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Article: [Research progress of human bocavirus infection in children].

Zhu, Xu / Wang, Lijie

Zhonghua wei zhong bing ji jiu yi xue

2023 Volume 35, Issue 5, Page(s) 548–553

Abstract: Human bocavirus is a novel pathogen first detected in respiratory tract samples in 2005. People of different ages can be infected by human bocavirus. Children are the susceptible population, especially the infants aged from 6-24 months old. The epidemic ... ...

Abstract	Human bocavirus is a novel pathogen first detected in respiratory tract samples in 2005. People of different ages can be infected by human bocavirus. Children are the susceptible population, especially the infants aged from 6-24 months old. The epidemic season varies in different regions due to the differences in climate and geographical location, and it mainly occurs in autumn and winter. It's demonstrated that human bocavirus-1 is closely related to respiratory system diseases and even causes life-threatening critical illness. Also, the severity of symptom is positively correlated with viral load. Co-infections between human bocavirus-1 and other viruses often present high frequency occurrence. Human bocavirus-1 interferes immune function of host by inhibiting interferon secrete pathway. Currently, it remains limited knowledge and understanding of the roles of human bocavirus 2-4 in diseases, but the gastrointestinal diseases should be paid more attention. Detection of human bocavirus DNA by traditional polymerase chain reaction (PCR) assay shouldn't be regarded as conclusive diagnostic basis. Instead, combined with mRNA and specific antigen detection, it is beneficial to improve the accuracy of diagnosis. Till now, the knowledge of human bocavirus remains poorly studied, which is deserved to further progress.
MeSH term(s)	Infant ; Humans ; Child ; Child, Preschool ; Human bocavirus ; Climate ; Coinfection ; Epidemics ; Interferons
Chemical Substances	Interferons (9008-11-1)
Language	Chinese
Publishing date	2023-06-12
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	2095-4352
ISSN	2095-4352
DOI	10.3760/cma.j.cn121430-20220804-00714
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Article ; Online: Fully Portraying Patch Area Scaling with Resolution

Qianning Zhang / Zhu Xu

Land, Vol 10, Iss 3, p

An Analytics and Descriptive Statistics-Combined Approach

2021 Volume 262

Abstract: Scale effects are inherent in spatial analysis. Quantitative knowledge about them is necessary for properly interpreting and scaling analysis results. The objective of this study was to systematically model patch area scaling and the associated ... ...

Abstract	Scale effects are inherent in spatial analysis. Quantitative knowledge about them is necessary for properly interpreting and scaling analysis results. The objective of this study was to systematically model patch area scaling and the associated uncertainty. A hybrid approach was taken to tackle the difficulty involved. Recognizing that patch’s size and shape play the key role in shaping its scaling behavior, a function model of patch area scaling based on patch morphology was first conceptually formulated. It was then substantiated by sampling and interpolating in the scale-integrated domain of patch morphology, which is characterized by a one-dimensional size index, namely the relative support range (RSR), and a compactness index, namely filling . The area scaling model obtained unveils a simple consistent scaling pattern of all patches and an overall fading range between 0.12 and 3.16 in terms of RSR. The uncertainty model built exhibits a filling -dependent pattern of the variance of patch area, which can be as large as 0.67 (i.e., 67%) in terms of standard deviation. The models were validated by using them to predict patch and class area scaling of the test patches and landscapes. This study demonstrated the basic feasibility of analytically modeling scaling behavior. It also revealed the uncertainty of scale effects is very significant due to the inevitable randomness in rasterization.
Keywords	scale effect ; spatial aggregation ; scaling model ; uncertainty ; patch area ; land use and land cover ; Agriculture ; S
Subject code	910
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Role of Cockayne Syndrome Group B Protein in Replication Stress: Implications for Cancer Therapy.

Walker, John R / Zhu, Xu-Dong

International journal of molecular sciences

2022 Volume 23, Issue 18

Abstract: A variety of endogenous and exogenous insults are capable of impeding replication fork progression, leading to replication stress. Several SNF2 fork remodelers have been shown to play critical roles in resolving this replication stress, utilizing ... ...

Abstract	A variety of endogenous and exogenous insults are capable of impeding replication fork progression, leading to replication stress. Several SNF2 fork remodelers have been shown to play critical roles in resolving this replication stress, utilizing different pathways dependent upon the nature of the DNA lesion, location on the DNA, and the stage of the cell cycle, to complete DNA replication in a manner preserving genetic integrity. Under certain conditions, however, the attempted repair may lead to additional genetic instability. Cockayne syndrome group B (CSB) protein, a SNF2 chromatin remodeler best known for its role in transcription-coupled nucleotide excision repair, has recently been shown to catalyze fork reversal, a pathway that can provide stability of stalled forks and allow resumption of DNA synthesis without chromosome breakage. Prolonged stalling of replication forks may collapse to give rise to DNA double-strand breaks, which are preferentially repaired by homology-directed recombination. CSB plays a role in repairing collapsed forks by promoting break-induced replication in S phase and early mitosis. In this review, we discuss roles of CSB in regulating the sources of replication stress, replication stress response, as well as the implications of CSB for cancer therapy.
MeSH term(s)	Chromatin ; Cockayne Syndrome/genetics ; DNA/metabolism ; DNA Repair ; DNA Replication ; DNA-Binding Proteins/metabolism ; Humans ; Neoplasms/genetics ; Neoplasms/therapy
Chemical Substances	Chromatin ; DNA-Binding Proteins ; DNA (9007-49-2)
Language	English
Publishing date	2022-09-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms231810212
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Article ; Online: The contributions of AI in the development of ideological and political perspectives in education

Zhang, Tingting / Lu, Xiangpeng / Zhu, Xu / Zhang, Jing

Heliyon. 2023 Mar., v. 9, no. 3 p.e13403-

2023

Abstract: Opportunities and difficulties have arisen for the educational system as a result of the development of "artificial intelligence" technology. In the era of "artificial intelligence", the main features of ideological and political education in colleges ... ...

Abstract	Opportunities and difficulties have arisen for the educational system as a result of the development of "artificial intelligence" technology. In the era of "artificial intelligence", the main features of ideological and political education in colleges are the development of the intelligence revolution, the development of teaching concepts, and the omnipotence of teaching content, and teaching methods. This study further explores the necessity and development of "artificial intelligence technology" in college ideological and political education through a questionnaire survey, and promotes the organic integration of artificial intelligence and ideological and political education. The results show that [1] College students have positive attitudes toward the application of artificial intelligence in college ideological and political education, and college students are looking forward to the intelligent services and changes brought by artificial intelligence technology in college ideological and political education [2]. According to the results of the questionnaire survey, this paper proposes the development path of college ideological and political education in the era of artificial intelligence, that is, schools and teachers need to improve the transformation of traditional education as well as the construction of contemporary Internet education. This study offers the possibility of interdisciplinary research, expands the scope of ideological and political education research, and provides a reference for front-line teaching to a certain extent.
Keywords	Internet ; artificial intelligence ; education ; educational research ; interdisciplinary research ; politics ; questionnaires ; surveys ; Colleges ; Ideological and political education ; Precision education ; Big data
Language	English
Dates of publication	2023-03
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e13403
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: ARNTL2 upregulation of ACOT7 promotes NSCLC cell proliferation through inhibition of apoptosis and ferroptosis.

Wang, Tao / Wang, Kai / Zhu, Xu / Chen, Nan

BMC molecular and cell biology

2023 Volume 24, Issue 1, Page(s) 14

Abstract: Background: Recent studies have reported that the circadian transcription factor aryl hydrocarbon receptor nuclear translocator like 2 (ARNTL2) promotes the metastatic progression of lung adenocarcinoma. However, the molecular mechanisms of ARNTL2 in ... ...

Abstract	Background: Recent studies have reported that the circadian transcription factor aryl hydrocarbon receptor nuclear translocator like 2 (ARNTL2) promotes the metastatic progression of lung adenocarcinoma. However, the molecular mechanisms of ARNTL2 in non-small cell lung cancer (NSCLC) cell growth and proliferation remain to be explored. Methods: The expression of ARNTL2 and acyl-CoA thioesterase 7 (ACOT7) in lung cancer patients was analyzed based on TCGA database. Gain-of-function of ARNTL2 and ACOT7 was conducted by transfecting the cells with plasmids or lentivirus. Knockdown assay was carried out by siRNAs. Western blot and qRT-PCR were performed to check the protein and mRNA expression. Dual luciferase and ChIP-qPCR assay was applied to check the interaction of ARNTL2 on ACOT7's promoter sequence. Triglyceride level, MDA production, the activity of casapase 3 to caspase 7, and lipid ROS were measured by indicated assay kit. Cellular function was detected by CCK8, colony formation and flow cytometry analysis of cell death and cell cycle. Results: We demonstrated that ARNTL2 upregulation of ACOT7 was critical for NSCLC cell growth and proliferation. Firstly, overexpression of ARNTL2 conferred the poor prognosis of LUAD patients and supported the proliferation of NSCLC cells. Based on molecular experiments, we showed that ARNTL2 potentiated the transcription activity of ACOT7 gene via direct binding to ACOT7's promoter sequence. ACOT7 high expression was correlated with the worse prognosis of LUAD patients. Gain-of-function and loss-of-function experiments revealed that AOCT7 contributed to NSCLC cell growth and proliferation. ACOT7 regulated the apoptosis and ferroptosis of NSCLC cells, while exhibited no effect on cell cycle progression. ACOT7 overexpression also potentiated fatty acid synthesis and suppressed lipid peroxidation. Lastly, we showed that ARNTL2 knockdown and overexpression inhibited and promoted the cellular triglyceride production and subsequent cell proliferation, which could be reversed by ACOT7 overexpression and knockdown. Conclusion: Our study illustrated the oncogenic function of ARNTL2/ACOT7 axis in the development of NSCLC. Targeting ARNTL2 or ACOT7 might be promising therapeutic strategies for NSCLC patients with highly expressed ARNTL2.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/pathology ; Up-Regulation/genetics ; Lung Neoplasms/metabolism ; Ferroptosis/genetics ; Apoptosis/genetics ; Cell Proliferation/genetics ; ARNTL Transcription Factors/genetics
Chemical Substances	BMAL2 protein, human ; ARNTL Transcription Factors
Language	English
Publishing date	2023-03-31
Publishing country	England
Document type	Journal Article
ISSN	2661-8850
ISSN (online)	2661-8850
DOI	10.1186/s12860-022-00450-5
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Article: The contributions of AI in the development of ideological and political perspectives in education.

Zhang, Tingting / Lu, Xiangpeng / Zhu, Xu / Zhang, Jing

Heliyon

2023 Volume 9, Issue 3, Page(s) e13403

Abstract	Opportunities and difficulties have arisen for the educational system as a result of the development of "artificial intelligence" technology. In the era of "artificial intelligence", the main features of ideological and political education in colleges are the development of the intelligence revolution, the development of teaching concepts, and the omnipotence of teaching content, and teaching methods. This study further explores the necessity and development of "artificial intelligence technology" in college ideological and political education through a questionnaire survey, and promotes the organic integration of artificial intelligence and ideological and political education. The results show that [1] College students have positive attitudes toward the application of artificial intelligence in college ideological and political education, and college students are looking forward to the intelligent services and changes brought by artificial intelligence technology in college ideological and political education [2]. According to the results of the questionnaire survey, this paper proposes the development path of college ideological and political education in the era of artificial intelligence, that is, schools and teachers need to improve the transformation of traditional education as well as the construction of contemporary Internet education. This study offers the possibility of interdisciplinary research, expands the scope of ideological and political education research, and provides a reference for front-line teaching to a certain extent.
Language	English
Publishing date	2023-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e13403
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Article ; Online: A tunable wide-angle narrowband perfect absorber based on an optical cavity containing hyperbolic metamaterials.

Xie, Zhenlong / Zhu, Xu / Deng, Yijing / Chen, Yihang

Physical chemistry chemical physics : PCCP

2023 Volume 25, Issue 42, Page(s) 29358–29364

Abstract: We demonstrate that wide-angle narrowband absorption can be achieved from a microcavity where a hyperbolic metamaterial and a dielectric layer are sandwiched between two metal reflectors. As the incident angle changes, the phase-shift variation in the ... ...

Abstract	We demonstrate that wide-angle narrowband absorption can be achieved from a microcavity where a hyperbolic metamaterial and a dielectric layer are sandwiched between two metal reflectors. As the incident angle changes, the phase-shift variation in the hyperbolic metamaterial can compensate that in the dielectric layer and, consequently, result in the angle-insensitive Fabry-Perot resonance in the proposed cavity. Silicon, indium tin oxide (ITO), and gold layers are used to construct the microcavity to produce a narrow absorption band in the near-infrared region. Our device exhibits good absorption stability over a wide angle range of incidence from 0° to 70°. Moreover, the absorption wavelength can be tuned by changing the thickness of the resonator. The presented absorber may find potential applications in the design of narrowband thermophotovoltaic emitters, sensitive detectors, filters,
Language	English
Publishing date	2023-11-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d3cp04051h
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Article ; Online: TRIM29 knockdown prevented the colon cancer progression through decreasing the ubiquitination levels of KRT5.

Sun, Lihui / Wang, Dawei / Chen, Zhenyu / Zhu, Xu

Open life sciences

2023 Volume 18, Issue 1, Page(s) 20220711

Abstract: To investigate the specific role of TRIM29 in colon cancer progression, bioinformatic analysis was performed on TRIM29. Colon cancer tissues were collected and colon cancer cells were cultured for further experiments. Cell viability and proliferation ... ...

Abstract	To investigate the specific role of TRIM29 in colon cancer progression, bioinformatic analysis was performed on TRIM29. Colon cancer tissues were collected and colon cancer cells were cultured for further experiments. Cell viability and proliferation were determined using CCK-8, colony formation, and EDU staining assays. The mRNA and protein levels of TRIM29 and KRT5 were determined using quantitative real-time PCR and western blotting, respectively. The interaction between TRIM29 and KRT5 was detected using a co-immunoprecipitation (CO-IP) assay. Cycloheximide treatment was performed to analyse the stability of KRT5. TRIM29 was upregulated in colon cancer tissues and cells. TRIM29 knockdown decreased the cell viability and proliferation and ubiquitination levels of KRT5 and enhanced the protein stability and expression of KRT5. The CO-IP assay confirmed that TRIM29 and KRT5 binded to each other. KRT5 knockdown neutralises the inhibitory effect of sh-TRIM29 on colon cancer cell growth and TRIM29 knockdown prevented the proliferation of colon cancer cells by decreasing ubiquitination of KRT5, which enhanced the protein stability and expression of KRT5 in cancer cells. Thus, targeting TRIM29-mediated ubiquitination levels of KRT5 might be a new direction for colon cancer therapy.
Language	English
Publishing date	2023-08-30
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2817958-4
ISSN	2391-5412 ; 2391-5412
ISSN (online)	2391-5412
ISSN	2391-5412
DOI	10.1515/biol-2022-0711
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Article: Comparison of two echocardiography-based methods for evaluating pediatric left ventricular diastolic dysfunction.

Xiang, Xue / Zhu, Xu / Zheng, Min / Tang, Yi

Frontiers in pediatrics

2023 Volume 11, Page(s) 1206314

Abstract: Objectives: To investigate the consistency between the 2016 America Society of Echocardiography (ASE)/European Association of Cardiovascular Imaging (EACVI) guideline-based recommendations and the body surface area (BSA)-transformed : Methods: ... ...

Abstract	Objectives: To investigate the consistency between the 2016 America Society of Echocardiography (ASE)/European Association of Cardiovascular Imaging (EACVI) guideline-based recommendations and the body surface area (BSA)-transformed Methods: Clinical data of children with heart failure (HF) and those with a high risk of HF and a low risk of HF were collected from the Children's Hospital of Chongqing Medical University between March 2021 and October 2022. The mitral annular Results: A total of 132 children with HF, 189 with a high risk of HF, and 231 with a low risk of HF, were enrolled. The consistency of the two criteria in evaluating LVDF in children with HF and with high risk of HF was moderate, with weighted kappa coefficients of 0.566 and 0.468, respectively ( Conclusions: The
Language	English
Publishing date	2023-09-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2023.1206314
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Article ; Online: Low blood carotenoid status in dementia and mild cognitive impairment: A systematic review and meta-analysis.

Wang, Lin / Zhao, Tie / Zhu, Xu / Jiang, Qinghua

BMC geriatrics

2023 Volume 23, Issue 1, Page(s) 195

Abstract: Background: Given their potent antioxidation properties, carotenoids play a role in delaying and preventing dementia and mild cognitive impairment (MCI). However, observational studies have found inconsistent results regarding the associations between ... ...

Abstract	Background: Given their potent antioxidation properties, carotenoids play a role in delaying and preventing dementia and mild cognitive impairment (MCI). However, observational studies have found inconsistent results regarding the associations between blood carotenoid levels and the risk of dementia and MCI. We conducted this systematic review and meta-analysis to investigate the relationship between blood carotenoid levels and the risk of dementia and MCI. Methods: A systematic search was performed in the Web of Science, PubMed, Embase, and Cochrane Library electronic databases to retrieve relevant English articles published from their inception until February 23, 2023. Study quality was assessed by the Newcastle-Ottawa scale. Standardized mean differences (SMDs) and 95% confidence intervals (CIs) were pooled using random-effect meta-analyses. Ultimately, 23 studies (n = 6610) involving 1422 patients with dementia, 435 patients with MCI, and 4753 controls were included. Results: Our meta-analysis showed that patients with dementia had lower blood lycopene (SMD: -0.521; 95%CI: -0.741, -0.301), α-carotene (SMD: -0.489; 95%CI: -0.697, -0.281), β-carotene (SMD: -0.476; 95%CI: -0.784, -0.168), lutein (SMD: -0.516; 95%CI: -0.753, -0.279), zeaxanthin (SMD: -0.571; 95%CI: -0.910, -0.232) and β-cryptoxanthin (SMD: -0.617; 95%CI: -0.953, -0.281) than the controls. Our results indicated that blood carotenoid levels were significantly lower in patients with dementia than in controls, despite high heterogeneity across the studies. Owing to insufficient data, we did not observe a similar and stable relationship between blood carotenoid levels and MCI. Conclusions: Our meta-analysis indicated that lower blood carotenoid levels may be a risk factor for dementia and MCI.
MeSH term(s)	Humans ; Cognitive Dysfunction/diagnosis ; Carotenoids ; beta Carotene ; Lutein ; Dementia/diagnosis
Chemical Substances	Carotenoids (36-88-4) ; beta Carotene (01YAE03M7J) ; Lutein (X72A60C9MT)
Language	English
Publishing date	2023-03-30
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-023-03900-7
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