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  1. Artikel: Extraction, characterization and anti-oxidant activity of polysaccharide from red

    Kang, Jia / Zhao, Jue / He, Lan-Fang / Li, Li-Xia / Zhu, Zhong-Kai / Tian, Meng-Liang

    Frontiers in nutrition

    2023  Band 10, Seite(n) 1183096

    Abstract: Red ginseng ... ...

    Abstract Red ginseng and
    Sprache Englisch
    Erscheinungsdatum 2023-05-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2023.1183096
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  2. Artikel ; Online: First-in-human experience with a novel transcatheter direct annuloplasty system for severe atrial functional mitral regurgitation.

    Zhu, Zhong-Kai / Zhao, Zhen-Gang / Zhang, Ting-Chao / Chen, Fei / Wei, Xin / Liang, Yu-Jia / Feng, Yuan / Chen, Mao

    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

    2023  Band 19, Heft 11, Seite(n) e953–e954

    Mesh-Begriff(e) Humans ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/surgery ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Cardiac Catheterization ; Mitral Valve Annuloplasty ; Treatment Outcome ; Heart Valve Prosthesis Implantation
    Sprache Englisch
    Erscheinungsdatum 2023-12-18
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 2457174-X
    ISSN 1969-6213 ; 1774-024X
    ISSN (online) 1969-6213
    ISSN 1774-024X
    DOI 10.4244/EIJ-D-23-00302
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Snaring Self-Expanding Devices to Facilitate Transcatheter Aortic Valve Replacement in Patients with Complex Aortic Anatomies.

    Yao, Yi-Jun / Zhao, Zhen-Gang / Wang, Xi / Peng, Yong / Wei, Jia-Fu / He, Sen / Li, Yi-Jian / He, Jing-Jing / Zhu, Zhong-Kai / Feng, Yuan / Chen, Mao

    Journal of clinical medicine

    2023  Band 12, Heft 15

    Abstract: The snare-assisted technique has been described to facilitate transcatheter aortic valve replacement (TAVR) delivery system advancement in complex aortic anatomies. However, the evidence is limited to case reports. To evaluate the safety profile of the ... ...

    Abstract The snare-assisted technique has been described to facilitate transcatheter aortic valve replacement (TAVR) delivery system advancement in complex aortic anatomies. However, the evidence is limited to case reports. To evaluate the safety profile of the snare-facilitated approach and its impact on self-expanding (SE) TAVR outcomes, we collected consecutive patients who underwent transfemoral SE-TAVR for aortic stenosis, using propensity score matching (PSM) separately in tricuspid and type-0 and type-1 bicuspid aortic valve morphology between the snare and non-snare groups. In 766 patients, despite the snare group having significantly larger annulus angulation and maximal ascending aortic diameter, both groups achieved comparable 30-day device success rates, regardless of first-generation or new-generation valve use. After PSM, the snare group had a significantly lower new permanent pacemaker implantation rate among 193 type-0 patients (3.3% vs. 18.3%,
    Sprache Englisch
    Erscheinungsdatum 2023-08-01
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12155067
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  4. Artikel: Yellow- and green-cotyledon seeds of black soybean: Phytochemical and bioactive differences determine edibility and medical applications

    Yang, Cai-qiong / Zheng, Lu / Wu, Hai-jun / Zhu, Zhong-kai / Zou, Yuan-feng / Deng, Jun-cai / Qin, Wen-ting / Zhang, Jing / Zhang, Qing / Wang, Xiao-chun / Yang, Wen-yu / Liu, Jiang

    Food bioscience. 2021 Feb., v. 39

    2021  

    Abstract: Black soybean seed (BSS) is a traditional edible and medical food. The cotyledons of BSS are either yellow or green, but that difference's effect on functional and bioactivities are not clear. In the present study, the concentrations of the main ... ...

    Abstract Black soybean seed (BSS) is a traditional edible and medical food. The cotyledons of BSS are either yellow or green, but that difference's effect on functional and bioactivities are not clear. In the present study, the concentrations of the main functional components, including anthocyanins, isoflavones, fatty acids, protein, and polysaccharides, and in vitro antioxidant activities of yellow-cotyledon and green-cotyledon BSS (YBS and GBS, respectively) were compared. The anti-fatigue activities of the ethanol extract of BSS (EEB) were evaluated using mouse swimming endurance tests. Additionally, a metabolomics comparison between YBS and GBS was done using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF MS) on high doses of EEB-treated mouse plasma. The results indicated that YBS showed significantly higher contents of anthocyanin and protein, and stronger antioxidant activity and anti-fatigue activity than GBS; while GBS showed higher levels of isoflavone, stearic acid, and polysaccharide. By infusing the feed with EEB, the swimming time of mice increased in a dose-dependent manner. The metabolomics results suggested that the anti-fatigue effect of EEB correlated well with serotonin and melatonin biosynthesis in vivo. All of the above results showed that BSS has anti-fatigue potential and might be used as a potential source of functional food ingredients.
    Schlagwörter anthocyanins ; antioxidant activity ; biosynthesis ; cotyledons ; dose response ; ethanol ; functional foods ; ingredients ; isoflavones ; mass spectrometry ; melatonin ; metabolomics ; mice ; polysaccharides ; serotonin ; soybeans ; stearic acid ; swimming ; ultra-performance liquid chromatography
    Sprache Englisch
    Erscheinungsverlauf 2021-02
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    Anmerkung NAL-light
    ISSN 2212-4292
    DOI 10.1016/j.fbio.2020.100842
    Datenquelle NAL Katalog (AGRICOLA)

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  5. Artikel: [Diagnostic Application of Invasive Cardiopulmonary Exercise Test in Patients with Unexplained Dyspnea].

    Li, Zhuo-Lin / He, Yang-Ke / Xiang, Ya-Jie / Yi, Xin / Zhu, Zhong-Kai / Li, Ai-Ling / Xiang, Rui / Han, Xiao-Li / Wang, Pu / Huang, Wei

    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

    2021  Band 52, Heft 1, Seite(n) 142–148

    Abstract: Objective: To explore the clinical diagnostic application of invasive cardiopulmonary exercise test (iCPET) in patients with unexplained dyspnea.: Methods: A retrospective analysis was conducted, covering patients with a chief complaint of exertional ...

    Abstract Objective: To explore the clinical diagnostic application of invasive cardiopulmonary exercise test (iCPET) in patients with unexplained dyspnea.
    Methods: A retrospective analysis was conducted, covering patients with a chief complaint of exertional dyspnea between May 5, 2017 and October 1, 2020. Right cardiac catheterization examination was performed on patients whose cause had not been identified through routine examination, and further iCPET was performed on patients if no clear etiology was identified through right cardiac catheterization. According to the results and the diagnostic criteria of iCPET, patients showing no obvious abnormalities in the right cardiac catheterization examination were divided into four subgroups: exercise-induced pulmonary arterial hypertension (eiPAH), exercise-induced heart failure with preserved ejection fraction (eiHFpEF), preload failure, and oxidative myopathy. By comparing the lab test, echocardiography, right heart catheter and iCPET peak exercise data of the subgroups, the disease distribution and exercise hemodynamic characteristics of patients with unexplained dyspnea examined by iCPET were described.
    Results: Of the 1 046 patients with exertional dyspnea, 771 were diagnosed with routine examination, while among the remaining 275 patients, 131 (47.6%) were diagnosed with right cardiac catheterization and 144 (52.4%) showed no clear etiology after routine examination and right cardiac catheterization. Of these 144 patients, 49 (34.0%) received iCPET with a median exercise time of 375 s. A total of 47 patients completed the examination, with a male-to-female ratio of 0.27∶1 and an average age of (47.9±14.4) years old. Among the 47 patients, 76.6% (36/47) aged between 20 and 59 and 78.7% (36/47) lived in urban areas. The preload failure group (
    Mesh-Begriff(e) Adult ; Cardiac Catheterization ; Dyspnea/etiology ; Exercise Test ; Exercise Tolerance ; Female ; Heart Failure/diagnosis ; Heart Failure/diagnostic imaging ; Humans ; Male ; Middle Aged ; Pulmonary Wedge Pressure ; Retrospective Studies
    Sprache Chinesisch
    Erscheinungsdatum 2021-01-20
    Erscheinungsland China
    Dokumenttyp Journal Article
    ZDB-ID 2106840-9
    ISSN 1672-173X
    ISSN 1672-173X
    DOI 10.12182/20210160205
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  6. Artikel ; Online: Characterization of inulin-type fructans from two species of Radix Codonopsis and their oxidative defense activation and prebiotic activities.

    Zou, Yuan-Feng / Zhang, Yan-Yun / Zhu, Zhong-Kai / Fu, Yu-Ping / Paulsen, Berit S / Huang, Chao / Feng, Bin / Li, Li-Xia / Chen, Xing-Fu / Jia, Ren-Yong / Song, Xu / He, Chang-Liang / Yin, Li-Zi / Ye, Gang / Lv, Cheng / Yin, Zhong-Qiong

    Journal of the science of food and agriculture

    2020  Band 101, Heft 6, Seite(n) 2491–2499

    Abstract: Background: Codonopsis pilosula and C. tangshen are both plants widely used in traditional Chinese medicine. Polysaccharides, which are their primary active components, are thought to be important in their extensive use. In this study, two neutral ... ...

    Abstract Background: Codonopsis pilosula and C. tangshen are both plants widely used in traditional Chinese medicine. Polysaccharides, which are their primary active components, are thought to be important in their extensive use. In this study, two neutral polysaccharide fractions of C. pilosula (CPPN) and C. tangshen (CTPN) were obtained by fractionation on a DEAE-Sepharose column and characterized.
    Results: It was confirmed that the neutral polymers CPPN and CTPN were β-(2,1)-linked inulin-type fructans with non-reducing terminal glucose, and degree of polymerization (DP) of 19.6 and 25.2, respectively. The antioxidant and prebiotic activities in vitro were assayed based on IPEC-J2 cell lines and five strains of Lactobacillus. Results indicated that the effects of CPPN and CTPN were increased antioxidant defense in intestinal epithelial cells through enhanced cell viability, improved expression of total antioxidant capacity, glutathione peroxidase, superoxide dismutase and catalase, and reduced levels of malondialdehyde and lactic dehydrogenase. The prebiotic activity of CPPN and CTPN was demonstrated by the promoting effect on Lactobacillus proliferation in vitro. The different biological activities obtained between the two fractions are probably due to the different DP and thus molecular weights of CPPN and CTPN.
    Conclusion: The inulin fractions from C. pilosula and C. tangshen were natural sources of potential intestinal antioxidants as well as prebiotics, which will be valuable in further studies and new applications of inulin-containing health products. © 2020 Society of Chemical Industry.
    Mesh-Begriff(e) Antioxidants/chemistry ; Antioxidants/isolation & purification ; Antioxidants/pharmacology ; Cell Line ; Cell Survival/drug effects ; Codonopsis/chemistry ; Codonopsis/classification ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/isolation & purification ; Drugs, Chinese Herbal/pharmacology ; Epithelial Cells/cytology ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Fructans/chemistry ; Fructans/isolation & purification ; Fructans/pharmacology ; Humans ; Inulin/chemistry ; Inulin/isolation & purification ; Inulin/pharmacology ; Lactobacillus/drug effects ; Lactobacillus/growth & development ; Oxidative Stress/drug effects ; Polymerization ; Prebiotics/analysis
    Chemische Substanzen Antioxidants ; Drugs, Chinese Herbal ; Fructans ; Prebiotics ; Inulin (9005-80-5)
    Sprache Englisch
    Erscheinungsdatum 2020-10-26
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 184116-6
    ISSN 1097-0010 ; 0022-5142
    ISSN (online) 1097-0010
    ISSN 0022-5142
    DOI 10.1002/jsfa.10875
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Characterization of an antioxidant pectic polysaccharide from Platycodon grandiflorus.

    Zou, Yuan-Feng / Chen, Mengsi / Fu, Yu-Ping / Zhu, Zhong-Kai / Zhang, Yan-Yun / Paulsen, Berit Smestad / Rise, Frode / Chen, Yu-Long / Yang, Yong-Zhi / Jia, Ren-Yong / Li, Li-Xia / Song, Xu / Tang, Hua-Qiao / Feng, Bin / Lv, Cheng / Ye, Gang / Wu, Ding-Tao / Yin, Zhong-Qiong / Huang, Chao

    International journal of biological macromolecules

    2021  Band 175, Seite(n) 473–480

    Abstract: Platycodonis Radix is widely used as homology of medicine and food in China; polysaccharides are thought to be one of its functional constituents. In this study, a pectic polysaccharide, PGP-I-I, was obtained from the root of the traditional medicine ... ...

    Abstract Platycodonis Radix is widely used as homology of medicine and food in China; polysaccharides are thought to be one of its functional constituents. In this study, a pectic polysaccharide, PGP-I-I, was obtained from the root of the traditional medicine plant Platycodon grandiflorus through ion exchange chromatography and gel filtration. This was characterized being mainly composed of 1,5-α-L-arabinan and both arabinogalactan type I (AG-I) and II chains linked to rhamnogalacturonan I (RG-I) backbone linked to longer galacturonan chains. In vitro bioactivity study showed that PGP-I-I could restore the intestinal cellular antioxidant defense under the condition of hydrogen peroxide (H
    Mesh-Begriff(e) Animals ; Antioxidants/chemistry ; Antioxidants/isolation & purification ; Cell Line ; Chromatography, Gel ; Chromatography, Ion Exchange ; Dietary Carbohydrates ; Galactans/chemistry ; Hydrogen Peroxide ; Pectins/chemistry ; Plant Extracts/chemistry ; Plant Roots/chemistry ; Platycodon/chemistry ; Polysaccharides/chemistry ; Swine
    Chemische Substanzen Antioxidants ; Dietary Carbohydrates ; Galactans ; Plant Extracts ; Polysaccharides ; rhamnogalacturonan I ; araban (11078-27-6) ; Pectins (89NA02M4RX) ; Hydrogen Peroxide (BBX060AN9V) ; arabinogalactan (SL4SX1O487) ; polygalacturonic acid (VV3XD4CL04)
    Sprache Englisch
    Erscheinungsdatum 2021-02-08
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2021.02.041
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Sex Difference in Outcomes Following Transcatheter Aortic Valve Replacement in Bicuspid Aortic Stenosis.

    He, Jing-Jing / Xiong, Tian-Yuan / Yao, Yi-Jun / Peng, Yong / Wei, Jia-Fu / He, Sen / Chen, Yong / Li, Qiao / Zhao, Zhen-Gang / Wei, Xin / Zhou, Wen-Xia / Liang, Yu-Jia / Tang, Hong / Chen, Guo / Zhou, Xuan / Zheng, Ming-Xia / Meng, Wei / Liao, Yan-Biao / Li, Yi-Jian /
    Li, Yi-Ming / Chen, Fei / Ou, Yuan-Weixiang / Liu, Qi / Li, Xi / Wang, Xi / Zhang, Yi / Zhu, Zhong-Kai / Yang, Hao-Ran / Jia, Kai-Yu / Chen, Mao / Feng, Yuan

    JACC. Cardiovascular interventions

    2022  Band 15, Heft 16, Seite(n) 1652–1660

    Abstract: Background: It is unknown whether the sex difference whereby female transcatheter aortic valve replacement (TAVR) candidates had a lower risk profile, a higher incidence of in-hospital complications, but more favorable short- and long-term survival ... ...

    Abstract Background: It is unknown whether the sex difference whereby female transcatheter aortic valve replacement (TAVR) candidates had a lower risk profile, a higher incidence of in-hospital complications, but more favorable short- and long-term survival observed in tricuspid cohorts undergoing TAVR would persist in patients with bicuspid aortic valves (BAVs).
    Objectives: The aim of this study was to reexamine the impact of sex on outcomes following TAVR in patients with BAVs.
    Methods: In this single-center study, patients with BAVs undergoing TAVR for severe aortic stenosis from 2012 to 2021 were retrospectively included. Baseline characteristics, aortic root anatomy, and in-hospital and 1-year valve hemodynamic status and survival were compared between sexes.
    Results: A total of 510 patients with BAVs were included. At baseline, women presented with fewer comorbidities. Men had a greater proportion of Sievers type 1 BAV, higher calcium volumes (549.2 ± 408.4 mm
    Conclusions: In patients with BAVs undergoing TAVR, women presented with fewer comorbidities, while men had a greater proportion of type 1 BAV, more calcification, and larger aortic roots. In-hospital outcomes favored men, with fewer complications except for the need for second valve implantation, but 1-year survival was comparable between sexes.
    Mesh-Begriff(e) Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/etiology ; Aortic Valve Stenosis/surgery ; Bicuspid Aortic Valve Disease ; Female ; Humans ; Male ; Retrospective Studies ; Sex Characteristics ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2022-07-27
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2022.06.036
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Patients With Bicuspid Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis.

    Zhang, Yi / Xiong, Tian-Yuan / Li, Yi-Ming / Yao, Yi-Jun / He, Jing-Jing / Yang, Hao-Ran / Zhu, Zhong-Kai / Chen, Fei / Ou, Yuanweixiang / Wang, Xi / Liu, Qi / Li, Xi / Li, Yi-Jian / Liao, Yan-Biao / Huang, Fang-Yang / Zhao, Zhen-Gang / Li, Qiao / Wei, Xin / Peng, Yong /
    He, Sen / Wei, Jia-Fu / Zhou, Wen-Xia / Zheng, Ming-Xia / Bao, Yun / Zhou, Xuan / Tang, Hong / Meng, Wei / Feng, Yuan / Chen, Mao

    Frontiers in cardiovascular medicine

    2022  Band 9, Seite(n) 794850

    Abstract: Objective: We sought to conduct a systematic review and meta-analysis of clinical adverse events in patients undergoing transcatheter aortic valve replacement (TAVR) with bicuspid aortic valve (BAV) vs. tricuspid aortic valve (TAV) anatomy and the ... ...

    Abstract Objective: We sought to conduct a systematic review and meta-analysis of clinical adverse events in patients undergoing transcatheter aortic valve replacement (TAVR) with bicuspid aortic valve (BAV) vs. tricuspid aortic valve (TAV) anatomy and the efficacy of balloon-expandable (BE) vs. self-expanding (SE) valves in the BAV population. Comparisons aforementioned will be made stratified into early- and new-generation devices. Differences of prosthetic geometry on CT between patients with BAV and TAV were presented. In addition, BAV morphological presentations in included studies were summarized.
    Method: Observational studies and a randomized controlled trial of patients with BAV undergoing TAVR were included according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline.
    Results: A total of 43 studies were included in the final analysis. In patients undergoing TAVR, type 1 BAV was the most common phenotype and type 2 BAV accounted for the least. Significant higher risks of conversion to surgical aortic valve replacement (SAVR), the need of a second valve, a moderate or severe paravalvular leakage (PVL), device failure, acute kidney injury (AKI), and stroke were observed in patients with BAV than in patients with TAV during hospitalization. BAV had a higher risk of new permanent pacemaker implantation (PPI) both at hospitalization and a 30-day follow-up. Risk of 1-year mortality was significantly lower in patients with BAV than that with TAV [odds ratio (OR) = 0.85, 95% CI 0.75-0.97,
    Conclusions: Despite higher risks of conversion to SAVR, the need of a second valve, moderate or severe PVL, device failure, AKI, stroke, and new PPI, TAVR seems to be a viable option for selected patients with severe bicuspid aortic stenosis (AS), which demonstrated a potential benefit of 1-year survival, especially among lower surgical risk population using new-generation devices. Larger randomized studies are needed to guide patient selection and verified the durable performance of THVs in the BAV population.
    Sprache Englisch
    Erscheinungsdatum 2022-03-16
    Erscheinungsland Switzerland
    Dokumenttyp Systematic Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.794850
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: A Polysaccharide Isolated from

    Zou, Yuan-Feng / Zhang, Yan-Yun / Fu, Yu-Ping / Inngjerdingen, Kari Tvete / Paulsen, Berit Smestad / Feng, Bin / Zhu, Zhong-Kai / Li, Li-Xia / Jia, Ren-Yong / Huang, Chao / Song, Xu / Lv, Cheng / Ye, Gang / Liang, Xiao-Xia / He, Chang-Liang / Yin, Li-Zi / Yin, Zhong-Qiong

    Molecules (Basel, Switzerland)

    2019  Band 24, Heft 20

    Abstract: In this study, an acidic polysaccharide ... ...

    Abstract In this study, an acidic polysaccharide from
    Mesh-Begriff(e) Animals ; Cell Survival/drug effects ; Codonopsis/chemistry ; Hydrolysis ; Immunity, Mucosal/drug effects ; Immunologic Factors/chemistry ; Immunologic Factors/pharmacology ; Immunomodulation/drug effects ; Mice ; Molecular Structure ; Monosaccharides/chemistry ; Peyer's Patches/drug effects ; Peyer's Patches/immunology ; Peyer's Patches/metabolism ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Polysaccharides/chemistry ; Polysaccharides/pharmacology ; Spectrum Analysis
    Chemische Substanzen Immunologic Factors ; Monosaccharides ; Plant Extracts ; Polysaccharides
    Sprache Englisch
    Erscheinungsdatum 2019-10-09
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules24203632
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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