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Article: Study on Acoustic Emission Characteristics of Fatigue Damage of A7N01 Aluminum Alloy for High-Speed Trains.

Zhu, Ronghua / Fang, Song / Sun, Weibing / Chi, Dazhao

2023 Volume 16, Issue 12

Abstract: Online monitoring of the fatigue damage process of A7N01 aluminum alloy base metal and weld seam was conducted based on acoustic emission (AE) and digital microscopic imaging technology. The AE signals were recorded during the fatigue tests and analyzed ... ...

Abstract	Online monitoring of the fatigue damage process of A7N01 aluminum alloy base metal and weld seam was conducted based on acoustic emission (AE) and digital microscopic imaging technology. The AE signals were recorded during the fatigue tests and analyzed using the AE characteristic parameter method. Fatigue fracture was observed using scanning electron microscopy (SEM) to analyze the source mechanism of AE. The AE results show that the AE count and rise time can effectively predict the initiation of fatigue microcracks in A7N01 aluminum alloy. The digital image monitoring results of a notch tip verified the prediction of fatigue microcracks using the AE characteristic parameters. In addition, the AE characteristics of the A7N01 aluminum alloy under different fatigue parameters were studied, and the relationships between the AE characteristic values of the base metal and weld seam and the crack propagation rate were calculated using the seven-point recurrence polynomial method. These provide a basis for predicting the remaining fatigue damage in the A7N01 aluminum alloy. The present work indicates that AE technology can be used to monitor the fatigue damage evolution of welded aluminum alloy structures.
Language	English
Publishing date	2023-06-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16124362
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Article ; Online: CEUS in prediction of early recurrence of hepatocellular carcinoma after curative resection and to stratify the risk of early recurrence: a retrospective observational study.

Huang, Zhe / Zhu, Rong-Hua / Li, Shan-Shan / Luo, Hong-Chang / Li, Kai-Yan

Abdominal radiology (New York)

2024

Abstract: Purpose: Early recurrence (ER) after surgery is related to early death in patients with hepatocellular carcinoma (HCC) after radical resection. To explore the role of preoperative contrast-enhanced ultrasound (CEUS) in predicting ER of HCC after ... ...

Abstract	Purpose: Early recurrence (ER) after surgery is related to early death in patients with hepatocellular carcinoma (HCC) after radical resection. To explore the role of preoperative contrast-enhanced ultrasound (CEUS) in predicting ER of HCC after curative resection and to stratify the risk of ER. Materials and methods: This study evaluated consecutive 556 patients with HCC who were examined by CEUS during the 2 weeks before curative resection between January 2011 and December 2018. ER was defined as intrahepatic and/or extrahepatic recurrence within 2 year after resection of HCC. Univariate and logistic regression analyses were performed to identify independent risk factors for ER after surgical resection of HCC. Recurrence-free time (RFS) rates were analyzed and compared by log-rank test. Results: ER occurred in 307 (55.2%) of the 556 patients. Univariate and multivariate analyses revealed that a tumor size ≥ 30 mm and satellite nodules seen on CEUS, DL(deep learning) radiomics reoccurrence score based on the frame of image with the maximum intensity of CEUS and an elevated alpha-fetoprotein level were significantly associated with ER (P < .05). Based on the number of predictors present, patients with CEUS LR-5 HCC were stratified into three risk subgroups: risk group 3 (high-risk patients, 4 predictors), risk group 2 (medium-risk patients, 2-3 predictors), and risk group 1 (low-risk patients, 0-1 predictor). The 2-year RFS rate was 19.4% in risk group 3, 40.9% in risk group 2, and 48.1% in risk group 1; the corresponding mean RFS times were 14.0 ± 2.9 months, 43.7 ± 6.6 months, and 55.5 ± 2.8 months, respectively (P < .001). Conclusions: Tumor size ≥ 30 mm and satellite nodules seen on CEUS, DL radiomics reoccurrence score based on the frame of image with the maximum intensity of CEUS and an elevated alpha-fetoprotein level can predict ER of HCC.
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2839786-1
ISSN	2366-0058 ; 2366-004X
ISSN (online)	2366-0058
ISSN	2366-004X
DOI	10.1007/s00261-024-04252-5
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Zs.A 1262: Show issues

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Article: Antarctic Snow Failure Mechanics: Analysis, Simulations, and Applications.

Xiao, Enzhao / Li, Shengquan / Matin Nazar, Ali / Zhu, Ronghua / Wang, Yihe

Materials (Basel, Switzerland)

2024 Volume 17, Issue 7

Abstract: Snow failure is the process by which the stability of snow or snow-covered slopes is destroyed, resulting in the collapse or release of snow. Heavy snowfall, low temperatures, and volatile weather typically cause consequences in Antarctica, which can ... ...

Abstract	Snow failure is the process by which the stability of snow or snow-covered slopes is destroyed, resulting in the collapse or release of snow. Heavy snowfall, low temperatures, and volatile weather typically cause consequences in Antarctica, which can occur at different scales, from small, localized collapses to massive avalanches, and result in significant risk to human activities and infrastructures. Understanding snow damage is critical to assessing potential hazards associated with snow-covered terrain and implementing effective risk mitigation strategies. This review discusses the theoretical models and numerical simulation methods commonly used in Antarctic snow failure research. We focus on the various theoretical models proposed in the literature, including the fiber bundle model (FBM), discrete element model (DEM), cellular automata (CA) model, and continuous cavity-expansion penetration (CCEP) model. In addition, we overview some methods to acquire the three-dimensional solid models and the related advantages and disadvantages. Then, we discuss some critical numerical techniques used to simulate the snow failure process, such as the finite element method (FEM) and three-dimensional (3D) material point method (MPM), highlighting their features in capturing the complex behavior of snow failure. Eventually, different case studies and the experimental validation of these models and simulation methods in the context of Antarctic snow failure are presented, as well as the application of snow failure research to facility construction. This review provides a comprehensive analysis of snow properties, essential numerical simulation methods, and related applications to enhance our understanding of Antarctic snow failure, which offer valuable resources for designing and managing potential infrastructure in Antarctica.
Language	English
Publishing date	2024-03-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma17071490
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Article ; Online: Solitary Fibrous Tumor of the Prostate Shown on FAPI PET/CT.

Yang, Tianshuo / Zhu, Ronghua / Guo, Zhongying / Niu, Xiaobing / Tao, Weijing

Clinical nuclear medicine

2023 Volume 48, Issue 6, Page(s) 530–531

Abstract: Abstract: Solitary fibrous tumors are fibroblast tumors that occur mainly in the peritoneum, extremities, and pleura. Here, we report the MRI, FDG PET/CT, and FAPI PET/CT findings of a rare prostate solitary fibrous tumor. A 57-year-old man was ... ...

Abstract	Abstract: Solitary fibrous tumors are fibroblast tumors that occur mainly in the peritoneum, extremities, and pleura. Here, we report the MRI, FDG PET/CT, and FAPI PET/CT findings of a rare prostate solitary fibrous tumor. A 57-year-old man was pathologically diagnosed with a solitary fibrous tumor. To detect any systemic metastases or other primary lesions, the patient underwent FDG PET/CT and FAPI PET/CT examination sequentially. Mild FDG uptake was observed in the primary prostatic lesion, but there was a significant uptake of FAPI in the prostate. This case highlighted that FAPI PET/CT may outperform FDG PET/CT in identifying solitary fibrous tumors.
MeSH term(s)	Male ; Humans ; Middle Aged ; Positron Emission Tomography Computed Tomography ; Prostate ; Fluorodeoxyglucose F18 ; Solitary Fibrous Tumors/diagnostic imaging ; Hemangiopericytoma ; Gallium Radioisotopes
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Gallium Radioisotopes
Language	English
Publishing date	2023-03-26
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000004635
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Zs.A 1276: Show issues

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Article ; Online: Preparation of BSA-coated Au Nanoparticles Contrast Agent and Its Application in PETCT Imaging.

Wei, Jing / Li, Pingwei / Zhang, Huai / Zhu, Ronghua

Cellular and molecular biology (Noisy-le-Grand, France)

2022 Volume 68, Issue 3, Page(s) 158–170

Abstract: Tumors are the biggest opponents in the history of human diseases, and they cannot be eliminated so far. The only way to treat tumors is to detect them early so that the survival rate can be improved by early treatment. For tumor detection, CT scan is ... ...

Abstract	Tumors are the biggest opponents in the history of human diseases, and they cannot be eliminated so far. The only way to treat tumors is to detect them early so that the survival rate can be improved by early treatment. For tumor detection, CT scan is the most commonly used, and PET/CT is an enhanced version of CT technology. Although PET/CT can produce relatively clear images of the human body, due to the complex structure of the human body, there are many ghosts and shadows, and the images cannot be accurately judged. Therefore, this paper aims to prepare high-definition nanoparticle contrast agents, hoping to make PET/CT images clearer and easier to distinguish. In this paper, the advantages of gold nanoparticles are fully analyzed for the preparation of contrast agents, and a gold nano-contrast agent coated with bovine serum albumin (BSA) is proposed. Gold nanoparticles (GNRs) were prepared by the traditional induction method and their properties were analyzed. Finally, taking mice as the experimental object, a comparative experiment was carried out, and the toxicological and optical properties were analyzed. The experimental results show that the adsorption performance of the BSA-coated gold nanoparticles prepared in this paper is more than 90% at different temperatures. And through the comparison experiment, the contrast agent prepared in this paper has an increased signal-to-noise(StN) ratio change rate of more than 50%, which can be well applied to PET/CT imaging.
MeSH term(s)	Animals ; Contrast Media ; Gold/chemistry ; Humans ; Metal Nanoparticles ; Mice ; Nanoparticles/chemistry ; Neoplasms ; Positron Emission Tomography Computed Tomography ; Serum Albumin, Bovine/chemistry
Chemical Substances	Contrast Media ; Serum Albumin, Bovine (27432CM55Q) ; Gold (7440-57-5)
Language	English
Publishing date	2022-03-31
Publishing country	France
Document type	Journal Article
ZDB-ID	1161779-2
ISSN	1165-158X ; 0145-5680
ISSN (online)	1165-158X
ISSN	0145-5680
DOI	10.14715/cmb/2022.68.3.19
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Zs.A 3812: Show issues

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Article ; Online: HCC treated with immune checkpoint inhibitors: a hyper-enhanced rim on Sonazoid-CEUS Kupffer phase images is a predictor of tumor response.

Huang, Zhe / Zhu, Rong-Hua / Xin, Jun-Yi / Li, Kai-Yan

European radiology

2022 Volume 33, Issue 6, Page(s) 4389–4400

Abstract: Objectives: We aimed to evaluate the efficacy of anti-programmed cell death 1 (PD-1)/programmed death-ligand 1 (PD-L1) antibody therapy by assessing the hyper-enhanced rim phenomenon of hepatocellular carcinoma (HCC) on Sonazoid-contrast-enhanced ... ...

Abstract	Objectives: We aimed to evaluate the efficacy of anti-programmed cell death 1 (PD-1)/programmed death-ligand 1 (PD-L1) antibody therapy by assessing the hyper-enhanced rim phenomenon of hepatocellular carcinoma (HCC) on Sonazoid-contrast-enhanced ultrasound (CEUS) Kupffer phase images. Methods: This retrospective study included 61 patients with HCC who received anti-PD-1/PD-L1 antibody therapy from August 1, 2020, to January 31, 2022. We compared the progression-free survival (PFS) of patients with hyper-enhanced rim+ and hyper-enhanced rim-nodules and the time to nodule progression (TTnP) of hyper-enhanced rim+ and hyper-enhanced rim- nodules. Results: Thirty-nine patients received postoperative therapy, and 22 patients had unresectable HCC. The mean PFS was 11.8 months (95% confidence interval [CI]: 8.7-14.9) for patients with hyper-enhanced rim+ HCC nodules and 16.5 months (95% CI: 14.9-18.1) for patients with hyper-enhanced rim- HCC nodules in the surgery group (p = 0.017). The mean PFS was 9.2 months (95% CI: 3.6-14.8) for patients with hyper-enhanced rim+ HCC nodules and 17.8 months (95% CI: 14.9-20.6) for patients with hyper-enhanced rim- HCC nodules in the non-surgery group (p = 0.015). For hyper-enhanced rim+ HCC nodules, TTnP for each nodule exceeding the specified threshold was 10.1 months, whereas that for hyper-enhanced rim- HCC nodules was 17.6 months (p = 0 .018). The disease control rate was 42.9% (3/7) for hyper-enhanced rim+ HCC nodules and 85.7% (21/24) for hyper-enhanced rim- HCC nodules (p = 0.013). Conclusions: The presence of hyper-enhanced rim on the Kupffer phase images obtained via the non-invasive Sonazoid-CEUS is a promising imaging biomarker for predicting unfavorable response with anti-PD-1/PD-L1 therapy in patients with HCC. Key points: • The mean progression-free survival was 11.8 months for patients with hyper-enhanced rim+ HCC nodules and 16.5 months for patients with hyper-enhanced rim- HCC nodules in the surgery group. • The mean progression-free survival was 9.2 months for patients with hyper-enhanced rim+ HCC nodules and 17.8 months for patients with hyper-enhanced rim- HCC nodules in the non-surgery group. • The disease control rate was 42.9% for hyper-enhanced rim+ HCC nodules and 85.7% for hyper-enhanced rim- HCC nodules (p = 0.013).
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/drug therapy ; Liver Neoplasms/pathology ; Immune Checkpoint Inhibitors ; B7-H1 Antigen ; Retrospective Studies ; Contrast Media
Chemical Substances	Sonazoid ; Immune Checkpoint Inhibitors ; B7-H1 Antigen ; Contrast Media
Language	English
Publishing date	2022-12-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-022-09339-5
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Zs.A 3300: Show issues

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Article: Pharmacokinetics and bioequivalence of two metoprolol succinate extended release tablets in healthy Chinese subjects under fasting and fed conditions.

Yang, Xiding / Zhu, Ronghua / Chen, Xiaojun / Li, Jingjing / Luo, Guirong / Yang, Lingfeng / Fan, Xiao / Yan, Qiangyong / Peng, Wenxing / Fang, Pingfei

International journal of clinical pharmacology and therapeutics

2024 Volume 62, Issue 2, Page(s) 101–108

Abstract: Aims: The aims of this study were to evaluate and compare the pharmacokinetic profiles and establish bioequivalence of test and reference metoprolol succinate extended-release (ER) tablets in healthy Chinese subjects under fasting and fed conditions.: ...

Abstract	Aims: The aims of this study were to evaluate and compare the pharmacokinetic profiles and establish bioequivalence of test and reference metoprolol succinate extended-release (ER) tablets in healthy Chinese subjects under fasting and fed conditions. Materials and methods: Subjects were randomly assigned to either the fasting or the fed group and also to one of the two treatment sequences (test-reference or reference-test), according to which they received a single 47.5-mg dose of the test or reference metoprolol ER tablet in the study periods. During each period, blood samples were collected at pre-dose and at intervals up to 48 hours after dosing. Plasma concentrations of metoprolol were determined by liquid chromatography. The safety of both ER tablets was monitored throughout the study. Results: 60 subjects were enrolled and all completed the study, with 30 participants each in the fasting and fed groups. In both groups, the 90% confidence intervals for AUC Conclusion: The test metoprolol ER tablet was bioequivalent to the reference metoprolol ER tablet (Betaloc ZOK) in healthy Chinese subjects measured under both fasting and fed conditions. Both formulations were well tolerated by all study participants.
MeSH term(s)	Humans ; Therapeutic Equivalency ; Metoprolol/adverse effects ; Cross-Over Studies ; Fasting ; Area Under Curve ; Healthy Volunteers ; Tablets ; China
Chemical Substances	Metoprolol (GEB06NHM23) ; Tablets
Language	English
Publishing date	2024-01-04
Publishing country	Germany
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	124384-6
ISSN	0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
ISSN	0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
DOI	10.5414/CP204474
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Article ; Online: Clone Selection Artificial Intelligence Algorithm-Based Positron Emission Tomography-Computed Tomography Image Information Data Analysis for the Qualitative Diagnosis of Serous Cavity Effusion in Patients with Malignant Tumors.

Wei, Jing / Li, Pingwei / Zhang, Huai / Zhu, Ronghua

Journal of healthcare engineering

2021 Volume 2021, Page(s) 4272411

Abstract: This study aimed to investigate the application of positron emission tomography- (PET-) computed tomography (CT) image information data combined with serous cavity effusion based on clone selection artificial intelligence algorithm in the diagnosis of ... ...

Abstract	This study aimed to investigate the application of positron emission tomography- (PET-) computed tomography (CT) image information data combined with serous cavity effusion based on clone selection artificial intelligence algorithm in the diagnosis of patients with malignant tumors. A total of 97 patients with PET-CT scanning and empirically confirmed as serous cavity effusion were retrospectively analyzed in this study. The clone selection artificial intelligence algorithm was applied to register the PET-CT images, and the patients were rolled into a benign effusion group and a malignant effusion group according to the benign and malignant conditions of the serous cavity effusion. Besides, the causes of patients from the two groups were analyzed, and there was a comparison of their physiological conditions. Subsequently, CT values of different KeV, lipid/water, water/iodine, and water/calcium concentrations were measured, and the differences of the above quantitative parameters between benign and malignant serous cavity effusion were compared, as well as the registration results of the clone algorithm. The results showed that the registration time and misalignment times of clonal selection algorithm (13.88, 0) were lower than those of genetic algorithm (18.72, 8). There were marked differences in CT values of 40-60 keV and 130-140 keV between the two groups. The concentrations of lipid/water, water/iodine, and water/calcium in basal substances of the malignant effusion group were obviously higher than the concentrations of the benign effusion group (
MeSH term(s)	Algorithms ; Artificial Intelligence ; Clone Cells ; Data Analysis ; Diagnosis, Differential ; Humans ; Pleural Effusion, Malignant ; Positron Emission Tomography Computed Tomography ; Retrospective Studies ; Sensitivity and Specificity
Language	English
Publishing date	2021-12-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2545054-2
ISSN	2040-2309 ; 2040-2295
ISSN (online)	2040-2309
ISSN	2040-2295
DOI	10.1155/2021/4272411
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Article ; Online: YOLOX-DG robotic detection systems for large-scale underwater concrete structures.

Zhang, Chenjie / Ma, Hongkuan / Chen, Zhaochang / Li, Shengquan / Ma, Zhongze / Huang, Hui / Zhu, Ronghua / Jiao, Pengcheng

iScience

2024 Volume 27, Issue 4, Page(s) 109337

Abstract: Large-scale complex underwater concrete structures have structural damage and the traditional damage detection method mostly uses manual identification, which is inaccurate and inefficient. Therefore, robotic detection systems have been proposed to ... ...

Abstract	Large-scale complex underwater concrete structures have structural damage and the traditional damage detection method mostly uses manual identification, which is inaccurate and inefficient. Therefore, robotic detection systems have been proposed to replace manual identification for underwater concrete structures in ocean engineering. However, the highly corrosive and disruptive environment of the ocean poses great difficulties for the application. Here, we develop a manta ray-inspired underwater robot with well controllability to establish the damage datasets of underwater concrete structures, proposing the YOLOX-DG algorithm to improve the damage detection accuracy, and integrating the model into the robotic detection systems for underwater concrete damages. Eventually, the system is used for ocean testing in real applications (i.e., underwater marine harbors around the East China Sea), and satisfactory detection performance is obtained. The reported manta ray-inspired robotic detection system can be used to accurately monitor and analyze the underwater regions.
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2024.109337
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Article ; Online: Effect of propranolol on pharmacokinetics of clozapine in schizophrenic patients: a meta-analysis.

Yang, Xiding / Yan, Qiangyong / Yang, Lingfeng / Li, Jingjing / Fan, Xiao / Chen, Jindong / Wu, Haishan / Yang, Yongyu / Zhu, Ronghua / Fang, Pingfei

European journal of clinical pharmacology

2024

Abstract: Purpose: Clozapine is the effective therapy for treatment-refractory schizophrenia. However, the use of clozapine is limited by its adverse effects. As propranolol is frequently used for the prevention and treatment of clozapine-induced tachycardia, we ... ...

Abstract	Purpose: Clozapine is the effective therapy for treatment-refractory schizophrenia. However, the use of clozapine is limited by its adverse effects. As propranolol is frequently used for the prevention and treatment of clozapine-induced tachycardia, we performed a meta-analysis to evaluate the effects of propranolol on steady state pharmacokinetics of clozapine in schizophrenic patients. Methods: We included 16 retrospective studies on the effects of propranolol on steady state pharmacokinetics of clozapine in schizophrenic patients, with data from both generic and brand name treatment phases in eight clozapine bioequivalence studies conducted in a single center in China from 2018 to 2022. Review Manager 5.4 was used for meta-analysis of the included studies. Results: The SMDs with 95% CIs of AUC Conclusion: The combination with propranolol could significantly increase systemic exposure and extended T
Language	English
Publishing date	2024-04-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	121960-1
ISSN	1432-1041 ; 0031-6970
ISSN (online)	1432-1041
ISSN	0031-6970
DOI	10.1007/s00228-024-03690-w
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