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Article: Bioinformatics-based identification of miR-542-5p as a predictive biomarker in breast cancer therapy

Zhu, Qiong-Ni / Helen Renaud / Ying Guo

Hereditas. 2018 Dec., v. 155, no. 1

2018

Abstract: BACKGROUND: Tamoxifen is the first-line hormone therapy for estrogen receptor alpha positive (ERα+) breast cancer. However, about 40% of patients with ERα + breast cancer who receive tamoxifen therapy eventually develop resistance resulting in a poor ... ...

Abstract	BACKGROUND: Tamoxifen is the first-line hormone therapy for estrogen receptor alpha positive (ERα+) breast cancer. However, about 40% of patients with ERα + breast cancer who receive tamoxifen therapy eventually develop resistance resulting in a poor prognosis. The aim of this study was to mine available data sets in the Gene Expression Omnibus (GEO) database, including in vitro (cell lines) and in vivo (tissue samples), and to identify all miRNAs associated with tamoxifen resistance (TamR) in breast cancer. Secondly, this study aimed to predict the key gene regulatory networks of newly found TamR-related miRNAs and evaluate the potential role of the miRNAs and targets as potential prognosis biomarkers for breast cancer patients. RESULT: Microarray data sets from two different studies were used from the GEO database: 1. GSE66607: miRNA of MCF-7 TamR cells; 2. GSE37405: TamR tissues. Differentially expressed microRNAs (miRNAs) were identified in both data sets and 5 differentially expressed miRNAs were found to overlap between the two data sets. Profiles of GSE37405 and data from the Kaplan-Meier Plotter Database (KMPD) along with Gene Expression Profiling Interactive Analysis (GEPIA) were used to reveal the relationship between these 5 miRNAs and overall survival. The results showed that has-miR-542-5p was the only miRNA associated with overall survival of ERα + breast cancer patients who received adjuvant tamoxifen. Targets of has-miR-542-5p were predicted by miRanda and TargetScan, and the mRNA expression of the three 3 target gene, Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta (YWHAB), Lymphocyte Antigen 9 (LY9), and Secreted Frizzled Related Protein 1 (SFRP1) were associated with overall survival in 2 different databases. Copy-number alterations (CNAs) of SFRP1 confer survival disadvantage to breast cancer patients and alter the mRNA expression of SFRP1 in cBioPortal database. CONCLUSION: This study indicates that miRNA has-miR-542-5p is associated with TamR and can predict prognosis of breast cancer patients. Furthermore, has-miR-542-5p may be acting through a mechanism involving the target genes YWHAB, LY9, and SFRP1. Overall, has-miR-542-5p is a predictive biomarker and potential target for therapy of breast cancer patients.
Keywords	adjuvants ; biomarkers ; breast neoplasms ; cell lines ; data collection ; databases ; estrogen receptors ; gene expression ; gene expression regulation ; gene regulatory networks ; hormone replacement therapy ; messenger RNA ; microRNA ; microarray technology ; patients ; prognosis ; tamoxifen
Language	English
Dates of publication	2018-12
Size	p. 17.
Publishing place	BioMed Central
Document type	Article
ZDB-ID	214294-6
ISSN	1601-5223 ; 0018-0661
ISSN (online)	1601-5223
ISSN	0018-0661
DOI	10.1186/s41065-018-0055-7
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Bioinformatics-based identification of miR-542-5p as a predictive biomarker in breast cancer therapy.

Zhu, Qiong-Ni / Renaud, Helen / Guo, Ying

Hereditas

2018 Volume 155, Page(s) 17

Abstract: Background: Tamoxifen is the first-line hormone therapy for estrogen receptor alpha positive (ERα+) breast cancer. However, about 40% of patients with ERα + breast cancer who receive tamoxifen therapy eventually develop resistance resulting in a poor ... ...

Abstract	Background: Tamoxifen is the first-line hormone therapy for estrogen receptor alpha positive (ERα+) breast cancer. However, about 40% of patients with ERα + breast cancer who receive tamoxifen therapy eventually develop resistance resulting in a poor prognosis. The aim of this study was to mine available data sets in the Gene Expression Omnibus (GEO) database, including in vitro (cell lines) and in vivo (tissue samples), and to identify all miRNAs associated with tamoxifen resistance (TamR) in breast cancer. Secondly, this study aimed to predict the key gene regulatory networks of newly found TamR-related miRNAs and evaluate the potential role of the miRNAs and targets as potential prognosis biomarkers for breast cancer patients. Result: Microarray data sets from two different studies were used from the GEO database: 1. GSE66607: miRNA of MCF-7 TamR cells; 2. GSE37405: TamR tissues. Differentially expressed microRNAs (miRNAs) were identified in both data sets and 5 differentially expressed miRNAs were found to overlap between the two data sets. Profiles of GSE37405 and data from the Kaplan-Meier Plotter Database (KMPD) along with Gene Expression Profiling Interactive Analysis (GEPIA) were used to reveal the relationship between these 5 miRNAs and overall survival. The results showed that has-miR-542-5p was the only miRNA associated with overall survival of ERα + breast cancer patients who received adjuvant tamoxifen. Targets of has-miR-542-5p were predicted by miRanda and TargetScan, and the mRNA expression of the three 3 target gene, Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta (YWHAB), Lymphocyte Antigen 9 (LY9), and Secreted Frizzled Related Protein 1 (SFRP1) were associated with overall survival in 2 different databases. Copy-number alterations (CNAs) of SFRP1 confer survival disadvantage to breast cancer patients and alter the mRNA expression of SFRP1 in cBioPortal database. Conclusion: This study indicates that miRNA has-miR-542-5p is associated with TamR and can predict prognosis of breast cancer patients. Furthermore, has-miR-542-5p may be acting through a mechanism involving the target genes YWHAB, LY9, and SFRP1. Overall, has-miR-542-5p is a predictive biomarker and potential target for therapy of breast cancer patients.
MeSH term(s)	Biomarkers ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Computational Biology ; Drug Resistance, Neoplasm/genetics ; Female ; Gene Expression Profiling ; Humans ; MCF-7 Cells ; MicroRNAs/genetics ; Oligonucleotide Array Sequence Analysis ; Tamoxifen/therapeutic use
Chemical Substances	Biomarkers ; MIRN542 microRNA, human ; MicroRNAs ; Tamoxifen (094ZI81Y45)
Language	English
Publishing date	2018-01-15
Publishing country	England
Document type	Journal Article
ZDB-ID	214294-6
ISSN	1601-5223 ; 0018-0661
ISSN (online)	1601-5223
ISSN	0018-0661
DOI	10.1186/s41065-018-0055-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: MALAT1: a potential biomarker in cancer.

Li, Zhi-Xing / Zhu, Qiong-Ni / Zhang, Hai-Bo / Hu, Yang / Wang, Guo / Zhu, Yuan-Shan

Cancer management and research

2018 Volume 10, Page(s) 6757–6768

Abstract: Purpose: The research of long non-coding RNAs (lncRNAs) has become a new passion with the discovery of abundant new lncRNAs and extensive investigation of their roles in various diseases, especially in cancers. Metastasis associated in lung ... ...

Abstract	Purpose: The research of long non-coding RNAs (lncRNAs) has become a new passion with the discovery of abundant new lncRNAs and extensive investigation of their roles in various diseases, especially in cancers. Metastasis associated in lung adenocarcinoma transcript 1 (MALAT1) emerges as a hotspot, which has been reported to be involved in dysregulation of cell signaling and closely correlated with cancer development, progression, and response to therapy. This review is a brief update of the current knowledge related to the role of MALAT1 in cancer-associated molecular pathways and pathophysiology and possible determinants for MALAT1 to function as a biomarker, aiming to stimulate the basic investigation of lncRNA MALAT1 as well as its translation to clinical applications. Methods: We have selected vast literature from electronic databases including studies associated with its clinical significance and the pivotal functions in cancer processes such as cell proliferation, apoptosis, metastasis, immunity, angiogenesis, and drug resistance. Results: Studies have shown that aberrant expression of MALAT1 is related to cancer pathophysiology with the potential to be translated clinically and MALAT1 can regulate cancer processes by interacting with molecules, such as proteins, RNAs and DNAs, and further altering different signal pathways. Conclusion: MALAT1 lncRNA promises to be a potential biomarker for cancer diagnosis as well as prognosis. Additionally, it might be a therapeutic target for human cancers.
Language	English
Publishing date	2018-12-06
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2508013-1
ISSN	1179-1322
ISSN	1179-1322
DOI	10.2147/CMAR.S169406
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Article: Emerging role of long non-coding RNAs in cisplatin resistance.

Hu, Yang / Zhu, Qiong-Ni / Deng, Jun-Li / Li, Zhi-Xing / Wang, Guo / Zhu, Yuan-Shan

OncoTargets and therapy

2018 Volume 11, Page(s) 3185–3194

Abstract: Cisplatin (CDDP) is one of the most commonly used chemotherapy drugs for the treatment of various cancers. Although platinum-based therapies are highly efficacious against rapidly proliferating malignant tumors, the development of CDDP resistance results ...

Abstract	Cisplatin (CDDP) is one of the most commonly used chemotherapy drugs for the treatment of various cancers. Although platinum-based therapies are highly efficacious against rapidly proliferating malignant tumors, the development of CDDP resistance results in significant relapse as well as decreased overall survival rates, which is a significant obstacle in CDDP-based cancer therapy. Long non-coding RNAs (lncRNAs) are involved in cancer development and progression by the regulation of processes related to chromatin remodeling, transcription, and posttranscriptional processing. Emerging evidence has recently highlighted the roles of lncRNAs in the development of CDDP resistance. In this review, we discuss the roles and mechanisms of lncRNAs in CDDP chemoresistance, including changes in cellular uptake or efflux of a drug, intracellular detoxification, DNA repair, apoptosis, autophagy, cell stemness, and the related signaling pathways, aiming to provide potential lncRNA-targeted strategies for overcoming drug resistance in cancer therapy.
Language	English
Publishing date	2018-05-28
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2495130-4
ISSN	1178-6930
ISSN	1178-6930
DOI	10.2147/OTT.S158104
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Article: Ontogeny, aging, and gender-related changes in hepatic multidrug resistant protein genes in rats

Zhu, Qiong-Ni / Jie Liu / Shang-Fu Xu / Wei-Yu Hou / Yuan-Fu Lu

Life sciences. 2017 Feb. 01, v. 170

2017

Abstract: Multidrug resistance proteins (Mrps) are efflux transporters playing important roles in endogenous substances and xenobiotics transport out of the liver. Children, elderly, gender and physio-pathological conditions could influence their expression and ... ...

Abstract	Multidrug resistance proteins (Mrps) are efflux transporters playing important roles in endogenous substances and xenobiotics transport out of the liver. Children, elderly, gender and physio-pathological conditions could influence their expression and result in changes in drug disposition.This study was aimed to examine the development-, aging-, and sex-dependent changes in Mrp1â4 and ATP-binding cassette sub-family G member 2 (Abcg2) gene expressions in livers of rats.The livers from male and female SD rats at development (â2, 1,7,14,21,28,35, and 60d) and aging (28, 60, 180 and 540d) were collected and total RNA was isolated, purified and subjected to real-time RT-PCR analysis.Results showed that expression of Mrp1 was low, while Abcg2 and Mrp2 were the high in the liver. Mrp1 expression decreased with maturity but remained constant to 540d, while Mrp3 and 4 increased with liver development, reached the peak with maturity at 35â60days of age, and slightly reduced with aging. Mrp2 and Abcg2 were high at 7days of age and maintained at relative high levels till maturity, while Abcg2 was reduced during aging. Females had higher Mrp3 and Abcg2 mRNA expression than male rats, while male rats had higher Mrp2 and Mrp4 mRNA expression.The expression of hepatic Mrp1â4 and Abcg2 mRNA during development, aging in male and female rats was characterized, which could be fundamental to our understanding of age- and sex-associated variations in drug disposition in children, elderly, and women.
Keywords	ABC transporters ; children ; drugs ; elderly ; females ; gene expression ; genes ; liver ; males ; messenger RNA ; multiple drug resistance ; ontogeny ; quantitative polymerase chain reaction ; rats ; reverse transcriptase polymerase chain reaction ; women ; xenobiotics
Language	English
Dates of publication	2017-0201
Size	p. 108-114.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2016.11.022
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Ontogeny, aging, and gender-related changes in hepatic multidrug resistant protein genes in rats.

Zhu, Qiong-Ni / Hou, Wei-Yu / Xu, Shang-Fu / Lu, Yuan-Fu / Liu, Jie

Life sciences

2017 Volume 170, Page(s) 108–114

Abstract	Multidrug resistance proteins (Mrps) are efflux transporters playing important roles in endogenous substances and xenobiotics transport out of the liver. Children, elderly, gender and physio-pathological conditions could influence their expression and result in changes in drug disposition. Aim: This study was aimed to examine the development-, aging-, and sex-dependent changes in Mrp1-4 and ATP-binding cassette sub-family G member 2 (Abcg2) gene expressions in livers of rats. Main methods: The livers from male and female SD rats at development (-2, 1,7,14,21,28,35, and 60d) and aging (28, 60, 180 and 540d) were collected and total RNA was isolated, purified and subjected to real-time RT-PCR analysis. Key findings: Results showed that expression of Mrp1 was low, while Abcg2 and Mrp2 were the high in the liver. Mrp1 expression decreased with maturity but remained constant to 540d, while Mrp3 and 4 increased with liver development, reached the peak with maturity at 35-60days of age, and slightly reduced with aging. Mrp2 and Abcg2 were high at 7days of age and maintained at relative high levels till maturity, while Abcg2 was reduced during aging. Females had higher Mrp3 and Abcg2 mRNA expression than male rats, while male rats had higher Mrp2 and Mrp4 mRNA expression. Significance: The expression of hepatic Mrp1-4 and Abcg2 mRNA during development, aging in male and female rats was characterized, which could be fundamental to our understanding of age- and sex-associated variations in drug disposition in children, elderly, and women.
MeSH term(s)	ATP Binding Cassette Transporter, Sub-Family G, Member 2/metabolism ; ATP-Binding Cassette Transporters/metabolism ; Aging ; Animals ; Female ; Gene Expression Regulation ; Liver/metabolism ; Male ; Multidrug Resistance-Associated Proteins/metabolism ; Rats ; Rats, Sprague-Dawley ; Real-Time Polymerase Chain Reaction ; Xenobiotics
Chemical Substances	ATP Binding Cassette Transporter, Sub-Family G, Member 2 ; Abcc2 protein, rat ; Abcc4 protein, rat ; Abcg2 protein, rat ; Multidrug Resistance-Associated Proteins ; Xenobiotics ; multidrug resistance-associated protein 3 (1YV0492L5Z) ; multidrug resistance-associated protein 1 (Y49M64GZ4Q)
Language	English
Publishing date	2017-02-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2016.11.022
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: LncRNA H19 is a major mediator of doxorubicin chemoresistance in breast cancer cells through a cullin4A-MDR1 pathway.

Zhu, Qiong-Ni / Wang, Guo / Guo, Ying / Peng, Yan / Zhang, Rui / Deng, Jun-Li / Li, Zhi-Xing / Zhu, Yuan-Shan

Oncotarget

2017 Volume 8, Issue 54, Page(s) 91990–92003

Abstract: Development of chemoresistance is a persistent problem during cancer treatment. Long non-coding RNAs (LncRNAs) are currently emerging as an integral functional component of the human genome and as critical regulators of cancer development and progression. ...

Abstract	Development of chemoresistance is a persistent problem during cancer treatment. Long non-coding RNAs (LncRNAs) are currently emerging as an integral functional component of the human genome and as critical regulators of cancer development and progression. In the present study, we investigated the role and molecular mechanism of H19 lncRNA in chemoresistance development by using doxorubicin (Dox) resistance in breast cancer cells as a model system.
Language	English
Publishing date	2017-11-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.21121
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Article: Rutaecarpine effects on expression of hepatic phase-1, phase-2 metabolism and transporter genes as a basis of herb–drug interactions

Zhu, Qiong-Ni / Zhang, Dan / Jin, Tao / Wu, Qin / Liu, Jie / Lu, Yuan-Fu

Journal of ethnopharmacology. 2013 May 2, v. 147, no. 1

2013

Abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Rutaecarpine is an alkaloid of Evodia rutaecarpa which is traditionally used to treat human diseases. Rutaecarpine has been used in combination with other drugs in the treatment of disorders and found to produce herb–drug ... ...

Abstract	ETHNOPHARMACOLOGICAL RELEVANCE: Rutaecarpine is an alkaloid of Evodia rutaecarpa which is traditionally used to treat human diseases. Rutaecarpine has been used in combination with other drugs in the treatment of disorders and found to produce herb–drug interactions. The basis of these herb–drug interactions is not completely understood. AIM OF STUDY: To examine the effects of rutaecarpine on the expression of drug processing genes, including Phase-1 (P450 enzyme genes), Phase-2 (glucuronidation and sulfation genes) and Phase-3 (drug transporters) in liver of mice. MATERIALS AND METHODS: Mice were orally administered rutaecarpine at the doses of 10, 20, and 30mg/kg for consecutive 7 days. Twenty-four hours after the last dose, blood and liver were collected. Total RNA was isolated, purified, and subjected to real-time RT-PCR analysis of genes of interest. RESULTS: Rutaecarpine administration induced Cyp1a2, 2b10 and 2e1 as previously reported. Cyp3a11 and Cyp4a10 were also induced. For phase-2 enzyme genes, rutaecarpine increased glucuronyltransferases (Ugt1a1 and Ugt1a6), but had no effects on sulfotransferase (Sult1a1 and Sult1b1). Most interestingly, rutaecarpine increased hepatic uptake of organic anion transporting peptides (Oatp1a1, Oayp1a4, Oatp1b2, and Oatp2b1) and induced efflux transporter such as multidrug resistance-associated proteins (Mrp1, Mrp2, Mrp3, and Mrp4), especially at the doses of 20mg/kg and above. CONCLUSION: The interactions of rutaecarpine with drugs involve not only the induction of cytochrome P450 enzyme genes, but also the induction of hepatic transporters and phase-2 enzyme genes. The effects of rutaecarpine on these drug processing genes could play integrated roles in producing herb–drug interactions.
Keywords	Euodia ; RNA ; blood ; cytochrome P-450 ; drugs ; genes ; human diseases ; liver ; metabolism ; mice ; oral administration ; transporters
Language	English
Dates of publication	2013-0502
Size	p. 215-219.
Publishing place	Elsevier Ireland Ltd
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2013.03.005
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Rutaecarpine effects on expression of hepatic phase-1, phase-2 metabolism and transporter genes as a basis of herb-drug interactions.

Zhu, Qiong-Ni / Zhang, Dan / Jin, Tao / Wu, Qin / Liu, Jie / Lu, Yuan-Fu

Journal of ethnopharmacology

2013 Volume 147, Issue 1, Page(s) 215–219

Abstract: Ethnopharmacological relevance: Rutaecarpine is an alkaloid of Evodia rutaecarpa which is traditionally used to treat human diseases. Rutaecarpine has been used in combination with other drugs in the treatment of disorders and found to produce herb-drug ...

Abstract	Ethnopharmacological relevance: Rutaecarpine is an alkaloid of Evodia rutaecarpa which is traditionally used to treat human diseases. Rutaecarpine has been used in combination with other drugs in the treatment of disorders and found to produce herb-drug interactions. The basis of these herb-drug interactions is not completely understood. Aim of study: To examine the effects of rutaecarpine on the expression of drug processing genes, including Phase-1 (P450 enzyme genes), Phase-2 (glucuronidation and sulfation genes) and Phase-3 (drug transporters) in liver of mice. Materials and methods: Mice were orally administered rutaecarpine at the doses of 10, 20, and 30 mg/kg for consecutive 7 days. Twenty-four hours after the last dose, blood and liver were collected. Total RNA was isolated, purified, and subjected to real-time RT-PCR analysis of genes of interest. Results: Rutaecarpine administration induced Cyp1a2, 2b10 and 2e1 as previously reported. Cyp3a11 and Cyp4a10 were also induced. For phase-2 enzyme genes, rutaecarpine increased glucuronyltransferases (Ugt1a1 and Ugt1a6), but had no effects on sulfotransferase (Sult1a1 and Sult1b1). Most interestingly, rutaecarpine increased hepatic uptake of organic anion transporting peptides (Oatp1a1, Oayp1a4, Oatp1b2, and Oatp2b1) and induced efflux transporter such as multidrug resistance-associated proteins (Mrp1, Mrp2, Mrp3, and Mrp4), especially at the doses of 20mg/kg and above. Conclusion: The interactions of rutaecarpine with drugs involve not only the induction of cytochrome P450 enzyme genes, but also the induction of hepatic transporters and phase-2 enzyme genes. The effects of rutaecarpine on these drug processing genes could play integrated roles in producing herb-drug interactions.
MeSH term(s)	Administration, Oral ; Animals ; Cytochrome P-450 Enzyme System/biosynthesis ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Enzyme Induction ; Glucuronosyltransferase/biosynthesis ; Glucuronosyltransferase/genetics ; Glucuronosyltransferase/metabolism ; Herb-Drug Interactions ; Indole Alkaloids/administration & dosage ; Indole Alkaloids/pharmacology ; Liver/drug effects ; Liver/enzymology ; Male ; Membrane Transport Proteins/drug effects ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism ; Metabolic Detoxication, Phase I ; Metabolic Detoxication, Phase II ; Mice ; Plant Extracts/administration & dosage ; Plant Extracts/pharmacology ; Quinazolines/administration & dosage ; Quinazolines/pharmacology ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; Substrate Specificity ; Sulfotransferases/genetics ; Sulfotransferases/metabolism ; Up-Regulation
Chemical Substances	Indole Alkaloids ; Membrane Transport Proteins ; Plant Extracts ; Quinazolines ; rutecarpine (8XZV289PRY) ; Cytochrome P-450 Enzyme System (9035-51-2) ; Glucuronosyltransferase (EC 2.4.1.17) ; Sulfotransferases (EC 2.8.2.-)
Language	English
Publishing date	2013-05-02
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2013.03.005
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Article: [Distinct effect of Wansheng Huafeng Dan containing ardisia crenata on renal transporters, mercury accumulation and Kim-1 expression from mercuric chloride].

Zhu, Qiong-Ni / Lu, Yuan-Fu / Shi, Jing-Zhen / Wu, Qin / Zhang, Feng / Shi, Jing-Shan / Liu, Jie

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2014 Volume 39, Issue 10, Page(s) 1892–1896

Abstract: To study the effect of Wansheng Huafeng Dan (WSHFD) and mercuric chloride on renal mercury (Hg) extraction transporters (Oat1, Oct2), renal mercury excretion transporters (Mrp4, Mate2K), renal mercury accumulation and kidney injury molecule-1 (Kim-1). ... ...

Abstract	To study the effect of Wansheng Huafeng Dan (WSHFD) and mercuric chloride on renal mercury (Hg) extraction transporters (Oat1, Oct2), renal mercury excretion transporters (Mrp4, Mate2K), renal mercury accumulation and kidney injury molecule-1 (Kim-1). The ancient prescription of WSHFD containing 10-fold Hg caused much lower renal mercury accumulation and renal toxicity than HgCl2 in rats, with less effect on renal transporters than HgCl2. The above indicators had no significant difference in WSHFDO, WSHFD2 and WSHFD3 groups, indicating no effect of WSHFD with reduced or no cinnabar.
MeSH term(s)	Animals ; Ardisia/chemistry ; Biological Transport/drug effects ; Cell Adhesion Molecules/genetics ; Cell Adhesion Molecules/metabolism ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/adverse effects ; Gene Expression/drug effects ; Kidney/drug effects ; Kidney/metabolism ; Male ; Mercuric Chloride/metabolism ; Multidrug Resistance-Associated Proteins/genetics ; Multidrug Resistance-Associated Proteins/metabolism ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Abcc4 protein, rat ; Cell Adhesion Molecules ; Drugs, Chinese Herbal ; Havcr1protein, rat ; Multidrug Resistance-Associated Proteins ; Mercuric Chloride (53GH7MZT1R)
Language	Chinese
Publishing date	2014-05
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
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