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Article ; Online: Causal associations between 25-hydroxyvitamin D levels and NMOSD: a two-Sample Mendelian randomization analysis.

Zhu, Yunfei / Zhou, Xiaoling / Jia, Jingjin / Xue, Qun

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2024 Volume 45, Issue 5, Page(s) 2379–2381

MeSH term(s)	Humans ; Mendelian Randomization Analysis ; Vitamin D/analogs & derivatives ; Causality ; Genome-Wide Association Study ; Polymorphism, Single Nucleotide/genetics
Chemical Substances	25-hydroxyvitamin D (A288AR3C9H) ; Vitamin D (1406-16-2)
Language	English
Publishing date	2024-01-04
Publishing country	Italy
Document type	Letter
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-023-07290-x
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Article: Single-Cell Sequencing Combined with Transcriptome Sequencing Constructs a Predictive Model of Key Genes in Multiple Sclerosis and Explores Molecular Mechanisms Related to Cellular Communication.

Hu, Fangzhou / Zhu, Yunfei / Tian, Jingluan / Xu, Hua / Xue, Qun

Journal of inflammation research

2024 Volume 17, Page(s) 191–210

Abstract: Background: Multiple sclerosis (MS) causes chronic inflammation and demyelination of the central nervous system and comprises a class of neurodegenerative diseases in which interactions between multiple immune cell types mediate the involvement of MS ... ...

Abstract	Background: Multiple sclerosis (MS) causes chronic inflammation and demyelination of the central nervous system and comprises a class of neurodegenerative diseases in which interactions between multiple immune cell types mediate the involvement of MS development. However, the early diagnosis and treatment of MS remain challenging. Methods: Gene expression profiles of MS patients were obtained from the Gene Expression Omnibus (GEO) database. Single-cell and intercellular communication analyses were performed to identify candidate gene sets. Predictive models were constructed using LASSO regression. Relationships between genes and immune cells were analyzed by single sample gene set enrichment analysis (ssGSEA). The molecular mechanisms of key genes were explored using gene enrichment analysis. An miRNA network was constructed to search for target miRNAs related to key genes, and related transcription factors were searched by transcriptional regulation analysis. We utilized the GeneCard database to detect the correlations between disease-regulated genes and key genes. We verified the mRNA expression of 4 key genes by reverse transcription-quantitative PCR (RT‒qPCR). Results: Monocyte marker genes were selected as candidate gene sets. Conclusion: The prediction model constructed with the
Language	English
Publishing date	2024-01-09
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494878-0
ISSN	1178-7031
ISSN	1178-7031
DOI	10.2147/JIR.S442684
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Article ; Online: Vitamin D status and neuromyelitis optica spectrum disease: A systematic review and meta-analysis.

Zhu, Yunfei / Cao, Shugang / Hu, Fangzhou / Zhou, Xiaoling / Xue, Qun

Clinical neurology and neurosurgery

2024 Volume 239, Page(s) 108190

Abstract: Background and objective: There's an increasing body of evidence on vitamin D deficiency and the risk of neuromyelitis optica spectrum disorder (NMOSD). The aim of this meta-analysis was to assess serum vitamin D levels in patients with NMOSD versus ... ...

Abstract	Background and objective: There's an increasing body of evidence on vitamin D deficiency and the risk of neuromyelitis optica spectrum disorder (NMOSD). The aim of this meta-analysis was to assess serum vitamin D levels in patients with NMOSD versus healthy controls. Methods: We searched PubMed, EMBASE, Cochrane Library, Web of Science and CNKI for publications up to November 2022 and explored the relationship between NMOSD and serum vitamin D levels. The standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated using a random-effects model. Subgroup analysis and sensitivity analysis were applied to explore the sources of heterogeneity. Begg's test, Egger's test, and Egger's funnel plot were adopted to evaluate publication bias. Results: 6 studies (including 319 patients and 595 healthy controls) met the inclusion criteria and all compared vitamin D levels in patients with NMOSD versus healthy controls. Levels of serum vitamin D detected in NMOSD patients were significantly lower than those in healthy controls (SMD=-1.57, 95% CI=-2.27 ∼ -0.87, P<0.001, I Conclusion: Patients with NMOSD showed significantly reduced vitamin D levels compared with healthy controls. Our findings highlighted the importance of measuring vitamin D levels in patients with NMOSD. Multi-center randomized controlled trials with large samples will further confirm whether the association is casual and modifiable.
MeSH term(s)	Humans ; Vitamin D ; Neuromyelitis Optica ; Vitamins
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins
Language	English
Publishing date	2024-03-08
Publishing country	Netherlands
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	193107-6
ISSN	1872-6968 ; 0303-8467
ISSN (online)	1872-6968
ISSN	0303-8467
DOI	10.1016/j.clineuro.2024.108190
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Article ; Online: Enlarged perivascular spaces in autoimmune glial fibrillary acidic protein astrocytopathy.

Cao, Shugang / Zhu, Yunfei / Xia, Mingwu / Xue, Qun

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2023 Volume 44, Issue 10, Page(s) 3751–3754

MeSH term(s)	Humans ; Glial Fibrillary Acidic Protein ; Autoimmune Diseases of the Nervous System/diagnostic imaging ; Brain/metabolism ; Astrocytes ; Autoantibodies/metabolism
Chemical Substances	Glial Fibrillary Acidic Protein ; Autoantibodies
Language	English
Publishing date	2023-06-26
Publishing country	Italy
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-023-06892-9
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Zs.A 1877: Show issues

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Article ; Online: Reader Response: Frequency of Asymptomatic Optic Nerve Enhancement in a Large Retrospective Cohort of Patients With Aquaporin-4+ NMOSD.

Cao, Shugang / Zhu, Yunfei / Xue, Qun / Xia, Mingwu

Neurology

2022 Volume 100, Issue 6, Page(s) 309–310

MeSH term(s)	Humans ; Retrospective Studies ; Aquaporin 4 ; Optic Nerve/diagnostic imaging ; Neuromyelitis Optica/diagnostic imaging ; Autoantibodies ; Optic Neuritis
Chemical Substances	Aquaporin 4 ; Autoantibodies
Language	English
Publishing date	2022-12-11
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000206847
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Ui II Zs.153: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Neurometabolic and Brain Functional Alterations Associated with Cognitive Impairment in Patients with Myasthenia Gravis: A Combined

Zhou, Xiaoling / Yang, Yang / Zhu, Feng / Chen, Xiang / Zhu, Yunfei / Gui, Tiantian / Li, Yonggang / Xue, Qun

Neuroscience

2024 Volume 544, Page(s) 12–27

Abstract: Whether patients with myasthenia gravis (MG) exhibit cognitive impairment is controversial. Also the underlying mechanisms are unknown. We aimed to investigate alterations in cognitive function, neurometabolite levels, and brain function in patients with ...

Abstract	Whether patients with myasthenia gravis (MG) exhibit cognitive impairment is controversial. Also the underlying mechanisms are unknown. We aimed to investigate alterations in cognitive function, neurometabolite levels, and brain function in patients with MG and to explore the associations between abnormal regional brain functional activity, neurometabolite concentrations in the MPFC and left thalamus, and cognitive activity in patients with MG. Neuropsychological tests, proton magnetic resonance spectroscopy, and resting-state functional magnetic resonance imaging were performed on 41 patients with MG and 45 race-, sex-, age-, and education-matched healthy controls (HCs). The results suggest that MG is accompanied by cognitive decline, as indicated by global cognitive function, visual-spatial function, language, memory, abnormalities in regional brain functional activity, and neurometabolite alterations (including GABA, NAA, and Cho) in the medial prefrontal cortex (MPFC) and left thalamus. Cognitive impairment in patients with MG may be related to abnormal regional brain functional activity and changes in neurometabolites, and regional brain functional activity may be modulated by specific neurometabolites.
MeSH term(s)	Humans ; Magnetic Resonance Imaging/methods ; Brain/diagnostic imaging ; Cognitive Dysfunction/diagnostic imaging ; Proton Magnetic Resonance Spectroscopy/methods ; Myasthenia Gravis/complications ; Myasthenia Gravis/diagnostic imaging
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	196739-3
ISSN	1873-7544 ; 0306-4522
ISSN (online)	1873-7544
ISSN	0306-4522
DOI	10.1016/j.neuroscience.2024.02.021
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Zs.A 1215: Show issues

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Article ; Online: Asymptomatic spinal lesions in patients with AQP4-IgG-positive NMOSD: A real-world cohort study.

Cao, Shugang / Zhu, Yunfei / Wu, Xiaosan / Du, Jing / Xu, Si / Cui, Ping / Li, Qi / Xia, Mingwu / Xue, Qun / Tian, Yanghua

Annals of clinical and translational neurology

2024 Volume 11, Issue 4, Page(s) 905–915

Abstract: Objective: This study aims to explore the frequency and influencing factors of asymptomatic spinal lesions (ASLs) and their impact on subsequent relapses in patients with AQP4-IgG-positive NMOSD (AQP4-NMOSD) in a real-world setting.: Methods: We ... ...

Abstract	Objective: This study aims to explore the frequency and influencing factors of asymptomatic spinal lesions (ASLs) and their impact on subsequent relapses in patients with AQP4-IgG-positive NMOSD (AQP4-NMOSD) in a real-world setting. Methods: We retrospectively reviewed clinical information and spinal MRI data from AQP4-NMOSD patients who had at least one spinal cord MRI during their follow-ups. Kaplan-Meier curves and Cox proportional hazards models were employed to ascertain potential predictors of remission ASLs and to investigate factors associated with subsequent relapses. Results: In this study, we included 129 patients with AQP4-NMOSD and reviewed 173 spinal MRIs during attacks and 89 spinal MRIs during remission. Among these, 6 ASLs (3.5%) were identified during acute attacks, while 8 ASLs (9%) were found during remission. Remission ASLs were linked to the use of immunosuppressive agents, particularly conventional ones, whereas no patients using rituximab developed ASLs (p = 0.005). Kaplan-Meier curve analysis indicated that patients with ASLs had a significantly higher relapse risk (HR = 4.658, 95% CI: 1.519-14.285, p = 0.007) compared to those without. Additionally, the use of mycophenolate mofetil (HR = 0.027, 95% CI: 0.003-0.260, p = 0.002) and rituximab (HR = 0.035, 95% CI: 0.006-0.203, p < 0.001) significantly reduced the relapse risk. However, after accounting for other factors, the presence of ASLs did not exhibit a significant impact on subsequent relapses (HR = 2.297, 95% CI: 0.652-8.085, p = 0.195). Interpretation: ASLs may be observed in patients with AQP4-NMOSD. The presence of ASLs may signify an underlying inflammatory activity due to insufficient immunotherapy. The administration of immunosuppressive agents plays a key role in the presence of remission ASLs and the likelihood of subsequent relapses.
MeSH term(s)	Humans ; Neuromyelitis Optica/drug therapy ; Cohort Studies ; Aquaporin 4 ; Rituximab/therapeutic use ; Retrospective Studies ; Immunosuppressive Agents/therapeutic use ; Recurrence ; Immunoglobulin G
Chemical Substances	Aquaporin 4 ; Rituximab (4F4X42SYQ6) ; Immunosuppressive Agents ; Immunoglobulin G
Language	English
Publishing date	2024-02-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2740696-9
ISSN	2328-9503 ; 2328-9503
ISSN (online)	2328-9503
ISSN	2328-9503
DOI	10.1002/acn3.52007
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Article ; Online: Insight into the influence of pH on the precipitation induced by bacteria

Li, Lixia / Liu, Tianle / Jiang, Guosheng / Fang, Changliang / Zheng, Shaojun / Qu, Bo / Zhu, Yunfei

Soil Use and Management. 2022 Oct., v. 38, no. 4 p.1628-1643

2022

Abstract: In recent years, microbial mineralization has aroused great attention in soil remediation. The pH is one of the critical factors that control the microbial mineralization process. However, the interaction mechanism between the environment pH and the ... ...

Abstract	In recent years, microbial mineralization has aroused great attention in soil remediation. The pH is one of the critical factors that control the microbial mineralization process. However, the interaction mechanism between the environment pH and the mineralization process has not been clarified yet. This paper focused on the growth of bacteria, urease activity and the calcium utilization rate. Besides, we detected the particle size distribution, morphological characteristics and the composition of precipitations formed at different pH. Moreover, we evaluated the triaxial compressive strength of sand columns processed by different pH consolidation solutions. Additionally, the volume fraction of precipitations and its spatial distribution in sand columns were analysed by X‐ray CT. The results demonstrated that pH significantly influences the growth of bacteria and urease activity, especially in the bacteria's early growth stage. This paper also indicates that the environmental pH impacts the volume fraction of precipitations, affecting the consolidation properties. We also found a negative correlation between the cohesion and the total volume fraction of precipitations. In contrast, there was a positive correlation between the friction angle and the total volume fraction of precipitations. Moreover, we observed that the precipitations mainly distributed in the pores and throats, increasing the sand particles’ roughness. Furthermore, we proposed four cementing models for the spatial relationship between the precipitations and the sand particles, which provides new insight into the consolidation mechanism. This paper guides us to promote this environmentally friendly technology to treat soil liquefaction and desertification.
Keywords	X-radiation ; administrative management ; calcium ; cohesion ; compression strength ; desertification ; developmental stages ; friction ; mineralization ; pH ; particle size distribution ; roughness ; sand ; soil ; soil liquefaction ; soil remediation ; sustainable technology ; urease
Language	English
Dates of publication	2022-10
Size	p. 1628-1643.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	742151-5
ISSN	1475-2743 ; 0266-0032
ISSN (online)	1475-2743
ISSN	0266-0032
DOI	10.1111/sum.12779
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Synthetic MRI in the detection and quantitative evaluation of sacroiliac joint lesions in axial spondyloarthritis.

Zhang, Ke / Liu, Chaoran / Zhu, Yunfei / Li, Wenjuan / Li, Ximeng / Zheng, Jing / Hong, Guobin

Frontiers in immunology

2022 Volume 13, Page(s) 1000314

Abstract: Objective: Our primary objective was to verify the hypothesis that synthetic magnetic resonance imaging (MRI) is similar to conventional MRI in detecting sacroiliac joint lesions in patients with axial spondyloarthritis (axSpA). A secondary objective ... ...

Abstract	Objective: Our primary objective was to verify the hypothesis that synthetic magnetic resonance imaging (MRI) is similar to conventional MRI in detecting sacroiliac joint lesions in patients with axial spondyloarthritis (axSpA). A secondary objective was to assess the quantitative value of synthetic mapping in bone marrow edema (BME) and fat metaplasia. Methods: A total of 132 axSpA patients who underwent synthetic and conventional MRI from October 2019 to March 2021 were included in this prospective study. Two independent readers visually evaluated active inflammatory (BME, capsulitis, enthesitis, and inflammation at site of erosion) and structural lesions (erosion, sclerosis, ankylosis, and fat metaplasia) of the sacroiliac joints on conventional and synthetic magnetic resonance (MR) images. In addition, T1, T2, and proton density (PD) values, which were generated by synthetic mapping, were used to further quantitatively evaluate BME and fat metaplasia. A McNemar test was used to compare the differences between the two methods in the detection of sacroiliac joint lesions. Intraclass correlation coefficients (ICCs) were used to assess the inter-reader consistency of quantitative values. Mann-Whitney tests were performed, and receiver operating characteristic (ROC) curves were created for all quantitative analyses. Results: There were no statistical difference between synthetic and conventional MRI in the detection of sacroiliac joint lesions (all Conclusion: Synthetic MRI is as effective as conventional MRI in detecting sacroiliac joint lesions in patients with axSpA. Furthermore, synthetic mapping can accurately quantify BME and fat metaplasia.
MeSH term(s)	Axial Spondyloarthritis ; Bone Marrow Diseases/diagnosis ; Bone Marrow Diseases/pathology ; Edema ; Humans ; Magnetic Resonance Imaging/methods ; Metaplasia/pathology ; Prospective Studies ; Protons ; Sacroiliac Joint/diagnostic imaging ; Sacroiliac Joint/pathology ; Spondylarthritis/diagnosis
Chemical Substances	Protons
Language	English
Publishing date	2022-09-26
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.1000314
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Article: Preparation and Evaluation Mechanic Damping Properties of Fused Silica Powder@Polyurethane Urea/Cement Composites.

Cheng, Hao / Yan, Peihui / Wan, Fei / Feng, Chao / Zhu, Yunfei / Lv, Ping / Ma, Mingliang

Materials (Basel, Switzerland)

2022 Volume 15, Issue 14

Abstract: In this paper, cement based on fused silica powder @ polyurethane urea (FSP@PUU) with a micro constrained damping structure was studied. Firstly, FSP@PUU core-shell particles were prepared by heterogeneous stepwise addition polymerization method and ... ...

Abstract	In this paper, cement based on fused silica powder @ polyurethane urea (FSP@PUU) with a micro constrained damping structure was studied. Firstly, FSP@PUU core-shell particles were prepared by heterogeneous stepwise addition polymerization method and added into cement paste as damping filler to form a micro-constrained damping structure inside cement paste. The mechanical property and damping performance of cement-based composites were characterized by compressive strength, dynamic mechanical analysis (DMA) test and modal vibration test. The results showed that the damping performance of FSP @ PUU cement-based composites was affected by temperature, and the loss tangent of cement with 6wt% FSP@PUU increased to about 0.057 at -35 °C to 35 °C, which was 1.5 times cement paste within the glass transition temperature. With 6 wt% FSP@PUU, the damping ratio of cement-based composites increased by 58% compared with cement paste in the frequency range of 175-300 Hz, while the compressive strength decreased by only 5%. The cement with suitable FSP@PUU possesses excellent damping performance.
Language	English
Publishing date	2022-07-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15144827
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