Article ; Online: Surgical stress induced tumor immune suppressive environment.
2024 Volume 45, Issue 4, Page(s) 185–198
Abstract: Despite significant advances in cancer treatment over the decades, surgical resection remains a prominent management approach for solid neoplasms. Unfortunately, accumulating evidence suggests that surgical stress caused by tumor resection may ... ...
| Abstract | Despite significant advances in cancer treatment over the decades, surgical resection remains a prominent management approach for solid neoplasms. Unfortunately, accumulating evidence suggests that surgical stress caused by tumor resection may potentially trigger postoperative metastatic niche formation. Surgical stress not only activates the sympathetic-adrenomedullary axis and hypothalamic-pituitary-adrenocortical axis but also induces hypoxia and hypercoagulable state. These adverse factors can negatively impact the immune system by downregulating immune effector cells and upregulating immune suppressor cells, which contribute to the colonization and progression of postoperative tumor metastatic niche. This review summarizes the effects of surgical stress on four types of immune effector cells (neutrophils, macrophages, natural killer cells and cytotoxic T lymphocytes) and two types of immunosuppressive cells (regulatory T cells and myeloid-derived suppressor cells), and discusses the immune mechanisms of postoperative tumor relapse and progression. Additionally, relevant therapeutic strategies to minimize the pro-tumorigenic effects of surgical stress are elucidated. |
|---|---|
| MeSH term(s) | Humans ; Neoplasm Recurrence, Local ; Neoplasms/drug therapy ; Macrophages ; Killer Cells, Natural ; Myeloid-Derived Suppressor Cells ; T-Lymphocytes, Regulatory ; Tumor Microenvironment |
| Language | English |
| Publishing date | 2024-02-29 |
| Publishing country | England |
| Document type | Review ; Journal Article |
| ZDB-ID | 603134-1 |
| ISSN | 1460-2180 ; 0143-3334 |
| ISSN (online) | 1460-2180 |
| ISSN | 0143-3334 |
| DOI | 10.1093/carcin/bgae012 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 1558: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.