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Article ; Online: Reservoir Characteristics and Formation Model of the Bauxite Gas Reservoir: The Benxi Formation in the LX Block, Northeast of Ordos Basin, China.

Yu, Shanshan / Zhao, Zhigang / Zhu, Yanhe / Zhu, Xiaomin / Lai, Jin / Li, Dan / Wang, Xiaolin

ACS omega

2024 Volume 9, Issue 16, Page(s) 18127–18136

Abstract: Recently, horizontal well L47-1CH in the Longdong area of the southwestern Ordos Basin made a significant breakthrough in bauxite natural gas exploration, changing the traditional geological understanding that bauxite could not form effective reservoirs. ...

Abstract	Recently, horizontal well L47-1CH in the Longdong area of the southwestern Ordos Basin made a significant breakthrough in bauxite natural gas exploration, changing the traditional geological understanding that bauxite could not form effective reservoirs. To further explore the exploration and development potential of bauxite natural gas reservoirs in the northeast of the Ordos Basin, it is urgent to carry out basic geological studies. This paper discusses the sedimentary environment, reservoir characteristics, and formation patterns of the bauxite gas reservoirs in the LX Block using trace elements, thin sections, X-ray diffraction, scanning electron microscopy, conventional physical properties, constant pressure mercury, etc. Then, the distribution pattern of bauxite was studied according to the restoration of the karst paleogeomorphology, and the formation model of bauxite was ultimately established. The results show that bauxite developed a clear triple-segment structure vertically, characterized by rich iron at the bottom, high aluminum at the middle, and low iron at the top. The mineral composition of the bauxite section mainly includes diaspore, iron minerals, titanium minerals, and birnessite. The types of pores mainly include intra- and intergranular dissolved pores, matrix-dissolved pores, intercrystalline pores, and microfractures. The porosity ranges from 1.51 to 9.90%, with a relatively good sorting and connectivity of the pore and throat. The bauxite was formed in a hot and humid climate, deposited in a shallow-water tidal flat and lagoon sedimentary environment with oxygen depleted, and experienced oscillatory regression during the deposition process. The thickness of bauxite is significantly controlled by karst paleogeomorphology, and it is mainly distributed at the negative terrain positions of karat pits and karst terraces. The above results can provide a geological basis for the exploration and development of bauxite in the Ordos Basin and similar basins worldwide.
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c10097
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Article: Reinforcement learning based variable damping control of wearable robotic limbs for maintaining astronaut pose during extravehicular activity.

Zhao, Sikai / Zheng, Tianjiao / Sui, Dongbao / Zhao, Jie / Zhu, Yanhe

Frontiers in neurorobotics

2023 Volume 17, Page(s) 1093718

Abstract: As astronauts perform on-orbit servicing of extravehicular activity (EVA) without the help of the space station's robotic arms, it will be rather difficult and labor-consuming to maintain the appropriate position in case of impact. In order to solve this ...

Abstract	As astronauts perform on-orbit servicing of extravehicular activity (EVA) without the help of the space station's robotic arms, it will be rather difficult and labor-consuming to maintain the appropriate position in case of impact. In order to solve this problem, we propose the development of a wearable robotic limb system for astronaut assistance and a variable damping control method for maintaining the astronaut's position. The requirements of the astronaut's impact-resisting ability during EVA were analyzed, including the capabilities of deviation resistance, fast return, oscillation resistance, and accurate return. To meet these needs, the system of the astronaut with robotic limbs was modeled and simplified. In combination with this simplified model and a reinforcement learning algorithm, a variable damping controller for the end of the robotic limb was obtained, which can regulate the dynamic performance of the robot end to resist oscillation after impact. A weightless simulation environment for the astronaut with robotic limbs was constructed. The simulation results demonstrate that the proposed method can meet the recommended requirements for maintaining an astronaut's position during EVA. No matter how the damping coefficient was set, the fixed damping control method failed to meet all four requirements at the same time. In comparison to the fixed damping control method, the variable damping controller proposed in this paper fully satisfied all the impact-resisting requirements by itself. It could prevent excessive deviation from the original position and was able to achieve a fast return to the starting point. The maximum deviation displacement was reduced by 39.3% and the recovery time was cut by 17.7%. Besides, it also had the ability to prevent reciprocating oscillation and return to the original position accurately.
Language	English
Publishing date	2023-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2453002-5
ISSN	1662-5218
ISSN	1662-5218
DOI	10.3389/fnbot.2023.1093718
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Article ; Online: A Graph-Based Hybrid Reconfiguration Deformation Planning for Modular Robots.

Wei, Ruopeng / Liu, Yubin / Dong, Huijuan / Zhu, Yanhe / Zhao, Jie

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 18

Abstract: The self-reconfigurable modular robotic system is a class of robots that can alter its configuration by rearranging the connectivity of their component modular units. The reconfiguration deformation planning problem is to find a sequence of ... ...

Abstract	The self-reconfigurable modular robotic system is a class of robots that can alter its configuration by rearranging the connectivity of their component modular units. The reconfiguration deformation planning problem is to find a sequence of reconfiguration actions to transform one reconfiguration into another. In this paper, a hybrid reconfiguration deformation planning algorithm for modular robots is presented to enable reconfiguration between initial and goal configurations. A hybrid algorithm is developed to decompose the configuration into subconfigurations with maximum commonality and implement distributed dynamic mapping of free vertices. The module mapping relationship between the initial and target configurations is then utilized to generate reconfiguration actions. Simulation and experiment results verify the effectiveness of the proposed algorithm.
Language	English
Publishing date	2023-09-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23187892
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Article ; Online: Sema3A alleviates viral myocarditis by modulating SIRT1 to regulate cardiomyocyte mitophagy

Lin, Lin / Wei, Jin / Zhu, Canzhan / Hao, Guanghua / Xue, Jiahong / Zhu, Yanhe / Wu, Ruiyun

Environmental Toxicology. 2023 June, v. 38, no. 6 p.1305-1317

2023

Abstract: Viral myocarditis (VMC) is a common myocardial inflammatory disease characterized by inflammatory cell infiltration and cardiomyocyte necrosis. Sema3A was reported to reduce cardiac inflammation and improve cardiac function after myocardial infarction, ... ...

Abstract	Viral myocarditis (VMC) is a common myocardial inflammatory disease characterized by inflammatory cell infiltration and cardiomyocyte necrosis. Sema3A was reported to reduce cardiac inflammation and improve cardiac function after myocardial infarction, but its role in VMC remains to be explored. Here, a VMC mouse model was established by infection with CVB3, and Sema3A was overexpressed in vivo by intraventricular injection of an adenovirus‐mediated Sema3A expression vector (Ad‐Sema3A). We found that Sema3A overexpression attenuated CVB3‐induced cardiac dysfunction and tissue inflammation. And Sema3A also reduced macrophage accumulation and NLRP3 inflammasome activation in the myocardium of VMC mice. In vitro, LPS was used to stimulate primary splenic macrophages to mimic the macrophage activation state in vivo. Activated macrophages were co‐cultured with primary mouse cardiomyocytes to evaluate macrophage infiltration‐induced cardiomyocyte damage. Ectopic expression of Sema3A in cardiomyocytes effectively protected cardiomyocytes from activated macrophage‐induced inflammation, apoptosis, and ROS accumulation. Mechanistically, cardiomyocyte‐expressed Sema3A mitigated macrophage infiltration‐caused cardiomyocyte dysfunction by promoting cardiomyocyte mitophagy and hindering NLRP3 inflammasome activation. Furthermore, NAM (a SIRT1 inhibitor) reversed the protective effect of Sema3A against activated macrophage‐induced cardiomyocyte dysfunction by suppressing cardiomyocyte mitophagy. In conclusion, Sema3A promoted cardiomyocyte mitophagy and suppressed inflammasome activation by regulating SIRT1, thereby attenuating macrophage infiltration‐induced cardiomyocyte injury in VMC.
Keywords	apoptosis ; cardiac output ; cardiomyocytes ; coculture ; ecotoxicology ; genetic vectors ; inflammasomes ; inflammation ; macrophage activation ; macrophages ; mice ; mitophagy ; models ; myocardial infarction ; myocarditis ; necrosis ; protective effect
Language	English
Dates of publication	2023-06
Size	p. 1305-1317.
Publishing place	John Wiley & Sons, Inc.
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	1463449-1
ISSN	1522-7278 ; 1520-4081
ISSN (online)	1522-7278
ISSN	1520-4081
DOI	10.1002/tox.23765
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Article: Symmetrical Efficient Gait Planning Based on Constrained Direct Collocation.

Chen, Boyang / Zang, Xizhe / Zhang, Yue / Gao, Liang / Zhu, Yanhe / Zhao, Jie

Micromachines

2023 Volume 14, Issue 2

Abstract: Biped locomotion provides more mobility and effectiveness compared with other methods. Animals have evolved efficient walking patterns that are pursued by biped robot researchers. Current researchers have observed that symmetry is a critical criterion to ...

Abstract	Biped locomotion provides more mobility and effectiveness compared with other methods. Animals have evolved efficient walking patterns that are pursued by biped robot researchers. Current researchers have observed that symmetry is a critical criterion to achieve efficient natural walking and usually realize symmetrical gait patterns through morphological characteristics using simplified dynamic models or artificial priors of the center of mass (CoM). However, few considerations of symmetry and energy consumption are introduced at the joint level, resulting in inefficient leg motion. In this paper, we propose a full-order biped gait planner in which the symmetry requirement, energy efficiency, and trajectory smoothness can all be involved at the joint level, and CoM motion is automatically determined without any morphological prior. In order to achieve a symmetrical and efficient walking pattern, we first investigated the characteristic of a completely symmetrical gait, and a group of nearly linear slacked constraints was designed for three phases of planning. Then a Constrained Direct Collocation (DIRCON)-based full-order biped gait planner with a weighted cost function for energy consumption and trajectory smoothness is proposed. A dynamic simulation with our newly designed robot model was performed in CoppliaSim to test the planner. Physical comparison experiments on a real robot device finally validated the symmetry characteristic and energy efficiency of the generated gait. In addition, a detailed presentation of the real biped robot is also provided.
Language	English
Publishing date	2023-02-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi14020417
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Article ; Online: Calcitriol Suppressed Isoproterenol-induced Proliferation of Cardiac Fibroblasts via Integrin β3/FAK/Akt Pathway.

Wang, Xin-Feng / Li, Qian / Sun, Xia / Zheng, Li-Ming / Cheng, Shao-Li / Zhu, Yan-He

Current medical science

2023 Volume 43, Issue 1, Page(s) 48–57

Abstract: Objective: Cardiac fibroblasts (CFs) proliferation and extracellular matrix deposition are important features of cardiac fibrosis. Various studies have indicated that vitamin D displays an anti-fibrotic property in chronic heart diseases. This study ... ...

Abstract	Objective: Cardiac fibroblasts (CFs) proliferation and extracellular matrix deposition are important features of cardiac fibrosis. Various studies have indicated that vitamin D displays an anti-fibrotic property in chronic heart diseases. This study explored the role of vitamin D in the growth of CFs via an integrin signaling pathway. Methods: MTT and 5-ethynyl-2'-deoxyuridine assays were performed to determine cell viability. Western blotting was performed to detect the expression of proliferating cell nuclear antigen (PCNA) and integrin signaling pathway. The fibronectin was observed by ELISA. Immunohistochemical staining was employed to evaluate the expression of integrin β3. Results: The PCNA expression in the CFs was enhanced after isoproterenol (ISO) stimulation accompanied by an elevated expression of integrin beta-3 (β3). The blockade of the integrin β3 with a specific integrin β3 antibody reduced the PCNA expression induced by the ISO. Decreasing the integrin β3 by siRNA reduced the ISO-triggered phosphorylation of FAK and Akt. Both the FAK inhibitor and Akt inhibitor suppressed the PCNA expression induced by the ISO in the CFs. Calcitriol (CAL), an active form of vitamin D, attenuated the ISO-induced CFs proliferation by downregulating the integrin β3 expression, and phosphorylation of FAK and Akt. Moreover, CAL reduced the increased levels of fibronectin and hydroxyproline in the CFs culture medium triggered by the ISO. The administration of calcitriol decreased the integrin β3 expression in the ISO-induced myocardial injury model. Conclusion: These findings revealed a novel role for CAL in suppressing the CFs growth by the downregulation of the integrin β3/FAK/Akt pathway.
MeSH term(s)	Humans ; Calcitriol/metabolism ; Calcitriol/pharmacology ; Fibronectins/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Isoproterenol ; Proliferating Cell Nuclear Antigen/metabolism ; Integrin beta3/genetics ; Integrin beta3/metabolism ; Vitamins ; Cell Proliferation ; Fibroblasts/metabolism
Chemical Substances	Calcitriol (FXC9231JVH) ; Fibronectins ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Isoproterenol (L628TT009W) ; Proliferating Cell Nuclear Antigen ; Integrin beta3 ; Vitamins
Language	English
Publishing date	2023-01-21
Publishing country	China
Document type	Journal Article
ZDB-ID	2931065-9
ISSN	2523-899X ; 2096-5230
ISSN (online)	2523-899X
ISSN	2096-5230
DOI	10.1007/s11596-022-2681-6
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Article ; Online: Sema3A alleviates viral myocarditis by modulating SIRT1 to regulate cardiomyocyte mitophagy.

Lin, Lin / Wei, Jin / Zhu, Canzhan / Hao, Guanghua / Xue, Jiahong / Zhu, Yanhe / Wu, Ruiyun

Environmental toxicology

2023 Volume 38, Issue 6, Page(s) 1305–1317

Abstract	Viral myocarditis (VMC) is a common myocardial inflammatory disease characterized by inflammatory cell infiltration and cardiomyocyte necrosis. Sema3A was reported to reduce cardiac inflammation and improve cardiac function after myocardial infarction, but its role in VMC remains to be explored. Here, a VMC mouse model was established by infection with CVB3, and Sema3A was overexpressed in vivo by intraventricular injection of an adenovirus-mediated Sema3A expression vector (Ad-Sema3A). We found that Sema3A overexpression attenuated CVB3-induced cardiac dysfunction and tissue inflammation. And Sema3A also reduced macrophage accumulation and NLRP3 inflammasome activation in the myocardium of VMC mice. In vitro, LPS was used to stimulate primary splenic macrophages to mimic the macrophage activation state in vivo. Activated macrophages were co-cultured with primary mouse cardiomyocytes to evaluate macrophage infiltration-induced cardiomyocyte damage. Ectopic expression of Sema3A in cardiomyocytes effectively protected cardiomyocytes from activated macrophage-induced inflammation, apoptosis, and ROS accumulation. Mechanistically, cardiomyocyte-expressed Sema3A mitigated macrophage infiltration-caused cardiomyocyte dysfunction by promoting cardiomyocyte mitophagy and hindering NLRP3 inflammasome activation. Furthermore, NAM (a SIRT1 inhibitor) reversed the protective effect of Sema3A against activated macrophage-induced cardiomyocyte dysfunction by suppressing cardiomyocyte mitophagy. In conclusion, Sema3A promoted cardiomyocyte mitophagy and suppressed inflammasome activation by regulating SIRT1, thereby attenuating macrophage infiltration-induced cardiomyocyte injury in VMC.
MeSH term(s)	Animals ; Mice ; Myocarditis ; Myocytes, Cardiac/metabolism ; Semaphorin-3A/metabolism ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Sirtuin 1/genetics ; Sirtuin 1/metabolism ; Mitophagy ; Coxsackievirus Infections/metabolism ; Inflammation/metabolism
Chemical Substances	Semaphorin-3A ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Sirtuin 1 (EC 3.5.1.-) ; Sirt1 protein, mouse (EC 3.5.1.-)
Language	English
Publishing date	2023-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1463449-1
ISSN	1522-7278 ; 1520-4081
ISSN (online)	1522-7278
ISSN	1520-4081
DOI	10.1002/tox.23765
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Article ; Online: Swimming Performance of the Frog-Inspired Soft Robot.

Fan, Jizhuang / Wang, Shuqi / Yu, Qingguo / Zhu, Yanhe

Soft robotics

2020 Volume 7, Issue 5, Page(s) 615–626

Abstract: This article presents a frog-inspired swimming soft robot whose joints are articulated pneumatic soft actuators. The soft actuator is designed and prepared by studying the biological structure and limb movement characteristics of frogs. A schematic limb ... ...

Abstract	This article presents a frog-inspired swimming soft robot whose joints are articulated pneumatic soft actuators. The soft actuator is designed and prepared by studying the biological structure and limb movement characteristics of frogs. A schematic limb motion diagram of the robot is established based on the kinematic model, and the design scheme is determined by a combined control system. The torso size is 0.175 × 0.100 × 0.060 m, which realizes frog-inspired swimming robot miniaturization. The experimental results show that the average propulsion speed during linear motion is 0.075 m/s, and the average turning speed is 15°/s. The rationality of the robot structural design and correctness of the control system are verified by prototype experiments.
MeSH term(s)	Animals ; Anura ; Biomechanical Phenomena ; Equipment Design ; Motion ; Robotics ; Swimming
Language	English
Publishing date	2020-05-13
Publishing country	United States
Document type	Journal Article
ISSN	2169-5180
ISSN (online)	2169-5180
DOI	10.1089/soro.2019.0094
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Article ; Online: GADF/GASF-HOG:feature extraction methods for hand movement classification from surface electromyography.

Xiao, Feiyun / Chen, Yanyan / Zhu, Yanhe

Journal of neural engineering

2020 Volume 17, Issue 4, Page(s) 46016

Abstract: Objective: Human intention gesture recognition is widely used in hand rehabilitation, artificial limb control, teleoperation, human-computer interaction and other fields. It has great application value, however, how to extract human intention gesture ... ...

Abstract	Objective: Human intention gesture recognition is widely used in hand rehabilitation, artificial limb control, teleoperation, human-computer interaction and other fields. It has great application value, however, how to extract human intention gesture accurately has been a research hotspot. Approach: Inspired by the image processing technology of machine vision, the surface electromyographic (sEMG) signal was selected as the source signal of motion intention in this work, and the original sEMG signal was converted into Gramian Angular Summation/Difference Field (GASF/GADF) image. Then, Histogram of Oriented Gradient (HOG) features of the corresponding GADF and GASF image were extracted. The extracted features are named as GASF-HOG and GADF-HOG. The Bagging method was used to map the features to six common gestures to realize the classification of intention gestures. Ten volunteers participated in the experiment, and the experimental data were used to verify the proposed method. Main results: The experimental results showed that the average accuracies of the proposed methods (GADF-HOG with Bagging, GASF-HOG with Bagging) were as follow: GADF-HOG with Bagging was with 95.73 ± 1.90%, and GASF-HOG with Bagging was with 93.63 ± 1.54%. Significance: The method proposed in this paper is inspired by image processing technology of machine vision, which provides a new idea about the human intention gesture recognition by combining the interdisciplinary knowledge.
MeSH term(s)	Algorithms ; Electromyography ; Gestures ; Hand ; Humans ; Movement ; Signal Processing, Computer-Assisted
Language	English
Publishing date	2020-07-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2170901-4
ISSN	1741-2552 ; 1741-2560
ISSN (online)	1741-2552
ISSN	1741-2560
DOI	10.1088/1741-2552/ab9db9
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Article ; Online: Corrigendum: Biologically inspired swimming robotic frog based on pneumatic soft actuators (2020

Fan, Jizhuang / Du, Qilong / Yu, Qingguo / Wang, Yi / Qi, Jiaming / Zhu, Yanhe

Bioinspiration & biomimetics

2022 Volume 17, Issue 4

Language	English
Publishing date	2022-05-23
Publishing country	England
Document type	Journal Article ; Published Erratum
ZDB-ID	2235670-8
ISSN	1748-3190 ; 1748-3182
ISSN (online)	1748-3190
ISSN	1748-3182
DOI	10.1088/1748-3190/ac65cb
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