan dongwu yu bijiao yixue, Vol 41, Iss 5, Pp 450-

    2021  Volume 454

    Abstract: Laboratory animal and laboratory safety management in medical colleges and universities is the basic guarantee for the safe operation of teaching laboratories and serves as an important link for the successful completion of teaching tasks in laboratories. ...

    Abstract Laboratory animal and laboratory safety management in medical colleges and universities is the basic guarantee for the safe operation of teaching laboratories and serves as an important link for the successful completion of teaching tasks in laboratories. Aiming at the safety status of common experimental animals and laboratories, the Experimental Teaching Center of Basic Medical College of Zhengzhou University trained medical freshmen on the characteristics of experimental animals and laboratory safety knowledge. PowerPoint courses, short video lectures, and flipped classrooms were used for offline training. The training contents included the correct use of experimental animals, safety management and laboratory safety knowledge. After training, an online examination was conducted, which 1 061 freshmen passed, and the passing rate was 99.90%. According to the analysis of the answers of the freshmen in the examination, the error rates of knowledge on microorganisms and dangerous chemicals were 20.35% and 14.89%, respectively. This suggests that training should be strengthened in these two aspects in the future. Through the training, the new medical students mastered the correct use of experimental animals, and their knowledge of laboratory safety increased. This will help to prevent future laboratory accidents.
    Keywords laboratory animals ; laboratory ; safety training ; medical freshmen ; Medicine ; R
    Subject code 600
    Language Chinese
    Publishing date 2021-10-01T00:00:00Z
    Publisher Editorial Office of Laboratory Animal and Comparative Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Carcinogenic and non-carcinogenic health risk assessment of organic compounds and heavy metals in electronic cigarettes.

    Zhao, Siyuan / Zhang, Xi / Wang, Junji / Lin, Jianzai / Cao, Deyan / Zhu, Meilin

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 16046

    Abstract: E-cigarettes are now very popular in the world. Compared to traditional cigarettes, e-cigarettes are often considered safer and healthier. However, their safety remains controversial and requires further research and regulation. In this study, we aimed ... ...

    Abstract E-cigarettes are now very popular in the world. Compared to traditional cigarettes, e-cigarettes are often considered safer and healthier. However, their safety remains controversial and requires further research and regulation. In this study, we aimed to understand the possible hazards to humans of four compounds (formaldehyde, acetaldehyde, acrolein, and acetone) and seven heavy metals (arsenic, cadmium, manganese, lead, copper, nickel, and chromium) contained in e-cigarette liquids and aerosols and perform a health risk assessment. We searched PubMed, CNKI, and other databases for relevant literature to obtain data on organic compounds and heavy metals in e-cigarette liquids and aerosols, and conducted acute, chronic, and carcinogenic risk assessments of various chemicals by different exposure routes. This study showed that exposure to four organic compounds and seven heavy metals in e-cigarette aerosols and e-liquids can cause varying levels of health risks in humans through different routes, with the inhalation route posing a higher overall risk than dermal exposure and oral intake. Various chemicals at high exposure doses can produce health risks beyond the acceptable range. E-cigarette designers must improve their products by changing the composition of the e-liquid and controlling the power of the device to reduce the health effects on humans.
    MeSH term(s) Humans ; Carcinogens/toxicity ; Electronic Nicotine Delivery Systems ; Carcinogenesis ; Metals, Heavy/toxicity ; Arsenic
    Chemical Substances Carcinogens ; Metals, Heavy ; Arsenic (N712M78A8G)
    Language English
    Publishing date 2023-09-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-43112-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The Diagnostic Performance of Tumor Stage on MRI for Predicting Prostate Cancer-Positive Surgical Margins: A Systematic Review and Meta-Analysis.

    Wang, Yu / Wu, Ying / Zhu, Meilin / Tian, Maoheng / Liu, Li / Yin, Longlin

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 15

    Abstract: Purpose: Surgical margin status in radical prostatectomy (RP) specimens is an established predictive indicator for determining biochemical prostate cancer recurrence and disease progression. Predicting positive surgical margins (PSMs) is of utmost ... ...

    Abstract Purpose: Surgical margin status in radical prostatectomy (RP) specimens is an established predictive indicator for determining biochemical prostate cancer recurrence and disease progression. Predicting positive surgical margins (PSMs) is of utmost importance. We sought to perform a meta-analysis evaluating the diagnostic utility of a high clinical tumor stage (≥3) on magnetic resonance imaging (MRI) for predicting PSMs.
    Method: A systematic search of the PubMed, Embase databases, and Cochrane Library was performed, covering the interval from 1 January 2000 to 31 December 2022, to identify relevant studies. The Quality Assessment of Diagnostic Accuracy Studies 2 method was used to evaluate the studies' quality. A hierarchical summary receiver operating characteristic plot was created depicting sensitivity and specificity data. Analyses of subgroups and meta-regression were used to investigate heterogeneity.
    Results: This meta-analysis comprised 13 studies with 3924 individuals in total. The pooled sensitivity and specificity values were 0.40 (95% CI, 0.32-0.49) and 0.75 (95% CI, 0.69-0.80), respectively, with an area under the receiver operating characteristic curve of 0.63 (95% CI, 0.59-0.67). The Higgins I2 statistics indicated moderate heterogeneity in sensitivity (I2 = 75.59%) and substantial heterogeneity in specificity (I2 = 86.77%). Area, prevalence of high Gleason scores (≥7), laparoscopic or robot-assisted techniques, field strength, functional technology, endorectal coil usage, and number of radiologists were significant factors responsible for heterogeneity (
    Conclusions: T stage on MRI has moderate diagnostic accuracy for predicting PSMs. When determining the treatment modality, clinicians should consider the factors contributing to heterogeneity for this purpose.
    Language English
    Publishing date 2023-07-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13152497
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  9. Article: Primary malignant melanoma of the esophagus combined with squamous cell carcinoma: A case report.

    Zhu, Mei-Lin / Wang, Ling-Yun / Bai, Xue-Qin / Wu, Chen / Liu, Xiang-Yu

    World journal of gastrointestinal surgery

    2023  Volume 15, Issue 2, Page(s) 287–293

    Abstract: Background: Primary malignant melanoma of the esophagus is a rare malignant tumor of the esophagus, and its combination with squamous cell carcinoma is also rare. Here, we report the diagnosis and treatment of a case of primary esophageal malignant ... ...

    Abstract Background: Primary malignant melanoma of the esophagus is a rare malignant tumor of the esophagus, and its combination with squamous cell carcinoma is also rare. Here, we report the diagnosis and treatment of a case of primary esophageal malignant melanoma combined with squamous cell carcinoma.
    Case summary: A middle-aged man underwent gastroscopy for dysphagia. Gastroscopy revealed multiple bulging esophageal lesions, and after pathologic and immunohistochemical analyses, the patient was finally diagnosed with "malignant melanoma with squamous cell carcinoma". This patient received comprehensive treatment. After one year of follow-up, the patient was in good condition, and the esophageal lesions seen on gastroscopy were controlled, but unfortunately, liver metastasis occurred.
    Conclusion: When multiple esophageal lesions are present, the possibility of multiple pathological sources should be considered. This patient was diagnosed with primary esophageal malignant melanoma combined with squamous cell carcinoma.
    Language English
    Publishing date 2023-02-21
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2573700-4
    ISSN 1948-9366
    ISSN 1948-9366
    DOI 10.4240/wjgs.v15.i2.287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Effects of acupuncture on obstructive sleep apnea-hypopnea syndrome: A meta-analysis.

    Lin, Jiamin / Kong, Yue / Chen, Hailan / Zhu, Meilin / Lv, Qian / Xu, Baoling / Zhu, Fangfang

    Research in nursing & health

    2023  Volume 46, Issue 2, Page(s) 220–235

    Abstract: Our study aimed to systematically evaluate the effect of acupuncture in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). Literature search of four Chinese databases and six English databases for studies published from the inception of ... ...

    Abstract Our study aimed to systematically evaluate the effect of acupuncture in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). Literature search of four Chinese databases and six English databases for studies published from the inception of each database to March 1, 2022 and identify relevant studies published in Chinese or English. Related randomized controlled trials of acupuncture for the treatment of OSAHS were included to analyze the efficacy of acupuncture. Two researchers independently reviewed all of the retrieved studies to screen for eligible studies and extract the required relevant data. Included studies were subjected to a methodological quality assessment using the Cochrane Manual 5.1.0, and to a meta-analysis using Cochrane Review Manager version 5.4. A total of 19 studies with 1365 participants were examined. Compared with the control group, the apnea-hypopnea index, lowest oxygen saturation, Epworth Sleepiness Scale, interleukin-6, tumor necrosis factor α, and nuclear factor κ-B indicators all exhibited statistically significant changes. Thus, acupuncture was effective in alleviating the state of hypoxia and sleepiness and reduced the inflammatory response and disease severity among reported patients with OSAHS. Therefore, acupuncture could be widely used in the clinical treatment of OSAHS patients as a complementary strategy and warrants further study.
    MeSH term(s) Humans ; Sleepiness ; Sleep Apnea, Obstructive/therapy ; Acupuncture Therapy ; Syndrome
    Language English
    Publishing date 2023-02-19
    Publishing country United States
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 424453-9
    ISSN 1098-240X ; 0160-6891
    ISSN (online) 1098-240X
    ISSN 0160-6891
    DOI 10.1002/nur.22302
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2224: Show issues Location:
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