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  1. Article ; Online: Bioinformatics analysis of the pathogenic link between Epstein-Barr virus infection, systemic lupus erythematosus and diffuse large B cell lymphoma.

    Zhu, Qian-Ying

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 6310

    Abstract: Epstein-Barr virus (EBV) is a risk factor for diffuse large B-cell lymphoma (DLBCL) and systemic lupus erythematosus (SLE). While prior research has suggested a potential correlation between SLE and DLBCL, the molecular mechanisms remain unclear. The ... ...

    Abstract Epstein-Barr virus (EBV) is a risk factor for diffuse large B-cell lymphoma (DLBCL) and systemic lupus erythematosus (SLE). While prior research has suggested a potential correlation between SLE and DLBCL, the molecular mechanisms remain unclear. The present study aimed to explore the contribution of EBV infection to the pathogenesis of DLBCL in the individuals with SLE using bioinformatics approaches. The Gene Expression Omnibus database was used to compile the gene expression profiles of EBV-infected B cells (GSE49628), SLE (GSE61635), and DLBCL (GSE32018). Altogether, 72 shared common differentially expressed genes (DEGs) were extracted and enrichment analysis of the shared genes showed that p53 signaling pathway was a common feature of the pathophysiology. Six hub genes were selected using protein-protein interaction (PPI) network analysis, including CDK1, KIF23, NEK2, TOP2A, NEIL3 and DEPDC1, which showed preferable diagnostic values for SLE and DLBCL and involved in immune cell infiltration and immune responses regulation. Finally, TF-gene and miRNA-gene regulatory networks and 10 potential drugs molecule were predicted. Our study revealed the potential molecular mechanisms by which EBV infection contribute to the susceptibility of DLBCL in SLE patients for the first time and identified future biomarkers and therapeutic targets for SLE and DLBCL.
    MeSH term(s) Humans ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/genetics ; Epstein-Barr Virus Infections/diagnosis ; Herpesvirus 4, Human/genetics ; Lymphoma, Large B-Cell, Diffuse/pathology ; Lupus Erythematosus, Systemic/genetics ; Lupus Erythematosus, Systemic/metabolism ; Computational Biology ; NIMA-Related Kinases ; Neoplasm Proteins ; GTPase-Activating Proteins
    Chemical Substances NEK2 protein, human (EC 2.7.11.1) ; NIMA-Related Kinases (EC 2.7.11.1) ; DEPDC1 protein, human ; Neoplasm Proteins ; GTPase-Activating Proteins
    Language English
    Publishing date 2023-04-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-33585-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Deciphering cotton genomic variations for "genes to jeans".

    Zhu, Qian-Hao

    Molecular plant

    2023  Volume 16, Issue 4, Page(s) 654–656

    MeSH term(s) Gossypium/genetics ; Genomics
    Language English
    Publishing date 2023-03-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2393618-6
    ISSN 1752-9867 ; 1674-2052
    ISSN (online) 1752-9867
    ISSN 1674-2052
    DOI 10.1016/j.molp.2023.03.002
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  3. Article: Calculation Method for the Cracking Resistance and Bearing Performance of SFRAC Beams.

    Zhu, Qian / Liu, Jie

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 13

    Abstract: The utilization of recycled aggregate (RCA) in preparing recycled concrete (RAC) is an effective measure to solve the increase in construction waste. Furthermore, applying RAC to flexural members is a viable practice. The addition of steel fiber to RAC ... ...

    Abstract The utilization of recycled aggregate (RCA) in preparing recycled concrete (RAC) is an effective measure to solve the increase in construction waste. Furthermore, applying RAC to flexural members is a viable practice. The addition of steel fiber to RAC to prepare steel fiber recycled concrete (SFRAC) solves the performance deterioration caused by the recycled aggregate, so it is necessary to study the effects of the recycled aggregate replacement rate and fiber-volume ratio on the crack resistance and bending performance of SFRAC beams. In this study, 13 beams were designed and manufactured, with the water-cement ratio, recycled aggregate replacement rate, and fiber-volume ratio as the primary variables, and the cracking moment and ultimate moment of the SFRAC beams were systematically studied. The results show that the cracking and ultimate moments of the SFRAC beams increased with decreases in the water-cement ratio or with increases in the fiber-volume ratio and were unaffected by the replacement rate of recycled aggregates. Based on the experimental results and theoretical analysis, a calculation model and formula for the cracking moment were established. The ultimate bearing capacity of SFRAC beams can be accurately determined using the ACI 318 and ACI 544 standards. The research results serve as a valuable reference for the design of SFRAC beams, effectively address the issue of performance degradation in RAC structural members, and promote the use of green building materials.
    Language English
    Publishing date 2023-07-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16134769
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  4. Article: Clinical Effect of Electroacupuncture on Acute Pancreatitis: Efficacies and Mechanisms.

    Yu, Xianqiang / Zhu, Qian

    Journal of inflammation research

    2023  Volume 16, Page(s) 3197–3203

    Abstract: Acute pancreatitis (AP) is a common acute abdomen and the number one cause of acute digestive hospitalizations in the United States. Abdominal pain is the main clinical manifestation of abdominal symptoms, so reducing the abdominal symptoms caused by ... ...

    Abstract Acute pancreatitis (AP) is a common acute abdomen and the number one cause of acute digestive hospitalizations in the United States. Abdominal pain is the main clinical manifestation of abdominal symptoms, so reducing the abdominal symptoms caused by inflammation is very important to alleviate the pain of patients. Electroacupuncture (EA) as a traditional Chinese medicine (TCM) therapy has significant conditioning effects on various inflammatory diseases including AP. Continuous studies in recent years have shown that EA conditioning has significant effects on reducing inflammation and regulating gastrointestinal symptoms in AP. At the same time, there is sufficient evidence to further elucidate the mechanism of EA. In this review, we will summarize the effect of EA on AP and its mechanism, so as to better serve clinical practice in the treatment of AP in the future.
    Language English
    Publishing date 2023-07-28
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2494878-0
    ISSN 1178-7031
    ISSN 1178-7031
    DOI 10.2147/JIR.S410618
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  5. Article ; Online: A Hidden Markov Random Field Model for Detecting Domain Organizations from Spatial Transcriptomic Data.

    Zhu, Qian

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 1935, Page(s) 251–268

    Abstract: Cells in complex tissues are organized by distinct microenvironments and anatomical structures. This spatial environment of cells is thought to be important for division of labor and other specialized functions of tissues. Recently developed spatial ... ...

    Abstract Cells in complex tissues are organized by distinct microenvironments and anatomical structures. This spatial environment of cells is thought to be important for division of labor and other specialized functions of tissues. Recently developed spatial transcriptomic technologies enable the quantification of expression of hundreds of genes while accounting for cells' spatial coordinates, providing an opportunity to study spatially organized structures. Here, we describe a computational pipeline for detecting the spatial organization of cells based on a hidden Markov random field model. We illustrate this pipeline with data generated from multiplexed smFISH from the adult mouse visual cortex.
    MeSH term(s) Algorithms ; Animals ; Computational Biology ; In Situ Hybridization, Fluorescence/methods ; Markov Chains ; Mice ; Transcriptome/genetics ; Visual Cortex/physiology
    Language English
    Publishing date 2019-02-13
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-9057-3_16
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  6. Article ; Online: Bacterial-derived sialidases inhibit porcine rotavirus OSU replication by interfering with the early steps of infection.

    Huang, Yucheng / Zhu, Qian / Wang, Yongqiang / Zhu, Kui

    Microbial pathogenesis

    2024  Volume 190, Page(s) 106628

    Abstract: Rotavirus infections in suckling and weaning piglets cause severe dehydration and death, resulting in significant economic losses in the pig breeding industry. With the continuous emergence of porcine rotavirus (PoRV) variants and poor vaccine cross- ... ...

    Abstract Rotavirus infections in suckling and weaning piglets cause severe dehydration and death, resulting in significant economic losses in the pig breeding industry. With the continuous emergence of porcine rotavirus (PoRV) variants and poor vaccine cross-protection among various genotypes, there is an urgent need to develop alternative strategies such as seeking effective antiviral products from nature, microbial metabolites and virus-host protein interaction. Sialidases play a crucial role in various physiopathological processes and offer a promising target for developing antivirus drugs. However, the effect of bacterial-derived sialidases on the infection of PoRVs remains largely unknown. Herein, we investigated the impact of bacterial-derived sialidases (sialidase Cp and Vc) on PoRV strain OSU(Group A) infection, using differentiated epithelial monkey kidney cells (MA104) as a model. Our results indicated that the pretreatment of MA104 with exogenous sialidases effectively suppressed PoRV OSU in a concentration-dependent manner. Notably, even at a concentration of 0.01 μU/mL, sialidases significantly inhibited the virus (MOI = 0.01). Meanwhile, we found that sialidase Vc pretreatment sharply reduced the binding rate of PoRV OSU. Last, we demonstrated that PoRV OSU might recognize α-2,3-linked sialic acid as the primary attachment factor in MA104. Our findings provide new insights into the underlying mechanism of PoRV OSU infections, shedding lights on the development of alternative antivirus approaches based on bacteria-virus interaction.
    MeSH term(s) Animals ; Neuraminidase/metabolism ; Neuraminidase/genetics ; Rotavirus/drug effects ; Rotavirus/physiology ; Swine ; Virus Replication/drug effects ; Rotavirus Infections ; Cell Line ; Epithelial Cells/virology ; Epithelial Cells/microbiology ; Virus Attachment/drug effects ; N-Acetylneuraminic Acid/metabolism ; N-Acetylneuraminic Acid/pharmacology ; Antiviral Agents/pharmacology ; Haplorhini ; Swine Diseases/virology ; Swine Diseases/microbiology
    Chemical Substances Neuraminidase (EC 3.2.1.18) ; N-Acetylneuraminic Acid (GZP2782OP0) ; Antiviral Agents
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 632772-2
    ISSN 1096-1208 ; 0882-4010
    ISSN (online) 1096-1208
    ISSN 0882-4010
    DOI 10.1016/j.micpath.2024.106628
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2136: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: The evolutionary landscape and expression pattern of plant lincRNAs.

    Chen, Li / Zhu, Qian-Hao

    RNA biology

    2022  Volume 19, Issue 1, Page(s) 1190–1207

    Abstract: Long intergenic non-coding RNAs (lincRNAs) are important regulators of cellular processes, including development and stress response. Many lincRNAs have been bioinformatically identified in plants, but their evolutionary dynamics and expression ... ...

    Abstract Long intergenic non-coding RNAs (lincRNAs) are important regulators of cellular processes, including development and stress response. Many lincRNAs have been bioinformatically identified in plants, but their evolutionary dynamics and expression characteristics are still elusive. Here, we systematically identified thousands of lincRNAs in 26 plant species, including 6 non-flowering plants, investigated the conservation of the identified lincRNAs in different levels of plant lineages based on sequence and/or synteny homology and explored characteristics of the conserved lincRNAs during plant evolution and their co-expression relationship with protein-coding genes (PCGs). In addition to confirmation of the features well documented in literature for lincRNAs, such as species-specific, fewer exons, tissue-specific expression patterns and less abundantly expressed, we revealed that histone modification signals and/or binding sites of transcription factors were enriched in the conserved lincRNAs, implying their biological functionalities, as demonstrated by identifying conserved lincRNAs related to flower development in both the Brassicaceae and grass families and ancient lincRNAs potentially functioning in meristem development of non-flowering plants. Compared to PCGs, lincRNAs are more likely to be associated with transposable elements (TEs), but with different characteristics in different evolutionary lineages, for instance, the types of TEs and the variable level of association in lincRNAs with different conservativeness. Together, these results provide a comprehensive view on the evolutionary landscape of plant lincRNAs and shed new insights on the conservation and functionality of plant lincRNAs.
    MeSH term(s) Humans ; RNA, Long Noncoding/genetics ; DNA Transposable Elements/genetics ; Brassicaceae/genetics ; Exons
    Chemical Substances RNA, Long Noncoding ; DNA Transposable Elements
    Language English
    Publishing date 2022-11-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2159587-2
    ISSN 1555-8584 ; 1555-8584
    ISSN (online) 1555-8584
    ISSN 1555-8584
    DOI 10.1080/15476286.2022.2144609
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  8. Article ; Online: α

    Yao, Feiqun / Zhu, Qian

    publication RETRACTED

    Disease markers

    2022  Volume 2022, Page(s) 8205707

    Abstract: Objective: This study is aimed at investigating the mechanism of : Methods: Cardiomyocytes were exposed to OGD and then treated with : Results: α: Conclusions: ... ...

    Abstract Objective: This study is aimed at investigating the mechanism of
    Methods: Cardiomyocytes were exposed to OGD and then treated with
    Results: α
    Conclusions: α
    MeSH term(s) Apoptosis Regulatory Proteins/metabolism ; Glucose/metabolism ; Humans ; Inflammation/metabolism ; Myocytes, Cardiac/metabolism ; NF-kappa B/metabolism ; Naphthalenes ; Oxidative Stress ; Oxygen/metabolism ; Oxygen/pharmacology ; Proto-Oncogene Proteins c-akt/metabolism
    Chemical Substances Apoptosis Regulatory Proteins ; NF-kappa B ; Naphthalenes ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Glucose (IY9XDZ35W2) ; Oxygen (S88TT14065) ; alpha-cyperone (ZL24SG1C2D)
    Language English
    Publishing date 2022-08-29
    Publishing country United States
    Document type Journal Article ; Retracted Publication
    ZDB-ID 604951-5
    ISSN 1875-8630 ; 0278-0240
    ISSN (online) 1875-8630
    ISSN 0278-0240
    DOI 10.1155/2022/8205707
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1856: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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    Einzelsignatur: Show issues

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  9. Article ; Online: Physical Graph-Based Spatiotemporal Fusion Approach for Process Fault Diagnosis.

    Zhang, Fengzhen / Jin, Qibing / Li, Dazi / Zhang, Yang / Zhu, Qian

    ACS omega

    2024  Volume 9, Issue 8, Page(s) 9486–9502

    Abstract: The rapid development of big data technology and machine learning has increasingly focused attention on fault diagnosis in complex chemical processes. However, data-driven approaches often overlook the inherent physical correlations within the system and ...

    Abstract The rapid development of big data technology and machine learning has increasingly focused attention on fault diagnosis in complex chemical processes. However, data-driven approaches often overlook the inherent physical correlations within the system and lack a robust mechanism for providing trusted explanations for fault diagnosis. To address this challenge, a graph-based fault diagnosis model framework is proposed along with a dependable fault node diagnosis analysis method. In order to enhance the extraction of chemical process features from a spatial perspective, a graph convolution network (GCN)-based node spatial encoding module is integrated. The construction of the adjacency matrix involves combining a priori knowledge of chemical processes with Pearson correlation, thereby incorporating the physical correlations between nodes. Simultaneously, to capture temporal dependencies in fault data, a spatiotemporal feature fusion module based on the long short-term memory network (LSTM) is employed. In terms of model training, a dual-supervision strategy is adopted to ensure stable convergence of the multiclass fault diagnosis model. For model inference, a multi-model voting strategy is designed to mitigate accuracy degradation resulting from model prediction bias. To tackle the interpretability challenge, a fault diagnosis analysis method based on node masking is designed, effectively identifying critical nodes contributing to system faults. Experimental validation on the Tennessee Eastman process demonstrates the effectiveness of the proposed model, achieving high accuracy in fault diagnosis. The average fault diagnosis rate for all fault types reaches 0.9844, showcasing state-of-the-art performance in fault diagnosis.
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c09122
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  10. Article ; Online: Synthesis of the Reducing-end Hexasaccharide Fragment of Marine Lipopolysaccharide Axinelloside A.

    Zhang, Haoliang / Zeng, Changgen / Zhu, Qian / Zhu, Dapeng / Yu, Biao

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2024  Volume 30, Issue 16, Page(s) e202304180

    Abstract: Chemical synthesis of an orthogonally protected hexasaccharide relevant to the reducing-end half of axinelloside A, a highly sulfated marine lipopolysaccharide, is disclosed. The synthesis features preparation of the scyllo-inositol unit via a Ferrier- ... ...

    Abstract Chemical synthesis of an orthogonally protected hexasaccharide relevant to the reducing-end half of axinelloside A, a highly sulfated marine lipopolysaccharide, is disclosed. The synthesis features preparation of the scyllo-inositol unit via a Ferrier-type-II rearrangement, construction of the 1,2-cis-glycosidic bonds via remote participation, and concise [2+2+2] assembly via Au(I)-catalyzed glycosylation.
    MeSH term(s) Lipopolysaccharides ; Glycosylation ; Glycosides ; Sulfates
    Chemical Substances axinelloside A ; Lipopolysaccharides ; Glycosides ; Sulfates
    Language English
    Publishing date 2024-01-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202304180
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