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Article: Deep learning-assisted diagnosis of femoral trochlear dysplasia based on magnetic resonance imaging measurements.

Xu, Sheng-Ming / Dong, Dong / Li, Wei / Bai, Tian / Zhu, Ming-Zhu / Gu, Gui-Shan

World journal of clinical cases

2023 Volume 11, Issue 7, Page(s) 1477–1487

Abstract: Background: Femoral trochlear dysplasia (FTD) is an important risk factor for patellar instability. Dejour classification is widely used at present and relies on standard lateral X-rays, which are not common in clinical work. Therefore, magnetic ... ...

Abstract	Background: Femoral trochlear dysplasia (FTD) is an important risk factor for patellar instability. Dejour classification is widely used at present and relies on standard lateral X-rays, which are not common in clinical work. Therefore, magnetic resonance imaging (MRI) has become the first choice for the diagnosis of FTD. However, manually measuring is tedious, time-consuming, and easily produces great variability. Aim: To use artificial intelligence (AI) to assist diagnosing FTD on MRI images and to evaluate its reliability. Methods: We searched 464 knee MRI cases between January 2019 and December 2020, including FTD ( Results: The accuracy, sensitivity, specificity, positive predictive value and negative predictive value of the AI model ranged from 0.74-0.96. All values were superior to junior doctors and intermediate doctors, similar to senior doctors. However, diagnostic time was much lower than that of junior doctors and intermediate doctors. Conclusion: The diagnosis of FTD on knee MRI can be aided by AI and can be achieved with a high level of accuracy.
Language	English
Publishing date	2023-03-12
Publishing country	United States
Document type	Journal Article
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v11.i7.1477
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Article ; Online: Pallamins A-C, ent-labdane and pallavicinin based dimers from the Chinese liverwort Pallavicinia ambigua (mitt.) stephani.

Li, Yi / Li, Xiao-Bin / Zhou, Jin-Chuan / Xu, Ze-Jun / Zhu, Ming-Zhu / Zong, Yan / Zhang, Jiao-Zhen / Han, Jing-Jing / Tang, Ya-Jie / Lou, Hong-Xiang

Phytochemistry

2023 Volume 212, Page(s) 113702

Abstract: Three unprecedented ent-labdane and pallavicinin based dimers pallamins A-C formed via [4 + 2] Diels-Alder cycloaddition, together with eight biosynthetically related monomers were isolated from Pallavicinia ambigua. Their structures were determined by ... ...

Abstract	Three unprecedented ent-labdane and pallavicinin based dimers pallamins A-C formed via [4 + 2] Diels-Alder cycloaddition, together with eight biosynthetically related monomers were isolated from Pallavicinia ambigua. Their structures were determined by the extensive analysis of HRESIMS and NMR spectra. The absolute configurations of the labdane dimers were determined by single crystal X-ray diffraction of the homologous labdane units, and
MeSH term(s)	Animals ; Diterpenes/pharmacology ; Diterpenes/chemistry ; Hepatophyta/chemistry ; Molecular Structure ; Zebrafish ; China
Chemical Substances	Diterpenes ; labdane ; pallavicinin (156250-64-5)
Language	English
Publishing date	2023-05-04
Publishing country	England
Document type	Journal Article
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2023.113702
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Article ; Online: Ent-eudesmane sesquiterpenoids from the Chinese liverwort Chiloscyphus polyanthus.

Zhu, Ming-Zhu / Li, Yi / Zhou, Jin-Chuan / Lv, Dong-Xue / Fu, Xiao-Jie / Liang, Zhen / Yuan, Shuang-Zhi / Han, Jing-Jing / Zhang, Jiao-Zhen / Xu, Ze-Jun / Chang, Wen-Qiang / Lou, Hong-Xiang

Phytochemistry

2023 Volume 214, Page(s) 113796

Abstract: Seven previously undescribed ent-eudesmane sesquiterpenoids (1-7), as well as seven known analogs (8-14), were isolated from the Chinese liverwort Chiloscyphus polyanthus var. rivularis. Their structures were established based on comprehensive ... ...

Abstract	- Seven previously undescribed ent-eudesmane sesquiterpenoids (1-7), as well as seven known analogs (8-14), were isolated from the Chinese liverwort Chiloscyphus polyanthus var. rivularis. Their structures were established based on comprehensive spectroscopy analysis, electronic circular dichroism calculations, as well as biosynthetic considerations. The cytotoxicity against HepG2 (Human hepatocellular carcinomas) cancer cell line, and antifungal activity against Candida albicans SC5314 of all isolated ent-eudesmane sesquiterpenoids were preliminarily tested, results showed that the tested compounds did not display obvious cytotoxicity and antifungal activities under the tested concentration.
MeSH term(s)	Antifungal Agents/pharmacology ; Antifungal Agents/chemistry ; China ; Hepatophyta/chemistry ; Molecular Structure ; Sesquiterpenes/chemistry ; Sesquiterpenes, Eudesmane/pharmacology ; Sesquiterpenes, Eudesmane/chemistry ; Hep G2 Cells/drug effects ; Humans ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology
Chemical Substances	Antifungal Agents ; eudesmane (473-11-0) ; Sesquiterpenes ; Sesquiterpenes, Eudesmane ; Antineoplastic Agents
Language	English
Publishing date	2023-07-25
Publishing country	England
Document type	Journal Article
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2023.113796
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Article ; Online: Pallamins A–C, ent-labdane and pallavicinin based dimers from the Chinese liverwort Pallavicinia ambigua (mitt.) stephani

Li, Yi / Li, Xiao-Bin / Zhou, Jin-Chuan / Xu, Ze-Jun / Zhu, Ming-Zhu / Zong, Yan / Zhang, Jiao-Zhen / Han, Jing-Jing / Tang, Ya-Jie / Lou, Hong-Xiang

Phytochemistry. 2023 Aug., v. 212 p.113702-

2023

Abstract: Three unprecedented ent-labdane and pallavicinin based dimers pallamins A–C formed via [4 + 2] Diels-Alder cycloaddition, together with eight biosynthetically related monomers were isolated from Pallavicinia ambigua. Their structures were determined by ... ...

Abstract	Three unprecedented ent-labdane and pallavicinin based dimers pallamins A–C formed via [4 + 2] Diels-Alder cycloaddition, together with eight biosynthetically related monomers were isolated from Pallavicinia ambigua. Their structures were determined by the extensive analysis of HRESIMS and NMR spectra. The absolute configurations of the labdane dimers were determined by single crystal X-ray diffraction of the homologous labdane units, and ¹³C NMR and ECD calculations. Moreover, a preliminary evaluation of the anti-inflammatory activities of the isolated compounds was performed using the zebrafish model. Three of the monomers demonstrated significant anti-inflammatory activity.
Keywords	Danio rerio ; X-ray diffraction ; anti-inflammatory activity ; cycloaddition reactions ; labdane ; models ; mosses and liverworts ; plant biochemistry ; Pallavicinia ambigua ; Pallaviciniaceae ; Diterpene dimers ; [4 + 2] diels-alder cycloaddition ; Theoretical calculations
Language	English
Dates of publication	2023-08
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2023.113702
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Article ; Online: Photoredox-Catalyzed Cascade Reactions Involving Aryl Radical: Total Synthesis of (±)-Norascyronone A and (±)-Eudesmol.

Xu, Ze-Jun / Liu, Xu-Yuan / Zhu, Ming-Zhu / Xu, Yu-Liang / Yu, Yue / Xu, Hai-Ruo / Cheng, Ai-Xia / Lou, Hong-Xiang

Organic letters

2021 Volume 23, Issue 23, Page(s) 9073–9077

Abstract: Herein, we have developed two types of photoredox-catalyzed cascade reactions using diaryliodonium salts for the concise synthesis of norascyronone A and β-eudesmol. A rationally designed photoredox-catalyzed arylation/cyclization/Friedel-Crafts cascade ... ...

Abstract	Herein, we have developed two types of photoredox-catalyzed cascade reactions using diaryliodonium salts for the concise synthesis of norascyronone A and β-eudesmol. A rationally designed photoredox-catalyzed arylation/cyclization/Friedel-Crafts cascade reaction of enone was exploited to generate the norascyronone polycyclic skeleton. A visible-light-induced radical cyclization/acyloxy-migration reaction was explored to forge the decalin skeleton of eudesmol, and mechanistic studies indicated the reaction was initiated by one-electron oxidation of the enol ester.
Language	English
Publishing date	2021-11-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.1c03319
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Article: Photoredox-Catalyzed Cascade Reactions Involving Aryl Radical: Total Synthesis of (±)-Norascyronone A and (±)-Eudesmol

Xu, Ze-Jun / Liu, Xu-Yuan / Zhu, Ming-Zhu / Xu, Yu-Liang / Yu, Yue / Xu, Hai-Ruo / Cheng, Ai-Xia / Lou, Hong-Xiang

Organic letters. 2021 Nov. 19, v. 23, no. 23

2021

Abstract	Herein, we have developed two types of photoredox-catalyzed cascade reactions using diaryliodonium salts for the concise synthesis of norascyronone A and β-eudesmol. A rationally designed photoredox-catalyzed arylation/cyclization/Friedel–Crafts cascade reaction of enone was exploited to generate the norascyronone polycyclic skeleton. A visible-light-induced radical cyclization/acyloxy-migration reaction was explored to forge the decalin skeleton of eudesmol, and mechanistic studies indicated the reaction was initiated by one-electron oxidation of the enol ester.
Keywords	arylation ; chemical structure ; enols ; oxidation
Language	English
Dates of publication	2021-1119
Size	p. 9073-9077.
Publishing place	American Chemical Society
Document type	Article
ISSN	1523-7052
DOI	10.1021/acs.orglett.1c03319
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Article ; Online: Unprecedented 4,9-Seco-Oplopanane and Seven Drimane Sesquiterpenoids from the Chinese Liverwort Lejeunea flava (Sw.) Nees.

Zhu, Ming-Zhu / Li, Yi / Zhou, Jin-Chuan / Wang, Tian / Qian, Li-Lin / Zhang, Jiao-Zhen / Han, Jing-Jing / Xu, Ze-Jun / Shen, Tao / Lou, Hong-Xiang

Chemistry & biodiversity

2022 Volume 19, Issue 9, Page(s) e202200559

Abstract: An unprecedented 4,9-seco-oplopanane (1), two undescribed drimane epimers (2 and 3), and five known drimane sesquiterpenoids (4-8) were isolated from the Chinese liverwort Lejeunea flava (Sw.) Nees. The structures of the new sesquiterpenoids were ... ...

Abstract	An unprecedented 4,9-seco-oplopanane (1), two undescribed drimane epimers (2 and 3), and five known drimane sesquiterpenoids (4-8) were isolated from the Chinese liverwort Lejeunea flava (Sw.) Nees. The structures of the new sesquiterpenoids were determined using nuclear magnetic resonance spectroscopy, electronic circular dichroism calculations, and single-crystal X-ray diffraction measurements. The inhibitory capacity of the new compounds against nitric oxide production in lipopolysaccharide-induced RAW 264.7 murine macrophages, along with the cytotoxicity of the new compounds against A549 and HepG-2 human cancer cell lines, were discussed.
MeSH term(s)	Anemone ; Animals ; China ; Hepatophyta/chemistry ; Humans ; Lipopolysaccharides/pharmacology ; Mice ; Molecular Structure ; Nitric Oxide ; Polycyclic Sesquiterpenes ; Sesquiterpenes/chemistry ; Sesquiterpenes/pharmacology
Chemical Substances	Lipopolysaccharides ; Polycyclic Sesquiterpenes ; Sesquiterpenes ; drimane ; Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2022-08-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202200559
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Article: [Biosynthetic pathways of Polygonatum cyrtonema polysaccharide and diosgenin based on its transcriptomic data].

Zhu, Ming-Zhu / Yu, Nian-Jun / Wang, Qiu-Li / Zhou, An / Gu, Xiao / Han, Rong-Chun / Tong, Xiao-Hui / Peng, Dai-Yin

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2020 Volume 45, Issue 1, Page(s) 85–91

Abstract: Polygonatum cyrtonema belongs to the plant family Liliaceae, and its dried rhizome is one of the sources of Chinese traditional medicine of Polygonati Rhizoma. It possesses the dual function as both medicine and food. Its main chemical components are ... ...

Abstract	Polygonatum cyrtonema belongs to the plant family Liliaceae, and its dried rhizome is one of the sources of Chinese traditional medicine of Polygonati Rhizoma. It possesses the dual function as both medicine and food. Its main chemical components are polysaccharides and saponins. In order to understand the biosynthesis pathway of polysaccharides and diosgenin in P. cyrtonema, the corresponding transcriptomic data were obtained by extracting and sequencing the RNA of four parts of P. cyrtonema, namely, leaves, stems, rhizomes and roots. By adopting BGISEQ-500 sequencing platform, 42.03 Gb data were retrieved. Subsequently, the de novo assembly was carried out by Trinity software to obtain 137 233 transcripts, of which 68.13% of unigenes were annotated in seven databases including KEGG, GO, NR, NT, SwissProt, Pfam and KOG. Transcripts that may be involved in the biosynthesis of polysaccharides and diosgenin were analyzed by data mining. With help of qPCR, we validated expression data of four genes that were possibly involved in the biosynthesis of target metabolites. This experiment provides data for the study of biosynthetic pathways of P. cyrtonema secondary metabolites and the clarification of related structural gene functions.
MeSH term(s)	Biosynthetic Pathways ; Diosgenin/metabolism ; Gene Expression Profiling ; Phytochemicals/biosynthesis ; Polygonatum/genetics ; Polygonatum/metabolism ; Polysaccharides/biosynthesis ; Transcriptome
Chemical Substances	Phytochemicals ; Polysaccharides ; Diosgenin (K49P2K8WLX)
Language	Chinese
Publishing date	2020-04-01
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20191104.109
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Article ; Online: A Phase 3, randomized, non-inferiority study of a heterologous booster dose of SARS CoV-2 recombinant spike protein vaccine in adults.

Kulkarni, Prasad S / Gunale, Bhagwat / Kohli, Sunil / Lalwani, Sanjay / Tripathy, Srikanth / Kar, Sonali / Raut, Sidram / Kulkarni, Praveen / Apte, Aditi / Bavdekar, Ashish / Bhalla, Hira Lal / Plested, Joyce S / Cloney-Clark, Shane / Zhu, MingZhu / Kalkeri, Raj / Pryor, Melinda / Hamilton, Stephanie / Thakar, Madhuri / Sannidhi, Ranga S /

Baranwal, Punjita / Bhamare, Chetanraj / Dharmadhikari, Abhijeet / Gupta, Manish / Poonawalla, Cyrus S / Shaligram, Umesh / Kapse, Dhananjay

Scientific reports

2023 Volume 13, Issue 1, Page(s) 16579

Abstract: Due to waning immunity following primary immunization with COVID-19 vaccines, booster doses may be required. The present study assessed a heterologous booster of SII-NVX-CoV2373 (spike protein vaccine) in adults primed with viral vector and inactivated ... ...

Abstract	Due to waning immunity following primary immunization with COVID-19 vaccines, booster doses may be required. The present study assessed a heterologous booster of SII-NVX-CoV2373 (spike protein vaccine) in adults primed with viral vector and inactivated vaccines. In this Phase 3, observer-blind, randomized, active controlled study, a total of 372 adults primed with two doses of ChAdOx1 nCoV-19 (n = 186) or BBV152 (n = 186) at least six months ago, were randomized to receive a booster of SII-NVX-CoV2373 or control vaccine (homologous booster of ChAdOx1 nCoV-19 or BBV152). Anti-S IgG and neutralizing antibodies (nAbs) were assessed at days 1, 29, and 181. Non-inferiority (NI) of SII-NVX-CoV2373 to the control vaccine was assessed based on the ratio of geometric mean ELISA units (GMEU) of anti-S IgG and geometric mean titers (GMT) of nAbs (NI margin > 0.67) as well as seroresponse (≥ 2 fold-rise in titers) (NI margin -10%) at day 29. Safety was assessed throughout the study period. In both the ChAdOx1 nCoV-19 prime and BBV152 prime cohorts, 186 participants each received the study vaccines. In the ChAdOx1 nCoV-19 prime cohort, the GMEU ratio was 2.05 (95% CI 1.73, 2.43) and the GMT ratio was 1.89 (95% CI 1.55, 2.32) whereas the difference in the proportion of seroresponse was 49.32% (95% CI 36.49, 60.45) for anti-S IgG and 15% (95% CI 5.65, 25.05) for nAbs on day 29. In the BBV152 prime cohort, the GMEU ratio was 5.12 (95% CI 4.20, 6.24) and the GMT ratio was 4.80 (95% CI 3.76, 6.12) whereas the difference in the proportion of seroresponse was 74.08% (95% CI 63.24, 82.17) for anti-S IgG and 24.71% (95% CI 16.26, 34.62) for nAbs on day 29. The non-inferiority of SII-NVX-CoV2373 booster to the control vaccine for each prime cohort was met. SII-NVX-CoV2373 booster showed significantly higher immune responses than BBV152 homologous booster. On day 181, seroresponse rates were ≥ 70% in all the groups for both nAbs and anti-S IgG. Solicited adverse events reported were transient and mostly mild in severity in all the groups. No causally related SAE was reported. SII-NVX-CoV2373 as a heterologous booster induced non-inferior immune responses as compared to homologous boosters in adults primed with ChAdOx1 nCoV-19 and BBV152. SII-NVX-CoV2373 showed a numerically higher boosting effect than homologous boosters. The vaccine was also safe and well tolerated.
MeSH term(s)	Adult ; Humans ; COVID-19 Vaccines ; ChAdOx1 nCoV-19 ; Spike Glycoprotein, Coronavirus ; COVID-19/prevention & control ; Vaccines ; Antibodies, Neutralizing ; Immunoglobulin G ; Antibodies, Viral ; Immunogenicity, Vaccine
Chemical Substances	BBV152 COVID-19 vaccine (76JZE5DSN6) ; COVID-19 Vaccines ; ChAdOx1 nCoV-19 (B5S3K2V0G8) ; spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Vaccines ; Antibodies, Neutralizing ; Immunoglobulin G ; Antibodies, Viral
Language	English
Publishing date	2023-10-03
Publishing country	England
Document type	Randomized Controlled Trial ; Clinical Trial, Phase III ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-43578-w
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Article ; Online: Safety and Immunogenicity of SARS-CoV-2 Recombinant Spike Protein Vaccine in Children and Adolescents in India: A Phase 2-3 Randomized Clinical Trial.

Gunale, Bhagwat / Kapse, Dhananjay / Kar, Sonali / Bavdekar, Ashish / Kohli, Sunil / Lalwani, Sanjay / Meshram, Sushant / Raut, Abhishek / Kulkarni, Praveen / Samuel, Clarence / Munshi, Renuka / Gupta, Madhu / Plested, Joyce S / Cloney-Clark, Shane / Zhu, MingZhu / Pryor, Melinda / Hamilton, Stephanie / Thakar, Madhuri / Shete, Ashwini /

Dharmadhikari, Abhijeet / Bhamare, Chetanraj / Shaligram, Umesh / Poonawalla, Cyrus S / Mallory, Raburn M / Glenn, Gregory M / Kulkarni, Prasad S

JAMA pediatrics

2023

Abstract: Importance: The recombinant COVID-19 vaccine NVX-CoV2373 has demonstrated efficacy of approximately 90% in adults; however, its safety and efficacy in children is unknown.: Objective: To assess the noninferiority of SII-NVX-CoV2373 in children and ... ...

Abstract	Importance: The recombinant COVID-19 vaccine NVX-CoV2373 has demonstrated efficacy of approximately 90% in adults; however, its safety and efficacy in children is unknown. Objective: To assess the noninferiority of SII-NVX-CoV2373 in children and adolescents compared to adults and to evaluate its safety in comparison with placebo. Design, setting, and participants: This phase 2-3 observer-blind randomized clinical trial was conducted in 2 cohorts, children (aged 2 to 11 years) and adolescents (aged 12 to 17 years) between August 2021 and August 2022. Participants were randomized 3:1 to SII-NVX-CoV2373 or placebo and monitored for 179 days. The participants, study team, and laboratory staff were blinded. This was a multicenter study conducted across 10 tertiary care hospitals in India. Exclusion criteria included previous COVID-19 infection or vaccination, immunocompromised condition, and immunosuppressive medications. Interventions: Two doses of 0.5-mL SII-NVX-CoV2373 or placebo were administered intramuscularly on days 1 and 22. Main outcomes and measures: Primary outcomes were geometric mean titer ratio of both anti-spike (anti-S) IgG and neutralizing antibodies (NAbs) between both pediatric age groups to that of adults on day 36. Noninferiority was concluded if the lower bound of 95% CI of this ratio was greater than 0.67 for each age group. Both the antibodies were assessed for the index strain and for selected variants at various time points. Solicited adverse events (AEs) were recorded for 7 days after each vaccination, unsolicited AEs were recorded for 35 days, and serious AEs and AEs of special interest were recorded for 179 days. Results: A total of 460 children in each age cohort were randomized to receive vaccine or placebo. The mean (SD) age was 6.7 (2.7) years in the child cohort and 14.3 (1.6) years in the adolescent cohort; 231 participants (50.2%) in the child cohort and 218 in the adolescent cohort (47.4%) were female. Both anti-S IgG and NAb titers were markedly higher in the SII-NVX-CoV2373 group than in the placebo group on both day 36 and day 180. The geometric mean titer ratios compared to those in adults were 1.20 (95% CI, 1.08-1.34) and 1.52 (95% CI, 1.38-1.67) for anti-S IgG in adolescents and children, respectively; while for NAbs, they were 1.33 (95% CI, 1.17-1.50) and 1.93 (95% CI, 1.70-2.18) in adolescents and children, respectively, indicating noninferiority. SII-NVX-CoV2373 also showed immune responses against variants studied. Injection site reactions, fever, headache, malaise, and fatigue were common solicited AEs. There were no AEs of special interest and no causally related serious AEs. Conclusions and relevance: SII-NVX-CoV2373 was safe and well tolerated in children and adolescents in this study. The vaccine was highly immunogenic and may be used in pediatric vaccination against COVID-19. Trial registration: Clinical Trials Registry of India Identifier: CTRI/2021/02/031554.
Language	English
Publishing date	2023-07-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2701223-2
ISSN	2168-6211 ; 2168-6203
ISSN (online)	2168-6211
ISSN	2168-6203
DOI	10.1001/jamapediatrics.2023.2552
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