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Article ; Online: Preventive effect of low-carbohydrate high-fat dietary pattern on liver disease caused by alcohol consumption

Qiu, Jiannan / Dong, Fan / Zhuge, Hui / Han, Qiang / Li, Jiaomei / Guo, Rui / Dou, Xiaobing / Li, Jiayu / Li, Songtao

2024 Volume 15, Issue 2, Page(s) 732–746

Abstract: A low-carbohydrate high-fat (LCHF) dietary pattern has been reported to improve chronic metabolic diseases. However, whether and how the LCHF diet affects the pathological progression in patients with alcohol-related liver diseases (ALD) is largely ... ...

Abstract	A low-carbohydrate high-fat (LCHF) dietary pattern has been reported to improve chronic metabolic diseases. However, whether and how the LCHF diet affects the pathological progression in patients with alcohol-related liver diseases (ALD) is largely unknown. This study was conducted to evaluate the effect of the LCHF diet on ALD and clarify its potential mechanism(s). The ALD model was established by feeding C57BL/6N mice with a Lieber-DeCarli liquid alcohol diet with a modified carbohydrate/fat ratio under an isoenergetic pattern. After an eight-week intervention, we observed that the LCHF diet significantly reduced alcohol-induced hepatic steatosis and liver injury, along with improved lipid metabolic-related gene disorders and redox imbalance. The alcohol-stimulated increase in pro-inflammatory cytokine cytokines expression, including
MeSH term(s)	Humans ; Mice ; Animals ; Liver Diseases, Alcoholic/metabolism ; Dietary Patterns ; Mice, Inbred C57BL ; Liver/metabolism ; Ethanol/metabolism ; Alcohol Drinking ; Cytokines/metabolism ; Carbohydrates/pharmacology ; Lipids/pharmacology
Chemical Substances	Ethanol (3K9958V90M) ; Cytokines ; Carbohydrates ; Lipids
Language	English
Publishing date	2024-01-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d3fo04335e
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Article: The Tandem of Liquid Chromatography and Network Pharmacology for the Chemical Profiling of Pule'an Tablets and the Prediction of Mechanism of Action in Treating Prostatitis.

Zhuge, Hui / Ge, Zhiwei / Wang, Jiaojiao / Yao, Jianbiao / He, Jiayu / Wang, Yi / Wang, Yingchao / Tang, Yu

Pharmaceuticals (Basel, Switzerland)

2023 Volume 17, Issue 1

Abstract: Prostatitis, a prevalent urinary tract disorder in males, has a complex etiology that leads to severe clinical discomfort. Pule'an Tablets, a classic single-component formulation primarily based on rapeseed pollen, have been clinically proven to have a ... ...

Abstract	Prostatitis, a prevalent urinary tract disorder in males, has a complex etiology that leads to severe clinical discomfort. Pule'an Tablets, a classic single-component formulation primarily based on rapeseed pollen, have been clinically proven to have a beneficial therapeutic effect on both prostatitis and benign prostatic hyperplasia. However, there is currently a lack of research on the chemical composition and mechanisms of action of Pule'an Tablets in treating prostatitis. In this study, using liquid chromatography-mass spectrometry (LC-MS), a total of 53 compounds in Pule'an Tablets were identified, including flavonoids, phenylpropionamides, lipids, glucosinolates, and nucleic acids. Subsequently, through a network pharmacology analysis, potential target genes and their mechanisms of action were predicted accordingly. The results suggested that genes such as LPAR5, LPAR6, LPAR4, LPAR3, LPAR2, LPAR1, F2, ENPP2, MMP9, and TNF, along with pathways like prostate cancer, endocrine resistance, bladder cancer, and the IL-17 signaling pathway, may represent potential pathways involved in the therapeutic effects of Pule'an Tablets. This study represents the first systematic investigation into the chemical composition of Pule'an Tablets, shedding light on the potential mechanisms underlying their efficacy in treating prostatitis. These findings could serve as a valuable reference for future pharmacological research on Pule'an Tablets.
Language	English
Publishing date	2023-12-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph17010056
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Article ; Online: 1-Methylnicotinamide promotes hepatic steatosis in mice: A potential mechanism in chronic alcohol-induced fatty liver disease.

Lai, Shanglei / Ma, Yue / Hao, Liuyi / Ding, Qinchao / Chang, Kaixin / Zhuge, Hui / Qiu, Jiannan / Xu, Tiantian / Dou, Xiaobing / Li, Songtao

Biochimica et biophysica acta. Molecular and cell biology of lipids

2023 Volume 1868, Issue 4, Page(s) 159286

Abstract: Alcohol abuse and its related diseases are the major risk factors for human health. Alcohol-related liver disease (ALD) is a leading cause of morbidity and mortality worldwide. Although the mechanism of ALD has been widely investigated, liver metabolites ...

Abstract	Alcohol abuse and its related diseases are the major risk factors for human health. Alcohol-related liver disease (ALD) is a leading cause of morbidity and mortality worldwide. Although the mechanism of ALD has been widely investigated, liver metabolites associated with long-term alcohol intake-induced hepatic steatosis have not been well explored. In this study, we aimed to investigate the role and mechanisms of 1-methylnicotinamide (1-MNA), a metabolite during nicotinamide adenine dinucleotide (NAD
MeSH term(s)	Animals ; Mice ; Chronic Disease ; Ethanol/adverse effects ; Fatty Liver/chemically induced ; Fatty Liver, Alcoholic/genetics ; Mice, Inbred C57BL ; Sterol Regulatory Element Binding Protein 1/genetics ; Sterol Regulatory Element Binding Protein 1/metabolism
Chemical Substances	Ethanol (3K9958V90M) ; N(1)-methylnicotinamide (UM47085BXC) ; Sterol Regulatory Element Binding Protein 1
Language	English
Publishing date	2023-01-21
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	60-7
ISSN	1879-2618 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2618 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbalip.2023.159286
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Article ; Online: The micro-743a-3p-GSTM1 pathway is an endogenous protective mechanism against alcohol-related liver disease in mice.

Xu, Tiantian / Pan, Yan / Ding, Qinchao / Cao, Feiwei / Chang, Kaixin / Qiu, Jiannan / Zhuge, Hui / Hao, Liuyi / Wei, Haibin / Si, Caijuan / Dou, Xiaobing / Li, Songtao

Cellular & molecular biology letters

2024 Volume 29, Issue 1, Page(s) 35

Abstract: Background and aims: Epidemiological evidence suggests that the phenotype of glutathione S-transferase mu 1 (GSTM1), a hepatic high-expressed phase II detoxification enzyme, is closely associated with the incidence of alcohol-related liver disease (ALD). ...

Abstract	Background and aims: Epidemiological evidence suggests that the phenotype of glutathione S-transferase mu 1 (GSTM1), a hepatic high-expressed phase II detoxification enzyme, is closely associated with the incidence of alcohol-related liver disease (ALD). However, whether and how hepatic GSTM1 determines the development of ALD is largely unclear. This study was designed to elucidate the role and potential mechanism(s) of hepatic GSTM1 in the pathological process of ALD. Methods: GSTM1 was detected in the liver of various ALD mice models and cultured hepatocytes. Liver-specific GSTM1 or/and micro (miR)-743a-3p deficiency mice were generated by adenoassociated virus-8 delivered shRNA, respectively. The potential signal pathways involving in alcohol-regulated GSTM1 and GSTM1-associated ALD were explored via both genetic manipulation and pharmacological approaches. Results: GSTM1 was significantly upregulated in both chronic alcohol-induced mice liver and ethanol-exposed murine primary hepatocytes. Alcohol-reduced miR-743a-3p directly contributed to the upregulation of GSTM1, since liver specific silencing miR-743a-3p enhanced GSTM1 and miR-743a-3p loss protected alcohol-induced liver dysfunctions, which was significantly blocked by GSTM1 knockdown. GSTM1 loss robustly aggravated alcohol-induced hepatic steatosis, oxidative stress, inflammation, and early fibrotic-like changes, which was associated with the activation of apoptosis signal-regulating kinase 1 (ASK1), c-Jun N-terminal kinase (JNK), and p38. GSTM1 antagonized ASK1 phosphorylation and its downstream JNK/p38 signaling pathway upon chronic alcohol consumption via binding with ASK1. ASK1 blockage significantly rescued hepatic GSTM1 loss-enhanced disorders in alcohol-fed mice liver. Conclusions: Chronic alcohol consumption-induced upregulation of GSTM1 in the liver provides a feedback protection against hepatic steatosis and liver injury by counteracting ASK1 activation. Down-regulation of miR-743a-3p improves alcohol intake-induced hepatic steatosis and liver injury via direct targeting on GSTM1. The miR-743a-3p-GSTM1 axis functions as an innate protective pathway to defend the early stage of ALD.
MeSH term(s)	Animals ; Mice ; Glutathione Transferase/metabolism ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Liver/pathology ; MicroRNAs/metabolism ; Fatty Liver, Alcoholic/metabolism
Chemical Substances	Glutathione Transferase (EC 2.5.1.18) ; MicroRNAs ; Mirn743 microRNA, mouse ; glutathione S-transferase M1 (EC 2.5.1.18)
Language	English
Publishing date	2024-03-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2108724-6
ISSN	1689-1392 ; 1689-1392
ISSN (online)	1689-1392
ISSN	1689-1392
DOI	10.1186/s11658-024-00557-x
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Article ; Online: Lactobacillus plantarum ZY08 relieves chronic alcohol-induced hepatic steatosis and liver injury in mice via restoring intestinal flora homeostasis.

Ding, Qinchao / Cao, Feiwei / Lai, Shanglei / Zhuge, Hui / Chang, Kaixin / Valencak, Teresa G / Liu, Jianxin / Li, Songtao / Ren, Daxi

Food research international (Ottawa, Ont.)

2022 Volume 157, Page(s) 111259

Abstract: This present study was designed to test the protective role of two Lactobacillus plantarum strains, E680 and ZY08, against alcoholic liver disease (ALD) in C57BL/6 mice. The ALD mouse model was established by exposing the mice to a Lieber-DeCarli ethanol ...

Abstract	This present study was designed to test the protective role of two Lactobacillus plantarum strains, E680 and ZY08, against alcoholic liver disease (ALD) in C57BL/6 mice. The ALD mouse model was established by exposing the mice to a Lieber-DeCarli ethanol liquid diet. The two probiotic strains (10
MeSH term(s)	Animals ; Fatty Liver, Alcoholic/prevention & control ; Gastrointestinal Microbiome ; Homeostasis ; Lactobacillus plantarum ; Liver Diseases, Alcoholic/prevention & control ; Mice ; Mice, Inbred C57BL
Language	English
Publishing date	2022-04-16
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2022.111259
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Article ; Online: Lactobacillus plantarum ZY08 relieves chronic alcohol-induced hepatic steatosis and liver injury in mice via restoring intestinal flora homeostasis

Ding, Qinchao / Cao, Feiwei / Lai, Shanglei / Zhuge, Hui / Chang, Kaixin / Valencak, Teresa G. / Liu, Jianxin / Li, Songtao / Ren, Daxi

Food Research International. 2022 July, v. 157 p.111259-

2022

Abstract	This present study was designed to test the protective role of two Lactobacillus plantarum strains, E680 and ZY08, against alcoholic liver disease (ALD) in C57BL/6 mice. The ALD mouse model was established by exposing the mice to a Lieber-DeCarli ethanol liquid diet. The two probiotic strains (10⁹ cfu/day) were administered by oral gavage, respectively. Our data showed that L. plantarum ZY08, but not E680, intervention significantly mitigated alcohol-related hepatic steatosis, liver injury, intestinal barrier, and it alleviated plasma endotoxin (LPS) levels, and affected hepatic genes relating to lipid metabolism. Furthermore, Lactobacillus plantarum ZY08 effectively restored intestinal flora homeostasis via recovering flora abundance, including Blautia, Oscillibacter, Lachnoclostridium and Intestimonas, and consequently elevated intestinalshort-chain fatty acid (SCFA) content. More importantly, removing intestinal microorganisms through ABX gavage markedly abolished the beneficial aspects of Lactobacillus plantarum ZY08, indicating that the regulative role of Lactobacillus plantarum ZY08 contributed to its protective role against ALD. Overall, Lactobacillus plantarum ZY08 is a potential candidate for mitigating alcohol-induced hepatic steatosis and liver injury.
Keywords	Lactobacillus plantarum ; endotoxins ; ethanol ; fatty acids ; fatty liver ; flora ; food research ; homeostasis ; intestinal microorganisms ; intestines ; lipid metabolism ; liquid diet ; liver ; mice ; models ; probiotics ; protective effect ; Lactobacillus plantarum ZY08 ; Alcoholic liver disease ; Intestinal flora homeostasis ; Intestinal barrier function ; Hepatic steatosis ; Liver injury
Language	English
Dates of publication	2022-07
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2022.111259
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Article: Lactobacillus plantarum

Cao, Feiwei / Ding, Qinchao / Zhuge, Hui / Lai, Shanglei / Chang, Kaixin / Le, Chunyan / Yang, Guorong / Valencak, Teresa G / Li, Songtao / Ren, Daxi

Frontiers in nutrition

2023 Volume 9, Page(s) 1071284

Abstract: This present study was designed to explore the protective role ... ...

Abstract	This present study was designed to explore the protective role of
Language	English
Publishing date	2023-01-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2022.1071284
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Article: [Cloning and bioinformatic analysis of TAGLN2 cDNA of Bufo japonicus formosus].

Zhuge, Hui / Yuan, Jin-Qiang / Zhang, Shu-Fang / Yang, Xian-Yu

Yao xue xue bao = Acta pharmaceutica Sinica

2013 Volume 48, Issue 2, Page(s) 250–254

Abstract: To study the bioactive polypeptides included in Bufo skin and its secretions the plasmid skin cDNA library of adult Japanese toad Bufo japonicus formosus was prepared. The pSD64TR has been used as the vector and the cloning sites are Xho I and EcoR I. To ...

Abstract	To study the bioactive polypeptides included in Bufo skin and its secretions the plasmid skin cDNA library of adult Japanese toad Bufo japonicus formosus was prepared. The pSD64TR has been used as the vector and the cloning sites are Xho I and EcoR I. To screen cDNAs encoding bioactive components, the plasmid cDNA library was transformed into E. coli DH5 competent cells, and positive colonies were screened by colony PCR (polymerase chain reaction). The suspension of a single colony in LB medium was used as the template, SP6 (the upstream primer of the plasmid cDNA library) and a primer with Xho I site and polyT were used as the primers. As the result, 465 positive colonies out of 1 344 were obtained and their plasmid were collected and sequenced. By homologous analysis, it was found that one of the cDNAs encoding a peptide with high homolog with transgelin-2, which was registered in GenBank (accession number: JX197456), and it was indicated as a partial cDNA sequence with a deletion at the 5' end. The transcript is 997 bp consisting of 31 bp 5', 618 bp 3' untranslated region (UTR) and an open reading frame (ORF) of 348 bp encoding a polypeptide of 115 amino acids. In the putative protein product, there is a calponin homology domain, two cysteine residues for a disulfide bond and three a-helix domains, and five potential phosphorylation sites. The homologous analysis indicates 90% similarity with Xenopus (Silurana) tropicalis and 89% with Xenopus laevis, and 71%-85% with other species.
MeSH term(s)	Amino Acid Sequence ; Animals ; Base Sequence ; Bufonidae/genetics ; Bufonidae/metabolism ; Cloning, Molecular ; Gene Library ; Microfilament Proteins/chemistry ; Microfilament Proteins/genetics ; Microfilament Proteins/metabolism ; Muscle Proteins/chemistry ; Muscle Proteins/genetics ; Muscle Proteins/metabolism ; Open Reading Frames ; Phosphorylation ; Phylogeny ; Plasmids/genetics ; Sequence Homology, Amino Acid ; Skin/metabolism ; Xenopus/genetics
Chemical Substances	Microfilament Proteins ; Muscle Proteins ; transgelin
Language	Chinese
Publishing date	2013-02
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	788758-9
ISSN	0513-4870
ISSN	0513-4870
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Article: Cloning the sterol carrier protein 2 genes of Japanese toad (Bufo japonicus formosus) and Chinese toad (Bufo gargarizans) and its tissue expression analysis.

Ji, Yu-Cheng / Zhuge, Hui / Zhang, Shan-Shan / Zhang, Shu-Fang / Yang, Xian-Yu

Dong wu xue yan jiu = Zoological research

2014 Volume 35, Issue 5, Page(s) 398–403

Abstract: In this study, to clarify the bioactive polypeptides included in the skins and secretions of Bufo, we screened the Japanese toad (Bufo japonicus formosus) skin cDNA liary by colony polymerase chain reaction (PCR), and obtained a transcript of 1 075 bp ... ...

Abstract	In this study, to clarify the bioactive polypeptides included in the skins and secretions of Bufo, we screened the Japanese toad (Bufo japonicus formosus) skin cDNA liary by colony polymerase chain reaction (PCR), and obtained a transcript of 1 075 bp consisting of 1 37 bp 5' untranslated region (UTR), 515 bp 3' UTR and a 423 bp open reading frame (ORF) encoding a polypeptide of 140 amino acid residues (GenBank accession number: KF359945). Homolog analysis showed a 70%-96% homology with sterol carrier protein-2 (SCP-2) present in other animals, which is implicated in lipid metabolism of other organisms. The gene SCP-2 of Chinese toad (B. gargarizans) was cloned from a first strand cDNA of Bufo skin (GenBank accession number: KF381341) via PCR, whose encoding polypeptide has only one amino acid difference from that of Japanese toad. Tissue distribution analysis showed that SCP-2 expressed in all organs tested, though in the liver and spleen it manifested lower expression than in other organs. These findings might indicate SCP-2 being one of the active ingredients in toad skin. These findings may in turn have implications for further drug development from traditional Chinese medicine sources.
MeSH term(s)	Amino Acid Sequence ; Animals ; Base Sequence ; Bufonidae/genetics ; Bufonidae/metabolism ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Catalytic Domain ; Cloning, Molecular ; Gene Expression Regulation/physiology ; Molecular Sequence Data ; Phylogeny ; Species Specificity
Chemical Substances	Carrier Proteins ; sterol carrier proteins
Language	English
Publishing date	2014-10-09
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2196960-7
ISSN	0254-5853
ISSN	0254-5853
DOI	10.13918/j.issn.2095-8137.2014.5.398
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