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  1. Article: Mind the Gap: Bridging the Divide from Sequencing Data to Empiric Phenotypes in the Human Gut Microbiota.

    Fansler, Ryan T / Zhu, Wenhan

    mSystems

    2022  Volume 7, Issue 3, Page(s) e0020722

    Abstract: The gut microbiome exerts a powerful influence on human health and disease. Elucidating the underlying mechanisms of the microbiota's influence is hindered by the immense complexity of the gut microbial community and the glycans they forage. Despite a ... ...

    Abstract The gut microbiome exerts a powerful influence on human health and disease. Elucidating the underlying mechanisms of the microbiota's influence is hindered by the immense complexity of the gut microbial community and the glycans they forage. Despite a wealth of genomic and metagenomic sequencing information, there remains a lack of informative phenotypic measurements. Pudlo NA, Urs K, Crawford R, Pirani A, et al. (mSystems 7: e00947-21, 2022, https://doi.org/10.1128/msystems.00947-21) decode this complexity by introducing a scalable assay to measure specific carbohydrate utilization in the dominant microbiota phylum
    MeSH term(s) Humans ; Gastrointestinal Microbiome/genetics ; Bacteria/genetics ; Polysaccharides ; Microbiota ; Genomics
    Chemical Substances Polysaccharides
    Language English
    Publishing date 2022-06-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ISSN 2379-5077
    ISSN 2379-5077
    DOI 10.1128/msystems.00207-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Respire or expire-precision killing of Helicobacter pylori by targeting complex I respiration.

    Fansler, Ryan T / Spiga, Luisella / Langford, Madison / Zhu, Wenhan

    Cell chemical biology

    2023  Volume 30, Issue 5, Page(s) 417–419

    Abstract: In this issue of Cell Chemical Biology, Lettl et al. ...

    Abstract In this issue of Cell Chemical Biology, Lettl et al.
    MeSH term(s) Humans ; Helicobacter pylori ; Helicobacter Infections/drug therapy ; Gastrointestinal Microbiome
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2451-9448
    ISSN (online) 2451-9448
    DOI 10.1016/j.chembiol.2023.04.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Application of Medical Image Navigation Technology in Minimally Invasive Puncture Robot.

    Hu, Shuai / Lu, Rongjian / Zhu, Yinlong / Zhu, Wenhan / Jiang, Hongzhe / Bi, Suzhao

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 16

    Abstract: Microneedle puncture is a standard minimally invasive treatment and surgical method, which is widely used in extracting blood, tissues, and their secretions for pathological examination, needle-puncture-directed drug therapy, local anaesthesia, microwave ...

    Abstract Microneedle puncture is a standard minimally invasive treatment and surgical method, which is widely used in extracting blood, tissues, and their secretions for pathological examination, needle-puncture-directed drug therapy, local anaesthesia, microwave ablation needle therapy, radiotherapy, and other procedures. The use of robots for microneedle puncture has become a worldwide research hotspot, and medical imaging navigation technology plays an essential role in preoperative robotic puncture path planning, intraoperative assisted puncture, and surgical efficacy detection. This paper introduces medical imaging technology and minimally invasive puncture robots, reviews the current status of research on the application of medical imaging navigation technology in minimally invasive puncture robots, and points out its future development trends and challenges.
    MeSH term(s) Robotics ; Punctures ; Needles ; Radiofrequency Ablation ; Technology
    Language English
    Publishing date 2023-08-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23167196
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  4. Article ; Online: Weld Feature Extraction Based on Semantic Segmentation Network.

    Wang, Bin / Li, Fengshun / Lu, Rongjian / Ni, Xiaoyu / Zhu, Wenhan

    Sensors (Basel, Switzerland)

    2022  Volume 22, Issue 11

    Abstract: Laser welding is an indispensable link in most types of industrial production. The realization of welding automation by industrial robots can greatly improve production efficiency. In the research and development of the welding seam tracking system, ... ...

    Abstract Laser welding is an indispensable link in most types of industrial production. The realization of welding automation by industrial robots can greatly improve production efficiency. In the research and development of the welding seam tracking system, information on the position of the weld joint needs to be obtained accurately. For laser welding images with strong and complex interference, a weld tracking module was designed to capture real-time images of the weld, and a total of 737, 1920 × 1200 pixel weld images were captured using the device, of which 637 were used to create the dataset, and the other 100 were used as images to test the segmentation success rate. Based on the pixel-level segmentation capability of the semantic segmentation network, this study used an encoder-decoder architecture to design a lightweight network structure and introduced a channel attention mechanism. Compared to ERF-Net, SegNet, and DFA-Net, the network model in this paper has a fast segmentation speed and higher segmentation accuracy, with a success rate of 96% and remarkable segmentation results.
    MeSH term(s) Automation ; Image Processing, Computer-Assisted/methods ; Lasers ; Semantics ; Welding
    Language English
    Publishing date 2022-05-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s22114130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online: What Is an App Store? The Software Engineering Perspective

    Zhu, Wenhan / Proksch, Sebastian / German, Daniel M. / Godfrey, Michael W. / Li, Li / McIntosh, Shane

    2024  

    Abstract: App stores" are online software stores where end users may browse, purchase, download, and install software applications. By far, the best known app stores are associated with mobile platforms, such as Google Play for Android and Apple's App Store for ... ...

    Abstract "App stores" are online software stores where end users may browse, purchase, download, and install software applications. By far, the best known app stores are associated with mobile platforms, such as Google Play for Android and Apple's App Store for iOS. The ubiquity of smartphones has led to mobile app stores becoming a touchstone experience of modern living. However, most of app store research has concentrated on properties of the apps rather than the stores themselves. Today, there is a rich diversity of app stores and these stores have largely been overlooked by researchers: app stores exist on many distinctive platforms, are aimed at different classes of users, and have different end-goals beyond simply selling a standalone app to a smartphone user. We survey and characterize the broader dimensionality of app stores, and explore how and why they influence software development practices, such as system design and release management. We begin by collecting a set of app store examples from web search queries. By analyzing and curating the results, we derive a set of features common to app stores. We then build a dimensional model of app stores based on these features, and we fit each app store from our web search result set into this model. Next, we performed unsupervised clustering to the app stores to find their natural groupings. Our results suggest that app stores have become an essential stakeholder in modern software development. They control the distribution channel to end users and ensure that the applications are of suitable quality; in turn, this leads to developers adhering to various store guidelines when creating their applications. However, we found the app stores operational model could vary widely between stores, and this variability could in turn affect the generalizability of existing understanding of app stores.

    Comment: 41 pages
    Keywords Computer Science - Software Engineering
    Subject code 005
    Publishing date 2024-01-08
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Book ; Online: Head3D

    Cheng, Yuhao / Yan, Yichao / Zhu, Wenhan / Pan, Ye / Pan, Bowen / Yang, Xiaokang

    Complete 3D Head Generation via Tri-plane Feature Distillation

    2023  

    Abstract: Head generation with diverse identities is an important task in computer vision and computer graphics, widely used in multimedia applications. However, current full head generation methods require a large number of 3D scans or multi-view images to train ... ...

    Abstract Head generation with diverse identities is an important task in computer vision and computer graphics, widely used in multimedia applications. However, current full head generation methods require a large number of 3D scans or multi-view images to train the model, resulting in expensive data acquisition cost. To address this issue, we propose Head3D, a method to generate full 3D heads with limited multi-view images. Specifically, our approach first extracts facial priors represented by tri-planes learned in EG3D, a 3D-aware generative model, and then proposes feature distillation to deliver the 3D frontal faces into complete heads without compromising head integrity. To mitigate the domain gap between the face and head models, we present dual-discriminators to guide the frontal and back head generation, respectively. Our model achieves cost-efficient and diverse complete head generation with photo-realistic renderings and high-quality geometry representations. Extensive experiments demonstrate the effectiveness of our proposed Head3D, both qualitatively and quantitatively.
    Keywords Computer Science - Computer Vision and Pattern Recognition
    Subject code 004
    Publishing date 2023-03-28
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Assessing lake health in China: Challenges due to multiple coexisting standards

    Su, Yifan / Fan, Ziwu / Gan, Lin / Li, Yun / Fei, Guosong / Liu, Yang / Xie, Chen / Wu, Jingxiu / Sun, Jianhao / Zhu, Wenhan / Man, Jingtian

    Journal of Hydrology: Regional Studies. 2023 Apr., v. 46 p.101351-

    2023  

    Abstract: Yangcheng Lake is located northeast of Suzhou city, one of the most economically developed cities in the Yangtze River Delta plain, China. Yangcheng Lake serves as a storage pool for flood control and water diversion; as well as a potable water source ... ...

    Abstract Yangcheng Lake is located northeast of Suzhou city, one of the most economically developed cities in the Yangtze River Delta plain, China. Yangcheng Lake serves as a storage pool for flood control and water diversion; as well as a potable water source for Suzhou City. In recent years, summer cyanobacterial blooms began appearing in Yangcheng Lake, which urgently requires a health evaluation. Currently, there is a three-tier analysis system consisting of national, provincial, and local assessments in China. However, each tier has a unique set of standards, meaning that: 1) evaluations between tiers are not comparable and 2) conducting a unified survey and analyzing the results is exceedingly difficult. How to develop ways to standardize existing river and lake health evaluation systems in China become a global concern. Although the evaluation index system and assessment techniques are consistent throughout all three methods, they differ in their handling of index weights and assignment criteria. The health evaluation scores of Yangcheng Lake are in the Healthy to Sub-healthy range, with gradually decreasing health from east to west. This work synthesized the existing Chinese national-provincial-local health evaluation system and suggested standardizing the index system, index weights, and evaluation process to provide theoretical support for water resources management and water ecology restoration in freshwater water bodies in China.
    Keywords drinking water ; ecology ; flood control ; freshwater ; lakes ; river deltas ; rivers ; summer ; surveys ; China ; Yangtze River ; Health assessment normalization ; Aquatic ecological health ; Ecological integrity ; Yangcheng Lake
    Language English
    Dates of publication 2023-04
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2814784-4
    ISSN 2214-5818
    ISSN 2214-5818
    DOI 10.1016/j.ejrh.2023.101351
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Transition metals and host-microbe interactions in the inflamed intestine.

    Zhu, Wenhan / Spiga, Luisella / Winter, Sebastian

    Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine

    2019  Volume 32, Issue 3, Page(s) 369–384

    Abstract: Host-associated microbial communities provide critical functions for their hosts. Transition metals are essential for both the mammalian host and the majority of commensal bacteria. As such, access to transition metals is an important component of host- ... ...

    Abstract Host-associated microbial communities provide critical functions for their hosts. Transition metals are essential for both the mammalian host and the majority of commensal bacteria. As such, access to transition metals is an important component of host-microbe interactions in the gastrointestinal tract. In mammals, transition metal ions are often sequestered by metal binding proteins to limit microbial access under homeostatic conditions. In response to invading pathogens, the mammalian host further decreases availability of these micronutrients by regulating their trafficking or releasing high-affinity metal chelating proteins, a process termed nutritional immunity. Bacterial pathogens have evolved several mechanisms to subvert nutritional immunity. Here, we provide an overview on how metal ion availability shapes host-microbe interactions in the gut with a particular focus on intestinal inflammatory diseases.
    MeSH term(s) Animals ; Host Microbial Interactions ; Humans ; Intestines/microbiology ; Transition Elements/metabolism
    Chemical Substances Transition Elements
    Language English
    Publishing date 2019-02-20
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1112688-7
    ISSN 1572-8773 ; 0966-0844
    ISSN (online) 1572-8773
    ISSN 0966-0844
    DOI 10.1007/s10534-019-00182-8
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    In stock of ZB MED Cologne/Königswinter

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  9. Article ; Online: Cell biology and immunology lessons taught by Legionella pneumophila.

    Zhu, Wenhan / Luo, Zhao-Qing

    Science China. Life sciences

    2016  Volume 59, Issue 1, Page(s) 3–10

    Abstract: Legionella pneumophila is a facultative intracellular pathogen capable of replicating within a broad range of hosts. One unique feature of this pathogen is the cohort of ca. 300 virulence factors (effectors) delivered into host cells via its Dot/Icm type ...

    Abstract Legionella pneumophila is a facultative intracellular pathogen capable of replicating within a broad range of hosts. One unique feature of this pathogen is the cohort of ca. 300 virulence factors (effectors) delivered into host cells via its Dot/Icm type IV secretion system. Study of these proteins has produced novel insights into the mechanisms of host function modulation by pathogens, the regulation of essential processes of eukaryotic cells and of immunosurveillance. In this review, we will briefly discuss the roles of some of these effectors in the creation of a niche permissive for bacterial replication in phagocytes and recent advancements in the dissection of the innate immune detection mechanisms by challenging immune cells with L. pneumophila.
    MeSH term(s) Host-Pathogen Interactions/immunology ; Humans ; Immunity, Innate ; Legionella pneumophila/immunology ; Legionella pneumophila/pathogenicity ; Legionella pneumophila/physiology ; Legionnaires' Disease/immunology ; Legionnaires' Disease/microbiology ; Models, Immunological ; Type IV Secretion Systems/immunology ; Virulence/immunology
    Chemical Substances Type IV Secretion Systems
    Language English
    Publishing date 2016-01
    Publishing country China
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ISSN 1869-1889
    ISSN (online) 1869-1889
    DOI 10.1007/s11427-015-4945-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online: An empirical study of question discussions on Stack Overflow

    Zhu, Wenhan / Zhang, Haoxiang / Hassan, Ahmed E. / Godfrey, Michael W.

    2021  

    Abstract: Stack Overflow provides a means for developers to exchange knowledge. While much previous research on Stack Overflow has focused on questions and answers (Q&A), recent work has shown that discussions in comments also contain rich information. On Stack ... ...

    Abstract Stack Overflow provides a means for developers to exchange knowledge. While much previous research on Stack Overflow has focused on questions and answers (Q&A), recent work has shown that discussions in comments also contain rich information. On Stack Overflow, discussions through comments and chat rooms can be tied to questions or answers. In this paper, we conduct an empirical study that focuses on the nature of question discussions. We observe that: (1) Question discussions occur at all phases of the Q&A process, with most beginning before the first answer is received. (2) Both askers and answerers actively participate in question discussions; the likelihood of their participation increases as the number of comments increases. (3) There is a strong correlation between the number of question comments and the question answering time (i.e., more discussed questions receive answers more slowly); also, questions with a small number of comments are likely to be answered more quickly than questions with no discussion. Our findings suggest that question discussions contain a rich trove of data that is integral to the Q&A processes on Stack Overflow. We further suggest how future research can leverage the information in question discussions, along with the commonly studied Q&A information.

    Comment: 27 pages, 9 figures
    Keywords Computer Science - Software Engineering
    Publishing date 2021-09-27
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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