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  1. Article: [Traditional Chinese medicine health care from "long term taking" drugs in Shen Nong's Classic of Materia Medica].

    Yu, Qian / Zhou, Peng / Zhang, Jian-Jun / Wang, Lin-Yuan / Zhuang, Peng-Wei / Zhang, Yan-Jun

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2023  Volume 48, Issue 3, Page(s) 835–840

    Abstract: Taking drugs for a long term" is a qualitative expression of medication method based on the efficacy and safety of Chinese medicine, and the study on it is conducive to the full utilization of the efficacy and rational use of drugs. There are 148 drugs ... ...

    Abstract "Taking drugs for a long term" is a qualitative expression of medication method based on the efficacy and safety of Chinese medicine, and the study on it is conducive to the full utilization of the efficacy and rational use of drugs. There are 148 drugs that can be taken for a long time recorded in Shen Nong's Classic of Materia Medica, accounting for 41% of the total drugs. This paper analyzed three-grade classification, natural qualities, four properties and five flavors, and efficacy features of the "long-term taking" drugs(LTTD), thus exploring the herbal source of traditional Chinese medicine health care and the rationality of effect accumulation by long-term taking. It was found that there were more than 110 top-grade LTTD in Shen Nong's Classic of Materia Medica, most of which were herbs, with sweet flavor, flat property, and no toxicity. The efficacies were mainly making body feel light and agile(Qingshen) and prolonging life. Eighty-three LTTD were included in the Chinese Pharmacopoeia(2020 edition). In the modern classification, tonic LTTD accounted for the most, followed by damp-draining diuretic LTTD and exterior-releasing LTTD. Twenty LTTD were included in the "List of Medicinal and Edible Products" and 21 were in the "List of Products Used for Health-care Food", involving in various modern health care effects, such as enhancing immunity, assisting in reducing blood lipids, and anti-oxidation. Shen Nong's Classic of Materia Medica is the classic source of traditional Chinese medicine health care, and its medication thought of taking drugs for a long term to accumulate effects has guiding significance for the regulation of sub-health and chronic diseases nowadays. The efficacy and safety of LTTD have been examined in practice for a long time, and some of the drugs are edible, which is unique in the whole cycle of health-care service, especially in line with the health-care needs in the aging society under the concept of Big Health. However, some records in the book are limited by the understanding of the times, which should be scientifically studied according to the Chinese Pharmacopoeia and the related regulations and technical requirements, under the attitude of eliminating falsifications and preserving the truth and keeping the right essence, so as to achieve further improvement, innovation, and development.
    MeSH term(s) Humans ; Delivery of Health Care ; Materia Medica ; Medicine, Chinese Traditional
    Chemical Substances Materia Medica
    Language Chinese
    Publishing date 2023-03-06
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.20220608.401
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Intestinal Mucosal Barrier Is Regulated by Intestinal Tract Neuro-Immune Interplay.

    You, Xin-Yu / Zhang, Han-Yu / Han, Xu / Wang, Fang / Zhuang, Peng-Wei / Zhang, Yan-Jun

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 659716

    Abstract: Inflammatory bowel disease, irritable bowel syndrome and severe central nervous system injury can lead to intestinal mucosal barrier damage, which can cause endotoxin/enterobacteria translocation to induce infection and is closely related to the ... ...

    Abstract Inflammatory bowel disease, irritable bowel syndrome and severe central nervous system injury can lead to intestinal mucosal barrier damage, which can cause endotoxin/enterobacteria translocation to induce infection and is closely related to the progression of metabolic diseases, cardiovascular and cerebrovascular diseases, tumors and other diseases. Hence, repairing the intestinal barrier represents a potential therapeutic target for many diseases. Enteral afferent nerves, efferent nerves and the intrinsic enteric nervous system (ENS) play key roles in regulating intestinal physiological homeostasis and coping with acute stress. Furthermore, innervation actively regulates immunity and induces inherent and adaptive immune responses through complex processes, such as secreting neurotransmitters or hormones and regulating their corresponding receptors. In addition, intestinal microorganisms and their metabolites play a regulatory role in the intestinal mucosal barrier. This paper primarily discusses the interactions between norepinephrine and β-adrenergic receptors, cholinergic anti-inflammatory pathways, nociceptive receptors, complex ENS networks, gut microbes and various immune cells with their secreted cytokines to summarize the key roles in regulating intestinal inflammation and improving mucosal barrier function.
    Language English
    Publishing date 2021-05-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.659716
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Neuroimmune crosstalk in central nervous system injury-induced infection and pharmacological intervention.

    Huang, Ying-Ying / Li, Xueli / Li, Xiaojin / Sheng, Yuan-Yuan / Zhuang, Peng-Wei / Zhang, Yan-Jun

    Brain research bulletin

    2019  Volume 153, Page(s) 232–238

    Abstract: Infection (such as pneumonia and urinary tract infection) is one of the leading causes of death in patients with acute central nervous system (CNS) injury, which also greatly affects the patients' prognosis and quality of life. Antibiotics are commonly ... ...

    Abstract Infection (such as pneumonia and urinary tract infection) is one of the leading causes of death in patients with acute central nervous system (CNS) injury, which also greatly affects the patients' prognosis and quality of life. Antibiotics are commonly used for the treatment of various infections, however, available evidence demonstrate that prophylactic antibiotic treatments for CNS injury-induced infection have been unsuccessful. Effective approaches for prevention of CNS injury induced-infection remain scarce, therefore, better understanding the molecular and cellular mechanisms of infection post-CNS injury may aid in the development of efficacious therapeutic options. CNS injury-induced infection is confirmed affected by the sympathetic/parasympathetic nervous system, hypothalamic-pituitary-adrenal axis, and even brain-gut axis. In this review, we summarized the mechanisms of CNS injury- induced infection, crosstalk between the CNS and the immune system and current pharmacological intervention to provide ideas for the development of new anti- infective therapeutic strategies.
    MeSH term(s) Animals ; Brain/physiology ; Central Nervous System/immunology ; Central Nervous System/injuries ; Central Nervous System/physiology ; Gastrointestinal Microbiome/physiology ; Humans ; Hypothalamo-Hypophyseal System/immunology ; Immune System ; Infections ; Neuroimmunomodulation/immunology ; Neuroimmunomodulation/physiology ; Pituitary-Adrenal System/immunology
    Language English
    Publishing date 2019-09-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 197620-5
    ISSN 1873-2747 ; 0361-9230
    ISSN (online) 1873-2747
    ISSN 0361-9230
    DOI 10.1016/j.brainresbull.2019.09.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Bidirectional Brain-gut-microbiota Axis in increased intestinal permeability induced by central nervous system injury.

    Li, Xiao-Jin / You, Xin-Yu / Wang, Cong-Ying / Li, Xue-Li / Sheng, Yuan-Yuan / Zhuang, Peng-Wei / Zhang, Yan-Jun

    CNS neuroscience & therapeutics

    2020  Volume 26, Issue 8, Page(s) 783–790

    Abstract: Central nervous system injuries may lead to the disorders of the hypothalamic-pituitary-adrenal axis, autonomic nervous system, and enteric nervous system. These effects then cause the changes in the intestinal microenvironment, such as a disordered ... ...

    Abstract Central nervous system injuries may lead to the disorders of the hypothalamic-pituitary-adrenal axis, autonomic nervous system, and enteric nervous system. These effects then cause the changes in the intestinal microenvironment, such as a disordered intestinal immune system as well as alterations of intestinal bacteria. Ultimately, this leads to an increase in intestinal permeability. Inflammatory factors produced by the interactions between intestinal neurons and immune cells as well as the secretions and metabolites of intestinal flora can then migrate through the intestinal barrier, which will aggravate any peripheral inflammation and the central nervous system injury. The brain-gut-microbiota axis is a complex system that plays a crucial role in the occurrence and development of central nervous system diseases. It may also increase the consequences of preventative treatment. In this context, here we have summarized the factors that can lead to the increased intestinal permeability and some of the possible outcomes.
    MeSH term(s) Animals ; Brain/metabolism ; Brain/physiopathology ; Central Nervous System Diseases/metabolism ; Central Nervous System Diseases/physiopathology ; Enteric Nervous System/metabolism ; Enteric Nervous System/physiopathology ; Gastrointestinal Microbiome/physiology ; Humans ; Hypothalamo-Hypophyseal System/metabolism ; Hypothalamo-Hypophyseal System/physiopathology ; Intestinal Absorption/physiology ; Permeability ; Pituitary-Adrenal System/metabolism ; Pituitary-Adrenal System/physiopathology
    Language English
    Publishing date 2020-05-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2423461-8
    ISSN 1755-5949 ; 1755-5930
    ISSN (online) 1755-5949
    ISSN 1755-5930
    DOI 10.1111/cns.13401
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Toxic effects of combination of Aconiti Lateralis Radix Praeparata with Trichosanthis Fructus on inflammatory response and myocardial fibrosis in pressure overload rats based on β

    Sun, Feng-Jiao / Sheng, Yuan-Yuan / Fan, Shan-Shan / Zhang, Yan-Jun / Zhuang, Peng-Wei / Han, Juan

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2019  Volume 44, Issue 19, Page(s) 4212–4218

    Abstract: To study the effects of combination of Aconiti Lateralis Radix Praeparata( Fuzi) with Trichosanthis Fructus( Gualou) on cardiac function,electrocardiogram,inflammatory response and myocardial fibrosis in pressure overload( PO) rats,and further explore ... ...

    Abstract To study the effects of combination of Aconiti Lateralis Radix Praeparata( Fuzi) with Trichosanthis Fructus( Gualou) on cardiac function,electrocardiogram,inflammatory response and myocardial fibrosis in pressure overload( PO) rats,and further explore the mechanism based on β
    MeSH term(s) Aconitum ; Animals ; Drugs, Chinese Herbal ; Fibrosis ; Fruit ; Rats ; Signal Transduction
    Chemical Substances Drugs, Chinese Herbal
    Language Chinese
    Publishing date 2019-12-23
    Publishing country China
    Document type Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.20190505.402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Screening, verification, and analysis of biomarkers for drug-induced cardiac toxicity in vitro based on RTCA coupled with PCR Array technology.

    Zhang, Lu / Xu, Meng-Xi / Yin, Qing-Sheng / Zhu, Cai-Ying / Cheng, Xue-Lian / Ren, Yi-Ran / Zhuang, Peng-Wei / Zhang, Yan-Jun

    Toxicology letters

    2017  Volume 268, Page(s) 17–25

    Abstract: Cardiotoxicity is one of the most serious side effects of new drugs. Early detection of the drug induced cardiotoxicity based on the biomarkers provides an important preventative strategy for detecting potential cardiotoxicity of candidate drugs. In this ...

    Abstract Cardiotoxicity is one of the most serious side effects of new drugs. Early detection of the drug induced cardiotoxicity based on the biomarkers provides an important preventative strategy for detecting potential cardiotoxicity of candidate drugs. In this study, we aim to identify the predictive genomics biomarkers for drug-induced cardiac toxicity based on the RTCA coupled with PCR Array technology in primary cells. Three prototypical cardiotoxic compounds (doxorubicin, isoproterenol, ouabain) with different mechanisms were firstly real-time monitored to diagnose the cytotoxicity by using the RTCA, while the functional alterations of cardiomyocytes were also monitored by analyzing the beating frequency of cardiomyocytes. Then cardiac specific toxicity gene expression changes were studied by using the technology of PCR Array, which can detect the changes of 84 cardiac functions related genes. Rps6kb1 was identified to be the common cardiac biomarkers by using multivariate statistical and integration analyses. The biomarker was further verified by selecting other drugs with or without cardiotoxicity, and the results showed that the gene exhibited specific changes in cardiac toxicity. Moreover, IPA was applied to combine relevant pathways of Rps6kb1, and identify the main types of cardiac toxicity. These results would further enrich the evaluating strategy of drug-induced cardiotoxicity in vitro, and Rps6kb1 could be used as the specific biomarker of cardiotoxcity during safety assessment of the novel drug candidates.
    MeSH term(s) Animals ; Animals, Newborn ; Cardiotoxicity ; Cells, Cultured ; Dose-Response Relationship, Drug ; Doxorubicin/toxicity ; Gene Expression Profiling/methods ; Gene Expression Regulation/drug effects ; Genetic Markers ; Heart Diseases/chemically induced ; Heart Diseases/genetics ; Heart Diseases/metabolism ; Heart Diseases/physiopathology ; Heart Rate/drug effects ; Isoproterenol/toxicity ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Oligonucleotide Array Sequence Analysis ; Ouabain/toxicity ; Rats, Sprague-Dawley ; Real-Time Polymerase Chain Reaction ; Reproducibility of Results ; Reverse Transcriptase Polymerase Chain Reaction ; Ribosomal Protein S6 Kinases, 70-kDa/genetics ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism ; Toxicity Tests
    Chemical Substances Genetic Markers ; Ouabain (5ACL011P69) ; Doxorubicin (80168379AG) ; Ribosomal Protein S6 Kinases, 70-kDa (EC 2.7.11.1) ; ribosomal protein S6 kinase, 70kD, polypeptide 1 (EC 2.7.11.1) ; Isoproterenol (L628TT009W)
    Language English
    Publishing date 2017-02-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 433788-8
    ISSN 1879-3169 ; 0378-4274
    ISSN (online) 1879-3169
    ISSN 0378-4274
    DOI 10.1016/j.toxlet.2017.01.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Synergistic Promotion on Tyrosinase Inhibition by Antioxidants.

    Wang, Yan / Hao, Mi-Mi / Sun, Ying / Wang, Li-Feng / Wang, Hao / Zhang, Yan-Jun / Li, Hong-Yan / Zhuang, Peng-Wei / Yang, Zhen

    Molecules (Basel, Switzerland)

    2018  Volume 23, Issue 1

    Abstract: When exposed to ultraviolet radiation, the human skin produces profuse reactive oxygen species (ROS), which in turn activate a variety of biological responses. Mounting ROS levels activate tyrosinase by mobilizing α-melanocyte-stimulating hormone in the ... ...

    Abstract When exposed to ultraviolet radiation, the human skin produces profuse reactive oxygen species (ROS), which in turn activate a variety of biological responses. Mounting ROS levels activate tyrosinase by mobilizing α-melanocyte-stimulating hormone in the epidermis and finally stimulates the melanocytes to produce melanin. Meanwhile, the Keap1-Nrf2/ARE pathway, which removes ROS, is activated at increased ROS levels, and antioxidant compounds facilitates the dissociation of Nrf2. In this study, we explored the possible suppressing effects of antioxidant compounds and tyrosine inhibitors on melanin formation and the promotory effects of these compounds on ROS scavenging. The antioxidant activity of glabridin (GLA), resveratrol (RES), oxyresveratrol (OXYR), and phenylethylresorcinol (PR) were investigated via the stable free radical 2,2-diphenyl-1-picrylhydrazyl method. The inhibitory effects of the four compounds and their mixtures on tyrosinase were evaluated. l-Tyrosine or 3-(3,4-dihydroxyphenyl)-l-alanine (l-DOPA) was used as a substrate. The results showed that all mixtures did not exhibit synergistic effects with the l-tyrosine as a substrate, suggesting that l-tyrosine is not suitable as a substrate. However, the mixtures of "GLA:RES," "GLA:OXYR," "OXYR:RES," and "PR:RES" demonstrated synergistic effects (CI < 0.9,
    MeSH term(s) Antioxidants/chemistry ; Antioxidants/pharmacology ; Drug Synergism ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Humans ; Isoflavones/pharmacology ; Kelch-Like ECH-Associated Protein 1/chemistry ; Kelch-Like ECH-Associated Protein 1/metabolism ; Melanocytes/drug effects ; Melanocytes/metabolism ; Melanocytes/radiation effects ; Molecular Docking Simulation ; Monophenol Monooxygenase/antagonists & inhibitors ; Monophenol Monooxygenase/chemistry ; Monophenol Monooxygenase/metabolism ; Phenols/pharmacology ; Plant Extracts/pharmacology ; Resorcinols/pharmacology ; Stilbenes/pharmacology ; Ultraviolet Rays
    Chemical Substances Antioxidants ; Enzyme Inhibitors ; Isoflavones ; Kelch-Like ECH-Associated Protein 1 ; Phenols ; Plant Extracts ; Resorcinols ; Stilbenes ; puag-haad (4721-07-7) ; Monophenol Monooxygenase (EC 1.14.18.1) ; glabridin (HOC5567T41) ; resveratrol (Q369O8926L)
    Language English
    Publishing date 2018-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules23010106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Looking for agonists of β2 adrenergic receptor from Fuzi and Chuanwu by virtual screening and dual-luciferase reporter assay.

    Yang, Zhen / Lu, Zhi-Qiang / Zhang, Yan-Jun / Li, Yu-Bo / Wang, Zeng-Yong / Zhang, Yan-Ling / Zhuang, Peng-Wei / Bai, Gang

    Journal of Asian natural products research

    2015  Volume 18, Issue 6, Page(s) 550–561

    Abstract: More and more studies demonstrated that β2 adrenergic receptor (β2-AR) plays a crucial role for the treatment of heart failure. Chuanwu and Fuzi have been used over thousands of years in China for the treatment of heart failure. Considering the effects ... ...

    Abstract More and more studies demonstrated that β2 adrenergic receptor (β2-AR) plays a crucial role for the treatment of heart failure. Chuanwu and Fuzi have been used over thousands of years in China for the treatment of heart failure. Considering the effects of these herbs are very similar to β2-AR agonists, we presume whether β2-AR agonists can be found from Fuzi and Chuanwu. Fuzi and Chuanwu decoction were used to receive the luciferase reporter activity assay to verify the hypothesis, and the result is positive and encouraging. For it is very difficult to get all of the monomer compounds of Fuzi and Chuanwu, virtual screening was used to find potential β2-AR agonists and a cell-based β2-AR agonist functional evaluation model, combined with a luciferase reporter assay system, was used to confirm the final result. In this research, 45 compounds were identified as β2-AR agonists, and four compounds were verified and the rest need further experiment.
    MeSH term(s) Adrenergic beta-2 Receptor Agonists/pharmacology ; China ; Humans ; Luciferases/metabolism ; Molecular Structure ; Plant Extracts/chemistry ; Signal Transduction/drug effects
    Chemical Substances Adrenergic beta-2 Receptor Agonists ; Plant Extracts ; fuzi drug herbal ; Luciferases (EC 1.13.12.-)
    Language English
    Publishing date 2015-12-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2077926-4
    ISSN 1477-2213 ; 1028-6020
    ISSN (online) 1477-2213
    ISSN 1028-6020
    DOI 10.1080/10286020.2015.1123692
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: [Effect of Qishen Yiqi droplet on adenylate contents in myocardium of cor pulmonale rats].

    Geng, Shi-Han / Shan, Qiu-Yue / Xu, Meng-Xi / Zhang, Yi-Dan / Song, Li-Li / Hou, Ning / Zhang, Wen / Zhang, Mi-Xia / Zhuang, Peng-Wei / Zhang, Yan-Jun

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2017  Volume 42, Issue 1, Page(s) 170–174

    Abstract: Cor pulmonale rat models were induced by a single intraperitoneal injection of monocrotaline(MCT), and the sham group received a single intraperitioneal injection of normal saline. After the model rats received intragastric administration of Qishen Yiqi ... ...

    Abstract Cor pulmonale rat models were induced by a single intraperitoneal injection of monocrotaline(MCT), and the sham group received a single intraperitioneal injection of normal saline. After the model rats received intragastric administration of Qishen Yiqi droplet(QS) for 6 weeks, the contents of adenylate(ATP, ADP and AMP) in right myocardial tissues were measured by HPLC, and then the metabolism changes in myocardium of cor pulmonale rats with QS were investigated. The results showed that ATP, ADP, and AMP were well separated, with a good linearity within a certain range of concentration; and the recovery rates were within the range of 90%-108%. As compared with model group, the level of ATP was significantly elevated in high-dose treatment group; ADP contents showed an increasing trend and AMP contents showed a decreasing trend, indicating that QS could significantly improve energy metabolism system in myocardium. By using the HPLC, a qualitative and quantitative analysis method was given for the determination of ATP, ADP and AMP contents in myocardium, providing a method for energy metabolism measurement in biological samples.
    Language Chinese
    Publishing date 2017-01
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.20161222.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Baicalin regulates neuronal fate decision in neural stem/progenitor cells and stimulates hippocampal neurogenesis in adult rats.

    Zhuang, Peng-Wei / Cui, Guang-Zhi / Zhang, Yan-Jun / Zhang, Mi-Xia / Guo, Hong / Zhang, Jin-Bao / Lu, Zhi-Qiang / Isaiah, Adejobi-Oluwaniyi / Lin, Ying-Xue

    CNS neuroscience & therapeutics

    2013  Volume 19, Issue 3, Page(s) 154–162

    Abstract: Background: Recent studies revealed that baicalin, a flavonoid compound derived from the root of Scutellaria baicalensis Georgi, could promote neuron differentiation of NSPCs after commencing the differentiation process in vitro. However, this may not ... ...

    Abstract Background: Recent studies revealed that baicalin, a flavonoid compound derived from the root of Scutellaria baicalensis Georgi, could promote neuron differentiation of NSPCs after commencing the differentiation process in vitro. However, this may not be the most efficacious strategy to determinate cell fate. Here, we have investigated whether baicalin can influence early events of neuron generation and stimulate adult neurogenesis.
    Results: Transient exposure of NSPCs to baicalin during proliferation could activate Mash1 to alter the differential fate and increase the proportion of cells expressing neuronal markers. Seven days after, rats were exposed to transient cerebral ischemia, they were treated for 3 weeks with baicalin, BrdU labeling study showed that exposure to baicalin increased the number of newly generated cells in hippocampus, BrdU/NeuN double staining analysis indicated that baicalin could promote new neuron production after cerebral ischemia. Additionally, Morris water maze test showed that delayed postischemic treatment with baicalin improved cognitive impairment.
    Conclusions: These results identify the existence of a single molecule, baicalin, which can specify the neuronal fate of multipotent NSPCs and stimulate neurogenesis, making it a promising candidate for developing clinically relevant strategies to manipulate neuronal fate of NSPCs for brain repair.
    MeSH term(s) Animals ; Dentate Gyrus/drug effects ; Flavonoids/pharmacology ; Gene Expression Regulation/drug effects ; Hippocampus/cytology ; Hippocampus/drug effects ; Learning/drug effects ; Male ; Memory/drug effects ; Neural Stem Cells/drug effects ; Neurogenesis/drug effects ; Rats ; Rats, Wistar
    Chemical Substances Flavonoids ; baicalin (347Q89U4M5)
    Language English
    Publishing date 2013-01-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2423461-8
    ISSN 1755-5949 ; 1755-5930
    ISSN (online) 1755-5949
    ISSN 1755-5930
    DOI 10.1111/cns.12050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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