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Article: Clinical evidence and potential mechanisms of traditional Chinese medicine for refractory heart failure: a literature review and perspectives.

Guo, Liuli / Yang, Zhihua / Feng, Wenshuai / Liu, Yiman / Li, Zhenzhen / Zhuang, Pengwei / Ren, Ming

2024 Volume 11, Page(s) 1369642

Abstract: Refractory heart failure (RHF), or end-stage heart failure, has a poor prognosis and high case fatality rate, making it one of the therapeutic difficulties in the cardiovascular field. Despite the continuous abundance of methods and means for treating ... ...

Abstract	Refractory heart failure (RHF), or end-stage heart failure, has a poor prognosis and high case fatality rate, making it one of the therapeutic difficulties in the cardiovascular field. Despite the continuous abundance of methods and means for treating RHF in modern medicine, it still cannot meet the clinical needs of patients with RHF. How to further reduce the mortality rate and readmission rate of patients with RHF and improve their quality of life is still a difficult point in current research. In China, traditional Chinese medicine (TCM) has been widely used and has accumulated rich experience in the treatment of RHF due to its unique efficacy and safety advantages. Based on this, we comprehensively summarized and analyzed the clinical evidence and mechanism of action of TCM in the treatment of RHF and proposed urgent scientific issues and future research strategies for the treatment of RHF with TCM, to provide reference for the treatment of RHF.
Language	English
Publishing date	2024-04-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2024.1369642
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Traditional Chinese medicine health care from "long term taking" drugs in Shen Nong's Classic of Materia Medica].

Yu, Qian / Zhou, Peng / Zhang, Jian-Jun / Wang, Lin-Yuan / Zhuang, Peng-Wei / Zhang, Yan-Jun

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2023 Volume 48, Issue 3, Page(s) 835–840

Abstract: Taking drugs for a long term" is a qualitative expression of medication method based on the efficacy and safety of Chinese medicine, and the study on it is conducive to the full utilization of the efficacy and rational use of drugs. There are 148 drugs ... ...

Abstract	"Taking drugs for a long term" is a qualitative expression of medication method based on the efficacy and safety of Chinese medicine, and the study on it is conducive to the full utilization of the efficacy and rational use of drugs. There are 148 drugs that can be taken for a long time recorded in Shen Nong's Classic of Materia Medica, accounting for 41% of the total drugs. This paper analyzed three-grade classification, natural qualities, four properties and five flavors, and efficacy features of the "long-term taking" drugs(LTTD), thus exploring the herbal source of traditional Chinese medicine health care and the rationality of effect accumulation by long-term taking. It was found that there were more than 110 top-grade LTTD in Shen Nong's Classic of Materia Medica, most of which were herbs, with sweet flavor, flat property, and no toxicity. The efficacies were mainly making body feel light and agile(Qingshen) and prolonging life. Eighty-three LTTD were included in the Chinese Pharmacopoeia(2020 edition). In the modern classification, tonic LTTD accounted for the most, followed by damp-draining diuretic LTTD and exterior-releasing LTTD. Twenty LTTD were included in the "List of Medicinal and Edible Products" and 21 were in the "List of Products Used for Health-care Food", involving in various modern health care effects, such as enhancing immunity, assisting in reducing blood lipids, and anti-oxidation. Shen Nong's Classic of Materia Medica is the classic source of traditional Chinese medicine health care, and its medication thought of taking drugs for a long term to accumulate effects has guiding significance for the regulation of sub-health and chronic diseases nowadays. The efficacy and safety of LTTD have been examined in practice for a long time, and some of the drugs are edible, which is unique in the whole cycle of health-care service, especially in line with the health-care needs in the aging society under the concept of Big Health. However, some records in the book are limited by the understanding of the times, which should be scientifically studied according to the Chinese Pharmacopoeia and the related regulations and technical requirements, under the attitude of eliminating falsifications and preserving the truth and keeping the right essence, so as to achieve further improvement, innovation, and development.
MeSH term(s)	Humans ; Delivery of Health Care ; Materia Medica ; Medicine, Chinese Traditional
Chemical Substances	Materia Medica
Language	Chinese
Publishing date	2023-03-06
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20220608.401
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Zs.A 3056: Show issues

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Article ; Online: Clinical value-oriented research paradigm about inheritance and innovation development of TCM dominant diseases.

Li, Dongna / Guo, Hong / Niu, Lin / Yin, Qingsheng / Zhang, Yanjun / Zhuang, Pengwei

Chinese herbal medicines

2023 Volume 15, Issue 4, Page(s) 476–484

Abstract: Modern medicine has made remarkable achievements in safeguarding people's life and health, however, it is increasingly found that in the face of complex diseases, selective targeting of single target is often difficult to produce a comprehensive ... ...

Abstract	Modern medicine has made remarkable achievements in safeguarding people's life and health, however, it is increasingly found that in the face of complex diseases, selective targeting of single target is often difficult to produce a comprehensive rehabilitation effect, and is prone to induce drug resistance, toxic side effects. Traditional Chinese medicine (TCM) has a long history of clinical application, and its clinical value in the treatment of complex diseases such as cardiovascular and cerebrovascular diseases, digestive diseases, skin diseases, rheumatism and immunity diseases, and adjuvant treatment of tumors has been proven to have obvious advantages. However, its modern research is relatively lagging behind, and in the face of the aging society and the characteristics of the modern disease spectrum, the traditional knowledge-driven research paradigm seems to be stuck in a bottleneck and difficult to make greater breakthroughs. Focusing on the key issues of TCM development in the new era, the clinical value-oriented strategy becomes to be a new research paradigm of TCM inheritance and innovation development, and dominant diseases would be the focus of the TCM inheritance and innovation development, which has been highly valued in recent years by the TCM academia and the relevant national management departments. Based on the clinical value, a series of policies are formulated for the selection and evaluation of the TCM dominant diseases (TCMDD), and exploratory researches about the clinical efficacy characteristics, the modern scientific connotation interpretation were carried out. The clinical value-oriented research paradigm of TCMDD inheritance and innovation development has been initially formed, which is characterized by strong policy support as the guarantee, systematic and standardized selection and evaluation methods as the driving force, scientific and effective research on internal mechanisms as the expansion, and effective clinical guidelines and principles as the transformation, which is of great value in promoting the high-quality development of the industries and undertaking of TCM. In this paper, the main policy support, selection and evaluation methods, therapeutic effect characterization, and modern scientific connotation research strategies of TCMDD in recent years have been comprehensively sorted out, with a view to providing the healthy and benign development of the research on TCMDD.
Language	English
Publishing date	2023-10-16
Publishing country	Singapore
Document type	Journal Article ; Review
ISSN	2589-3610
ISSN (online)	2589-3610
DOI	10.1016/j.chmed.2023.09.002
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Article ; Online: Function and therapeutic value of astrocytes in diabetic cognitive impairment.

Meng, Fanyu / Fu, Jiafeng / Zhang, Lin / Guo, Mengqing / Zhuang, Pengwei / Yin, Qingsheng / Zhang, Yanjun

Neurochemistry international

2023 Volume 169, Page(s) 105591

Abstract: Diabetic cognitive impairment (DCI) is a complex complication of diabetes in the central nervous system, and its pathological mechanism is still being explored. Astrocytes are abundant glial cells in central nervous system that perform diverse functions ... ...

Abstract	Diabetic cognitive impairment (DCI) is a complex complication of diabetes in the central nervous system, and its pathological mechanism is still being explored. Astrocytes are abundant glial cells in central nervous system that perform diverse functions in health and disease. Accumulating excellent research has identified astrocyte dysfunction in many neurodegenerative diseases (such as Alzheimer's disease, aging and Parkinson's disease), and summarized and discussed its pathological mechanisms and potential therapeutic value. However, the contribution of astrocytes to DCI has been largely overlooked. In this review, we first systematically summarized the effects and mechanisms of diabetes on brain astrocytes, and found that the diabetic environment (such as hyperglycemia, advanced glycation end products and cerebral insulin resistance) mediated brain reactive astrogliosis, which was specifically reflected in the changes of cell morphology and the remodeling of signature molecules. Secondly, we emphasized the contribution and potential targets of reactive astrogliosis to DCI, and found that reactive astrogliosis-induced increased blood-brain barrier permeability, glymphatic system dysfunction, neuroinflammation, abnormal cell communication and cholesterol metabolism dysregulation worsened cognitive function. In addition, we summarized effective strategies for treating DCI by targeting astrocytes. Finally, we discuss the application of new techniques in astrocytes, including single-cell transcriptome, in situ sequencing, and prospected new functions, new subsets and new targets of astrocytes in DCI.
MeSH term(s)	Humans ; Astrocytes/metabolism ; Gliosis/metabolism ; Brain/pathology ; Diabetes Mellitus/metabolism ; Inflammation/metabolism ; Cognitive Dysfunction/metabolism
Language	English
Publishing date	2023-08-04
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	283190-9
ISSN	1872-9754 ; 0197-0186
ISSN (online)	1872-9754
ISSN	0197-0186
DOI	10.1016/j.neuint.2023.105591
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Zs.A 1610: Show issues

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Article ; Online: Network pharmacology integrated with experimental verification reveals the antipyretic characteristics and mechanism of Zi Xue powder.

Zhang, Hanyu / Ge, Shining / Diao, Fengyin / Song, Wen / Zhang, Ying / Zhuang, Pengwei / Zhang, Yanjun

Pharmaceutical biology

2023 Volume 61, Issue 1, Page(s) 1512–1524

Abstract: Context: Zi Xue Powder (ZXP) is a traditional formula for the treatment of fever. However, the potential mechanism of action of ZXP remains unknown.: Objective: This study elucidates the antipyretic characteristics of ZXP and the mechanism by which ... ...

Abstract	Context: Zi Xue Powder (ZXP) is a traditional formula for the treatment of fever. However, the potential mechanism of action of ZXP remains unknown. Objective: This study elucidates the antipyretic characteristics of ZXP and the mechanism by which ZXP alleviates fever. Materials and methods: The key targets and underlying fever-reducing mechanisms of ZXP were predicted using network pharmacology and molecular docking. The targets of ZXP anti-fever active ingredient were obtained by searching TCMSP, STITCH and HERB. Moreover, male Sprague-Dawley rats were randomly divided into four groups: control, lipopolysaccharide (LPS), ZXP (0.54, 1.08, 2.16 g/kg), and positive control (acetaminophen, 0.045 g/kg); the fever model was established by intraperitoneal LPS injection. After the fever model was established at 0.5 h, the rats were administered treatment by gavage, and the anal temperature changes of each group were observed over 10 h after treatment. After 10 h, ELISA and Western blot analysis were used to further investigate the mechanism of ZXP. Results: Network pharmacology analysis showed that MAPK was a crucial pathway through which ZXP suppresses fever. The results showed that ZXP (2.16 g/kg) decreased PGE2, CRH, TNF-a, IL-6, and IL-1β levels while increasing AVP level compared to the LPS group. Furthermore, the intervention of ZXP inhibited the activation of MAPK pathway in LPS-induced fever rats. Conclusions: This study provides new insights into the mechanism by which ZXP reduces fever and provides important information and new research ideas for the discovery of antipyretic compounds from traditional Chinese medicine.
MeSH term(s)	Rats ; Male ; Animals ; Antipyretics/pharmacology ; Antipyretics/therapeutic use ; Rats, Sprague-Dawley ; Powders/adverse effects ; Molecular Docking Simulation ; Lipopolysaccharides/toxicity ; Network Pharmacology ; Fever/drug therapy ; Fever/chemically induced ; Drugs, Chinese Herbal/adverse effects
Chemical Substances	Antipyretics ; Powders ; Lipopolysaccharides ; Drugs, Chinese Herbal
Language	English
Publishing date	2023-12-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2023.2287658
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Zs.B 1300: Show issues

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Article ; Online: Lizhong decoction ameliorates pulmonary infection secondary to severe traumatic brain injury in rats by regulating the intestinal physical barrier and immune response

Miao, Yulu / Fan, Xuejin / Wei, Luge / Wang, Bin / Diao, Fengyin / Fu, Jiafeng / Zhuang, Pengwei / Zhang, Yanjun

Journal of Ethnopharmacology. 2023 July, v. 311 p.116346-

2023

Abstract: The pathogenesis of pulmonary infection secondary to severe traumatic brain injury (sTBI) is closely related to damage to the intestinal barrier. Lizhong decoction (LZD) is a prominent traditional Chinese medicine (TCM) that is widely used in clinical ... ...

Abstract	The pathogenesis of pulmonary infection secondary to severe traumatic brain injury (sTBI) is closely related to damage to the intestinal barrier. Lizhong decoction (LZD) is a prominent traditional Chinese medicine (TCM) that is widely used in clinical treatment to regulate gastrointestinal movement and enhance resistance. Nevertheless, the role and mechanism of LZD in lung infection secondary to sTBI have yet to be elucidated. Here, we evaluate the therapeutic effect of LZD on pulmonary infection secondary to sTBI in rats and discuss potential regulatory mechanisms. The chemical constituents of LZD were analyzed by ultra-high performance liquid chromatography-Q Exactive-tandem mass spectrometry(UPLC-QE-MS/MS). The efficacy of LZD on rats with lung infection secondary to sTBI was examined by changes in brain morphology, coma time, brain water content, mNSS score, colony counts, 16S rRNA/RNaseP/MRP30 kDa(16S/RPP30), myeloperoxidase (MPO) content and pathology of lung tissue. The concentration of fluorescein isothiocyanate(FITC)-dextran in serum and the contents of secretory immunoglobulin A (SIgA) in colon tissue were detected by enzyme-linked immunosorbent assay (ELISA). Subsequently, Alcian Blue Periodic acid Schiff (AB-PAS) was used to detect colonic goblet cells. Immunofluorescence (IF) was used to detect the expression of tight junction proteins. The proportions of CD3⁺ cell, CD4⁺CD8⁺ T cells, CD45⁺ cell and CD103+ cells in the colon were analyzed by flow cytometry (FC). In addition, colon transcriptomics were analyzed by Illumina mRNA-Seq sequencing. Real-time quantitative polymerase chain reaction (qRT‒PCR) was used to verify the genes associated with LZD alleviation of intestinal barrier function. Twenty-nine chemical constituents of LZD were revealed with UPLC-QE-MS/MS analysis. Administration of LZD significantly reduced colony counts, 16S/RPP30 and MPO content in lung infection secondary to sTBI rats. In addition, LZD also reduced the serum FITC-glucan content and the SIgA content of the colon. Additionally, LZD significantly increased the number of colonic goblet cells and the expression of tight junction proteins. Furthermore, LZD significantly decreased the proportion of CD3⁺ cell, CD4⁺CD8⁺ T cells,CD45+ and CD103+ cells in colon tissue. Transcriptomic analysis identified 22 upregulated genes and 56 downregulated genes in sTBI compared to the sham group. The levels of seven genes were recovered after LZD treatment. qRT‒PCR successfully validated two genes (Jchain and IL-6) at the mRNA level. LZD can improves sTBI secondary lung infection by regulating the intestinal physical barrier and immune response. Thees results suggested that LZD may be a prospective treatment for pulmonary infection secondary to sTBI.
Keywords	Oriental traditional medicine ; blood serum ; brain ; brain damage ; colon ; coma ; enzyme-linked immunosorbent assay ; flow cytometry ; fluorescein ; fluorescent antibody technique ; gene expression ; immune response ; immunoglobulin A ; interleukin-6 ; isothiocyanates ; lungs ; mass spectrometry ; myeloperoxidase ; pathogenesis ; quantitative polymerase chain reaction ; therapeutics ; tight junctions ; transcriptomics ; water content ; Lizhong decoction ; Lung infection secondary to sTBI ; Intestinal barrier ; Tight junction
Language	English
Dates of publication	2023-07
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116346
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Quality assessment of traditional Chinese medicine using quality biomarkers: Compound DanShen dripping pills as an example

Shen, Qian / Wu, Yu / Li, Zhen / Wu, Xin / Wang, Yu / Chen, Yuanxing / Zhuang, Pengwei / Guo, Hong / Zhang, Yanjun

Phytochemical Analysis. 2023 July, v. 34, no. 5 p.580-593

2023

Abstract: BACKGROUND: The quality control of traditional Chinese medicine (TCM) is one of the main topics in TCM modernisation research. To date, the overwhelming majority of research has focused on chemical ingredients in the quality control of TCM. However, ... ...

Abstract	BACKGROUND: The quality control of traditional Chinese medicine (TCM) is one of the main topics in TCM modernisation research. To date, the overwhelming majority of research has focused on chemical ingredients in the quality control of TCM. However, detecting a single or multiple chemical components cannot fully demonstrate the specificity and correlation between quality and efficacy. PURPOSE: To solve the problem that the association between quality control and efficacy is lacking. The present study was designed to establish a methodology for quality control based on quality biomarkers (Q‐biomarkers) and the vasodilatation efficacy of compound DanShen dripping pills (CDDP) as a case. METHODS: Guided by the basic principles of Q‐biomarkers, the compounds in TCM were determined by ultra‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry. Predicted targets were screened through network pharmacology. The potential Q‐biomarkers were further screened through proteomics and partial least squares regression analysis. The protein–protein interaction network that combines both predicted targets and potential Q‐biomarkers was constructed to screen Q‐biomarkers. RESULTS: There were 32 components and 79 predictive targets for CDDP. Proteomic results indicated that the expression of 23 differential proteins changed as pharmacodynamic and componential changes. CPSF6, RILP11, TMEM209, COQ7, VPS18, PPPP1CA, NF2, and ARFRP1 highly correlated with vasodilation. Protein interaction network analysis showed that NF2 and PPPP1CA were closely related to predicted proteins. Thus, NF2 and PPPP1CA could be considered as Q‐biomarkers of CDDP. CONCLUSION: Our preliminary study suggested the feasibility of the Q‐biomarkers theory in the quality of TCM. The concept of Q‐biomarkers provided a powerful method to strengthen the link between clinical efficacy and the quality of TCM. In conclusion, a novel, more scientific, and standard quality control method was established in this study.
Keywords	Oriental traditional medicine ; biomarkers ; mass spectrometry ; modernization ; pharmacodynamics ; phytochemicals ; protein-protein interactions ; proteomics ; quality control ; regression analysis ; ultra-performance liquid chromatography ; vasodilation
Language	English
Dates of publication	2023-07
Size	p. 580-593.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	1073576-8
ISSN	1099-1565 ; 0958-0344
ISSN (online)	1099-1565
ISSN	0958-0344
DOI	10.1002/pca.3238
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 4608: Show issues

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Article: Storax Inhibits Caveolae-Mediated Transcytosis at Blood-Brain Barrier After Ischemic Stroke in Rats.

Zhou, Min / Li, Dongna / Shen, Qian / Gao, Lei / Zhuang, Pengwei / Zhang, Yanjun / Guo, Hong

Frontiers in pharmacology

2022 Volume 13, Page(s) 876235

Abstract: Background and Purpose: ...

Abstract	Background and Purpose:
Language	English
Publishing date	2022-07-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.876235
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Article ; Online: A Systematic Review of

Wang, Qirou / Wang, Jia / Li, Nannan / Liu, Junyu / Zhou, Jingna / Zhuang, Pengwei / Chen, Haixia

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 2

Abstract: 1) Background: ...

Abstract	(1) Background:
MeSH term(s)	Diabetes Complications/drug therapy ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/metabolism ; Humans ; Hypoglycemic Agents/adverse effects ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/pharmacokinetics ; Hypoglycemic Agents/pharmacology ; Insulin Resistance ; Lipid Metabolism/drug effects ; Medicine, East Asian Traditional ; Orthosiphon/chemistry ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plants, Medicinal/chemistry
Chemical Substances	Hypoglycemic Agents ; Plant Extracts
Language	English
Publishing date	2022-01-10
Publishing country	Switzerland
Document type	Journal Article ; Systematic Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27020444
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Article ; Online: Construction of the Gal-NH

Li, Ruilin / Zhou, Jingna / Zhang, Xiaoyu / Wang, Yajie / Wang, Jia / Zhang, Min / He, Chengwei / Zhuang, Pengwei / Chen, Haixia

International journal of biological macromolecules

2023 Volume 253, Issue Pt 3, Page(s) 126780

Abstract: Luteolin is a kind of natural flavonoid with great potential for lipid accumulation intervention. However, the poor water solubility and non-targeted release greatly diminish its efficiency. In this study, 4-aminophenyl β-D-galactopyranoside (Gal- ... ...

Abstract	Luteolin is a kind of natural flavonoid with great potential for lipid accumulation intervention. However, the poor water solubility and non-targeted release greatly diminish its efficiency. In this study, 4-aminophenyl β-D-galactopyranoside (Gal-NH
MeSH term(s)	Luteolin/pharmacology ; Morus ; Muramidase ; Polysaccharides/pharmacology ; Nanoparticles/chemistry ; Lipids
Chemical Substances	Luteolin (KUX1ZNC9J2) ; Muramidase (EC 3.2.1.17) ; Polysaccharides ; Lipids
Language	English
Publishing date	2023-09-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.126780
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