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Article ; Online: Review of Territorial Space Use Zoning Based on CiteSpace

Zhu Peijuan / Xie Yuxin / Zhou Guohua / Zhang Yong / Wang Nan

Redai dili, Vol 42, Iss 4, Pp 519-

2022 Volume 532

Abstract: The paper reviews the current focus and future direction of China's research in the field of territorial space use zoning and aims to provide a scientific basis for China's spatial planning and territorial and spatial land management with the wider goal ... ...

Abstract	The paper reviews the current focus and future direction of China's research in the field of territorial space use zoning and aims to provide a scientific basis for China's spatial planning and territorial and spatial land management with the wider goal of improving the system of ecological civilization to promote the modernization of national governance systems and governance capacities. We use CiteSpace, a visualization software and method of bibliometric analysis, to create a knowledge map and systematically categorize the research trends and development context of territorial space use zoning research, based on 662 relevant papers published from 1979 to 2020 and cited on HowNet. Research on territorial space use zoning in China continues to emerge, and the number of published papers is increasing. The research was divided into three stages: the land use zoning stage (1992-2006), the natural ecological space use zoning stage (2007-2017), and the territorial space use zoning stage (2018-present). The main research keywords in the three periods show that scholars have consistently maintained an enthusiasm for the study of "land use". The keyword "land use" had a high centrality of 0.28. Close cooperation among authors formed a large-scale scientific research cluster. Colleges and universities published the most, followed by scientific research institutions and public institutions; the main outputs of public institutions such as China Land Surveying and Planning Institute are policy documents, the influence of which should not be underestimated. 2) The research on territorial space use zoning was national policy-oriented under the profound influence of the changing background of the times. Zoning theory developed from the theory of geographical differentiation and advantageous location into the concept of main functional zone regulation, and then to the present concept of sustainable development. Zoning systems were constantly optimized, and research focuses were diverse. Some provinces and cities conducted ...
Keywords	territorial spatial planning ; use zoning ; land use ; zoning regulation ; citespace ; Geography (General) ; G1-922
Subject code	720
Language	Chinese
Publishing date	2022-04-01T00:00:00Z
Publisher	Editorial Committee of Tropical Geography
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Multi-Scenario Simulation of Land Use and Landscape Ecological Risk Response Based on Planning Control.

Wang, Nan / Zhu, Peijuan / Zhou, Guohua / Xing, Xudong / Zhang, Yong

International journal of environmental research and public health

2022 Volume 19, Issue 21

Abstract: This study applied territorial spatial planning control to a land use multi-scenario simulation in Changde, China, and measured the landscape ecological risk response. It embedded five planning control schemes, respectively, involving inertial ... ...

Abstract	This study applied territorial spatial planning control to a land use multi-scenario simulation in Changde, China, and measured the landscape ecological risk response. It embedded five planning control schemes, respectively, involving inertial development, urban expansion size quantity control, ecological spatial structure control, land use zoning control, and comprehensive control. Findings show that: (1) Woodland and arable land in Changde occupy 31.10% and 43.35% of land use, respectively, and constitute the main functional space of the research area. The scale of construction land in Changde has enlarged continuously, with ecological space represented by woodland and water constantly squeezed and occupied. (2) Comprehensive control has the most remarkable restraining effect on the disordered spread of construction land, while ecological space structure control is the most effective way to control ecological land shrinkage. (3) The overall landscape ecological risk index expanded over 2009-2018, presenting an S-type time evolution curve of "sharp increase-mitigation". Landscape ecological risk presents a single-core, double-layer circle structure with the north and east regions as the core, attenuating to the periphery. (4) Landscape ecological risk under land use zoning control increased significantly more than in other scenarios. Comprehensive control best prevented landscape ecological risk and restrained the disorderly expansion of construction land.
MeSH term(s)	Conservation of Natural Resources ; Ecosystem ; Forests ; Computer Simulation ; City Planning ; China ; Cities
Language	English
Publishing date	2022-11-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph192114289
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Article ; Online: Physiologically based pharmacokinetic-pharmacodynamic evaluation of meropenem plus fosfomycin in paediatrics.

Martins, Frederico S / Zhu, Peijuan / Heinrichs, M Tobias / Sy, Sherwin K B

British journal of clinical pharmacology

2020 Volume 87, Issue 3, Page(s) 1012–1023

Abstract: Aims: The objective of the current study was to evaluate paediatric dosing regimens for meropenem plus fosfomycin that generate sufficient coverage against multidrug-resistant bacteria.: Methods: The physiologically based pharmacokinetic (PBPK) ... ...

Abstract	Aims: The objective of the current study was to evaluate paediatric dosing regimens for meropenem plus fosfomycin that generate sufficient coverage against multidrug-resistant bacteria. Methods: The physiologically based pharmacokinetic (PBPK) models of meropenem and fosfomycin were developed from previously published pharmacokinetic studies in five populations: healthy subjects of Japanese origin, and healthy adults, geriatric, paediatric and renally impaired of primarily Caucasian origins. Pharmacodynamic (PD) analyses were carried out by evaluating dosing regimens that achieved a ≥90% joint probability of target attainment (PTA), which was defined as the minimum of the marginal probabilities to achieve the target PD index of each antibiotic. For meropenem, the percentage of time over a 24-hour period wherein the free drug concentration was above the minimum inhibitory concentration (fT > MIC) of at least 40% was its PD target. The fosfomycin PD index was described by fAUC/MIC of at least 40.8. Results: For coadministration consisting of 20 mg/kg meropenem q8h as a 3-hour infusion and 35 mg/kg fosfomycin q8h also as a 3-hour infusion in a virtual paediatric population between 1 month and 12 years of age with normal renal function and a corresponding body weight between 3 and 50 kg, a joint PTA ≥ 90% is achieved at MICs of 16 and 64 mg/L for meropenem and fosfomycin coadministration, respectively, against Klebsiella pneumoniae and Pseudomonas aeruginosa. Conclusion: The current study identified potentially effective paediatric dosing regimens for meropenem plus fosfomycin coadministration against multidrug-resistant bacteria.
MeSH term(s)	Adult ; Aged ; Anti-Bacterial Agents/pharmacology ; Child ; Fosfomycin/pharmacology ; Humans ; Meropenem ; Microbial Sensitivity Tests ; Monte Carlo Method ; Pediatrics
Chemical Substances	Anti-Bacterial Agents ; Fosfomycin (2N81MY12TE) ; Meropenem (FV9J3JU8B1)
Language	English
Publishing date	2020-07-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	188974-6
ISSN	1365-2125 ; 0306-5251 ; 0264-3774
ISSN (online)	1365-2125
ISSN	0306-5251 ; 0264-3774
DOI	10.1111/bcp.14456
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Article ; Online: Application of Pharmacometric Analysis in the Design of Clinical Pharmacology Studies for Biosimilar Development.

Zhu, Peijuan / Sy, Sherwin K B / Skerjanec, Andrej

The AAPS journal

2018 Volume 20, Issue 2, Page(s) 40

Abstract: This article provides an overview of four case studies to demonstrate the utility of pharmacometric analysis in biosimilar development to help design sensitive clinical pharmacology studies for the demonstration of biosimilarity. The two major factors ... ...

Abstract	This article provides an overview of four case studies to demonstrate the utility of pharmacometric analysis in biosimilar development to help design sensitive clinical pharmacology studies for the demonstration of biosimilarity. The two major factors that determine the sensitivity of a clinical pharmacokinetic/pharmacodynamic (PK/PD) study to demonstrate biosimilarity are the size of the potential difference to be detected (signal) and the inter-subject variability (noise), both of which can be characterized and predicted using pharmacometric approaches. To maximize the chance to detect any potential difference between the proposed biosimilar and the reference drug, the dose selected for the clinical pharmacology study should fall on the steep part of the dose-response curve. Pharmacometric analysis can be used to characterize the dose-response relationship using PD- or PK/PD-linked models. The understanding of the PD endpoints in terms of dynamic range of the response and the location of the studied dose on the dose-response curve can provide strategic advantage in the trial design. To reduce the inter-subject variability (noise), pharmacometric analysis can help avoid high variability associated with low doses, and decrease variability by controlling certain covariates in the inclusion/exclusion criteria. Pharmacometric analysis also can help select or justify margins for the equivalence test of PD endpoints. Pharmacometric analysis will assume an ever-increasing role in the clinical development of biosimilar drugs, as it helps to ensure that sufficient sensitivity is built into the study design to detect potential PK and PD differences.
MeSH term(s)	Biological Variation, Population ; Biosimilar Pharmaceuticals/pharmacology ; Clinical Trials as Topic ; Dose-Response Relationship, Drug ; Drug Development/methods ; Humans ; Models, Biological ; Patient Selection ; Pharmaceutical Research/methods ; Research Design ; Treatment Outcome
Chemical Substances	Biosimilar Pharmaceuticals
Language	English
Publishing date	2018-03-07
Publishing country	United States
Document type	Evaluation Studies ; Journal Article
ISSN	1550-7416
ISSN (online)	1550-7416
DOI	10.1208/s12248-018-0196-7
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Article ; Online: Using Clinical PK/PD Studies to Support No Clinically Meaningful Differences Between a Proposed Biosimilar and the Reference Product.

Zhu, Peijuan / Ji, Ping / Wang, Yaning

The AAPS journal

2018 Volume 20, Issue 5, Page(s) 89

MeSH term(s)	Animals ; Biosimilar Pharmaceuticals/administration & dosage ; Biosimilar Pharmaceuticals/adverse effects ; Biosimilar Pharmaceuticals/pharmacokinetics ; Drug Approval/methods ; Drug Development/methods ; Humans ; Minimal Clinically Important Difference ; Models, Biological ; Risk Assessment ; Therapeutic Equivalency ; Workflow
Chemical Substances	Biosimilar Pharmaceuticals
Language	English
Publishing date	2018-08-09
Publishing country	United States
Document type	Congress
ISSN	1550-7416
ISSN (online)	1550-7416
DOI	10.1208/s12248-018-0246-1
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Article ; Online: Prediction of Tissue Exposures of Meropenem, Colistin, and Sulbactam in Pediatrics Using Physiologically Based Pharmacokinetic Modeling.

Zhu, Shixing / Zhang, Jiayuan / Lv, Zhihua / Zhu, Peijuan / Oo, Charles / Yu, Mingming / Sy, Sherwin K B

Clinical pharmacokinetics

2022 Volume 61, Issue 10, Page(s) 1427–1441

Abstract: Background: The combination of polymyxins, meropenem, and sulbactam demonstrated efficacy against multi-drug-resistant bacillus Acinetobacter baumannii. These three antibiotics are commonly used against major blood, skin, lung, and heart muscle ... ...

Abstract	Background: The combination of polymyxins, meropenem, and sulbactam demonstrated efficacy against multi-drug-resistant bacillus Acinetobacter baumannii. These three antibiotics are commonly used against major blood, skin, lung, and heart muscle infections. Objective: The objective of this study was to predict drug disposition and extrapolate the efficacy in these tissues using a physiologically based pharmacokinetic modeling approach that linked drug exposures to their target pharmacodynamic indices associated with antimicrobial activities against A. baumannii. Methods: An adult physiologically based pharmacokinetic model was developed for meropenem, colistin, and sulbactam and scaled to pediatrics accounting for both renal and non-renal clearances. The model reliability was evaluated by comparing simulated plasma and tissue drug exposures to observed data. Target pharmacodynamic indices were used to evaluate whether pediatric and adult dosing regimens provided sufficient coverage. Results: The modeled plasma drug exposures in adults and pediatric patients were consistent with reported literature data. The mean fold errors for meropenem, colistin, and sulbactam were in the range of 0.710-1.37, 0.981-1.47, and 0.647-1.39, respectively. Simulated exposures in the blood, skin, lung, and heart were consistent with reported penetration rates. In a virtual pediatric population aged from 2 to < 18 years, the interpretive breakpoints were achieved in 85-90% of subjects for their targeted pharmacodynamic indices after administration of pediatric dosing regimens consisting of 30 mg/kg of meropenem, and 40 mg/kg of sulbactam three times daily as a 3-h or continuous infusion and 5 mg/kg/day of colistin base activity. Conclusions: The physiologically based pharmacokinetic modeling supports pediatric dosing regimens of meropenem/colistin/sulbactam in a co-administration setting against infections in the blood, lung, skin, and heart tissues due to A. baumannii.
MeSH term(s)	Acinetobacter Infections/drug therapy ; Acinetobacter baumannii ; Adult ; Anti-Bacterial Agents/pharmacokinetics ; Child ; Colistin ; Humans ; Meropenem/pharmacology ; Reproducibility of Results ; Sulbactam/pharmacokinetics
Chemical Substances	Anti-Bacterial Agents ; Meropenem (FV9J3JU8B1) ; Sulbactam (S4TF6I2330) ; Colistin (Z67X93HJG1)
Language	English
Publishing date	2022-08-10
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	197627-8
ISSN	1179-1926 ; 0312-5963
ISSN (online)	1179-1926
ISSN	0312-5963
DOI	10.1007/s40262-022-01161-y
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Article: Pharmacokinetic/Pharmacodynamic Evaluation of Aztreonam/Amoxicillin/Clavulanate Combination against New Delhi Metallo-β-Lactamase and Serine-β-Lactamase Co-Producing

Zhang, Jiayuan / Wu, Mengyuan / Diao, Shuo / Zhu, Shixing / Song, Chu / Yue, Jiali / Martins, Frederico S / Zhu, Peijuan / Lv, Zhihua / Zhu, Yuanqi / Yu, Mingming / Sy, Sherwin K B

Pharmaceutics

2023 Volume 15, Issue 1

Abstract: This study aimed to examine specific niches and usage for the aztreonam/amoxicillin/clavulanate combination and to use population pharmacokinetic simulations of clinical dosing regimens to predict the impact of this combination on restricting mutant ... ...

Abstract	This study aimed to examine specific niches and usage for the aztreonam/amoxicillin/clavulanate combination and to use population pharmacokinetic simulations of clinical dosing regimens to predict the impact of this combination on restricting mutant selection. The in vitro susceptibility of 19 New-Delhi metallo-β-lactamase (NDM)-producing clinical isolates to amoxicillin/clavulanate and aztreonam alone and in co-administration was determined based on the minimum inhibitory concentration (MIC) and mutant prevention concentration (MPC). The fractions of a 24-h duration that the free drug concentration was within the mutant selection window (fTMSW) and above the MPC (fT>MPC) in both plasma and epithelial lining fluid were determined from simulations of 10,000 subject profiles based on regimens by renal function categories. This combination reduced the MIC of aztreonam and amoxicillin/clavulanate to values below their clinical breakpoint in 7/9 K. pneumoniae and 8/9 E. coli, depending on the β-lactamase genes detected in the isolate. In the majority of the tested isolates, the combination resulted in fT>MPC > 90% and fTMSW < 10% for both aztreonam and amoxicillin/clavulanate. Clinical dosing regimens of aztreonam and amoxicillin/clavulanate were sufficient to provide mutant restriction coverage for MPC and MIC ≤ 4 mg/L. This combination has limited coverage against NDM- and extended-spectrum β-lactamase co-producing E. coli and K. pneumoniae and is not effective against isolates carrying plasmid-mediated AmpC and KPC-2. This study offers a potential scope and limitations as to where the aztreonam/amoxicillin/clavulanate combination may succeed or fail.
Language	English
Publishing date	2023-01-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15010251
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Article ; Online: Physiologically-based pharmacokinetic modeling to inform dosing regimens and routes of administration of rifampicin and colistin combination against Acinetobacter baumannii.

Zhang, Jiayuan / Song, Chu / Wu, Mengyuan / Yue, Jiali / Zhu, Shixing / Zhu, Peijuan / Oo, Charles / Schlender, Jan-Frederik / Lv, Zhihua / Zhu, Yuanqi / Sy, Sherwin K B / Yu, Mingming

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2023 Volume 185, Page(s) 106443

Abstract: Background: Carbapenem-resistant Acinetobacter baumannii (CRAB) is resistant to major antibiotics such as penicillin, cephalosporin, fluoroquinolone and aminoglycoside, and has become a significant nosocomial pathogen. The efficacy of rifampicin and ... ...

Abstract	Background: Carbapenem-resistant Acinetobacter baumannii (CRAB) is resistant to major antibiotics such as penicillin, cephalosporin, fluoroquinolone and aminoglycoside, and has become a significant nosocomial pathogen. The efficacy of rifampicin and colistin combination against CRAB could be dependent on the administration routes and drug concentrations at the site of infection. Objective: The objective is to predict drug disposition in biological tissues. Treatment efficacy is extrapolated by assessing respective pharmacodynamic (PD) indices, as well as parameters associated with the emergence of resistance. Methods: Physiologically-based pharmacokinetic models of rifampicin and colistin were utilized to predict tissue exposures. Dosing regimens and administration routes for combination therapy were evaluated in terms of in vitro antimicrobial susceptibility of A. baumannii associated with targeted PD indices and resistance parameters. Results: Simulated exposures in blood, heart, lung, skin and brain were consistent with reported penetration rates. The results demonstrated that a combination of colistin and rifampicin using conventional intravenous (i.v.) doses could achieve effective exposures in the blood and skin. However, for lung infections, colistin by inhalation would be required due to low lung penetration from intravenous route. Inhaled colistin alone provided good PD coverage but this practice could encourage the emergence of additional resistance which may be overcome by a combination regimen that includes inhaled rifampicin. Conclusion: This in silico extrapolation provides valuable information on dosing regimens and routes of administration against CRAB infections in specific tissues. The PBPK modeling approach could be a non-invasive way to inform therapeutic benefits of combination antimicrobial therapy.
MeSH term(s)	Humans ; Colistin ; Rifampin/pharmacology ; Acinetobacter baumannii ; Acinetobacter Infections/drug therapy ; Anti-Bacterial Agents ; Microbial Sensitivity Tests ; Drug Resistance, Multiple, Bacterial
Chemical Substances	Colistin (Z67X93HJG1) ; Rifampin (VJT6J7R4TR) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-04-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1154366-8
ISSN	1879-0720 ; 0928-0987
ISSN (online)	1879-0720
ISSN	0928-0987
DOI	10.1016/j.ejps.2023.106443
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Article ; Online: Trial Design and Statistical Considerations on the Assessment of Pharmacodynamic Similarity.

Zhu, Peijuan / Hsu, Chyi-Hung / Liao, Jason / Xu, Steven / Zhang, Liping / Zhou, Honghui

The AAPS journal

2019 Volume 21, Issue 3, Page(s) 47

Abstract: Pharmacodynamics (PD) similarity is an important component to support the claim of similarity between two drugs or devices. This article investigates the trial design and statistical considerations in the equivalence test of PD endpoints. Using bone ... ...

Abstract	Pharmacodynamics (PD) similarity is an important component to support the claim of similarity between two drugs or devices. This article investigates the trial design and statistical considerations in the equivalence test of PD endpoints. Using bone resorption marker CTX as a case study, the relationship between the PD readouts and drug potency was explored to evaluate the sensitivity of the PD endpoint and guide equivalence margin selection. For PD data that have high baseline variability, one conventional similarity assessment method was to apply baseline-normalization followed by the standard bioequivalence (BE) test (Lancet Haematol. 4:e350-61, 2017, Ann Rheum Dis. 2017). This study showcased the drawbacks of the conventional method for PD data that were close to inhibition saturation, as the baseline-normalization significantly skewed the distribution of the PD data toward non-log-normal. In such cases, the standard BE test can produce an inflated type I error. Alternatively, ANCOVA, when applied to the un-normalized PD data with the baseline as a covariate, produced a satisfactory type I error with sufficient power. Therefore, ANCOVA was recommended for equivalence test of PD markers that has a saturated inhibition profile and high variability at baseline. Moreover, the relationship between PD readouts and drug potency was used to explore the sensitivity of the PD endpoint and it could help justify the equivalence margins, since the standard 80% to 125% BE margin often does not apply to PD. Finally, a decision tree was proposed to help guide the design of the PD equivalence study in the choice of PD endpoints and statistical methods.
MeSH term(s)	Analysis of Variance ; Clinical Trials as Topic ; Collagen Type I/blood ; Computer Simulation ; Datasets as Topic ; Decision Trees ; Denosumab/pharmacology ; Humans ; Models, Biological ; Osteoporosis/blood ; Osteoporosis/drug therapy ; Peptides/blood ; Regression Analysis ; Research Design ; Therapeutic Equivalency
Chemical Substances	Collagen Type I ; Peptides ; collagen type I trimeric cross-linked peptide ; Denosumab (4EQZ6YO2HI)
Language	English
Publishing date	2019-04-03
Publishing country	United States
Document type	Journal Article
ISSN	1550-7416
ISSN (online)	1550-7416
DOI	10.1208/s12248-019-0321-2
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Article: The combination effect of meropenem/sulbactam/polymyxin-B on the pharmacodynamic parameters for mutant selection windows against carbapenem-resistant

Zhang, Jiayuan / Diao, Shuo / Liu, Yanfei / Wang, Hongxiang / Liu, Yuwei / Zhu, Shixing / Feng, Kun / Tang, Xiaoqian / Oo, Charles / Zhu, Peijuan / Lv, Zhihua / Yu, Mingming / Sy, Sherwin K B / Zhu, Yuanqi

Frontiers in microbiology

2022 Volume 13, Page(s) 1024702

Abstract: The objective of this study was to evaluate whether combinations of sulbactam, meropenem, and polymyxin-B could reduce or close the gap of mutant selection window (MSW) of individual antibiotics ... ...

Abstract	The objective of this study was to evaluate whether combinations of sulbactam, meropenem, and polymyxin-B could reduce or close the gap of mutant selection window (MSW) of individual antibiotics against
Language	English
Publishing date	2022-11-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2022.1024702
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