Article ; Online: Adjuvant Transarterial Chemoembolization for Patients with Intrahepatic Cholangiocarcinoma after Surgical Resection: A Systematic Review and Meta-analysis.
Journal of gastrointestinal and liver diseases : JGLD
2022 Volume 31, Issue 2, Page(s) 215–222
Abstract: Aim: To investigate the efficacy of postoperative adjuvant transarterial chemoembolization (TACE) in patients with intrahepatic cholangiocarcinoma (ICC) after resection.: Methods: Studies were systematically searched until August 2021 in the ... ...
| Abstract | Aim: To investigate the efficacy of postoperative adjuvant transarterial chemoembolization (TACE) in patients with intrahepatic cholangiocarcinoma (ICC) after resection. Methods: Studies were systematically searched until August 2021 in the following databases: MEDLINE, EMBASE, PUBMED, Web of Science, Cochrane Library, Science Direct, and Springer Link. Overall survival (OS) and recurrence-free survival (RFS) were considered as the main outcomes. Pooled hazard ratio (HR) with 95% confidence interval (95%CI) was reported as results for the survival data. Subgroup analysis was conducted on the outcomes stratified by early-stage ICC and intra-arterial chemotherapeutic regimen. Results: Eleven studies with 2,757 patients were finally included in the study. The pooled HR of OS was 0.68 (95%CI: 0.50-0.87, I 2 =83.7%). The pooled HR of RFS was 1.00 (95%CI: 0.69-1.31, I 2 =88%). Receipt of postoperative adjuvant TACE improved the OS in the early-stage ICC subgroup (HR=0.68, 95%CI: 0.50-0.86, I 2 =54%). Addition of carboplatin could slightly improve the OS (HR=0.6, 95%CI: 0.35-0.85, I 2 =48%). But receipt of postoperative adjuvant TACE (HR=1.06, 95%CI: 0.83-1.29, I 2 =41.2%) or use of carboplatin (HR=1.30, 95%CI: 0.93-1.67, I 2 =0%) caused no significant improvement in the RFS in the early-stage ICC subgroup. Conclusions: Postoperative adjuvant TACE could improve the OS in ICC patients after hepatectomy but could not prevent late recurrence. Survival benefit was also found in early-stage ICC patients undergoing postoperative adjuvant TACE after hepatectomy. Addition or non-addition of carboplatin in chemoembolization showed a similar OS outcome. |
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| MeSH term(s) | Bile Duct Neoplasms/surgery ; Bile Ducts, Intrahepatic/pathology ; Carboplatin/therapeutic use ; Carcinoma, Hepatocellular/pathology ; Chemoembolization, Therapeutic/adverse effects ; Chemoembolization, Therapeutic/methods ; Cholangiocarcinoma/pathology ; Cholangiocarcinoma/therapy ; Hepatectomy/adverse effects ; Hepatectomy/methods ; Humans ; Liver Neoplasms/pathology ; Treatment Outcome |
| Chemical Substances | Carboplatin (BG3F62OND5) |
| Language | English |
| Publishing date | 2022-06-12 |
| Publishing country | Romania |
| Document type | Meta-Analysis ; Systematic Review |
| ZDB-ID | 2427021-0 |
| ISSN | 1842-1121 ; 1841-8724 |
| ISSN (online) | 1842-1121 |
| ISSN | 1841-8724 |
| DOI | 10.15403/jgld-4207 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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