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Article ; Online: Autophagosome biogenesis and organelle homeostasis in plant cells.

Zhuang, Xiaohong / Li, Baiying / Jiang, Liwen

2024

Abstract: Autophagy is one of the major highly inducible degradation processes in response to plant developmental and environmental signals. In response to different stimuli, cellular materials, including proteins and organelles, can be sequestered into a double ... ...

Abstract	Autophagy is one of the major highly inducible degradation processes in response to plant developmental and environmental signals. In response to different stimuli, cellular materials, including proteins and organelles, can be sequestered into a double membrane autophagosome structure either selectively or non-selectively. The formation of an autophagosome as well as its delivery into the vacuole involves complex and dynamic membrane processes. The identification and characterization of the conserved autophagy-related (ATG) proteins and their related regulators have greatly advanced our understanding of the molecular mechanism underlying autophagosome biogenesis and function in plant cells. Autophagosome biogenesis is tightly regulated by the coordination of multiple ATG and non-ATG proteins, and selective cargo recruitment. This review updates our current knowledge of autophagosome biogenesis, with special emphasis on the core molecular machinery that drives autophagosome formation, and autophagosome-organelle interactions under abiotic stress conditions.
Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Journal Article
ZDB-ID	623171-8
ISSN	1532-298X ; 1040-4651
ISSN (online)	1532-298X
ISSN	1040-4651
DOI	10.1093/plcell/koae099
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Article ; Online: A century journey of organelles research in the plant endomembrane system.

Zhuang, Xiaohong / Li, Ruixi / Jiang, Liwen

The Plant cell

2024 Volume 36, Issue 5, Page(s) 1312–1333

Abstract: We are entering an exciting century in the study of the plant organelles in the endomembrane system. Over the past century, especially within the past 50 years, tremendous advancements have been made in the complex plant cell to generate a much clearer ... ...

Abstract	We are entering an exciting century in the study of the plant organelles in the endomembrane system. Over the past century, especially within the past 50 years, tremendous advancements have been made in the complex plant cell to generate a much clearer and informative picture of plant organelles, including the molecular/morphological features, dynamic/spatial behavior, and physiological functions. Importantly, all these discoveries and achievements in the identification and characterization of organelles in the endomembrane system would not have been possible without: (1) the innovations and timely applications of various state-of-art cell biology tools and technologies for organelle biology research; (2) the continuous efforts in developing and characterizing new organelle markers by the plant biology community; and (3) the landmark studies on the identification and characterization of the elusive organelles. While molecular aspects and results for individual organelles have been extensively reviewed, the development of the techniques for organelle research in plant cell biology is less appreciated. As one of the ASPB Centennial Reviews on "organelle biology," here we aim to take a journey across a century of organelle biology research in plants by highlighting the important tools (or landmark technologies) and key scientists that contributed to visualize organelles. We then highlight the landmark studies leading to the identification and characterization of individual organelles in the plant endomembrane systems.
MeSH term(s)	Organelles/metabolism ; Organelles/physiology ; Plants/metabolism ; History, 20th Century ; History, 21st Century ; Plant Cells/physiology ; Intracellular Membranes/metabolism
Language	English
Publishing date	2024-01-16
Publishing country	England
Document type	Journal Article ; Review ; Historical Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	623171-8
ISSN	1532-298X ; 1040-4651
ISSN (online)	1532-298X
ISSN	1040-4651
DOI	10.1093/plcell/koae004
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Article ; Online: Subscaling of a cytosolic RNA binding protein governs cell size homeostasis in the multiple fission alga Chlamydomonas.

Liu, Dianyi / Lopez-Paz, Cristina / Li, Yubing / Zhuang, Xiaohong / Umen, James

PLoS genetics

2024 Volume 20, Issue 3, Page(s) e1010503

Abstract: Coordination of growth and division in eukaryotic cells is essential for populations of proliferating cells to maintain size homeostasis, but the underlying mechanisms that govern cell size have only been investigated in a few taxa. The green alga ... ...

Abstract	Coordination of growth and division in eukaryotic cells is essential for populations of proliferating cells to maintain size homeostasis, but the underlying mechanisms that govern cell size have only been investigated in a few taxa. The green alga Chlamydomonas reinhardtii (Chlamydomonas) proliferates using a multiple fission cell cycle that involves a long G1 phase followed by a rapid series of successive S and M phases (S/M) that produces 2n daughter cells. Two control points show cell-size dependence: the Commitment control point in mid-G1 phase requires the attainment of a minimum size to enable at least one mitotic division during S/M, and the S/M control point where mother cell size governs cell division number (n), ensuring that daughter distributions are uniform. tny1 mutants pass Commitment at a smaller size than wild type and undergo extra divisions during S/M phase to produce small daughters, indicating that TNY1 functions to inhibit size-dependent cell cycle progression. TNY1 encodes a cytosolic hnRNP A-related RNA binding protein and is produced once per cell cycle during S/M phase where it is apportioned to daughter cells, and then remains at constant absolute abundance as cells grow, a property known as subscaling. Altering the dosage of TNY1 in heterozygous diploids or through mis-expression increased Commitment cell size and daughter cell size, indicating that TNY1 is a limiting factor for both size control points. Epistasis placed TNY1 function upstream of the retinoblastoma tumor suppressor complex (RBC) and one of its regulators, Cyclin-Dependent Kinase G1 (CDKG1). Moreover, CDKG1 protein and mRNA were found to over-accumulate in tny1 cells suggesting that CDKG1 may be a direct target of repression by TNY1. Our data expand the potential roles of subscaling proteins outside the nucleus and imply a control mechanism that ties TNY1 accumulation to pre-division mother cell size.
MeSH term(s)	Chlamydomonas/metabolism ; Cell Cycle/genetics ; Cell Division ; Cyclin-Dependent Kinases/genetics ; RNA-Binding Proteins/genetics ; Cell Size
Chemical Substances	Cyclin-Dependent Kinases (EC 2.7.11.22) ; RNA-Binding Proteins
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2186725-2
ISSN	1553-7404 ; 1553-7390
ISSN (online)	1553-7404
ISSN	1553-7390
DOI	10.1371/journal.pgen.1010503
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Article ; Online: Chemical characterization and source apportionment of PM

Wang, Lukai / Zhuang, Xiaohong / Bao, Hongxu / Ma, Chunlei / Ma, Chen / Yang, Guangchao

Environmental science and pollution research international

2024

Abstract: To investigate the influence of COVID-19 lockdown measures on ... ...

Abstract	To investigate the influence of COVID-19 lockdown measures on PM
Language	English
Publishing date	2024-04-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-024-33473-w
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Article: An Update on Coat Protein Complexes for Vesicle Formation in Plant Post-Golgi Trafficking.

Law, Kai Ching / Chung, Ka Kit / Zhuang, Xiaohong

Frontiers in plant science

2022 Volume 13, Page(s) 826007

Abstract: Endomembrane trafficking is an evolutionarily conserved process for all eukaryotic organisms. It is a fundamental and essential process for the transportation of proteins, lipids, or cellular metabolites. The aforementioned cellular components are sorted ...

Abstract	Endomembrane trafficking is an evolutionarily conserved process for all eukaryotic organisms. It is a fundamental and essential process for the transportation of proteins, lipids, or cellular metabolites. The aforementioned cellular components are sorted across multiple membrane-bounded organelles. In plant cells, the endomembrane mainly consists of the nuclear envelope, endoplasmic reticulum (ER), Golgi apparatus, trans-Golgi network or early endosome (TGN/EE), prevacuolar compartments or multivesicular bodies (PVCs/MVBs), and vacuole. Among them, Golgi apparatus and TGN represent two central sorting intermediates for cargo secretion and recycling from other compartments by anterograde or retrograde trafficking. Several protein sorting machineries have been identified to function in these pathways for cargo recognition and vesicle assembly. Exciting progress has been made in recent years to provide novel insights into the sorting complexes and also the underlying sorting mechanisms in plants. Here, we will highlight the recent findings for the adaptor protein (AP) complexes, retromer, and retriever complexes, and also their functions in the related coated vesicle formation in post-Golgi trafficking.
Language	English
Publishing date	2022-02-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2022.826007
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Article: Chloroplast Degradation: Multiple Routes Into the Vacuole.

Zhuang, Xiaohong / Jiang, Liwen

Frontiers in plant science

2019 Volume 10, Page(s) 359

Abstract: Chloroplasts provide energy for all plants by producing sugar during photosynthesis. To adapt to various environmental and developmental cues, plants have developed specific strategies to control chloroplast homeostasis in plant cells, including ... ...

Abstract	Chloroplasts provide energy for all plants by producing sugar during photosynthesis. To adapt to various environmental and developmental cues, plants have developed specific strategies to control chloroplast homeostasis in plant cells, including chloroplast degradation during leaf senescence and the transition of chloroplasts into other types of plastids during the day-night cycle. In recent years, autophagy has emerged as an essential mechanism for selective degradation of chloroplast materials (also known as chlorophagy) in the vacuole. Different types of membrane structures have been implicated to involve in the delivery of distinct chloroplast contents. Here we provide a current overview on chlorophagy and discuss the possible chloroplast receptors and upstream signals in this process.
Language	English
Publishing date	2019-03-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2711035-7
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2019.00359
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Article ; Online: AS1 expression in prostate cancer and its effects on proliferation and invasion of prostate cancer cells.

Li, Yuxin / Zhuang, Xiaohong / Zhuang, Li / Liu, Hongjian

Cancer biomarkers : section A of Disease markers

2021 Volume 32, Issue 3, Page(s) 271–279

Abstract: This paper aimed at investigating AS1 expression in prostate cancer (PCa) and its effects on the proliferation and invasion of prostate cancer cells (PCCs). The prostate tissues and the matched adjacent normal prostate tissues excised and preserved ... ...

Abstract	This paper aimed at investigating AS1 expression in prostate cancer (PCa) and its effects on the proliferation and invasion of prostate cancer cells (PCCs). The prostate tissues and the matched adjacent normal prostate tissues excised and preserved during radical prostatectomy in our hospital were collected. The LncRNA NCK1-AS1 expression was detected. PCa patients were followed up for three years to analyze their prognosis. The correlation of LncRNA NCK1-AS1 expression with clinicopathological features was analyzed. Human normal prostate cells and human PCCs were selected, in which LncRNA NCK1-AS1 expression was tested to screen and then transfect the cells. Cell proliferation, invasion and migration were detected. Cell cycles and apoptosis were analyzed. Compared with the adjacent normal tissues, LncRNA NCK1-AS1 was highly expressed in the prostate cancer tissues. Its expression was remarkably different in those with different stages of TNM and with lymphatic metastasis or not. The prognosis of patients with high LncRNA NCK1-AS1 expression was remarkably poorer than that of those with low expression. Compared with the human normal prostate cells, LncRNA NCK1-AS1 expression in the human PCCs remarkably rose, with the greatest difference in 22Rv1 cells. Compared with the Blank group, cell proliferation and the number of plate cloned cells remarkably reduced in the sh-NCK1-AS1 group. Additionally, in this group, the number of invasive and migratory cells remarkably reduced; the expression of invasion-related protein E-cadherin remarkably rose but that of MMP-2 remarkably reduced; cell cycles were arrested and the expression of cycle-related proteins (CDK4, CDK6, cyclin D1) remarkably reduced; the apoptotic rate and the expression of apoptosis-related protein Bax remarkably rose. LncRNA NCK1-AS1 is highly expressed in PCa, so its down-regulation can inhibit PCCs from proliferating and reduce the number of invasive cells.
MeSH term(s)	Adaptor Proteins, Signal Transducing/metabolism ; Aged ; Cell Proliferation ; Humans ; Male ; Neoplasm Invasiveness ; Oncogene Proteins/metabolism ; Prostatic Neoplasms/physiopathology ; Transfection
Chemical Substances	Adaptor Proteins, Signal Transducing ; Nck protein ; Oncogene Proteins
Language	English
Publishing date	2021-06-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2203517-5
ISSN	1875-8592 ; 1574-0153 ; 1875-8592
ISSN (online)	1875-8592 ; 1574-0153
ISSN	1875-8592
DOI	10.3233/CBM-203021
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Article ; Online: Plant Mitophagy in Comparison to Mammals: What Is Still Missing?

Ren, Kaike / Feng, Lanlan / Sun, Shuangli / Zhuang, Xiaohong

International journal of molecular sciences

2021 Volume 22, Issue 3

Abstract: Mitochondrial homeostasis refers to the balance of mitochondrial number and quality in a cell. It is maintained by mitochondrial biogenesis, mitochondrial fusion/fission, and the clearance of unwanted/damaged mitochondria. Mitophagy represents a ... ...

Abstract	Mitochondrial homeostasis refers to the balance of mitochondrial number and quality in a cell. It is maintained by mitochondrial biogenesis, mitochondrial fusion/fission, and the clearance of unwanted/damaged mitochondria. Mitophagy represents a selective form of autophagy by sequestration of the potentially harmful mitochondrial materials into a double-membrane autophagosome, thus preventing the release of death inducers, which can trigger programmed cell death (PCD). Recent advances have also unveiled a close interconnection between mitophagy and mitochondrial dynamics, as well as PCD in both mammalian and plant cells. In this review, we will summarize and discuss recent findings on the interplay between mitophagy and mitochondrial dynamics, with a focus on the molecular evidence for mitophagy crosstalk with mitochondrial dynamics and PCD.
MeSH term(s)	Animals ; Apoptosis/genetics ; Autophagosomes/genetics ; Autophagosomes/metabolism ; Homeostasis ; Mammals ; Mitochondria/genetics ; Mitochondria/metabolism ; Mitochondrial Dynamics ; Mitophagy/genetics ; Mitophagy/physiology ; Molecular Chaperones/chemistry ; Molecular Chaperones/genetics ; Molecular Chaperones/metabolism ; Plants ; Proto-Oncogene Proteins c-bcl-2/chemistry ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Signal Transduction/genetics ; Signal Transduction/physiology ; Ubiquitin/genetics ; Ubiquitin/metabolism ; bcl-2-Associated X Protein/chemistry ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism
Chemical Substances	Molecular Chaperones ; Proto-Oncogene Proteins c-bcl-2 ; Ubiquitin ; bcl-2-Associated X Protein
Language	English
Publishing date	2021-01-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22031236
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Article ; Online: Analysis of Autophagic Activity Using ATG8 Lipidation Assay in

Luo, Mengqian / Zhuang, Xiaohong

Bio-protocol

2018 Volume 8, Issue 12, Page(s) e2880

Abstract: As a fundamental metabolic pathway to degrade and recycle cellular cargos, autophagy is highly induced upon stress, starvation and senescence conditions in plants. A double-membrane structure named autophagosome will form during this process for cargo ... ...

Abstract	As a fundamental metabolic pathway to degrade and recycle cellular cargos, autophagy is highly induced upon stress, starvation and senescence conditions in plants. A double-membrane structure named autophagosome will form during this process for cargo sequestration and delivery into the vacuole. A number of regulators have been characterized in plants, including the autophagy-related (ATG) proteins and other plant-specific proteins. Among them, ATG8 will undergo a lipidation process to become a membrane-bound ATG8-phosphatidylethanolamine form and mark the growing autophagosomal membrane as well as the completed autophagosome. Therefore, ATG8 has been regarded as a marker for autophagosomes; and biochemical detection of the membrane-associated form of ATG8 is used as one of the principal methods for measurement of autophagic activity. Here, we describe an ATG8 lipidation assay for detection of the ATG8-PE form using
Language	English
Publishing date	2018-06-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2833269-6
ISSN	2331-8325 ; 2331-8325
ISSN (online)	2331-8325
ISSN	2331-8325
DOI	10.21769/BioProtoc.2880
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Article ; Online: Review: Selective degradation of peroxisome by autophagy in plants: Mechanisms, functions, and perspectives.

Luo, Mengqian / Zhuang, Xiaohong

Plant science : an international journal of experimental plant biology

2018 Volume 274, Page(s) 485–491

Abstract: Peroxisome, a single-membrane organelle conserved in eukaryotic, is responsible for a series of oxidative reactions with its specific enzymatic components. A counterbalance between peroxisome biogenesis and degradation is crucial for the homeostasis of ... ...

Abstract	Peroxisome, a single-membrane organelle conserved in eukaryotic, is responsible for a series of oxidative reactions with its specific enzymatic components. A counterbalance between peroxisome biogenesis and degradation is crucial for the homeostasis of peroxisomes. One such degradation mechanism, termed pexophagy, is a type of selective autophagic process to deliver the excess/damaged peroxisomes into the vacuole. In plants, pexophagy is involved in the remodeling of seedlings and quality control of peroxisomes. Here, we describe the recent advance in plant pexophagy, with a focus to discuss the key regulators in plants in comparison with those in yeast and mammals, as well as future directions for pexophagy studies in plants.
MeSH term(s)	Autophagy ; Peroxisomes/metabolism ; Plants/metabolism ; Vacuoles/metabolism
Language	English
Publishing date	2018-07-02
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	742010-9
ISSN	1873-2259 ; 0168-9452
ISSN (online)	1873-2259
ISSN	0168-9452
DOI	10.1016/j.plantsci.2018.06.026
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