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Article ; Online: ICA/SDF-1α/PBMSCs loaded onto alginate and gelatin cross-linked scaffolds promote damaged cartilage repair.

Wang, Pengzhen / Zhu, Pingping / Yin, Wenhui / Wu, Jian / Zhang, Shaoheng

Journal of cellular and molecular medicine

2024 Volume 28, Issue 7, Page(s) e18236

Abstract: A three-dimensional alginate-coated scaffold (GAIS) was constructed in the present study to showcase the multidifferentiation potential of peripheral blood mesenchymal stem cells (PBMSCs) and to investigate the role and mechanism by which Icariin (ICA)/ ... ...

Abstract	A three-dimensional alginate-coated scaffold (GAIS) was constructed in the present study to showcase the multidifferentiation potential of peripheral blood mesenchymal stem cells (PBMSCs) and to investigate the role and mechanism by which Icariin (ICA)/stromal cell-derived factor (SDF-1α)/PBMSCs promote damaged articular repair. In addition, the ability of ICA, in combination with SDF-1α, to promote the migration and proliferation of stem cells was validated through the utilization of CCK-8 and migration experiments. The combination of ICA and SDF-1α inhibited the differentiation of PBMSCs into cartilage, as demonstrated by in vivo experiments and histological staining. Both PCR and western blot experiments showed that GAIS could upregulate the expression of particular genes in chondrocytes. In comparison to scaffolds devoid of alginate (G0), PBMSCs seeded into GAIS scaffolds exhibited a greater rate of proliferation, and the conditioned medium derived from scaffolds containing SDF-1α enhanced the capacity for cell migration. Moreover, after a 12-week treatment period, GAIS, when successfully transplanted into osteochondral defects of mice, was found to promote cartilage regeneration and repair. The findings, therefore, demonstrate that GAIS enhanced the in vitro capabilities of PBMSCs, including proliferation, migration, homing and chondrogenic differentiation. In addition, ICA and SDF-1α effectively collaborated to support cartilage formation in vivo. Thus, the ICA/SDF-1α/PBMSC-loaded biodegradable alginate-gelatin scaffolds showcase considerable potential for use in cartilage repair.
MeSH term(s)	Mice ; Animals ; Chemokine CXCL12/pharmacology ; Gelatin ; Cartilage ; Tissue Scaffolds ; Cell Movement
Chemical Substances	Chemokine CXCL12 ; Gelatin (9000-70-8)
Language	English
Publishing date	2024-03-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2074559-X
ISSN	1582-4934 ; 1582-4934 ; 1582-1838
ISSN (online)	1582-4934
ISSN	1582-4934 ; 1582-1838
DOI	10.1111/jcmm.18236
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Article: [Research Advances on Strategies to Promote Homing and Engraftment of Hematopoietic Stem Cells--Review].

Zhu, Ping-Ping / Wen, Rui-Ting / Yang, Zhi-Gang

Zhongguo shi yan xue ye xue za zhi

2023 Volume 31, Issue 4, Page(s) 1229–1232

Abstract: The homing and engraftment of hematopoietic stem cells (HSC) into bone marrow is the first critical step for successful clinical hematopoietic stem cell transplantation (HSCT). SDF-1 / CXCR4 is considered to be a very promising target to promote HSC ... ...

Abstract	The homing and engraftment of hematopoietic stem cells (HSC) into bone marrow is the first critical step for successful clinical hematopoietic stem cell transplantation (HSCT). SDF-1 / CXCR4 is considered to be a very promising target to promote HSC homing. In recent years, with the in-depth research on the HSC homing, a variety of new strategies for promoting HSC homing and engraftment have been explored, such as nuclear hormone receptor, histone deacetylase inhibitor, prostaglandin and metabolic regulation, so as to increase the success rate of HSCT and improve the survival of patients. In this review, the recent research advances in the mechanism of HSC homing and strategies to promote HSC homing and engraftment were summarized and discussed.
MeSH term(s)	Humans ; Hematopoietic Stem Cells/physiology ; Bone Marrow ; Hematopoietic Stem Cell Transplantation ; Gene Expression Regulation ; Prostaglandins/metabolism
Chemical Substances	Prostaglandins
Language	Chinese
Publishing date	2023-07-01
Publishing country	China
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2023.04.046
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Article ; Online: Cell Multi-Bernoulli (Cell-MB) Sensor Control for Multi-Object Search-While-Tracking (SWT).

LeGrand, Keith A / Zhu, Pingping / Ferrari, Silvia

IEEE transactions on pattern analysis and machine intelligence

2023 Volume 45, Issue 6, Page(s) 7195–7207

Abstract: Information-driven control can be used to develop intelligent sensors that can optimize their measurement value based on environmental feedback. In object tracking applications, sensor actions are chosen based on the expected reduction in uncertainty ... ...

Abstract	Information-driven control can be used to develop intelligent sensors that can optimize their measurement value based on environmental feedback. In object tracking applications, sensor actions are chosen based on the expected reduction in uncertainty also known as information gain. Random finite set (RFS) theory provides a formalism for quantifying and estimating information gain in multi-object tracking problems. However, estimating information gain in these applications remains computationally challenging. This paper presents a new tractable approximation of the RFS expected information gain applicable to sensor control for multi-object search and tracking. Unlike existing RFS approaches, the information gain approximation presented in this paper considers the contributions of non-ideal noisy measurements, missed detections, false alarms, and object appearance/disappearance. The effectiveness of the information-driven sensor control is demonstrated through two multi-vehicle search-while-tracking experiments using real video data from remote terrestrial and satellite sensors.
Language	English
Publishing date	2023-05-05
Publishing country	United States
Document type	Journal Article
ISSN	1939-3539
ISSN (online)	1939-3539
DOI	10.1109/TPAMI.2022.3223856
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Article ; Online: Regulation of noncoding RNAs in innate lymphoid cells.

Liu, Benyu / Zhang, Lingwei / Zhu, Pingping / Fan, Zusen

Cellular & molecular immunology

2023 Volume 20, Issue 5, Page(s) 543–545

MeSH term(s)	Immunity, Innate ; Lymphocytes ; RNA, Untranslated/genetics ; RNA, Long Noncoding/genetics ; MicroRNAs
Chemical Substances	RNA, Untranslated ; RNA, Long Noncoding ; MicroRNAs
Language	English
Publishing date	2023-03-09
Publishing country	China
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2435097-7
ISSN	2042-0226 ; 1672-7681
ISSN (online)	2042-0226
ISSN	1672-7681
DOI	10.1038/s41423-023-00993-3
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Article: Crosstalk between colorectal CSCs and immune cells in tumorigenesis, and strategies for targeting colorectal CSCs.

Zhao, Qi / Zong, Hong / Zhu, Pingping / Su, Chang / Tang, Wenxue / Chen, Zhenzhen / Jin, Shuiling

Experimental hematology & oncology

2024 Volume 13, Issue 1, Page(s) 6

Abstract: Cancer immunotherapy has emerged as a promising strategy in the treatment of colorectal cancer, and relapse after tumor immunotherapy has attracted increasing attention. Cancer stem cells (CSCs), a small subset of tumor cells with self-renewal and ... ...

Abstract	Cancer immunotherapy has emerged as a promising strategy in the treatment of colorectal cancer, and relapse after tumor immunotherapy has attracted increasing attention. Cancer stem cells (CSCs), a small subset of tumor cells with self-renewal and differentiation capacities, are resistant to traditional therapies such as radiotherapy and chemotherapy. Recently, CSCs have been proven to be the cells driving tumor relapse after immunotherapy. However, the mutual interactions between CSCs and cancer niche immune cells are largely uncharacterized. In this review, we focus on colorectal CSCs, CSC-immune cell interactions and CSC-based immunotherapy. Colorectal CSCs are characterized by robust expression of surface markers such as CD44, CD133 and Lgr5; hyperactivation of stemness-related signaling pathways, such as the Wnt/β-catenin, Hippo/Yap1, Jak/Stat and Notch pathways; and disordered epigenetic modifications, including DNA methylation, histone modification, chromatin remodeling, and noncoding RNA action. Moreover, colorectal CSCs express abnormal levels of immune-related genes such as MHC and immune checkpoint molecules and mutually interact with cancer niche cells in multiple tumorigenesis-related processes, including tumor initiation, maintenance, metastasis and drug resistance. To date, many therapies targeting CSCs have been evaluated, including monoclonal antibodies, antibody‒drug conjugates, bispecific antibodies, tumor vaccines adoptive cell therapy, and small molecule inhibitors. With the development of CSC-/niche-targeting technology, as well as the integration of multidisciplinary studies, novel therapies that eliminate CSCs and reverse their immunosuppressive microenvironment are expected to be developed for the treatment of solid tumors, including colorectal cancer.
Language	English
Publishing date	2024-01-22
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2669066-4
ISSN	2162-3619
ISSN	2162-3619
DOI	10.1186/s40164-024-00474-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Icariin activates far upstream element binding protein 1 to regulate hypoxia-inducible factor-1α and hypoxia-inducible factor-2α signaling and benefits chondrocytes.

Wang, Pengzhen / Zhu, Pingping / Zhang, Shaoheng / Yuan, Wei / Liu, Zhihe

PeerJ

2023 Volume 11, Page(s) e15917

Abstract: Icariin (ICA) is a typical flavonoid glycoside derived from epimedium plants. It has both anabolic and anti-catabolic effects to improve bone mineral density and reduce bone microstructural degradation. However, the effect and underlying mechanism of ICA ...

Abstract	Icariin (ICA) is a typical flavonoid glycoside derived from epimedium plants. It has both anabolic and anti-catabolic effects to improve bone mineral density and reduce bone microstructural degradation. However, the effect and underlying mechanism of ICA on the proliferation and metabolism of chondrocyte and synthesis of extracellular matrix are still unclear. This study aimed to investigate the role and regulation of far upstream element binding protein 1 (FUBP1) in chondrocytes treated with ICA to maintain homeostasis and suppress inflammatory responses. In the study, the effect of ICA on chondrocytes with overexpressed or silenced FUBP1 was detected by the MTS and single-cell cloning methods. The expression of hypoxia-inducible factor-1/2α (HIF-1/2α), FUBP1, matrix metalloproteinase (MMP)9, SRY-box transcription factor 9 (SOX9), and type II collagen (Col2α) in ATDC5 cells, a mouse chondrogenic cell line, treated with ICA was evaluated by immunoblotting. Western blotting revealed 1 µM ICA to have the most significant effect on chondrocytes. Alcian blue staining and colony formation assays showed that the promoting effect of ICA was insignificant in FUBP1-knockdown cells (
MeSH term(s)	Animals ; Mice ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Chondrocytes ; Matrix Metalloproteinase 9 ; Hypoxia
Chemical Substances	Hypoxia-Inducible Factor 1, alpha Subunit ; icariin (VNM47R2QSQ) ; Matrix Metalloproteinase 9 (EC 3.4.24.35)
Language	English
Publishing date	2023-08-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.15917
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Proliferation and Stemness of Peripheral Blood-Derived Mesenchymal Stromal Cells Were Enhanced by Hypoxia.

Wang, Pengzhen / Zhu, Pingping / Yu, Chaosheng / Wu, Jian

Frontiers in endocrinology

2022 Volume 13, Page(s) 873662

Abstract: This study aimed to address the dilemma of low peripheral blood-derived mesenchymal stromal cell (PBMSC) activity and reduced phenotype in bone or cartilage tissue engineering. Rat PBMSCs (rPBMSCs) were obtained by density gradient centrifugation, and ... ...

Abstract	This study aimed to address the dilemma of low peripheral blood-derived mesenchymal stromal cell (PBMSC) activity and reduced phenotype in bone or cartilage tissue engineering. Rat PBMSCs (rPBMSCs) were obtained by density gradient centrifugation, and stromal cell characteristics were confirmed by flow cytometry (FCM) and multi-differentiation potential induction experiments. Cell growth curve, viability experiments, and clone formation experiments were performed by [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium] (MTS) and cell counting, and the cell cycle was confirmed by cell FCM. The proliferation signal pathway and stemness-related proteins were detected by molecular methods including Western blot and real-time polymerase chain reaction.
MeSH term(s)	Adipocytes ; Animals ; Cell Differentiation ; Cell Proliferation ; Hypoxia/metabolism ; Mesenchymal Stem Cells ; Rats
Language	English
Publishing date	2022-05-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.873662
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Article ; Online: Corrigendum to "LncTIC1 interacts with β-catenin to drive liver TIC self-renewal and liver tumorigenesis" [Cancer Lett. 430 (2018) 88-96].

Chen, Zhenzhen / Yao, Lintong / Liu, Yating / Zhu, Pingping

Cancer letters

2022 Volume 545, Page(s) 215835

Language	English
Publishing date	2022-08-09
Publishing country	Ireland
Document type	Published Erratum
ZDB-ID	195674-7
ISSN	1872-7980 ; 0304-3835
ISSN (online)	1872-7980
ISSN	0304-3835
DOI	10.1016/j.canlet.2022.215835
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Zs.A 1177: Show issues

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Article ; Online: Assessment of heavy metals contamination and human health risk assessment of the commonly consumed medicinal herbs in China

Liu, Haiping / Tang, Jianfeng / Chen, Tongjun / Zhu, Pingping / Sun, Dongdong / Wang, Weiyun

Environ Sci Pollut Res. 2023 Jan., v. 30, no. 3 p.7345-7357

2023

Abstract: This study investigates heavy metal contamination of commonly consumed medicinal herbs and human health risks to the Chinese population arising from the consumption of herbs that contain potentially harmful elements. Food safety standards for Chinese ... ...

Abstract	This study investigates heavy metal contamination of commonly consumed medicinal herbs and human health risks to the Chinese population arising from the consumption of herbs that contain potentially harmful elements. Food safety standards for Chinese residents are becoming stricter, and much work in this field needs to be performed. This study examines Co, Ba, Fe, Cr, Mn, Ni, Zn, As, Cd, Pb, Cu, Be, Sb, and Bi concentrations in four regularly consumed Chinese herb species: Radix Paeoniae Alba (RPA), Radix Angelicae Dahuricae (RAD), Rhizoma Atractylodis Macrocephalae (RAM), and Radix Puerariae (RP). A pollution status examination and evaluation of heavy metals in RPA, RAD, RAM, and RP were performed. The human health risk assessment associated with the intake of potentially harmful elements in herbs was calculated in terms of the estimated daily intake (EDI), the target hazard quotient (THQ), the estimated hazard index (HI), and the lifetime cancer risk (CR). The mean single-factor pollution index (PI) showed that in the RPA, RAD, RAM, and RP samples, approximately 10.0%, 10.0%, 30.0%, and 10.0%, respectively, were polluted by Cd. The present study indicated that the pattern of consumption of the studied herbs in China does not seem to suggest an excessive health hazard associated with any of the toxic elements studied.
Keywords	Paeonia ; average daily intake ; food safety ; health effects assessments ; health hazards ; heavy metals ; human health ; pollution ; rhizomes ; risk ; toxicity ; China
Language	English
Dates of publication	2023-01
Size	p. 7345-7357.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-22647-z
Database	NAL-Catalogue (AGRICOLA)

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Article: Treatment and application of stem cells from different sources for cartilage injury: a literature review.

Wang, Pengzhen / Zhang, Shaoheng / Meng, Qingqi / Zhu, Pingping / Yuan, Wei

Annals of translational medicine

2022 Volume 10, Issue 10, Page(s) 610

Abstract: Background and objective: Cartilage defects and degeneration have a major impact on daily mobility and quality of life for millions of people worldwide. As the most effective seed cells for tissue engineering applications in regenerative medicine, ... ...

Abstract	Background and objective: Cartilage defects and degeneration have a major impact on daily mobility and quality of life for millions of people worldwide. As the most effective seed cells for tissue engineering applications in regenerative medicine, mesenchymal stem cells (MSCs) are pluripotent cells with mesoderm and neural crest origin. The combination of biomaterial scaffolds with stem cells and drugs for cartilage damage repair has brought much hope to the medical field. Methods: We searched and compared the literature on cartilage damage repaired by stem cells through PubMed and Web of Science method, this review summarizes the research progress of mesenchymal stem cells from various tissue sources in repairing articular cartilage injury. Key content and findings: We found that peripheral blood, bone marrow, umbilical cord blood, adipose tissue, and umbilical cord are classic stem cell sources. Stem cells can be stimulated by various growth factors, recombinant proteins, or important monomers to generate cartilage in vitro. At the same time, MSCs obtained from various sources can secrete different growth factors to further regulate their own cartilage formation. These stem cells may promote the cartilage damage repair by promoting differentiation and fighting inflammation. Conclusions: This review summarizes and discusses the advantages and disadvantages of the ability of MSCs from different sources to treat cartilage injury, and provides help and identification for the subsequent in-depth research and preclinical application of various MSCs.
Language	English
Publishing date	2022-05-30
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm-22-1715
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