Article ; Online: Cardiac myeloperoxidase activity is elevated in hypertensive pregnant rats.
2017 Volume 37, Issue 6, Page(s) 904–909
Abstract: Myeloperoxidase (MPO) is released from activated neutrophils. The inflammation in preeclampsia was found to be associated with endothelial dysfunction. We hypothesized that cardiac and circulating MPO levels are elevated in hypertensive pregnancy. ... ...
| Abstract | Myeloperoxidase (MPO) is released from activated neutrophils. The inflammation in preeclampsia was found to be associated with endothelial dysfunction. We hypothesized that cardiac and circulating MPO levels are elevated in hypertensive pregnancy. Systolic and diastolic blood pressure and heart rate were measured on pregnancy days 14, 16, 18 and 20 in normal pregnant and hypertensive pregnant rats. Left and right ventricle weights, the number of viable fetuses, litter size, fetal and placenta weights were recorded on gestational day 21. Circulating and cardiac MPO activities, soluble fms-like tyrosine kinase-1 (sFlt-1) and vascular endothelial growth factor (VEGF) and nitric oxide (NO) were detected. The results showed increases in cardiac (left, but not right ventricle) and circulating MPO activities, and concomitantly lower number of viable fetuses, litter size, and fetal and placenta weights, and decreases in NO in hypertensive pregnant rats. Also, the increases in circulating sFlt-1 and VEGF were found in hypertensive pregnant group. In conclusion, maternal and fetal detrimental changes along with increases in circulating sFlt-1 and VEGF in hypertensive pregnancy may be associated with increases in cardiac and circulating MPO activities, confirming the causative role of inflammatory response in preeclampsia. |
|||||
|---|---|---|---|---|---|---|
| MeSH term(s) | Animals ; Disease Models, Animal ; Female ; Fetus ; Gene Expression Regulation ; Gestational Age ; Heart Ventricles/metabolism ; Heart Ventricles/pathology ; Humans ; Litter Size ; Nitric Oxide/metabolism ; Peroxidase/genetics ; Peroxidase/metabolism ; Placenta/metabolism ; Placenta/pathology ; Pre-Eclampsia/genetics ; Pre-Eclampsia/metabolism ; Pre-Eclampsia/pathology ; Pregnancy ; Rats ; Rats, Inbred SHR ; Rats, Wistar ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism ; Vascular Endothelial Growth Factor Receptor-1/genetics ; Vascular Endothelial Growth Factor Receptor-1/metabolism | |||||
| Chemical Substances | Vascular Endothelial Growth Factor A ; vascular endothelial growth factor A, rat ; Nitric Oxide (31C4KY9ESH) ; Peroxidase (EC 1.11.1.7) ; Flt1 protein, rat (EC 2.7.10.1) ; Vascular Endothelial Growth Factor Receptor-1 (EC 2.7.10.1) | |||||
| Language | English | |||||
| Publishing date | 2017-12 | |||||
| Publishing country | China | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 2090603-1 | |||||
| ISSN | 1993-1352 ; 1672-0733 ; 0257-716X | |||||
| ISSN (online) | 1993-1352 | |||||
| ISSN | 1672-0733 ; 0257-716X | |||||
| DOI | 10.1007/s11596-017-1825-6 | |||||
| Shelf mark |
|
|||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.B 2627: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.