Article ; Online: Exploring new frontiers: cell surface vimentin as an emerging marker for circulating tumor cells and a promising therapeutic target in advanced gastric Cancer.
Journal of experimental & clinical cancer research : CR
2024 Volume 43, Issue 1, Page(s) 129
Abstract: Background: Circulating tumor cells (CTCs) hold immense promise in guiding treatment strategies for advanced gastric cancer (GC). However, their clinical impact has been limited due to challenges in identifying epithelial-mesenchymal transition (EMT)- ... ...
Abstract | Background: Circulating tumor cells (CTCs) hold immense promise in guiding treatment strategies for advanced gastric cancer (GC). However, their clinical impact has been limited due to challenges in identifying epithelial-mesenchymal transition (EMT)-CTCs using conventional methods. Methods: To bridge this knowledge gap, we established a detection platform for CTCs based on the distinctive biomarker cell surface vimentin (CSV). A prospective study involving 127 GC patients was conducted, comparing CTCs enumeration using both EpCAM and CSV. This approach enabled the detection of both regular and EMT-CTCs, providing a comprehensive analysis. Spiking assays and WES were employed to verify the reliability of this marker and technique. To explore the potential inducer of CSV Results: Our findings revealed the potential of CSV in predicting therapeutic responses and long-term prognosis for advanced GC patients. Additionally, compared to the conventional EpCAM-based CTCs detection method, the CSV-specific positive selection CTCs assay was significantly better for evaluating the therapeutic response and prognosis in advanced GC patients and successfully predicted disease progression 14.25 months earlier than radiology evaluation. Apart from its excellent role as a detection marker, CSV emerges as a promising therapeutic target for attenuating GC metastasis. It was found that fat mass and obesity associated protein (FTO) could act as a potential catalyst for CSV Conclusion: In summary, leveraging CSV as a universal CTCs marker represents a significant breakthrough in advancing personalized medicine for patients with advanced GC. This research not only paves the way for tailored therapeutic strategies but also underscores the pivotal role of CSV in enhancing GC management, opening new frontiers for precision medicine. |
---|---|
MeSH term(s) | Animals ; Female ; Humans ; Male ; Mice ; Middle Aged ; Biomarkers, Tumor/metabolism ; Cell Line, Tumor ; Epithelial-Mesenchymal Transition ; Neoplastic Cells, Circulating/metabolism ; Neoplastic Cells, Circulating/pathology ; Prospective Studies ; Stomach Neoplasms/pathology ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/genetics ; Vimentin/metabolism |
Chemical Substances | Biomarkers, Tumor ; Vimentin ; VIM protein, human |
Language | English |
Publishing date | 2024-04-30 |
Publishing country | England |
Document type | Journal Article |
ZDB-ID | 803138-1 |
ISSN | 1756-9966 ; 0392-9078 |
ISSN (online) | 1756-9966 |
ISSN | 0392-9078 |
DOI | 10.1186/s13046-024-03043-6 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
Zs.A 2065: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.