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  1. AU="Zhu, Z Q"
  2. AU=Dinning W J AU=Dinning W J

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  1. Artikel ; Online: Characterization of physiological traits during development of the recalcitrant seeds of Quercus serrata.

    Xia, K / Zhu, Z-Q

    Plant biology (Stuttgart, Germany)

    2021  Band 23, Heft 6, Seite(n) 1000–1005

    Abstract: We investigated how developmental stage affects seed traits, including the relative level of desiccation tolerance of Quercus serrata. We tested the hypothesis that the relative level of desiccation tolerance is a quantitative trait associated with seed ... ...

    Abstract We investigated how developmental stage affects seed traits, including the relative level of desiccation tolerance of Quercus serrata. We tested the hypothesis that the relative level of desiccation tolerance is a quantitative trait associated with seed development and that a maximum relative level of desiccation tolerance is reached during development. Seed growth and physiological traits of Q. serrata from a subtropical forest were examined in detail during the developmental process. During seed development, the relative level of desiccation tolerance and other seed traits of Q. serrata varied. Dry matter accumulation in seed components increased rapidly beginning in mid-August, and moisture content declined. At the peak period of seed dispersal in late September, seeds were fully mature, with 100% germination. Relative level of desiccation tolerance increased up to the point of peak dispersal; however, at this time seeds were still recalcitrant. Post-mature development was accompanied by further increases in seed dry matter and decreases in moisture content, which led to a decrease in seed germination and relative level of desiccation tolerance. Our results suggest that in species with recalcitrant seeds, the relative level of desiccation tolerance and other seed traits are quantitative at the intraspecific level. The relative level of desiccation tolerance for recalcitrant seeds does not increase infinitely during phase II of development. There is a maximum relative level of desiccation tolerance in recalcitrant seeds within a species.
    Mesh-Begriff(e) Desiccation ; Germination ; Quercus ; Seed Dispersal ; Seeds
    Sprache Englisch
    Erscheinungsdatum 2021-07-26
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1464075-2
    ISSN 1438-8677 ; 1435-8603
    ISSN (online) 1438-8677
    ISSN 1435-8603
    DOI 10.1111/plb.13309
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: [Coronary artery bypass grafting surgery for treatment of an infant with Kawasaki disease: a case report].

    Luo, K / Zheng, J H / Zhu, Z Q / Sun, Q / Shen, J / Zhang, H

    Zhonghua xin xue guan bing za zhi

    2023  Band 51, Heft 7, Seite(n) 772–775

    Mesh-Begriff(e) Humans ; Infant ; Mucocutaneous Lymph Node Syndrome/surgery ; Coronary Artery Bypass/adverse effects ; Coronary Aneurysm/etiology ; Coronary Aneurysm/surgery ; Coronary Artery Disease/surgery
    Sprache Chinesisch
    Erscheinungsdatum 2023-06-28
    Erscheinungsland China
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 603425-1
    ISSN 0253-3758
    ISSN 0253-3758
    DOI 10.3760/cma.j.cn112148-20230202-00059
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: [Advances in genome-wide association study of pulmonary arterial hypertension].

    Zhu, Z Q / Sun, X L / Chen, X / Anniwaer, Ankejiang / Wang, M Y / Yang, S Q

    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases

    2022  Band 45, Heft 8, Seite(n) 813–818

    Abstract: Pulmonary arterial hypertension (PAH) is a complex disease caused by multiple factors, including idiopathic PAH, heritable PAH, disease related PAH etc. Due to the high genetic heterogeneity, clinical characteristics and prognosis of PAH patients vary ... ...

    Abstract Pulmonary arterial hypertension (PAH) is a complex disease caused by multiple factors, including idiopathic PAH, heritable PAH, disease related PAH etc. Due to the high genetic heterogeneity, clinical characteristics and prognosis of PAH patients vary greatly. At present, the specific pathogenesis of PAH is unclear, and the diagnosis and treatment of PAH remain to be explored. Therefore, the study of genetic susceptibility to PAH is of great significance for understanding the occurrence and development of the disease. With the development of genome-wide association study (GWAS), a large number of genetic variations related to etiology, clinical manifestations, prognosis and treatment of PAH have been identified. This review summarizes the recent progress in the application of GWAS in the study of genetic susceptibility of PAH, and provides new insights for further exploration of the development and individualized management of PAH.
    Mesh-Begriff(e) Familial Primary Pulmonary Hypertension ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Hypertension, Pulmonary/diagnosis ; Pulmonary Arterial Hypertension/genetics
    Sprache Chinesisch
    Erscheinungsdatum 2022-08-04
    Erscheinungsland China
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1027965-9
    ISSN 1001-0939
    ISSN 1001-0939
    DOI 10.3760/cma.j.cn112147-20220323-00227
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: [Effects of microRNA-182-5p on cell proliferation and invasion of esophageal squamous cell carcinoma and related molecular mechanisms].

    Zhu, Z Q / Hu, H F / Zheng, X Y / Wang, F

    Zhonghua zhong liu za zhi [Chinese journal of oncology

    2020  Band 42, Heft 8, Seite(n) 635–643

    Abstract: Objective: ...

    Abstract Objective:
    Mesh-Begriff(e) Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Esophageal Neoplasms/pathology ; Esophageal Squamous Cell Carcinoma/pathology ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs ; Neoplasm Invasiveness
    Chemische Substanzen MicroRNAs ; Mirn182 microRNA, human
    Sprache Chinesisch
    Erscheinungsdatum 2020-08-20
    Erscheinungsland China
    Dokumenttyp Journal Article
    ZDB-ID 603424-x
    ISSN 0253-3766
    ISSN 0253-3766
    DOI 10.3760/cma.j.cn112152-20200310-00191
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: [Recent advances of chronic cough].

    Zhang, Y N / Wang, T / Liu, D X / Xu, S / Zhu, Z Q

    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases

    2021  Band 44, Heft 7, Seite(n) 645–650

    Mesh-Begriff(e) Chronic Disease ; Cough ; Humans
    Sprache Chinesisch
    Erscheinungsdatum 2021-07-13
    Erscheinungsland China
    Dokumenttyp Journal Article
    ZDB-ID 1027965-9
    ISSN 1001-0939
    ISSN 1001-0939
    DOI 10.3760/cma.j.cn112147-20201201-01137
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: [Neurobehavior development of children with the transposition of the great arteries after arteries switch operation].

    Shi, B W / Liu, G / Zhu, Z Q

    Zhonghua er ke za zhi = Chinese journal of pediatrics

    2018  Band 56, Heft 2, Seite(n) 151–153

    Sprache Chinesisch
    Erscheinungsdatum 2018-02-02
    Erscheinungsland China
    Dokumenttyp Journal Article
    ZDB-ID 784523-6
    ISSN 0578-1310
    ISSN 0578-1310
    DOI 10.3760/cma.j.issn.0578-1310.2018.02.017
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Nirmatrelvir increases blood tacrolimus concentration in COVID-19 patients as determined by UHPLC-MS/MS method.

    Wu, Q-G / Zeng, L-Y / Li, F / Zhu, Z-Q / Yin, L / Meng, X-M / Zhang, L / Zhang, P / Jiang, X-H / Ling, Y / Zhang, L-J

    European review for medical and pharmacological sciences

    2023  Band 27, Heft 2, Seite(n) 818–825

    Abstract: Objective: Transplant recipients have a higher risk of SARS-CoV-2 infection owing to the use of immunosuppressive drugs like tacrolimus (FK506). FK506 and nirmatrelvir (NMV) (an anti-SARS-CoV-2 drug) are metabolized by cytochrome P450 3A4 and may have ... ...

    Abstract Objective: Transplant recipients have a higher risk of SARS-CoV-2 infection owing to the use of immunosuppressive drugs like tacrolimus (FK506). FK506 and nirmatrelvir (NMV) (an anti-SARS-CoV-2 drug) are metabolized by cytochrome P450 3A4 and may have potential drug-drug interactions. It is important to determine the effect of NMV on FK506 concentrations.
    Patients and methods: Following protein precipitation from blood, FK506 and its internal standard (FK506-13C,2d4) were detected by ultra-high performance liquid chromatography/tandem mass spectrometry (UHPLC-MS/MS). Total 22 blood samples (valley concentrations) from two coronavirus disease 2019 (COVID-19) patients were collected and analyzed for FK506 concentrations.
    Results: Blood levels of FK506 (0.5-100 ng/mL) showed good linearity. The UHPLC-MS/MS method was validated with intra- and inter-batch accuracies of 104.55-107.85%, and 99.52-108.01%, respectively, and precisions of < 15%. Mean blood FK506 concentration was 12.01 ng/mL (range, 3.15-33.1 ng/mL). Five-day co-administration with NMV increased the FK506 concentrations from 3.15 ng/mL to 33.1 ng/mL, returning to 3.36 ng/mL after a 9-day-washout.
    Conclusions: We developed a simple quantification method for therapeutic drug monitoring of FK506 in patients with COVID-19 using UHPLC-MS/MS with protein precipitation. We found that NMV increased FK506 blood concentration 10-fold. Therefore, it is necessary to re-consider co-administration of FK506 with NMV.
    Mesh-Begriff(e) Humans ; Tacrolimus ; Chromatography, High Pressure Liquid/methods ; Tandem Mass Spectrometry/methods ; COVID-19 ; SARS-CoV-2 ; Lactams ; Leucine ; Reproducibility of Results ; Drug Monitoring
    Chemische Substanzen Tacrolimus (WM0HAQ4WNM) ; Lactams ; Leucine (GMW67QNF9C)
    Sprache Englisch
    Erscheinungsdatum 2023-02-03
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202301_31083
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Corrigendum to "A2B5-positive oligodendrocyte precursor cell transplantation improves neurological deficits in rats following spinal cord contusion associated with changes in expression of factors involved in the Notch signaling pathway" [Neurochirurgie 68 (2) (2022) 188-95].

    Yuan, H / Fang, C-L / Deng, Y-P / Huang, J / Niu, R-Z / Chen, J-L / Chen, T-B / Zhu, Z-Q / Chen, L / Xiong, L-L / Wang, T-H

    Neuro-Chirurgie

    2023  Band 70, Heft 1, Seite(n) 101481

    Sprache Englisch
    Erscheinungsdatum 2023-11-04
    Erscheinungsland France
    Dokumenttyp Published Erratum
    ZDB-ID 207146-0
    ISSN 1773-0619 ; 0028-3770 ; 0150-9586
    ISSN (online) 1773-0619
    ISSN 0028-3770 ; 0150-9586
    DOI 10.1016/j.neuchi.2023.101481
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: [Investigation of drug resistance and multilocus sequence typing for differentiation of strains of

    Chen, Z J / Cao, Y S / Zai, S B / Hu, Y W / Zhu, Z Q

    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine

    2018  Band 52, Heft 9, Seite(n) 932–935

    Abstract: Objective: ...

    Abstract Objective:
    Mesh-Begriff(e) Antifungal Agents/pharmacology ; Candida tropicalis/classification ; Candida tropicalis/drug effects ; Candida tropicalis/genetics ; Candida tropicalis/isolation & purification ; China ; Drug Resistance, Fungal ; Humans ; Microbial Sensitivity Tests ; Multilocus Sequence Typing
    Chemische Substanzen Antifungal Agents
    Sprache Chinesisch
    Erscheinungsdatum 2018-09-08
    Erscheinungsland China
    Dokumenttyp Journal Article
    ZDB-ID 604575-3
    ISSN 0253-9624
    ISSN 0253-9624
    DOI 10.3760/cma.j.issn.0253-9624.2018.09.012
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Mitochondrial transfer RNA mutations and hypertension.

    Yin, S L / Lan, C / Pei, H / Zhu, Z Q

    Genetics and molecular research : GMR

    2015  Band 14, Heft 4, Seite(n) 17692–17698

    Abstract: Mutations in mitochondrial DNA have been found to be associated with hypertension. Of these, mitochondrial transfer RNA (mt-tRNA) is a hot spot for these pathogenic mutations. It is generally believed that these mutations may result in the failure of mt- ... ...

    Abstract Mutations in mitochondrial DNA have been found to be associated with hypertension. Of these, mitochondrial transfer RNA (mt-tRNA) is a hot spot for these pathogenic mutations. It is generally believed that these mutations may result in the failure of mt-tRNA metabolism, thereby worsening mitochondrial dysfunction and resulting in hypertension. mt-tRNA is known for its high frequency of polymorphisms and mutations, and the number of reports regarding mt-tRNA mutations and hypertension is increasing significantly. To better understand the molecular basis of maternally inherited hypertension, we reassessed the link between four mt-tRNA mutations (G15927A in tRNA(Thr), C7492T in tRNA(Ser(UCN)), A4386G in tRNA(Gln), and C14686T in tRNA(Glu)) and hypertension. We first used the phylogenetic approach to investigate the deleterious roles of these mutations, then we used RNA Fold Web Server to predict the minimum free energy of these mt-tRNAs with and without mutations. Using the pathogenicity scoring system, we found that the G15927A and C7492T mutations are classified as pathogenic while all other studied mutations are neutral polymorphisms. Our study provides valuable information for the detection of pathogenic mt-tRNA mutations in hypertension.
    Mesh-Begriff(e) DNA, Mitochondrial/genetics ; Humans ; Hypertension/genetics ; Hypertension/pathology ; Mitochondria/genetics ; Mutation ; Phylogeny ; Polymorphism, Genetic ; RNA, Transfer/genetics
    Chemische Substanzen DNA, Mitochondrial ; RNA, Transfer (9014-25-9)
    Sprache Englisch
    Erscheinungsdatum 2015-12-22
    Erscheinungsland Brazil
    Dokumenttyp Journal Article
    ZDB-ID 2114039-X
    ISSN 1676-5680 ; 1676-5680
    ISSN (online) 1676-5680
    ISSN 1676-5680
    DOI 10.4238/2015.December.21.42
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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