LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Back to previous search Search history
Advanced search

Your last searches

  1. AU="Zhu, Peng-Cheng"
  2. AU="Claus, Piet"

Search results

Result 1 - 10 of total 21

Search options

  1. Article: Colorectal image analysis for polyp diagnosis.

    Zhu, Peng-Cheng / Wan, Jing-Jing / Shao, Wei / Meng, Xian-Chun / Chen, Bo-Lun

    Frontiers in computational neuroscience

    2024  Volume 18, Page(s) 1356447

    Abstract: Colorectal polyp is an important early manifestation of colorectal cancer, which is significant for the prevention of colorectal cancer. Despite timely detection and manual intervention of colorectal polyps can reduce their chances of becoming cancerous, ...

    Abstract Colorectal polyp is an important early manifestation of colorectal cancer, which is significant for the prevention of colorectal cancer. Despite timely detection and manual intervention of colorectal polyps can reduce their chances of becoming cancerous, most existing methods ignore the uncertainties and location problems of polyps, causing a degradation in detection performance. To address these problems, in this paper, we propose a novel colorectal image analysis method for polyp diagnosis via PAM-Net. Specifically, a parallel attention module is designed to enhance the analysis of colorectal polyp images for improving the certainties of polyps. In addition, our method introduces the GWD loss to enhance the accuracy of polyp diagnosis from the perspective of polyp location. Extensive experimental results demonstrate the effectiveness of the proposed method compared with the SOTA baselines. This study enhances the performance of polyp detection accuracy and contributes to polyp detection in clinical medicine.
    Language English
    Publishing date 2024-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452964-3
    ISSN 1662-5188
    ISSN 1662-5188
    DOI 10.3389/fncom.2024.1356447
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Silencing EIF3A ameliorates pulmonary arterial hypertension through HDAC1 and PTEN/PI3K/AKT pathway in vitro and in vivo.

    Yang, Hai-Tao / Wang, Guan / Zhu, Peng-Cheng / Xiao, Zhao-Yang

    Experimental cell research

    2023  Volume 426, Issue 1, Page(s) 113555

    Abstract: Pulmonary vascular remodeling caused by the excessive proliferation of pulmonary arterial smooth muscle cells (PASMCs) is the hallmark feature of pulmonary arterial hypertension (PAH). Eukaryotic initiation factor 3 subunit A (EIF3A) exhibited ... ...

    Abstract Pulmonary vascular remodeling caused by the excessive proliferation of pulmonary arterial smooth muscle cells (PASMCs) is the hallmark feature of pulmonary arterial hypertension (PAH). Eukaryotic initiation factor 3 subunit A (EIF3A) exhibited proliferative activity in multiple cell types. The present study investigated the role of EIF3A in the progression of PAH. A monocrotaline (MCT)-induced PAH rat model was constructed, and adeno-associated virus type 1 (AAV1) carrying EIF3A shRNA was intratracheally delivered to PAH rats to block EIF3A expression. PASMCs were isolated from rats and treated with PDGF-BB to simulate PASMC proliferation, and shRNA for EIF3 was conducted to investigate the mechanism behind the role of EIF3A in PASMC function in vitro. EIF3A expression was upregulated in pulmonary arteries, and EIF3A inhibition effectively improved pulmonary hypertension and right ventricular hypertrophy and suppressed MCT-induced vascular remodeling in vivo. In addition, we found that genetic knockdown of EIF3A reduced PDGF-triggered proliferation and arrested cell cycle, accompanied by downregulated proliferation-related protein expression in PASMCs. Mechanistically, the histone deacetylase 1 (HDAC1)-mediated PTEN/PI3K/AKT pathway was recognized as a primary mechanism in PAH progression. Silencing EIF3A decreased HDAC1 expression, and further inhibited the excessive proliferation of PASMCs by increasing the phosphatase and tension homolog (PTEN) expression and suppressing the AKT phosphorylation. Notably, HDAC1 expression reversed the effect of silencing EIF3A on PAH and PTEN/PI3K/AKT pathway. Collectively, silencing EIF3A improved PAH by decreasing PASMC proliferation through the HDAC1-mediated PTEN/PI3K/AKT pathway. These findings suggest that targeting EIF3A may represent a potential approach for the treatment of PAH.
    MeSH term(s) Animals ; Rats ; Cell Proliferation/genetics ; Eukaryota/metabolism ; Histone Deacetylase 1/genetics ; Histone Deacetylase 1/metabolism ; Myocytes, Smooth Muscle/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism ; Pulmonary Arterial Hypertension/metabolism ; Pulmonary Artery/metabolism ; RNA, Small Interfering/metabolism ; Vascular Remodeling ; Eukaryotic Initiation Factor-3/genetics ; Eukaryotic Initiation Factor-3/metabolism
    Chemical Substances Hdac1 protein, rat (EC 3.5.1.98) ; Histone Deacetylase 1 (EC 3.5.1.98) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; PTEN Phosphohydrolase (EC 3.1.3.67) ; Pten protein, rat (EC 3.1.3.67) ; RNA, Small Interfering ; Eukaryotic Initiation Factor-3
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1493-x
    ISSN 1090-2422 ; 0014-4827
    ISSN (online) 1090-2422
    ISSN 0014-4827
    DOI 10.1016/j.yexcr.2023.113555
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Facile Synthesis of Boc-Protected Selenocystine and its Compatibility with Late-Stage Farnesylation at Cysteine Site.

    Zhu, Peng-Cheng / Chen, Yong-Xiang

    Protein and peptide letters

    2020  Volume 28, Issue 6, Page(s) 603–611

    Abstract: Background: The unique hypervariable C-terminal region (HVR) of K-Ras4B, one of the most frequently mutated proteins in many powerful cancers, contains a C-terminal farnesylated and methylated Cys and a poly-lysine motif, which decides the association ... ...

    Abstract Background: The unique hypervariable C-terminal region (HVR) of K-Ras4B, one of the most frequently mutated proteins in many powerful cancers, contains a C-terminal farnesylated and methylated Cys and a poly-lysine motif, which decides the association of K-Ras4B to the inner leaflet of plasma membrane for activating the downstream signaling activity. In our previous work, we inserted an additional Cys in K-Ras4B HVR peptide synthesis for NCL in the semi-synthesis of K-Ras4b protein, but it is not suitable for application in protein dimerization research. The recently developed selenocysteine (Sec, U) mediated native chemical ligation reaction followed by selective deselenization, which can help to broaden the scope of protein synthesis, requires the generation of the peptide fragment with an N-terminal Sec.
    Objective: To synthesize K-Ras4B HVR peptide containing both N-terminal Sec and C-terminal farnesylated and methylated Cys to achieve traceless protein semi-synthesis.
    Methods and results: We have developed a facile synthesis approach for producing Boc-Sec)2-OH using economic Se powder, which can facilitate scaling up preparation of peptides containing Sec at the N-terminus. Furthermore, we synthesized K-Ras4B HVR peptide containing selenocystine by utilization of Boc-Sec)2-OH. Finally, we took K-Ras4B HVR peptide as an example to test the compatibility of farnesylation reaction at Cys with the N-terminal Sec)2, and the farnesyl group was successfully added to the thiol group of Cys.
    MeSH term(s) Chemistry Techniques, Synthetic ; Cysteine/chemistry ; Cystine/analogs & derivatives ; Cystine/chemical synthesis ; Cystine/chemistry ; Humans ; Models, Molecular ; Organoselenium Compounds/chemical synthesis ; Organoselenium Compounds/chemistry ; Peptides/chemical synthesis ; Peptides/chemistry ; Protein Prenylation ; Proto-Oncogene Proteins p21(ras)/chemistry
    Chemical Substances KRAS protein, human ; Organoselenium Compounds ; Peptides ; selenocystine (1464-43-3) ; Cystine (48TCX9A1VT) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; Cysteine (K848JZ4886)
    Language English
    Publishing date 2020-12-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1280776-x
    ISSN 1875-5305 ; 0929-8665
    ISSN (online) 1875-5305
    ISSN 0929-8665
    DOI 10.2174/0929866527666201223094249
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4452: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Internationalization process, impact of slack resources, and role of the CEO

    Dutta, Dev K / Malhotra, Shavin / Zhu, PengCheng

    Journal of world business : JWB Vol. 51, No. 2 , p. 212-225

    the duality of structure and agency in evolution of cross-border acquisition decisions

    2016  Volume 51, Issue 2, Page(s) 212–225

    Author's details Dev K. Dutta, Shavin Malhotra, PengCheng Zhu
    Keywords Internationalization over time ; Cross-border acquisition decisions ; Structuration theory ; Slack resources ; CEO overconfidence ; CEO tenure
    Language English
    Publisher JAI Press
    Publishing place Greenwich, Conn. [u.a.]
    Document type Article
    ZDB-ID 1382307-3
    ISSN 1090-9516
    Database ECONomics Information System

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article: Idiosyncratic volatility and mergers and acquisitions in emerging markets

    Zhu, PengCheng / Jog, Vijay / Otchere, Isaac

    Emerging markets review Vol. 19 , p. 18-48

    2014  Volume 19, Page(s) 18–48

    Author's details PengCheng Zhu; Vijay Jog; Isaac Otchere
    Keywords Idiosyncratic volatility ; Mergers and acquisitions ; Emerging markets
    Language English
    Publisher Elsevier
    Publishing place Amsterdam [u.a.]
    Document type Article
    ZDB-ID 2025202X
    ISSN 1566-0141
    Database ECONomics Information System

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling.

    Yelland, Tamas / Garcia, Esther / Parry, Charles / Kowalczyk, Dominika / Wojnowska, Marta / Gohlke, Andrea / Zalar, Matja / Cameron, Kenneth / Goodwin, Gillian / Yu, Qing / Zhu, Peng-Cheng / ElMaghloob, Yasmin / Pugliese, Angelo / Archibald, Lewis / Jamieson, Andrew / Chen, Yong Xiang / McArthur, Duncan / Bower, Justin / Ismail, Shehab

    Journal of medicinal chemistry

    2022  Volume 65, Issue 3, Page(s) 1898–1914

    Abstract: RAS is a major anticancer drug target which requires membrane localization to activate downstream signal transduction. The direct inhibition of RAS has proven to be challenging. Here, we present a novel strategy for targeting RAS by stabilizing its ... ...

    Abstract RAS is a major anticancer drug target which requires membrane localization to activate downstream signal transduction. The direct inhibition of RAS has proven to be challenging. Here, we present a novel strategy for targeting RAS by stabilizing its interaction with the prenyl-binding protein PDE6D and disrupting its localization. Using rationally designed RAS point mutations, we were able to stabilize the RAS:PDE6D complex by increasing the affinity of RAS for PDE6D, which resulted in the redirection of RAS to the cytoplasm and the primary cilium and inhibition of oncogenic RAS/ERK signaling. We developed an SPR fragment screening and identified fragments that bind at the KRAS:PDE6D interface, as shown through cocrystal structures. Finally, we show that the stoichiometric ratios of KRAS:PDE6D vary in different cell lines, suggesting that the impact of this strategy might be cell-type-dependent. This study forms the foundation from which a potential anticancer small-molecule RAS:PDE6D complex stabilizer could be developed.
    MeSH term(s) Cell Line, Tumor ; Cell Membrane/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 6/metabolism ; Humans ; Peptides/pharmacology ; Protein Binding/drug effects ; Proto-Oncogene Proteins p21(ras)/analysis ; Proto-Oncogene Proteins p21(ras)/antagonists & inhibitors ; Proto-Oncogene Proteins p21(ras)/metabolism ; Signal Transduction/drug effects
    Chemical Substances KRAS protein, human ; Peptides ; PDE6D protein, human (EC 3.1.4.17) ; Cyclic Nucleotide Phosphodiesterases, Type 6 (EC 3.1.4.35) ; HRAS protein, human (EC 3.6.5.2) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.1c01265
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 151: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MB 1: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Thirty years of Canadian evidence on stock splits, reverse stock splits and stock dividends

    Jog, Vijay / Zhu, PengCheng

    Advances in quantitative analysis of finance and accounting : a research annual Vol. 6 , p. 83-115

    2008  Volume 6, Page(s) 83–115

    Author's details Vijay Jog and PengCheng Zhu
    Keywords Aktiensplit ; Dividende ; Kanada
    Language English
    Size graph. Darst.
    Publisher World Scientific
    Publishing place River Edge, NJ [u.a.]
    Document type Article
    ZDB-ID 1089104-3
    Database ECONomics Information System

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article: Partial acquisitions in emerging markets

    Zhu, PengCheng / Jog, Vijay / Otchere, Isaac

    The journal of corporate finance : contracting, governance and organization Vol. 17, No. 2 , p. 288-305

    a test of the strategic market entry and corporate control hypotheses

    2011  Volume 17, Issue 2, Page(s) 288–305

    Author's details PengCheng Zhu; Vijay Jog; Isaac Otchere
    Language English
    Publisher Elsevier
    Publishing place Amsterdam
    Document type Article
    ZDB-ID 1189269-9
    ISSN 0929-1199
    Database ECONomics Information System

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article: Synthesis and structures of Hexa-peri-hexabenzocoronene-based triptycenes

    Zhu, Peng-Cheng / Chun Zhang / Lian-Hui Peng / Ying Liu

    Tetrahedron letters. 2014 Jan. 08, v. 55

    2014  

    Abstract: A series of Hexa-peri-hexabenzocoronene-based triptycenes bearing mono-, di-, or tri-HBC moieties were synthesized from iodotriptycenes. Their structures were determined by NMR, MS spectra, and X-ray analysis. The planar HBC moieties displayed strong ... ...

    Abstract A series of Hexa-peri-hexabenzocoronene-based triptycenes bearing mono-, di-, or tri-HBC moieties were synthesized from iodotriptycenes. Their structures were determined by NMR, MS spectra, and X-ray analysis. The planar HBC moieties displayed strong deshielding effect to triptycene scaffold, resulting in significant downfield chemical shift of the two methenyl protons. Moreover, the HBC units are well separated in the triptycene scaffold, without quenching the fluorescent properties of each HBC unit.
    Keywords chemical reactions ; chemical structure ; fluorescence ; nuclear magnetic resonance spectroscopy ; organic compounds ; protons ; X-radiation
    Language English
    Dates of publication 2014-0108
    Size p. 521-524.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2013.11.085
    Database NAL-Catalogue (AGRICOLA)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2837: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Three-dimensional nanographene based on triptycene for detection of nitroaromatic explosives

    Zhu, Peng-Cheng / Chun Zhang / Jing-Tao Li / Liu-Ning Luo / Pei-Qian Cen

    Tetrahedron letters. 2014 Nov. 05, v. 55, no. 45

    2014  

    Abstract: 3D nanographene 1, with three HBC units arraying in the 3D triptycene scaffold, displayed strong intrinsic fluorescence properties and could be used as a detector for nitroaromatic explosives such as TNP with quenching efficiency Ksv of 1.8×104M−1 and ... ...

    Abstract 3D nanographene 1, with three HBC units arraying in the 3D triptycene scaffold, displayed strong intrinsic fluorescence properties and could be used as a detector for nitroaromatic explosives such as TNP with quenching efficiency Ksv of 1.8×104M−1 and sensitivity of 2.4ng/mm2, respectively.
    Keywords chemical reactions ; chemical structure ; explosives ; fluorescence ; organic compounds
    Language English
    Dates of publication 2014-1105
    Size p. 6277-6280.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2014.09.091
    Database NAL-Catalogue (AGRICOLA)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2837: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top