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  1. AU="Zhu, Zhengbin"
  2. AU="Michele Simeone"
  3. AU="Reynolds, Kimberly A"
  4. AU=Hua Cheng-Ge AU=Hua Cheng-Ge
  5. AU="Sorli, Luisa"
  6. AU=Ahmad Shah Adil Ishtiyaq
  7. AU="Bock, Thomas"
  8. AU=Chang Hyejung
  9. AU="Messer, Alison"
  10. AU="Samarzija, Miroslav"
  11. AU="Oh, Yun-Hee"
  12. AU="Ramos, Jairo"
  13. AU="Chauhan Kushwah, Vinita"
  14. AU="Winter, Katrin"
  15. AU="Berro, Julien"
  16. AU=Cummins Claire B.
  17. AU="Damholt, A"
  18. AU="Muthu, Santhosh Kumar"
  19. AU="Tysinger, Emma"
  20. AU=Covarrubias David
  21. AU="Dino Papeš"
  22. AU="Assis, Daniel Barbosa"
  23. AU="Lauquin, Guy J-M"

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  1. Artikel ; Online: Heartech® left ventricular partitioning device improves left ventricular systolic function of patients with chronic heart failure post-myocardial infarction at 1-year follow-up.

    Su, Xiuxiu / Yang, Wenbo / Zhu, Zhengbin / Zhang, Ruiyan / Fang, Yuehua

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2021  Band 99, Heft 1, Seite(n) 50–56

    Abstract: Objectives: This study presents 1-year follow-up data of echocardiographic outcomes in patients who received the Heartech® left ventricular (LV) partitioning device (LVPD) (Xinrui Medical Equipment Co. Ltd., Shanghai, China).: Background: Our first- ... ...

    Abstract Objectives: This study presents 1-year follow-up data of echocardiographic outcomes in patients who received the Heartech® left ventricular (LV) partitioning device (LVPD) (Xinrui Medical Equipment Co. Ltd., Shanghai, China).
    Background: Our first-in-man study of the Heartech® LVPD confirmed its safety and efficacy in patients with chronic heart failure (HF) post-myocardial infarction (MI) 1 month post-implantation. This subsequent study reports the echocardiographic outcomes of these patients at 1 year of follow-up.
    Methods: Fifteen patients with HF post-MI from three cardiac intervention centers in China were successfully implanted with the Heartech® LVPD via percutaneous ventricular restoration procedures. Echocardiographic parameters-including LV systolic function, diastolic function, two-dimensional speckle-tracking analysis, and right ventricular systolic function-were obtained before device implantation and at 1 month and 1 year postoperatively.
    Results: There was no deterioration of LV diastolic function, specific strain parameters, or right ventricular function at 1 year. Relative to the echocardiographic parameters recorded before the procedure, the LV ejection fraction (32.47 ± 6.98% vs. 42.5 ± 7.41%; p = .001) was significantly improved at 1 year, while the LV end-diastolic volume index (106.29 ± 28.01 vs. 83.30 ± 31.71; p = .005) and end-systolic volume index were significantly reduced (72.47 ± 22.77 vs. 50.00 ± 19.70; p = .001).
    Conclusions: One-year echocardiographic follow-up results confirmed that no deterioration of LV diastolic function or specific strain parameters was observed and LV systolic function was significantly improved in patients with HF post-MI who were implanted with the Heartech® LVPD.
    Mesh-Begriff(e) China ; Follow-Up Studies ; Heart Failure/diagnostic imaging ; Heart Failure/etiology ; Heart Failure/therapy ; Humans ; Myocardial Infarction/complications ; Myocardial Infarction/diagnostic imaging ; Stroke Volume ; Treatment Outcome ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/etiology ; Ventricular Dysfunction, Left/therapy ; Ventricular Function, Left
    Sprache Englisch
    Erscheinungsdatum 2021-01-27
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.29489
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  2. Artikel: Influence of LDL-Cholesterol Lowering on Coronary Plaque Progression of Non-Target Lesions in Patients Undergoing Percutaneous Coronary Intervention: Findings from a Retrospective Study.

    Quan, Weiwei / Han, Hui / Liu, Lili / Sun, Yi / Zhu, Zhengbin / Du, Run / Zhu, Tianqi / Zhang, Ruiyan

    Journal of clinical medicine

    2023  Band 12, Heft 3

    Abstract: The progression of NTLs after PCI accounts for a significant portion of future adverse cardiac events. The reduction in LDL-C reduces cardiovascular events. This has, however, not yet been shown in a real-world setting. We aimed to investigate the ... ...

    Abstract The progression of NTLs after PCI accounts for a significant portion of future adverse cardiac events. The reduction in LDL-C reduces cardiovascular events. This has, however, not yet been shown in a real-world setting. We aimed to investigate the association between LDL-C changes with progression in NTLs. A total of 847 patients with successful PCI were enrolled. Patients with follow-up LDL-C ≥ 1.4 mmol/L or percent reduction <50% compared to baseline were Non-optimal group (
    Sprache Englisch
    Erscheinungsdatum 2023-01-18
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12030785
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  3. Artikel ; Online: Enhanced tyrosine sulfation is associated with chronic kidney disease-related atherosclerosis.

    Dai, Daopeng / Zhu, Zhengbin / Han, Hui / Xu, Tian / Feng, Shuo / Zhang, Wenli / Ding, Fenghua / Zhang, Ruiyan / Zhu, Jinzhou

    BMC biology

    2023  Band 21, Heft 1, Seite(n) 151

    Abstract: Background: Chronic kidney disease (CKD) accelerates atherosclerosis, but the mechanisms remain unclear. Tyrosine sulfation has been recognized as a key post-translational modification (PTM) in regulation of various cellular processes, and the sulfated ... ...

    Abstract Background: Chronic kidney disease (CKD) accelerates atherosclerosis, but the mechanisms remain unclear. Tyrosine sulfation has been recognized as a key post-translational modification (PTM) in regulation of various cellular processes, and the sulfated adhesion molecules and chemokine receptors have been shown to participate in the pathogenesis of atherosclerosis via enhancement of monocyte/macrophage function. The levels of inorganic sulfate, the essential substrate for the sulfation reaction, are dramatically increased in patients with CKD, which indicates a change of sulfation status in CKD patients. Thus, in the present study, we detected the sulfation status in CKD patients and probed into the impact of sulfation on CKD-related atherosclerosis by targeting tyrosine sulfation function.
    Results: PBMCs from individuals with CKD showed higher amounts of total sulfotyrosine and tyrosylprotein sulfotransferase (TPST) type 1 and 2 protein levels. The plasma level of O-sulfotyrosine, the metabolic end product of tyrosine sulfation, increased significantly in CKD patients. Statistically, O-sulfotyrosine and the coronary atherosclerosis severity SYNTAX score positively correlated. Mechanically, more sulfate-positive nucleated cells in peripheral blood and more abundant infiltration of sulfated macrophages in deteriorated vascular plaques in CKD ApoE null mice were noted. Knockout of TPST1 and TPST2 decreased atherosclerosis and peritoneal macrophage adherence and migration in CKD condition. The sulfation of the chemokine receptors, CCR2 and CCR5, was increased in PBMCs from CKD patients.
    Conclusions: CKD is associated with increased sulfation status. Increased sulfation contributes to monocyte/macrophage activation and might be involved in CKD-related atherosclerosis. Inhibition of sulfation may suppress CKD-related atherosclerosis and is worthy of further study.
    Mesh-Begriff(e) Mice ; Animals ; Sulfotransferases/chemistry ; Sulfotransferases/genetics ; Sulfotransferases/metabolism ; Proteins/metabolism ; Tyrosine/metabolism ; Mice, Knockout ; Receptors, Chemokine/metabolism ; Atherosclerosis/complications ; Protein Processing, Post-Translational
    Chemische Substanzen Sulfotransferases (EC 2.8.2.-) ; Proteins ; Tyrosine (42HK56048U) ; Receptors, Chemokine
    Sprache Englisch
    Erscheinungsdatum 2023-07-10
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2133020-7
    ISSN 1741-7007 ; 1741-7007
    ISSN (online) 1741-7007
    ISSN 1741-7007
    DOI 10.1186/s12915-023-01641-y
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  4. Artikel ; Online: Unsupervised Landmark Detection-Based Spatiotemporal Motion Estimation for 4-D Dynamic Medical Images.

    Guo, Yuyu / Bi, Lei / Wei, Dongming / Chen, Liyun / Zhu, Zhengbin / Feng, Dagan / Zhang, Ruiyan / Wang, Qian / Kim, Jinman

    IEEE transactions on cybernetics

    2023  Band 53, Heft 6, Seite(n) 3532–3545

    Abstract: Motion estimation is a fundamental step in dynamic medical image processing for the assessment of target organ anatomy and function. However, existing image-based motion estimation methods, which optimize the motion field by evaluating the local image ... ...

    Abstract Motion estimation is a fundamental step in dynamic medical image processing for the assessment of target organ anatomy and function. However, existing image-based motion estimation methods, which optimize the motion field by evaluating the local image similarity, are prone to produce implausible estimation, especially in the presence of large motion. In addition, the correct anatomical topology is difficult to be preserved as the image global context is not well incorporated into motion estimation. In this study, we provide a novel motion estimation framework of dense-sparse-dense (DSD), which comprises two stages. In the first stage, we process the raw dense image to extract sparse landmarks to represent the target organ's anatomical topology, and discard the redundant information that is unnecessary for motion estimation. For this purpose, we introduce an unsupervised 3-D landmark detection network to extract spatially sparse but representative landmarks for the target organ's motion estimation. In the second stage, we derive the sparse motion displacement from the extracted sparse landmarks of two images of different time points. Then, we present a motion reconstruction network to construct the motion field by projecting the sparse landmarks' displacement back into the dense image domain. Furthermore, we employ the estimated motion field from our two-stage DSD framework as initialization and boost the motion estimation quality in light-weight yet effective iterative optimization. We evaluate our method on two dynamic medical imaging tasks to model cardiac motion and lung respiratory motion, respectively. Our method has produced superior motion estimation accuracy compared to the existing comparative methods. Besides, the extensive experimental results demonstrate that our solution can extract well-representative anatomical landmarks without any requirement of manual annotation. Our code is publicly available online: https://github.com/yyguo-sjtu/DSD-3D-Unsupervised-Landmark-Detection-Based-Motion-Estimation.
    Mesh-Begriff(e) Image Processing, Computer-Assisted/methods ; Motion
    Sprache Englisch
    Erscheinungsdatum 2023-05-17
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2168-2275
    ISSN (online) 2168-2275
    DOI 10.1109/TCYB.2021.3126817
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  5. Artikel ; Online: Optimal timing of coronary angiograms for patients with chronic kidney disease: association between the duration of kidney dysfunction and SYNTAX scores.

    Song, Bei / Dai, Daopeng / Liu, Shengjun / Zhu, Zhengbin / Ding, Fenghua / Zhu, Jinzhou / Zhang, Ruiyan

    Renal failure

    2021  Band 43, Heft 1, Seite(n) 307–312

    Abstract: Background: Chronic kidney disease (CKD) is associated with an increased risk of the progression of coronary artery disease (CAD). However, there are few data on the relationship between CAD severity and the duration of CKD. This study assessed the ... ...

    Abstract Background: Chronic kidney disease (CKD) is associated with an increased risk of the progression of coronary artery disease (CAD). However, there are few data on the relationship between CAD severity and the duration of CKD. This study assessed the predictive value of the duration of kidney dysfunction in CKD patients with CAD severity.
    Methods: In 145 patients (63.4% male,
    Results: Patients with high SYNTAX scores (≥ 22) had a greater prevalence of cardiovascular risk factors including age, gender, history of heart failure and smoking. In CKD patients, SYNTAX scores were positively correlated to duration of CKD and serum uric acid (UA), and negatively correlated to high-density lipoprotein-cholesterol (HDL-C) and ApoA1 levels. Univariate binary logistic regression and multivariate logistic analyses showed that SYNTAX scores correlated significantly with CKD duration, UA, and HDL-C. Receiver-operating characteristic analysis was used to explore a time point when coronary angiography application was economical and effective and yielded a Youden index of 6.5 years.
    Conclusions: Together, our results demonstrated that the duration of kidney dysfunction was an independent correlate of the severity of CAD in patients with CKD. Our findings suggest that coronary angiography should be considered for CKD patients with renal insufficiency having lasted for more than 6.5 years.
    Mesh-Begriff(e) Aged ; Aged, 80 and over ; Coronary Angiography/statistics & numerical data ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/etiology ; Coronary Artery Disease/pathology ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/pathology ; Disease Progression ; Female ; Glomerular Filtration Rate/physiology ; Heart Disease Risk Factors ; Humans ; Male ; Middle Aged ; ROC Curve ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/physiopathology ; Retrospective Studies ; Severity of Illness Index ; Time Factors
    Sprache Englisch
    Erscheinungsdatum 2021-02-03
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 632949-4
    ISSN 1525-6049 ; 0886-022X
    ISSN (online) 1525-6049
    ISSN 0886-022X
    DOI 10.1080/0886022X.2021.1880936
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  6. Artikel ; Online: Quantitative Data-Independent Acquisition Mass Spectrometry Proteomics and Weighted Correlation Network Analysis of Plasma Samples for the Discovery of Chronic Kidney Disease-Specific Atherosclerosis Risk Factors.

    Dai, Daopeng / Cheng, Zhiwei / Feng, Shuo / Zhu, Zhengbin / Yu, Jiwei / Zhang, Wenli / Lu, Hui / Zhang, Ruiyan / Zhu, Jinzhou

    DNA and cell biology

    2022  Band 41, Heft 11, Seite(n) 966–980

    Abstract: Chronic kidney disease (CKD) accelerates atherosclerosis. The mechanism of CKD-related atherosclerosis is complex, and CKD-specific risk factors may contribute to this process in addition to traditional risk factors such as hypertension, diabetes, and ... ...

    Abstract Chronic kidney disease (CKD) accelerates atherosclerosis. The mechanism of CKD-related atherosclerosis is complex, and CKD-specific risk factors may contribute to this process in addition to traditional risk factors such as hypertension, diabetes, and hypercholesterolemia. In the present study, to discover CKD-specific atherosclerosis risk factors, a total of 62 patients with different stages of kidney function were enrolled. All patients underwent coronary angiographies and the severity of coronary atherosclerosis was defined by the SYNTAX score. Patients were divided into different groups according to their kidney function levels and coronary atherosclerosis severity. Data-independent acquisition mass spectrometry was used to identify differentially expressed proteins (DEPs) in the plasma samples, and weighted correlation network analysis (WGCNA) was employed to identify significant protein modules and hub proteins related to CKD-specific atherosclerosis. The results showed that 10 DEPs associated with atherosclerosis were found in the comparative groups with modest and severe CKD. Through WGCNA, 1768 proteins were identified and 8 protein modules were established. Enrichment analyses of protein modules revealed functional clusters mainly associated with inflammation and the complement and coagulation cascade as atherosclerosis developed under CKD conditions. The results may help to better understand the mechanisms of CKD-related atherosclerosis and guide future research on developing treatments for CKD-related atherosclerosis.
    Mesh-Begriff(e) Humans ; Coronary Artery Disease ; Proteomics ; Renal Insufficiency, Chronic ; Atherosclerosis ; Risk Factors ; Mass Spectrometry
    Sprache Englisch
    Erscheinungsdatum 2022-10-17
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1024454-2
    ISSN 1557-7430 ; 0198-0238 ; 1044-5498
    ISSN (online) 1557-7430
    ISSN 0198-0238 ; 1044-5498
    DOI 10.1089/dna.2022.0200
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  7. Artikel: Association of Serum BAFF Levels with Cardiovascular Events in ST-Segment Elevation Myocardial Infarction.

    Wang, Ziyang / Wang, Yueying / Cui, Yuke / Chen, Zhiyong / Yi, Lei / Zhu, Zhengbin / Ni, Jingwei / Du, Run / Wang, Xiaoqun / Zhu, Jinzhou / Ding, Fenghua / Quan, Weiwei / Zhang, Ruiyan / Hu, Jian / Yan, Xiaoxiang

    Journal of clinical medicine

    2023  Band 12, Heft 4

    Abstract: Objectives: The B cell activating factor (BAFF) is a B cell survival factor involved in atherosclerosis and ischemia-reperfusion (IR) injury. This study sought to investigate whether BAFF is a potential predictor of poor outcomes in patients with ST- ... ...

    Abstract Objectives: The B cell activating factor (BAFF) is a B cell survival factor involved in atherosclerosis and ischemia-reperfusion (IR) injury. This study sought to investigate whether BAFF is a potential predictor of poor outcomes in patients with ST-segment elevation myocardial infarction (STEMI).
    Methods: We prospectively enrolled 299 patients with STEMI, and serum levels of BAFF were measured. All subjects were followed for three years. The primary endpoint was major adverse cardiovascular events (MACEs), including cardiovascular death, nonfatal reinfarction, hospitalization for heart failure (HF), and stroke. Multivariable Cox proportional hazards models were constructed to analyze the predictive value of BAFF for MACEs.
    Results: In multivariate analysis, BAFF was independently associated with risk of MACEs (adjusted HR 1.525, 95% CI 1.085-2.145;
    Conclusions: This study suggests that higher BAFF levels in the acute phase are an independent predictor of the incidence of MACEs in patients with STEMI.
    Sprache Englisch
    Erscheinungsdatum 2023-02-20
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12041692
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  8. Artikel ; Online: Predictive value of early left ventricular end-diastolic volume changes for late left ventricular remodeling after ST-elevation myocardial infarction.

    Yi, Lei / Zhu, Tianqi / Qu, Xuezheng / Buayiximu, Keremu / Feng, Shuo / Zhu, Zhengbin / Ni, Jingwei / Du, Run / Zhu, Jingzhou / Wang, Xiaoqun / Ding, Fenghua / Zhang, Ruiyan / Quan, Weiwei / Yan, Xiaoxiang

    Cardiology journal

    2023  

    Abstract: Backgroud: Left ventricular remodeling (LVR) is a major predictor of adverse outcomes in patients with acute ST-elevation myocardial infarction (STEMI). This study aimed to prospectively evaluate LVR in patients with STEMI who were successfully treated ... ...

    Abstract Backgroud: Left ventricular remodeling (LVR) is a major predictor of adverse outcomes in patients with acute ST-elevation myocardial infarction (STEMI). This study aimed to prospectively evaluate LVR in patients with STEMI who were successfully treated with primary percutaneous coronary intervention (PCI) and examine the relationship between early left ventricular dilation and late LVR.
    Methods: Overall 301 consecutive patients with STEMI who underwent primary PCI were included. Serial echocardiography was performed on the first day after PCI, on the day of discharge, at 1 month, and 6 months after discharge.
    Results: Left ventricular remodeling occurred in 57 (18.9%) patients during follow-up. Left ventricular end-diastolic volume (LVEDV) reduced from day 1 postoperative to discharge in the LVR group compared with that in the non-LVR (n-LVR) group. The rates of change in LVEDV (ΔLVEDV%) were -5.24 ± 16.02% and 5.05 ± 16.92%, respectively (p < 0.001). LVEDV increased in patients with LVR compared with n-LVR at 1-month and 6-month follow-ups (ΔLVEDV% 13.05 ± 14.89% vs. -1.9 ± 12.03%; 26.46 ± 14.05% vs. -3.42 ± 10.77%, p < 0.001). Receiver operating characteristic analysis showed that early changes in LVEDV, including ΔLVEDV% at discharge and 1-month postoperative, predicted late LVR with an area under the curve value of 0.80 (95% confidence interval 0.74-0.87, p < 0.0001).
    Conclusions: Decreased LVEDV at discharge and increased LVEDV at 1-month follow-up were both associated with late LVR at 6-month. Comprehensive and early monitoring of LVEDV changes may help to predict LVR.
    Sprache Englisch
    Erscheinungsdatum 2023-09-29
    Erscheinungsland Poland
    Dokumenttyp Journal Article
    ZDB-ID 2488680-4
    ISSN 1898-018X ; 1897-5593
    ISSN (online) 1898-018X
    ISSN 1897-5593
    DOI 10.5603/cj.90492
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  9. Artikel ; Online: Day-night pattern of acute ST-segment elevation myocardial infarction onset in patients with obstructive sleep apnea.

    Wang, Yueying / Buayiximu, Keremu / Zhu, Tianqi / Yan, Renyu / Zhu, Zhengbin / Ni, Jingwei / Du, Run / Zhu, Jinzhou / Wang, Xiaoqun / Ding, Fenghua / Yan, Xiaoxiang / Qu, Xuezheng / Li, Ping / Zhang, Ruiyan / Xu, Zhihong / Quan, Weiwei

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2023  Band 20, Heft 5, Seite(n) 765–775

    Abstract: Study objectives: Obstructive sleep apnea (OSA) is associated with acute nocturnal hemodynamic and neurohormonal abnormalities that may increase the risk of coronary events, especially during the nighttime. This study sought to investigate the day-night ...

    Abstract Study objectives: Obstructive sleep apnea (OSA) is associated with acute nocturnal hemodynamic and neurohormonal abnormalities that may increase the risk of coronary events, especially during the nighttime. This study sought to investigate the day-night pattern of acute ST-segment elevation myocardial infarction (STEMI) onset in patients with OSA and its impact on cardiovascular adverse events.
    Methods: We prospectively enrolled 397 patients with STEMI, for which the time of onset of chest pain was clearly identified. All participants were categorized into non-OSA (n = 280) and OSA (n = 117) groups. The association between STEMI onset time and major adverse cardiovascular and cerebrovascular events was estimated by Cox proportional hazards regression.
    Results: STEMI onset occurred from midnight to 5:59 am in 33% of patients with OSA, as compared with 15% in non-OSA patients (
    Conclusions: Patients with OSA exhibited a peak incidence of STEMI between midnight and 5:59 am, which showed an independent association with cardiovascular adverse events.
    Citation: Wang Y, Buayiximu K, Zhu T, et al. Day-night pattern of acute ST-segment elevation myocardial infarction onset in patients with obstructive sleep apnea.
    Mesh-Begriff(e) Humans ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/epidemiology ; Sleep Apnea, Obstructive/physiopathology ; Male ; Female ; Middle Aged ; ST Elevation Myocardial Infarction/complications ; ST Elevation Myocardial Infarction/epidemiology ; ST Elevation Myocardial Infarction/physiopathology ; Prospective Studies ; Risk Factors ; Aged ; Time Factors ; Circadian Rhythm/physiology
    Sprache Englisch
    Erscheinungsdatum 2023-12-08
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.10990
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  10. Artikel: Oncostatin M promotes infarct repair and improves cardiac function after myocardial infarction.

    Han, Hui / Dai, Daopeng / Du, Run / Hu, Jinquan / Zhu, Zhengbin / Lu, Lin / Zhu, Jinzhou / Zhang, Ruiyan

    American journal of translational research

    2021  Band 13, Heft 10, Seite(n) 11329–11340

    Abstract: Myocardial infarction (MI) is one of the leading causes of morbidity and mortality worldwide. The immune response plays a central role in post-MI cardiac repair. A growing body of evidence suggests that oncostatin M (OSM), a pleiomorphic cytokine of the ... ...

    Abstract Myocardial infarction (MI) is one of the leading causes of morbidity and mortality worldwide. The immune response plays a central role in post-MI cardiac repair. A growing body of evidence suggests that oncostatin M (OSM), a pleiomorphic cytokine of the interleukin (IL)-6 family, participates in the cardiac healing and remodeling process. However, previous studies have shown inconsistent results, and the exact mechanisms underlying this process have not yet been fully elucidated. We verified whether OSM is involved in the healing process and cardiac remodeling after MI and sought to explore its potential mechanisms. Our data implied OSM's role in facilitating the post-MI healing process in mice, manifested by improved cardiac functional performance and a reduction in fibrotic changes. Furthermore, our flow cytometry analysis revealed that OSM influences the dynamics of cardiac monocytes and macrophages. In mice with a blunted C-X-C motif receptor (CCR)2 signaling pathway, OSM reserved its protective roles and polarized cardiac macrophages toward a reparative phenotype. Moreover, OSM reduced the number of matrix metalloproteinase (MMP)-9
    Sprache Englisch
    Erscheinungsdatum 2021-10-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2471058-1
    ISSN 1943-8141
    ISSN 1943-8141
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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