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Article ; Online: Carrageenan/polyvinyl alcohol composite film reinforced with spermidine carbon dots: An active packaging material with dual-mode antibacterial activity.

Li, Fan / Zhu, Shuangshuang / Du, Yuhan / Zhe, Taotao / Ma, Kaixuan / Liu, Mengru / Wang, Li

International journal of biological macromolecules

2024 Volume 266, Issue Pt 2, Page(s) 131343

Abstract: Exploring biopolymer-based antibacterial packaging materials is promising to tackle the issues caused by petroleum plastic pollution and microbial contamination. Herein, a novel packaging material with two antibacterial modes, continuous and efficient, ... ...

Abstract	Exploring biopolymer-based antibacterial packaging materials is promising to tackle the issues caused by petroleum plastic pollution and microbial contamination. Herein, a novel packaging material with two antibacterial modes, continuous and efficient, is constructed by dispersing positively charged spermidine carbon dots (Spd-CDs) in a carrageenan/polyvinyl alcohol (CP) composite biopolymer. The obtained nanocomposite film (CP/CDs film) not only gradually releases the ultra-small Spd-CDs but also rapidly generates reactive oxygen species to inhibit the reproduction of E. coli and S. aureus. Benefiting from the complementary advantages of carrageenan and polyvinyl alcohol, as well as the addition of Spd-CDs, the CP/CDs films exhibit high transparency, good mechanical performance, water vapor barrier ability, low migration, etc. The CP/CDs film as a packaging material is validated to be effective in preventing microbial contamination of pork samples. Our prepared nanocomposite film with sustainability and efficient antibacterial properties is expected as food active packaging.
MeSH term(s)	Polyvinyl Alcohol/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Nanocomposites/chemistry ; Carrageenan/chemistry ; Carrageenan/pharmacology ; Food Packaging/methods ; Escherichia coli/drug effects ; Staphylococcus aureus/drug effects ; Spermidine/chemistry ; Spermidine/pharmacology ; Carbon/chemistry ; Quantum Dots/chemistry ; Microbial Sensitivity Tests ; Reactive Oxygen Species/metabolism
Chemical Substances	Polyvinyl Alcohol (9002-89-5) ; Anti-Bacterial Agents ; Carrageenan (9000-07-1) ; Spermidine (U87FK77H25) ; Carbon (7440-44-0) ; Reactive Oxygen Species
Language	English
Publishing date	2024-04-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.131343
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Zs.B 2374: Show issues

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Article ; Online: IgA Nephropathy Concomitant With Karyomegalic Interstitial Nephritis.

Wang, Ziliang / Ni, Xiaona / Zhu, Shuangshuang / Yue, Shuling

The American journal of the medical sciences

2020 Volume 360, Issue 3, Page(s) 287–292

Abstract: Immunoglobulin A (IgA) nephropathy is one of the most common glomerulonephritis characterized by the deposition of IgA in glomerular mesangium. Karyomegalic interstitial nephritis (KIN) is a rare interstitial nephritis with potential hereditary factors. ... ...

Abstract	Immunoglobulin A (IgA) nephropathy is one of the most common glomerulonephritis characterized by the deposition of IgA in glomerular mesangium. Karyomegalic interstitial nephritis (KIN) is a rare interstitial nephritis with potential hereditary factors. IgA nephropathy concomitant with KIN has not yet been reported. Herein, we describe the clinical course, ultrasonic images and gastrointestinal endoscopy findings of a 28-year-old-male patient with IgA nephropathy with KIN. The pathologic examination of the renal biopsy specimen demonstrated mild mesangial proliferative IgA nephropathy with KIN. Molecular genetic testing detected an abnormality in FAN1 gene. The heterozygous mutation was present on chromosome 15q13.3. However, IgA nephropathy with KIN is a rare disorder, and its pathogenesis is yet to be clarified.
MeSH term(s)	Adult ; Chromosomes, Human, Pair 15/genetics ; Endodeoxyribonucleases/genetics ; Exodeoxyribonucleases/genetics ; Frameshift Mutation ; Glomerular Mesangium ; Glomerulonephritis, IGA/drug therapy ; Glomerulonephritis, IGA/pathology ; Glomerulonephritis, IGA/physiopathology ; Heterozygote ; Humans ; Kidney Function Tests ; Male ; Multifunctional Enzymes/genetics ; Mutation, Missense ; Nephritis, Interstitial/genetics ; Nephritis, Interstitial/pathology ; Nephritis, Interstitial/physiopathology
Chemical Substances	Multifunctional Enzymes ; Endodeoxyribonucleases (EC 3.1.-) ; Exodeoxyribonucleases (EC 3.1.-) ; FAN1 protein, human (EC 3.1.-)
Language	English
Publishing date	2020-04-17
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	82078-7
ISSN	1538-2990 ; 0002-9629
ISSN (online)	1538-2990
ISSN	0002-9629
DOI	10.1016/j.amjms.2020.04.010
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Ua VI Zs.2/10: Show issues

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Article ; Online: In Reply to the Letter to the Editor Regarding "Myocardial strain using two-dimensional speckle-tracking echocardiography in acute cardiac allograft rejection: Methodological issues on diagnostic value".

Zhu, Shuangshuang / Zhang, Li / Xie, Mingxing

Echocardiography (Mount Kisco, N.Y.)

2020 Volume 37, Issue 6, Page(s) 984–985

MeSH term(s)	Allografts ; Echocardiography ; Heart Transplantation ; Humans
Language	English
Publishing date	2020-05-28
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	843645-9
ISSN	1540-8175 ; 0742-2822
ISSN (online)	1540-8175
ISSN	0742-2822
DOI	10.1111/echo.14744
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Zs.A 2170: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Adaptation of Melodic Intonation Therapy to a Tone Language: A Pilot Study of Tone-Rhythmic Therapy in Mandarin Chinese.

Chen, Wenjun / Qian, Qian / van de Weijer, Jeroen / Zhu, Shuangshuang / Wang, Manna

Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)

2022 Volume 75, Issue 2, Page(s) 104–116

Abstract: Introduction: Although melodic intonation therapy (MIT) has proven effective in individuals with non-fluent aphasia in a variety of western languages, its application to Mandarin-speaking aphasic patients has not been thoroughly studied. The adaptation ... ...

Abstract	Introduction: Although melodic intonation therapy (MIT) has proven effective in individuals with non-fluent aphasia in a variety of western languages, its application to Mandarin-speaking aphasic patients has not been thoroughly studied. The adaptation is complicated because Mandarin Chinese is a tone language with specific prosodic elements that differ from Indo-European languages. This study developed a Chinese-specific variant of MIT, i.e., tone-rhythmic therapy (TRT), and tested its efficacy in individuals with non-fluent aphasia. Methods: Six non-fluent aphasic patients were recruited; all of them were admitted to the study over 6 months after stroke and had received a standard program of language therapy. In the current research, tone and rhythmic practice were incorporated into the training procedures, and the adaptation was then examined in patients. The TRT treatment lasted 6 weeks, with five 50-min sessions per week. The Boston Diagnostic Aphasia Examination (BDAE) and the Functional Assessment of Communication Skills for Adults (FACS) tests were used to measure the change in the speech and language skills of patients. Results: The results showed that the patients had increased BDAE and FACS scores after intervention, and the treatment effect lasted for 6 months. Discussion: The modified MIT proved effective for Mandarin-speaking patients with non-fluent aphasia with lasting effects. Further studies evaluating its efficacy are needed for other types of aphasia and other tone languages.
MeSH term(s)	Adult ; Humans ; Aphasia/etiology ; Language ; Pilot Projects ; Stroke/complications ; Stroke/therapy
Language	English
Publishing date	2022-09-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1179765-4
ISSN	1421-9972 ; 1021-7762
ISSN (online)	1421-9972
ISSN	1021-7762
DOI	10.1159/000527225
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Ul II Zs.124: Show issues

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Article ; Online: Tone and vowel disruptions in Mandarin aphasia and apraxia of speech.

Chen, Wenjun / van de Weijer, Jeroen / Qian, Qian / Zhu, Shuangshuang / Wang, Manna

Clinical linguistics & phonetics

2022 Volume 37, Issue 8, Page(s) 742–765

Abstract: In this study, we investigated the lexical tones and vowels produced by ten speakers diagnosed with aphasia and coexisting apraxia of speech (A-AOS) and ten healthy participants, to compare their tone and vowel disruptions. We first judged the ... ...

Abstract	In this study, we investigated the lexical tones and vowels produced by ten speakers diagnosed with aphasia and coexisting apraxia of speech (A-AOS) and ten healthy participants, to compare their tone and vowel disruptions. We first judged the productions of both A-AOS and healthy participants and classified them into three categories, i.e. those by healthy speakers and rated as correct, those by A-AOS participants and rated as correct, and those by A-AOS participants and rated as incorrect. We then compared the perceptual results for the three groups based on their respective acoustic correlates to reveal the relations among different accuracy groups. Results showed that the numbers of tone and vowel disruptions by A-AOS speakers occurred on a comparable scale. In perception, approximately equal numbers of tones and vowels produced by A-AOS participants were identified as correct; however, acoustic parameters showed that, unlike vowels, the patients' tones categorised as correct by native Mandarin listeners differed considerably from those of the healthy speakers, suggesting that for Mandarin A-AOS patients, tones were in fact more disrupted than vowels in acoustic terms. Native Mandarin listeners seemed to be more tolerant of less well-targeted tones than less-well targeted vowels. The clinical implication is that tonal and segmental practice should be incorporated for Mandarin A-AOS patients to enhance their overall motor speech control.
MeSH term(s)	Humans ; Speech Perception ; Speech ; Phonetics ; Apraxias ; Aphasia ; Speech Acoustics
Language	English
Publishing date	2022-06-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639459-0
ISSN	1464-5076 ; 0269-9206
ISSN (online)	1464-5076
ISSN	0269-9206
DOI	10.1080/02699206.2022.2081611
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Zs.B 3258: Show issues

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Article ; Online: Protonated and deprotonated vanadyl imidazole tartrates for the mimics of the vanadium coordination in the FeV-cofactor of V-nitrogenase.

Zhu, Shuang-Shuang / Xie, Zhen-Lang / Deng, Lan / Wang, Si-Yuan / Ni, Lu-Bin / Zhou, Zhao-Hui

Dalton transactions (Cambridge, England : 2003)

2023 Volume 52, Issue 45, Page(s) 16849–16857

Abstract: Chiral imidazole-based oxidovanadium tartrates ( ... ...

Abstract	Chiral imidazole-based oxidovanadium tartrates (H
Language	English
Publishing date	2023-11-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d3dt02903d
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Article: Highly Sensitive Immunosensing of Carcinoembryonic Antigen Based on Gold Nanoparticles Dotted PB@PANI Core-Shell Nanocubes as a Signal Probe.

Feng, Dexiang / Chen, Lingzhi / Zhang, Ke / Zhu, Shuangshuang / Ying, Meichen / Jiang, Peng / Fu, Menglan / Wei, Yan / Li, Lihua

Journal of analytical methods in chemistry

2023 Volume 2023, Page(s) 7009624

Abstract: Herein, a method was developed for the sensitive monitoring of carcinoembryonic antigen (CEA) by gold nanoparticles dotted prussian blue@polyaniline core-shell nanocubes (Au NPs/PB@PANI). First, a facile low-temperature method was used to prepare the ... ...

Abstract	Herein, a method was developed for the sensitive monitoring of carcinoembryonic antigen (CEA) by gold nanoparticles dotted prussian blue@polyaniline core-shell nanocubes (Au NPs/PB@PANI). First, a facile low-temperature method was used to prepare the uniform PB@PANI core-shell nanocubes with the assistance of PVP, where PB acted as the electron transfer mediator to provide electrochemical signals, and the PANI with excellent conductivity and desirable chemical stability not only played the role of a protective layer to prevent etching of PB in basic media but also effectively improved electron transfer. Importantly, to further enhance the electrical conductivity and biocompatibility of PB@PANI and to further enhance the electrochemical signal and capture a large amount of Ab
Language	English
Publishing date	2023-04-07
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2654178-6
ISSN	2090-8873 ; 2090-8865
ISSN (online)	2090-8873
ISSN	2090-8865
DOI	10.1155/2023/7009624
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Article ; Online: Contrast-Enhanced Mammography Radiomics Analysis for Preoperative Prediction of Breast Cancer Molecular Subtypes.

Zhu, Shuangshuang / Wang, Simin / Guo, Sailing / Wu, Ruoxi / Zhang, Jinggang / Kong, Mengyu / Pan, Liang / Gu, Yajia / Yu, Shengnan

Academic radiology

2023

Abstract: Background: Predicting breast cancer molecular subtypes can help guide individualised clinical treatment of patients who need the rational preoperative treatment. This study aimed to investigate the efficacy of preoperative prediction of breast cancer ... ...

Abstract	Background: Predicting breast cancer molecular subtypes can help guide individualised clinical treatment of patients who need the rational preoperative treatment. This study aimed to investigate the efficacy of preoperative prediction of breast cancer molecular subtypes by contrast-enhanced mammography (CEM) radiomic features. Methods: This retrospective two-centre study included women with breast cancer who underwent CEM preoperatively between August 2016 and May 2022. We included 356 patients with 386 lesions, which were grouped into training (n = 162), internal test (n = 160) and external test sets (n = 64). Radiomics features were extracted from low-energy (LE) images and recombined (RC) images and selected. Three dichotomous tasks were established according to postoperative immunohistochemical results: Luminal vs. non-Luminal, human epidermal growth factor receptor (HER2)-enriched vs. non-HER2-enriched, and triple-negative breast cancer (TNBC) vs. non-TNBC. For each dichotomous task, the LE, RC, and LE+RC radiomics models were built by the support vector machine classifier. The prediction performance of the models was assessed by the area under the receiver operating characteristic curve (AUC). Then, the accuracy, sensitivity, specificity, positive predictive value, and negative predictive value were calculated for the models. DeLong's test was utilised to compare the AUCs. Results: Radiomics models based on CEM are valuable for predicting breast cancer molecular subtypes. The LE+RC model achieved the best performance in the test set. The LE+RC model predicted Luminal, HER2-enriched, and TNBC subtypes with AUCs of 0.93, 0.89, and 0.87 in the internal test set and 0.82, 0.83, and 0.69 in the external test set, respectively. In addition, the LE model performed more satisfactorily than the RC model. Conclusion: CEM radiomics features can effectively predict breast cancer molecular subtypes preoperatively, and the LE+RC model has the best predictive performance.
Language	English
Publishing date	2023-12-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1355509-1
ISSN	1878-4046 ; 1076-6332
ISSN (online)	1878-4046
ISSN	1076-6332
DOI	10.1016/j.acra.2023.12.005
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Zs.A 4594: Show issues

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Article ; Online: Echocardiographic assessment of pediatric heart transplantation: A single-center experience in China.

Xie, Yuji / Sun, Wei / Zhu, Shuangshuang / Zhang, Linyue / Zhang, Yanting / Zhang, Yiwei / Yang, Yun / Wang, Lufang / Zhao, Yang / Xiao, Sushan / Li, Yuman / Xie, Mingxing / Zhang, Li

Echocardiography (Mount Kisco, N.Y.)

2024 Volume 41, Issue 2, Page(s) e15771

Abstract: Background: Pediatric heart transplant (HT) has become the standard of care for end-stage heart failure in children worldwide. Serial echocardiographic evaluations of graft anatomy and function during follow-up are crucial for post-HT management. ... ...

Abstract	Background: Pediatric heart transplant (HT) has become the standard of care for end-stage heart failure in children worldwide. Serial echocardiographic evaluations of graft anatomy and function during follow-up are crucial for post-HT management. However, evolution of cardiac structure and function after pediatric HT has not been well described, especially during first year post-HT. This study aimed to characterize the evolution of cardiac structure and function after pediatric HT and investigate the correlation between biventricular function with adverse clinical outcomes. Methods: A single-center retrospective study of echocardiographic data obtained among 99 pediatric HT patients was conducted. Comprehensive echocardiographic examination was performed in all patients at 1-, 3-, 6-, 9- and 12-months post-HT. We obtained structural, functional and hemodynamic parameters from both left- and right-side heart, such as left ventricular stroke volume (LVSV), left ventricular ejection fraction (LVEF), right ventricular fractional area change (RVFAC), etc. The cardiac evolution of pediatric HT patients during first post-HT year was described and compared between different time points. We also explored the correlation between cardiac function and major adverse transplant events (MATEs). Results: 1) Evolution of left heart parameters: left atrial length, mitral E velocity, E/A ratio, LVSV and LVEF significantly increased while mitral A velocity significantly decreased over the first year after HT (P < .05). Compared with 1 month after HT, interventricular septum (IVS) and left ventricular posterior wall (LVPW) decreased at 3 months but increased afterwards. (2) Evolution of right heart parameters: right ventricular base diameter and mid-diameter; right ventricular length diameter, tricuspid E velocity, E/A ratio, tricuspid annular velocity e' at free wall, and RVFAC increased, while tricuspid A velocity decreased over the first year after HT (P < .05). (3) Univariate logistic regression model suggests that biventricular function parameters at 1-year post-HT (LVEF, RVFAC, tricuspid annular plane systolic excursion and tricuspid lateral annular systolic velocity) were associated with MATEs. Conclusion: Gradual improvement of LV and RV function was seen in pediatric HT patients within the first year. Biventricular function parameters associated with MATEs. The results of this study pave way for designing larger and longer follow-up of this population, potentially aiming at using multiparameter echocardiographic prediction of adverse events.
MeSH term(s)	Humans ; Child ; Stroke Volume ; Retrospective Studies ; Ventricular Function, Left ; Echocardiography/methods ; Heart Transplantation/adverse effects ; Ventricular Function, Right ; Ventricular Dysfunction, Right
Language	English
Publishing date	2024-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	843645-9
ISSN	1540-8175 ; 0742-2822
ISSN (online)	1540-8175
ISSN	0742-2822
DOI	10.1111/echo.15771
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Zs.A 2170: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 359: Show issues

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Article: Prognostic relevance of left atrial function and stiffness in heart failure with preserved ejection fraction patients with and without diabetes mellitus.

Zhu, Shuangshuang / Lin, Yixia / Zhang, Yanting / Wang, Guohua / Qian, Mingzhu / Gao, Lang / Ji, Mengmeng / Xie, Mingxing / Li, Yuman / Zhang, Li

Frontiers in cardiovascular medicine

2022 Volume 9, Page(s) 947639

Abstract: Background: Although the left atrium (LA) plays a key role in the pathophysiology and disease progression of heart failure with preserved ejection fraction (HFpEF), the impact of type 2 diabetes mellitus (T2DM) on LA function and stiffness in HFpEF ... ...

Abstract	Background: Although the left atrium (LA) plays a key role in the pathophysiology and disease progression of heart failure with preserved ejection fraction (HFpEF), the impact of type 2 diabetes mellitus (T2DM) on LA function and stiffness in HFpEF patients remains unclear. Furthermore, the prognostic value of different phases of LA function and stiffness is less well-established in HFpEF patients. Methods: This study prospectively enrolled 164 HFpEF patients who were in sinus rhythm at the time of echocardiography, including 61 (37%) HFpEF patients with T2DM. LA reservoir, conduit, and pump function were assessed using two-dimensional volume indices and speckle tracking echocardiography. The LA stiffness was calculated as the ratio of early mitral inflow velocity-to-early annular tissue velocity (E/e') and LA reservoir function. The primary end point was a combined outcome of heart failure hospitalization or death. Results: Left atrium reservoir function [measured by peak LA strain (LAS-peak)] and LA pump function (measured by LAS-active) remained significantly lower in the HFpEF patients with T2DM compared with those without T2DM, even after adjustment for potential confounders. In addition, the LA stiffness of HFpEF patients with T2DM was higher than those without T2DM. After a median follow-up of 13.7 months, 46 patients (28.1%) reached the composite end point. LAS-peak (hazard ratios: 0.88; 95% confidence interval: 0.81-0.95; Conclusion: Left atrium reservoir and pump function are impaired, whereas LA stiffness is increased in HFpEF patients with T2DM compared with those without T2DM. LAS-peak is a powerful predictor of adverse clinical outcomes and may be crucial for risk stratification in HFpEF patients with and without T2DM.
Language	English
Publishing date	2022-09-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.947639
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