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Article ; Online: Complications of moderate sedation versus monitored anesthesia care in endoscopic retrograde cholangiopancreatography: A retrospective analysis.

Ren, Aolin / Ni, Jingbin / Wang, Dutian / Zhu, Minmin

2023 Volume 46, Issue 7, Page(s) 2842–2843

MeSH term(s)	Humans ; Cholangiopancreatography, Endoscopic Retrograde/adverse effects ; Conscious Sedation/adverse effects ; Retrospective Studies ; Anesthesia/adverse effects ; Pancreatitis/etiology
Language	English
Publishing date	2023-02-02
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2023.01.067
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Zs.B 2831: Show issues

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Article ; Online: Efficient organized colorectal cancer screening in Shenzhen: a microsimulation modelling study.

Zhu, Minmin / Zhong, Xuan / Liao, Tong / Peng, Xiaolin / Lei, Lin / Peng, Ji / Cao, Yong

BMC public health

2024 Volume 24, Issue 1, Page(s) 655

Abstract: Background: Colorectal cancer (CRC) is a global health issue with noticeably high incidence and mortality. Microsimulation models offer a time-efficient method to dynamically analyze multiple screening strategies. The study aimed to identify the ... ...

Abstract	Background: Colorectal cancer (CRC) is a global health issue with noticeably high incidence and mortality. Microsimulation models offer a time-efficient method to dynamically analyze multiple screening strategies. The study aimed to identify the efficient organized CRC screening strategies for Shenzhen City. Methods: A microsimulation model named CMOST was employed to simulate CRC screening among 1 million people without migration in Shenzhen, with two CRC developing pathways and real-world participation rates. Initial screening included the National Colorectal Polyp Care score (NCPCS), fecal immunochemical test (FIT), and risk-stratification model (RS model), followed by diagnostic colonoscopy for positive results. Several start-ages (40, 45, 50 years), stop-ages (70, 75, 80 years), and screening intervals (annual, biennial, triennial) were assessed for each strategy. The efficiency of CRC screening was assessed by number of colonoscopies versus life-years gained (LYG). Results: The screening strategies reduced CRC lifetime incidence by 14-27 cases (30.9-59.0%) and mortality by 7-12 deaths (41.5-71.3%), yielded 83-155 LYG, while requiring 920 to 5901 colonoscopies per 1000 individuals. Out of 81 screening, 23 strategies were estimated efficient. Most of the efficient screening strategies started at age 40 (17 out of 23 strategies) and stopped at age 70 (13 out of 23 strategies). Predominant screening intervals identified were annual for NCPCS, biennial for FIT, and triennial for RS models. The incremental colonoscopies to LYG ratios of efficient screening increased with shorter intervals within the same test category. Compared with no screening, when screening at the same start-to-stop age and interval, the additional colonoscopies per LYG increased progressively for FIT, NCPCS and RS model. Conclusion: This study identifies efficient CRC screening strategies for the average-risk population in Shenzhen. Most efficient screening strategies indeed start at age 40, but the optimal starting age depends on the chosen willingness-to-pay threshold. Within insufficient colonoscopy resources, efficient FIT and NCPCS screening strategies might be CRC initial screening strategies. We acknowledged the age-dependency bias of the results with NCPCS and RS.
MeSH term(s)	Humans ; Adult ; Aged ; Early Detection of Cancer/methods ; Colonoscopy ; Risk Factors ; Colorectal Neoplasms/prevention & control ; Occult Blood ; Cost-Benefit Analysis ; Mass Screening/methods
Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-024-18201-w
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Article ; Online: Sirt7/HIC1 complex participates in hyperglycaemia-mediated EndMT via modulation of SDC1 expression in diabetic kidney disease and metabolic memory.

Lu, Lihong / Zhu, Minmin / Wu, Qichao / Sun, Zhirong / Chen, Xiangyuan / Miao, Changhong

Journal of cellular and molecular medicine

2024 Volume 28, Issue 9, Page(s) e18336

Abstract: Diabetic kidney disease (DKD), a primary microvascular complication arising from diabetes, may result in end-stage renal disease. Epigenetic regulation of endothelial mesenchymal transition (EndMT) has been recently reported to exert function in ... ...

Abstract	Diabetic kidney disease (DKD), a primary microvascular complication arising from diabetes, may result in end-stage renal disease. Epigenetic regulation of endothelial mesenchymal transition (EndMT) has been recently reported to exert function in metabolic memory and DKD. Here, we investigated the mechanism which Sirt7 modulated EndMT in human glomerular endothelial cells (HGECs) in the occurrence of metabolic memory in DKD. Lower levels of SDC1 and Sirt7 were noted in the glomeruli of both DKD patients and diabetes-induced renal injury rats, as well as in human glomerular endothelial cells (HGECs) with high blood sugar. Endothelial-to-mesenchymal transition (EndMT) was sustained despite the normalization of glycaemic control. We also found that Sirt7 overexpression associated with glucose normalization promoted the SDC1 expression and reversed EndMT in HGECs. Furthermore, the sh-Sirt7-mediated EndMT could be reversed by SDC1 overexpression. The ChIP assay revealed enrichment of Sirt7 and H3K18ac in the SDC1 promoter region. Furthermore, hypermethylated in cancer 1 (HIC1) was found to be associated with Sirt7. Overexpression of HIC1 with normoglycaemia reversed high glucose-mediated EndMT in HGECs. The knockdown of HIC1-mediated EndMT was reversed by SDC1 upregulation. In addition, the enrichment of HIC1 and Sirt7 was observed in the same promoter region of SDC1. The overexpressed Sirt7 reversed EndMT and improved renal function in insulin-treated diabetic models. This study demonstrated that the hyperglycaemia-mediated interaction between Sirt7 and HIC1 exerts a role in the metabolic memory in DKD by inactivating SDC1 transcription and mediating EndMT despite glucose normalization in HGECs.
MeSH term(s)	Syndecan-1/metabolism ; Syndecan-1/genetics ; Humans ; Animals ; Hyperglycemia/metabolism ; Hyperglycemia/genetics ; Diabetic Nephropathies/metabolism ; Diabetic Nephropathies/genetics ; Diabetic Nephropathies/pathology ; Rats ; Male ; Endothelial Cells/metabolism ; Sirtuins/metabolism ; Sirtuins/genetics ; Epithelial-Mesenchymal Transition/genetics ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/complications ; Rats, Sprague-Dawley ; Kidney Glomerulus/metabolism ; Kidney Glomerulus/pathology ; Epigenesis, Genetic ; Gene Expression Regulation ; Promoter Regions, Genetic ; Endothelial-Mesenchymal Transition ; Kruppel-Like Transcription Factors
Chemical Substances	Syndecan-1 ; SDC1 protein, human ; Sirtuins (EC 3.5.1.-) ; SIRT7 protein, human ; HIC1 protein, human ; Kruppel-Like Transcription Factors
Language	English
Publishing date	2024-04-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2074559-X
ISSN	1582-4934 ; 1582-4934 ; 1582-1838
ISSN (online)	1582-4934
ISSN	1582-4934 ; 1582-1838
DOI	10.1111/jcmm.18336
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Zs.A 5752: Show issues

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Article ; Online: Subchorionic Hematoma Volume Measured by Virtual Organ Computer-Aided Analysis in the Prediction of First-Trimester Pregnancy Outcome.

Xu, Chaoli / Wang, Wenrong / Yang, Bin / Zhu, Minmin

Ultrasound quarterly

2022 Volume 38, Issue 4, Page(s) 291–296

Abstract: Abstract: This study aimed to assess the association of subchorionic hematoma (SCH) size measured by virtual organ computer-aided analysis (VOCAL) with the first-trimester pregnancy outcome. A total of 139 first-trimester pregnancies from 6 to 12 weeks ... ...

Abstract	Abstract: This study aimed to assess the association of subchorionic hematoma (SCH) size measured by virtual organ computer-aided analysis (VOCAL) with the first-trimester pregnancy outcome. A total of 139 first-trimester pregnancies from 6 to 12 weeks of gestational age with SCH were included. The circumference, area, and volume of the SCH (Cs, As, and 3DVs) and gestational sac (Cg, Ag, and 3DVg) were automatically calculated by VOCAL. Interobserver agreement was assessed with the intraclass correlation coefficient and Bland-Altman plot. Odds ratios for the clinical and ultrasound characteristics of adverse pregnancy outcomes were estimated by univariate or multivariable logistic regression. There was high interobserver agreement in VOCAL measurements of the SCH and gestational sac (intraclass correlation coefficients, >0.900). By univariate regression analysis, women with adverse pregnancy outcomes were more likely to have vaginal bleeding, a larger As and 3DVs, and higher Cs/Cg, As/Ag, and 3DVs/3DVg ratios (all P < 0.05). In the multivariable regression analysis, a higher 3DVs/3DVg ratio of SCH (odds ratio, 1.034; 95% confidence interval [CI], 1.015-1.053; P = 0.000) and vaginal heavy bleeding had a significant positive relationship with the risk of adverse pregnancy outcomes (odds ratio, 7.846; 95% CI, 1.104-55.737; P = 0.039) remained associated with an increased risk of adverse pregnancy outcomes. With 11.87% as the cutoff, the receiver operating characteristic curve yielded a good predictive performance (area under the curve, 0.713) and high sensitivity (91.18%). The measurements of SCH by VOCAL provide high reliability for estimating the total hematoma burden in first-trimester pregnant patients. A greater volume proportion (3DVs/3DVg) of SCH worsens the pregnancy outcome, and a greater risk of adverse pregnancy outcome also associated with the severity of vaginal bleeding.
MeSH term(s)	Pregnancy ; Humans ; Female ; Pregnancy Trimester, First ; Pregnancy Outcome ; Reproducibility of Results ; Ultrasonography, Prenatal ; Pregnancy Complications/diagnostic imaging ; Uterine Hemorrhage/diagnostic imaging ; Uterine Hemorrhage/complications ; Hematoma/diagnostic imaging ; Hematoma/complications ; Computers
Language	English
Publishing date	2022-10-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	645107-x
ISSN	1536-0253 ; 0894-8771
ISSN (online)	1536-0253
ISSN	0894-8771
DOI	10.1097/RUQ.0000000000000627
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Zs.A 2485: Show issues

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Article ; Online: Predictive Models for Knee Pain in Middle-Aged and Elderly Individuals Based on Machine Learning Methods.

Liu, Lu / Zhu, Min-Min / Cai, Lin-Lin / Zhang, Xiao

Computational and mathematical methods in medicine

2022 Volume 2022, Page(s) 5005195

Abstract: Aim: This study used machine learning methods to develop a prediction model for knee pain in middle-aged and elderly individuals.: Methods: A total of 5386 individuals above 45 years old were obtained from the National Health and Nutrition ... ...

Abstract	Aim: This study used machine learning methods to develop a prediction model for knee pain in middle-aged and elderly individuals. Methods: A total of 5386 individuals above 45 years old were obtained from the National Health and Nutrition Examination Survey. Participants were randomly divided into a training set and a test set at a 7 : 3 ratio. The training set was used to create a prediction model, whereas the test set was used to validate the proposed model. We constructed multiple predictive models based on three machine learning methods: logistic regression, random forest, and Extreme Gradient Boosting. The model performance was evaluated by areas under the receiver (AUC), sensitivity, specificity, positive predictive value, and negative predictive value. Additionally, we created a simplified nomogram based on logistic regression for better clinical application. Results: About 31.4% (1690) individuals were with self-reported knee pain. The logistic regression showed that female gender (odds ratio [OR] = 1.28), pain elsewhere (OR = 4.64), and body mass index (OR = 1.05) were significantly associated with increased risk of knee pain. In the test set, the logistic regression (AUC = 0.71) showed similar but slightly higher accuracy than the random forest (AUC = 0.70), while the performance of the Extreme Gradient Boosting model was less reliable (AUC = 0.59). Based on mean decrease accuracy, the most important first five predictions were pain elsewhere, waist circumference, body mass index, age, and gender. Additionally, the most important first five predictions with the highest mean decrease Gini index were pain elsewhere, body mass index, waist circumference, triglycerides, and age. The nomogram model showed good discrimination ability with an AUC of 0.75 (0.73-0.77), a sensitivity of 0.72, specificity of 0.71, a positive predictive value of 0.45, and a negative predictive value of 0.88. Conclusion: This study proposed a convenient nomogram tool to evaluate the risk of knee pain for the middle-aged and elderly US population in primary care. All the input variables can be easily obtained in a clinical setting, and no additional radiologic assessments were required.
MeSH term(s)	Aged ; Female ; Humans ; Logistic Models ; Machine Learning ; Middle Aged ; Nutrition Surveys ; Pain/diagnosis ; Pain/etiology ; Triglycerides
Chemical Substances	Triglycerides
Language	English
Publishing date	2022-09-26
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2252430-7
ISSN	1748-6718 ; 1748-670X ; 1027-3662
ISSN (online)	1748-6718
ISSN	1748-670X ; 1027-3662
DOI	10.1155/2022/5005195
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Zs.A 6373: Show issues

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Article ; Online: Association between reversal agents (sugammadex vs. neostigmine) for neuromuscular block and postoperative pulmonary complications: A retrospective analysis.

Ren, Aolin / Fan, Meihan / Gu, Zhen / Liang, Xiao / Xu, Liuhang / Liu, Chengjun / Wang, Dutian / Chang, Hanxuan / Zhu, Minmin

British journal of clinical pharmacology

2024

Abstract: Aims: Residual neuromuscular blockade has been linked to pulmonary complications in the postoperative period. This study aimed to determine whether sugammadex was associated with a lower risk of postoperative pulmonary complications (PPCs) compared with ...

Abstract	Aims: Residual neuromuscular blockade has been linked to pulmonary complications in the postoperative period. This study aimed to determine whether sugammadex was associated with a lower risk of postoperative pulmonary complications (PPCs) compared with neostigmine. Methods: This retrospective cohort study was conducted in a tertiary academic medical center. Patients ≥18 year of age undergoing noncardiac surgical procedures with general anesthesia and mechanical ventilation were enrolled between January 2019 and September 2021. We identified all patients receiving rocuronium and reversal with neostigmine or sugammadex via electronic medical record review. The primary endpoint was a composite of PPCs (including pneumonia, atelectasis, respiratory failure, pulmonary embolism, pleural effusion, or pneumothorax). The incidence of PPCs was compared using propensity score analysis. Results: A total of 1786 patients were included in this study. Among these patients, 976 (54.6%) received neostigmine, and 810 (45.4%) received sugammadex. In the whole sample, PPCs occurred in 81 (4.54%) subjects (7.04% sugammadex vs. 2.46% neostigmine). Baseline covariates were well balanced between groups after overlap weighting. Patients in the sugammadex group had similar risk (overlap weighting OR: 0.75; 95% CI: 0.40 to 1.41) compared to neostigmine. The sensitivity analysis showed consistent results. In subgroup analysis, the interaction P-value for the reversal agents stratified by surgery duration was 0.011. Conclusion: There was no significant difference in the rate of PPCs when the neuromuscular blockade was reversed with sugammadex compared to neostigmine. Patients undergoing prolonged surgery may benefit from sugammadex, which needs to be further investigated.
Language	English
Publishing date	2024-04-07
Publishing country	England
Document type	Journal Article
ZDB-ID	188974-6
ISSN	1365-2125 ; 0306-5251 ; 0264-3774
ISSN (online)	1365-2125
ISSN	0306-5251 ; 0264-3774
DOI	10.1111/bcp.16056
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Zs.A 1118: Show issues

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Article ; Online: SirT7-mediated transcription of fascin in hyperglycemic glomerular endothelial cells contributes to EndMT in diabetic nephropathy.

Wu, Mengchen / Hao, Yingxiang / Wu, Xinwan / Zhu, Minmin / Chen, Xiangyuan / Qi, Jie / Yu, Zhuang / Xu, Hongjiao

Acta biochimica et biophysica Sinica

2024 Volume 56, Issue 4, Page(s) 586–596

Abstract: Diabetic nephropathy (DN) is the main cause of end-stage renal disease worldwide. It is reported that the endothelial-to-mesenchymal transition (EndMT) in glomerular endothelial cells plays an important role in DN. As a specific form of epithelial-to- ... ...

Abstract	Diabetic nephropathy (DN) is the main cause of end-stage renal disease worldwide. It is reported that the endothelial-to-mesenchymal transition (EndMT) in glomerular endothelial cells plays an important role in DN. As a specific form of epithelial-to-mesenchymal transition, EndMT may involve common regulators of epithelial-to-mesenchymal transition. Fascin has been shown to mediate epithelial-to-mesenchymal transition. In addition, SirT7 has been confir med to contribute to inflammation in hyperglycemic endothelial cells via the modulation of gene transcription. In this study, we speculate that SirT7 modulates fascin transcription and is thus involved in EndMT in hyperglycemic glomerular endothelial cells. Our data indicate that α-smooth muscle actin (α-SMA) and fascin levels are increased, while CD31 levels are decreased in the kidneys of DN rats. Consistently, our cellular experiments reveal that high glucose treatment elevates fascin levels and induces EndMT in human glomerular endothelial cells (HGECs). Moreover, silencing of
MeSH term(s)	Animals ; Humans ; Mice ; Rats ; Carrier Proteins ; Diabetic Nephropathies/genetics ; Diabetic Nephropathies/metabolism ; Endothelial Cells/metabolism ; Endothelial-Mesenchymal Transition ; Epithelial-Mesenchymal Transition ; Kidney/metabolism ; Microfilament Proteins
Chemical Substances	Carrier Proteins ; fascin (146808-54-0) ; Microfilament Proteins
Language	English
Publishing date	2024-03-07
Publishing country	China
Document type	Journal Article
ZDB-ID	2175256-4
ISSN	1745-7270 ; 0582-9879 ; 1672-9145
ISSN (online)	1745-7270
ISSN	0582-9879 ; 1672-9145
DOI	10.3724/abbs.2024002
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Article: Hybrid graphene-NiW nanofiber transparent electrodes for all-nanofiber-based pressure sensor

Zhu, Minmin / Zhao, Anwen / Wei, Can / Ren, Fuying / Zhao, Yida / Bao, Yiping / Guo, Huilu

Journal of materials science. 2022 Jan., v. 57, no. 4

2022

Abstract: Alloying technique as an ancient and practical instrument has been a diverse fabricator for desirable properties of materials. Herein, utilizing the alloying engineering, we have developed a two-step process for hybrid graphene-NiW nanofibers (Gr-NiW NFs) ...

Abstract	Alloying technique as an ancient and practical instrument has been a diverse fabricator for desirable properties of materials. Herein, utilizing the alloying engineering, we have developed a two-step process for hybrid graphene-NiW nanofibers (Gr-NiW NFs) transparent electrodes. Further analysis reveals that alloying NiW NFs significantly improve their mechanical performance, reducing the growth temperature of graphene down to ~ 700 °C or below, which is far less than that of ~ 1000 °C for graphene grown on Cu or Pt. More importantly, such Gr-NiW network has exhibited excellent transmittance in a broad wavelength and remarkable conductivity, which, in turn, could be tailored by the growth temperature and the W content. A high transmittance (84.2% at 550 nm) and low sheet resistance (125.4 Ohm/square) were observed at Ni NFs with 5 wt% W. The combination of excellent conductivity, high transparency and mechanical tunability makes it a promising candidate for wearable electronics and optoelectronics. Finally, an all-nanofiber-based pressure sensor on sandwiched Gr-NiW/P(VDF-TrFE)/Gr-NiW NFs was demonstrated, with high sensitivity (0.61 mV kPa⁻¹) and excellent operation stability. This work offers deep insights into the development of transparent graphene-based electrodes via alloy engineering.
Keywords	alloys ; electronics ; graphene ; nanofibers ; temperature ; transmittance ; wavelengths
Language	English
Dates of publication	2022-01
Size	p. 2627-2635.
Publishing place	Springer US
Document type	Article
ZDB-ID	2015305-3
ISSN	1573-4803 ; 0022-2461
ISSN (online)	1573-4803
ISSN	0022-2461
DOI	10.1007/s10853-021-06702-7
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Smart Sensing Multifunctionalities Based on Barium Strontium Titanate Thin Films.

Wang, Linghua / Zhu, Minmin / Shao, Yong / Zhao, Yida / Wei, Can / Gao, Langfeng / Bao, Yiping

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 19

Abstract: Sensors that have low power consumption, high scalability and the ability of rapidly detecting multitudinous external stimulus are of great value in cyber-physical interactive applications. Herein, we reported the fabrication of ferroelectric barium ... ...

Abstract	Sensors that have low power consumption, high scalability and the ability of rapidly detecting multitudinous external stimulus are of great value in cyber-physical interactive applications. Herein, we reported the fabrication of ferroelectric barium strontium titanate ((Ba
Language	English
Publishing date	2022-09-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22197183
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Article: Ultralow-Thermal-Budget-Driven IWO-Based Thin-Film Transistors and Application Explorations.

Jiang, Shanshan / He, Gang / Wang, Wenhao / Zhu, Minmin / Chen, Zhengquan / Gao, Qian / Liu, Yanmei

Nanomaterials (Basel, Switzerland)

2022 Volume 12, Issue 18

Abstract: Exploiting multifunctional thin film transistors (TFTs) by low-temperature manufacturing strategy is a crucial step toward flexible electronics. Herein, a multifunctional indium-tungsten-oxide (IWO)-based TFT, gated by solid-state chitosan electrolyte ... ...

Abstract	Exploiting multifunctional thin film transistors (TFTs) by low-temperature manufacturing strategy is a crucial step toward flexible electronics. Herein, a multifunctional indium-tungsten-oxide (IWO)-based TFT, gated by solid-state chitosan electrolyte membrane, is fabricated on paper substrate at room temperature. The chitosan exhibits a high specific electric-double-layer capacitance of 2.0 µF cm
Language	English
Publishing date	2022-09-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano12183243
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