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Article: Aptly chosen, effectively emphasizing the action and mechanism of antimycin A

Zhu, Linyan / Weng, Chenhong / Shen, Xiaoman / Zhu, Xiangdong

2024 Volume 15, Page(s) 1371850

Abstract: Rhizoctonia ... ...

Abstract	Rhizoctonia solani
Language	English
Publishing date	2024-04-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2024.1371850
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Analysis of the sodium pump subunit ATP1A3 in glioma patients: Potential value in prognostic prediction and immunotherapy.

Lan, Yu-Long / Zou, Shuang / Qin, Bing / Zhu, Xiangdong

International immunopharmacology

2024 Volume 133, Page(s) 112045

Abstract: The ATP1A3 gene is associated with the development and progression of neurological diseases. However, the pathological function and therapeutic value of ATP1A3 in glioblastoma (GBM) remains unknown. In this study, we tried to explore the correlation ... ...

Abstract	The ATP1A3 gene is associated with the development and progression of neurological diseases. However, the pathological function and therapeutic value of ATP1A3 in glioblastoma (GBM) remains unknown. In this study, we tried to explore the correlation between the ATP1A3 gene expression and immune features in GBM samples. We found that ATP1A3 gene expression levels showed significant negative correlation with immune checkpoints such as PD-L1, CTLA-4 and IDO1. Next, ATP1A3 gene expression levels showed significant negative correlation with the anti-cancer immune cell process, the immune score and stromal score. By grouping ATP1A3 expression levels, we found that that immunomodulator-related genes and tumor-associated immune cell effector gene expression levels were associated with lower ATP1A3 expression. In addition, immunotherapy prediction pathway activity and a majority of the anti-cancer immune cell process activity levels were also showed to be correlated with lower ATP1A3 gene expression. Further, nine prognostic factors were identified by prognostic analysis, and a GBM prognostic model (risk score) was established. We applied the model to the TCGA GBM training set sample and the GSE4412 validation set sample and found that patients in the high risk score subgroup had significantly shorter survival time, demonstrating the prognostic value and prognostic efficacy of the risk score. Furthermore, ATP1A3 overexpression has also been found to sensitize cancer cells to anti-PD-1 therapy. In conclusion, we showed that ATP1A3 is a highly promising treatment target in GBM and the risk score is an independent prognostic factor for cancer and can be used to help guide the prediction of survival time in patients with GBM.
Language	English
Publishing date	2024-04-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2024.112045
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Zs.A 5408: Show issues

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Article: A xanthine oxidase inhibit activity component from biotransformation of cholesterol by

Wei, Haixin / Yang, Chiguang / Weng, Chenhong / Zhu, Xiangdong

Heliyon

2023 Volume 9, Issue 3, Page(s) e14160

Abstract: Steroids are one of the most widely used groups of medicines presently. There are some steroid drugs that have acquired with the transformation of microorganism. It's indispensability to screen the strain that is able to utilize steroids to generate new ... ...

Abstract	Steroids are one of the most widely used groups of medicines presently. There are some steroid drugs that have acquired with the transformation of microorganism. It's indispensability to screen the strain that is able to utilize steroids to generate new products. This study has screened a transformation strain WHX1301 that have ability to convert cholesterol. Based on the 16S rRNA gene sequence comparison, the isolate WHX1301 has been demonstrated to most similar as
Language	English
Publishing date	2023-02-28
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e14160
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Article ; Online: A xanthine oxidase inhibit activity component from biotransformation of cholesterol by Streptomyces cellulosae WHX1301

Wei, Haixin / Yang, Chiguang / Weng, Chenhong / Zhu, Xiangdong

Heliyon. 2023 Feb. 28, p.e14160-

2023

Abstract	Steroids are one of the most widely used groups of medicines presently. There are some steroid drugs that have acquired with the transformation of microorganism. It's indispensability to screen the strain that is able to utilize steroids to generate new products. This study has screened a transformation strain WHX1301 that have ability to convert cholesterol. Based on the 16S rRNA gene sequence comparison, the isolate WHX1301 has been demonstrated to most similar as Streptomyces cellulosae. Separation and purification of transformation product were identifying by NMR and ESI-MS. The major of product was 2,7-dihydroxycholesterol, and the by-product were 7-Hydroxycholestane-3,5-diene, Cholesterane-3,5-diene. Fortunately, 2,7-dihydroxycholesterol has inhibitory activity against xanthine oxidase with a 34.8% inhibition rate at a concentration of 20 μg/ml. Using the resting cells of Streptomyces cellulosae WHX1301 to transform cholesterol, the product yield can reach 76%. Present paper is the first report regarding the microbial transformation of steroids by Streptomyces cellulosae.
Keywords	Streptomyces cellulosae ; biotransformation ; byproducts ; cholesterol ; nucleotide sequences ; sequence analysis ; xanthine oxidase ; Resting cell
Language	English
Dates of publication	2023-0228
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version ; Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e14160
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Article ; Online: Biomass inherent metal interfere carbothermal reduction modification of biochar for Cd immobilization.

Yang, Fulin / He, Zhelin / Yu, Fengbo / Zhou, Shoubiao / Zhu, Xiangdong

The Science of the total environment

2023 Volume 867, Page(s) 161425

Abstract: Metal salt laden are frequently used to enhance the heavy metal adsorption capacity of biochar. The present study indicates that CaS loading biochar can be modified from the carbothermal reduction reaction between ... ...

Abstract	Metal salt laden are frequently used to enhance the heavy metal adsorption capacity of biochar. The present study indicates that CaS loading biochar can be modified from the carbothermal reduction reaction between CaSO
MeSH term(s)	Cadmium ; Biomass ; Metals, Heavy ; Charcoal ; Adsorption
Chemical Substances	Cadmium (00BH33GNGH) ; biochar ; Metals, Heavy ; Charcoal (16291-96-6)
Language	English
Publishing date	2023-01-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.161425
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Zs.A 949: Show issues

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Article ; Online: How Does Green Finance Impact Chinese Urban Environmental Pollution? —A Case Study of Haze Pollution

Zhu Xiangdong / Zhu Shengjun / Huang Yongyuan / Huang Haifeng

Redai dili, Vol 41, Iss 1, Pp 55-

2021 Volume 66

Abstract: Green finance is a novel concept that combines environmental protection with finance. It aims at ensuring sustainable development by regulating investment and financing. The features of green finance meet the demands of China's economic transformation ... ...

Abstract	Green finance is a novel concept that combines environmental protection with finance. It aims at ensuring sustainable development by regulating investment and financing. The features of green finance meet the demands of China's economic transformation and environmental protection. Since 2015, green finance has increased rapidly in China and attracted a great deal of research. Previous studies focus on the concept, overseas experience, development models, and policy incentives, while green finance's environmental effect has been largely neglected. Theoretically, we deduce that as an innovation of environmental governance, green finance would potentially promote the impact of the existing environmental regulations. Moreover, both green finance and environmental regulations can alleviate pollution through upgrading the regional industrial structure and stimulating technological innovation. Moving on to regional heterogeneity, we hypothesize that the effects of the two kinds of environmental governance are varying across regions. This paper applies the econometric model to explore green finance's impact on the Chinese urban haze pollution and its interaction with environmental regulations, industrial structure, and technological level. Our dependent variable is the volume of the reduction of the haze pollution index in 289 Chinese prefectural cities. The scale of green finance in each city is denoted by the insuring scale of green bonds. Environmental regulation is denoted by a commonly used indicator system consisting of two kinds of contaminants: sulfur dioxide and liquid waste. Industrial structure is denoted by the percentage of the secondary industry to GDP in each city. Technological level is denoted by the number of selected patents over prefectural industrial output. We confirm the correlations between variables by descriptive analysis and apply the Spatial Durbin Model to test our hypothesis. The results show that green finance has significant spatial spillover, as a high level of regional green finance can ...
Keywords	green finance ; environmental regulation ; haze pollution ; structural effect ; technique effect ; Geography (General) ; G1-922
Subject code	339
Language	Chinese
Publishing date	2021-01-01T00:00:00Z
Publisher	Editorial Committee of Tropical Geography
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: One-pot synthesis of dual-sites adsorbent based on recycling spent Lithium-ion batteries: Matter cycle, orderly grafting, and copper adsorption

Hou, Huiliang / Zhong, Qifan / Zhang, Zhenhua / Zhu, Xiangdong / Song, Ying / Xiao, Jin

Journal of Cleaner Production. 2023 Apr. 19, p.137230-

2023 , Page(s) 137230–

Abstract: Waste carbon residue (WCR), a hazardous solid waste discharged from spent lithium-ion batteries recovery industry, have caused serious environmental pollution. In this work, WCR with ferric impurity was recycled as dual-sites adsorbents for efficient ... ...

Abstract	Waste carbon residue (WCR), a hazardous solid waste discharged from spent lithium-ion batteries recovery industry, have caused serious environmental pollution. In this work, WCR with ferric impurity was recycled as dual-sites adsorbents for efficient removal of Cu²⁺ in wastewater. The adsorbent, sulfhydryl grafting Fe(OH)₃/graphite (SFG), was synthesized by one-pot method. In this process, the ferric impurity was transformed into amorphous Fe(OH)₃ in-situ, and sulfhydryl (-SH) was orderly grafted on adsorbent surface by regulation of 3-(Trimethoxysilyl) propyl methacrylate (TPM). In the regulation, TPM combined adsorbent surface and cysteine molecule by its inorganic and organic ends. Furthermore, the filtrate and adsorbent could be reused many times. The adsorption kinetics followed the pseudo-second-order model, the isotherm fitted better with the Freundlich isotherm model, which indicated that the adsorption of Cu²⁺ on SFG was a multilayer and heterogeneous chemisorption process. Langmuir maximum adsorption capacity of Cu²⁺ was 185.2 mg/g which was higher than many similar adsorbents. Adsorption mechanisms were explored by material characterizations and DFT calculations. The –OH groups of Fe(OH)₃ reacted with Cu²⁺ via ion-exchange, the sulfur atom in –SH groups chelated with Cu²⁺ by transferring electrons to Cu atom. Synergistic effect of Fe(OH)₃, sulfhydryl, and TPM provided SFG with outstanding adsorptive performance to Cu²⁺ contamination.
Keywords	adsorbents ; adsorption ; carbon ; cysteine ; filtrates ; industry ; ion exchange ; models ; pollution ; solid wastes ; sorption isotherms ; sulfur ; synergism ; synthesis ; wastewater ; Recovery ; Fe(OH)3 ; Sulfhydryl ; Grafting regulation ; Cu2+ removal
Language	English
Dates of publication	2023-0419
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ISSN	0959-6526
DOI	10.1016/j.jclepro.2023.137230
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Collagen hydrogel viscoelasticity regulates MSC chondrogenesis in a ROCK-dependent manner.

Huang, Danyang / Li, Yuehong / Ma, Zihan / Lin, Hai / Zhu, Xiangdong / Xiao, Yun / Zhang, Xingdong

Science advances

2023 Volume 9, Issue 6, Page(s) eade9497

Abstract: Mesenchymal stem cell (MSC) chondrogenesis in three-dimensional (3D) culture involves dynamic changes in cytoskeleton architecture during mesenchymal condensation before morphogenesis. However, the mechanism linking dynamic mechanical properties of ... ...

Abstract	Mesenchymal stem cell (MSC) chondrogenesis in three-dimensional (3D) culture involves dynamic changes in cytoskeleton architecture during mesenchymal condensation before morphogenesis. However, the mechanism linking dynamic mechanical properties of matrix to cytoskeletal changes during chondrogenesis remains unclear. Here, we investigated how viscoelasticity, a time-dependent mechanical property of collagen hydrogel, coordinates MSC cytoskeleton changes at different stages of chondrogenesis. The viscoelasticity of collagen hydrogel was modulated by controlling the gelling process without chemical cross-linking. In slower-relaxing hydrogels, although a disordered cortical actin promoted early chondrogenic differentiation, persistent myosin hyperactivation resulted in Rho-associated kinase (ROCK)-dependent apoptosis. Meanwhile, faster-relaxing hydrogels promoted cell-matrix interactions and eventually facilitated long-term chondrogenesis with mitigated myosin hyperactivation and cell apoptosis, similar to the effect of ROCK inhibitors. The current work not only reveals how matrix viscoelasticity coordinates MSC chondrogenesis and survival in a ROCK-dependent manner but also highlights viscoelasticity as a design parameter for biomaterials for chondrogenic 3D culture.
MeSH term(s)	Hydrogels/pharmacology ; Hydrogels/chemistry ; Chondrogenesis/physiology ; Collagen/chemistry ; Cell Differentiation ; Mesenchymal Stem Cells ; Cells, Cultured
Chemical Substances	Hydrogels ; Collagen (9007-34-5)
Language	English
Publishing date	2023-02-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.ade9497
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Role of PPARγ Gene Polymorphisms, Gut Microbiota in Type 2 Diabetes: Current Progress and Future Prospects.

Zhao, Yi-Kun / Zhu, Xiang-Dong / Liu, Rong / Yang, Xia / Liang, Yong-Lin / Wang, Yan

Diabetes, metabolic syndrome and obesity : targets and therapy

2023 Volume 16, Page(s) 3557–3566

Abstract: Over the past decade, there has been a significant increase in studies investigating the relationship between the polymorphisms of the Peroxisome Proliferator-Activated Receptor gamma (PPARγ) gene and Type 2 Diabetes (T2D). PPARγ, a critical ... ...

Abstract	Over the past decade, there has been a significant increase in studies investigating the relationship between the polymorphisms of the Peroxisome Proliferator-Activated Receptor gamma (PPARγ) gene and Type 2 Diabetes (T2D). PPARγ, a critical transcription factor, plays a central role in lipid metabolism, insulin resistance, and inflammatory response. Concurrently, the influence of gut microbiota on the development of T2D has gained increasing attention, especially their role in affecting host metabolism, such as lipid metabolism and the PPARγ signaling pathway. This review provides a comprehensive analysis of recent studies on PPARγ gene polymorphisms and their association with T2D, with a specific emphasis on the implications of gut microbiota and their interaction with PPARγ pathways. We also discuss the potential of manipulating gut microbiota and targeting PPARγ gene polymorphisms in T2D management. By deepening our understanding of these relationships, we aim to pave the way for novel preventative and therapeutic strategies for T2D.
Language	English
Publishing date	2023-11-07
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2494854-8
ISSN	1178-7007
ISSN	1178-7007
DOI	10.2147/DMSO.S429825
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Article ; Online: Integrated Traditional Chinese and Western medicine for ulcerative colitis with diabetes: A protocol for systematic review and meta-analysis.

Lan, Yu-Ze / Bai, Ya-Li / Zhu, Xiang-Dong

Medicine

2021 Volume 100, Issue 4, Page(s) e24444

Abstract: Background: This study aimed to access the efficacy and safety of integrated Traditional Chinese and Western medicine treatment for patients with ulcerative colitis (UC) combined diabetes.: Methods: This protocol adheres to the preferred reporting ... ...

Abstract	Background: This study aimed to access the efficacy and safety of integrated Traditional Chinese and Western medicine treatment for patients with ulcerative colitis (UC) combined diabetes. Methods: This protocol adheres to the preferred reporting items for systematic reviews and meta-analysis protocol statement. We plan to search 8 electronic databases to identify qualifying studies published from database inception until December 1, 2020. The software of EndNote reference manager (X9) will be used to study selection. A pre-developed standardized data collection form will be used to extract from all eligible studies. For included studies, the quality will be assessed by Cochrane Risk of bias tool. The RevMan 5.3 software (Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014) developed by the Cochrane Collaboration will be used for all statistical analysis. If possible, meta-analysis will be undertaken for each of the outcomes. For continuous variable data, we will used mean differences with 95% confidence intervals (CIs) as summary statistics. For dichotomous variable data, we will calculate Mantel-Haenszel odds ratio with 95% CIs as summary statistics from the numbers of events in control and intervention groups. We will consider a result to be statistically significant if P < .05. If outcomes cannot be meta-analyzed, we will performer a descriptive analysis. Results: This study will be performed to test the efficacy and safety of integrated Traditional Chinese and Western medicine treatment for patients with UC combined diabetes. Conclusion: The results of our study will be published in a peer-reviewed journals, and we will promotion results in domestic and foreign conferences. Registration number: INPLASY2020120087. Ethics and dissemination: As a systematic review and meta-analysis which based on previously published literature, ethical approval, and informed consent from patients are not required.
MeSH term(s)	Adolescent ; Adult ; Aged ; Colitis, Ulcerative/complications ; Colitis, Ulcerative/therapy ; Combined Modality Therapy ; Delivery of Health Care, Integrated/methods ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/therapy ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/therapy ; Female ; Humans ; Male ; Medicine, Chinese Traditional/methods ; Meta-Analysis as Topic ; Middle Aged ; Randomized Controlled Trials as Topic ; Research Design ; Systematic Reviews as Topic ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2021-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000024444
Database	MEDical Literature Analysis and Retrieval System OnLINE

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