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  1. Article: ALKBH1

    Zhang, Xinxin / Zhou, Chunlei / Zhao, Yemu / Deng, Changmi / Wu, Haiyan / Zhuo, Zhenjian / He, Jing

    Journal of Cancer

    2024  Volume 15, Issue 2, Page(s) 526–532

    Abstract: Neuroblastoma is a highly malignant extracranial solid tumor in pediatrics. ALKBH1 as a recently discovered DNA N6-methyldeoxyadenosine (6mA) demethylase closely links to tumorigenesis. Whether ... ...

    Abstract Neuroblastoma is a highly malignant extracranial solid tumor in pediatrics. ALKBH1 as a recently discovered DNA N6-methyldeoxyadenosine (6mA) demethylase closely links to tumorigenesis. Whether the
    Language English
    Publishing date 2024-01-01
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2573318-7
    ISSN 1837-9664
    ISSN 1837-9664
    DOI 10.7150/jca.89271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Progress in building clinically relevant patient-derived tumor xenograft models for cancer research.

    Wang, Weijing / Li, Yongshu / Lin, Kaida / Wang, Xiaokang / Tu, Yanyang / Zhuo, Zhenjian

    Animal models and experimental medicine

    2023  Volume 6, Issue 5, Page(s) 381–398

    Abstract: Patient-derived tumor xenograft (PDX) models, a method involving the surgical extraction of tumor tissues from cancer patients and subsequent transplantation into immunodeficient mice, have emerged as a pivotal approach in translational research, ... ...

    Abstract Patient-derived tumor xenograft (PDX) models, a method involving the surgical extraction of tumor tissues from cancer patients and subsequent transplantation into immunodeficient mice, have emerged as a pivotal approach in translational research, particularly in advancing precision medicine. As the first stage of PDX development, the patient-derived orthotopic xenograft (PDOX) models implant tumor tissue in mice in the corresponding anatomical locations of the patient. The PDOX models have several advantages, including high fidelity to the original tumor, heightened drug sensitivity, and an elevated rate of successful transplantation. However, the PDOX models present significant challenges, requiring advanced surgical techniques and resource-intensive imaging technologies, which limit its application. And then, the humanized mouse models, as well as the zebrafish models, were developed. Humanized mouse models contain a human immune environment resembling the tumor and immune system interplay. The humanized mouse models are a hot topic in PDX model research. Regarding zebrafish patient-derived tumor xenografts (zPDX) and patient-derived organoids (PDO) as promising models for studying cancer and drug discovery, zPDX models are used to transplant tumors into zebrafish as novel personalized medical animal models with the advantage of reducing patient waiting time. PDO models provide a cost-effective approach for drug testing that replicates the in vivo environment and preserves important tumor-related information for patients. The present review highlights the functional characteristics of each new phase of PDX and provides insights into the challenges and prospective developments in this rapidly evolving field.
    MeSH term(s) Humans ; Animals ; Mice ; Heterografts ; Zebrafish ; Xenograft Model Antitumor Assays ; Prospective Studies ; Neoplasms ; Disease Models, Animal
    Language English
    Publishing date 2023-09-07
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 2576-2095
    ISSN (online) 2576-2095
    DOI 10.1002/ame2.12349
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The role of m6A modification in pediatric cancer.

    Chen, Yongping / Miao, Lei / Lin, Huiran / Zhuo, Zhenjian / He, Jing

    Biochimica et biophysica acta. Reviews on cancer

    2022  Volume 1877, Issue 2, Page(s) 188691

    Abstract: With the development of RNA modification research, the importance of N6-methyladenosine (m6A) in tumors cannot be ignored. m6A promotes the self-renewal of tumor stem cells and the proliferation of tumor cells. It affects post-transcriptional gene ... ...

    Abstract With the development of RNA modification research, the importance of N6-methyladenosine (m6A) in tumors cannot be ignored. m6A promotes the self-renewal of tumor stem cells and the proliferation of tumor cells. It affects post-transcriptional gene expression through epigenetic mechanisms, combining various factors to determine proteins' fate and altering the biological function. This modification process runs through the entire tumors, and genes affected by m6A modification may be the critical targets for cancers breakthroughs. Though generally less dangerous than adult cancer, pediatric cancer accounts for a significant proportion of child deaths. What is more alarming is that the occurrences of adult tumors are highly associated with the poor prognoses of pediatric tumors. Therefore, it is necessary to pay attention to the importance of pediatric cancer and discover new therapeutic targets, which will help improve the therapeutic effect and prognoses of the diseases. We collected and investigated m6A modification in pediatric cancers based on mRNA and non-coding RNA, finding that m6A factors were involved in glioma, hepatoblastoma, nephroblastoma, neuroblastoma, osteosarcoma, medulloblastoma, retinoblastoma, and acute lymphoblastic leukemia. Consequently, we summarized the relationships between the m6A factors and these pediatric cancers.
    MeSH term(s) Adenosine/metabolism ; Bone Neoplasms/genetics ; Child ; Epigenesis, Genetic ; Humans ; Osteosarcoma/genetics ; RNA, Messenger
    Chemical Substances RNA, Messenger ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2022-02-02
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2918802-7
    ISSN 1879-2561 ; 0304-419X
    ISSN (online) 1879-2561
    ISSN 0304-419X
    DOI 10.1016/j.bbcan.2022.188691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Nucleic acid therapy in pediatric cancer.

    Li, Yongshu / Huang, Bihui / Xue, Zhichao / Gao, Yunhua / Zhuo, Zhenjian

    Pharmacological research

    2022  Volume 184, Page(s) 106441

    Abstract: The overall survival, progress free survival, and life quality of cancer patients have improved due to the advance in minimally invasive surgery, precision radiotherapy, and various combined chemotherapy in the last decade. Furthermore, the discovery of ... ...

    Abstract The overall survival, progress free survival, and life quality of cancer patients have improved due to the advance in minimally invasive surgery, precision radiotherapy, and various combined chemotherapy in the last decade. Furthermore, the discovery of new types of therapeutics, such as immune checkpoint inhibitors and immune cell therapies have facilitated both patients and doctors to fight with cancers. Moreover, in the context of the development in biocompatible and cell type targeting nano-carriers as well as nucleic acid-based drugs for initiating and enhancing the anti-tumor response have come to the age. The treatment paradigms utilization of nucleic acids, including short interfering RNA (siRNA), antisense oligonucleotides (ASO), and messenger RNA (mRNA), can target specific protein expression to achieve the therapeutic effects. Over ten nucleic acid therapeutics have been approved by the FDA and EMA in rare diseases and genetic diseases as well as dozens of registered clinical trails for varies cancers. Though generally less dangerous of pediatric cancers than adult cancers was observed during the past decades, yet pediatric cancers accounted for a significant proportion of child deaths which hurt those family very deeply. Therefore, it is necessary to pay more attention for improving the treatment of pediatric cancer and discovering new nucleic acid therapeutics which may help to improve the therapeutic effect and prognoses in turns to ameliorate the survival period and quality of life for children patient. In this review, we focus on the nucleic acid therapy in pediatric cancers.
    MeSH term(s) Child ; Humans ; Immune Checkpoint Inhibitors ; Neoplasms/drug therapy ; Neoplasms/genetics ; Oligonucleotides, Antisense/therapeutic use ; Quality of Life ; RNA, Messenger ; RNA, Small Interfering/metabolism
    Chemical Substances Immune Checkpoint Inhibitors ; Oligonucleotides, Antisense ; RNA, Messenger ; RNA, Small Interfering
    Language English
    Publishing date 2022-09-09
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2022.106441
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 721: Show issues Location:
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  5. Article ; Online: Advances and Applications in Animal Models of Neuroblastoma

    TAN Zhigang / LIU Jinxin / ZHENG Chuya / LIAO Wenfeng / FENG Luping / PENG Hongli / YAN Xiu / ZHUO Zhenjian

    Shiyan dongwu yu bijiao yixue, Vol 43, Iss 3, Pp 288-

    2023  Volume 296

    Abstract: Neuroblastoma (NB) is one of the most common malignant solid tumors in children, ranks fourth in the incidence of pediatric tumors, and accounts for 15% of pediatric tumor deaths in children in China. Despite the development of new treatment options, the ...

    Abstract Neuroblastoma (NB) is one of the most common malignant solid tumors in children, ranks fourth in the incidence of pediatric tumors, and accounts for 15% of pediatric tumor deaths in children in China. Despite the development of new treatment options, the prognosis for high-risk patients is still poor. An animal model that can replicate the tumorigenesis of NB is an important tool for the prevention and treatment of NB. However, there are currently no animal models that can simulate all features of human NB. To provide a reference for the construction of animal models and treatment of NB, this article introduced several animal models of NB that have been extensively researched: the mouse, chick embryo chorioallantoic membrane, and zebrafish models. At the same time, it elaborated on the species, construction methods, characteristics, advantages and disadvantages, and research progress in NB.
    Keywords neuroblastoma ; animal model ; mice ; chick embryo chorioallantoic-membrane ; zebrafish ; Medicine ; R
    Subject code 616
    Language Chinese
    Publishing date 2023-06-01T00:00:00Z
    Publisher Editorial Office of Laboratory Animal and Comparative Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: The Genetic Changes of Hepatoblastoma.

    Chen, Huitong / Guan, Qian / Guo, Huiqin / Miao, Lei / Zhuo, Zhenjian

    Frontiers in oncology

    2021  Volume 11, Page(s) 690641

    Abstract: Hepatoblastoma is the most common malignant liver cancer in childhood. The etiology of hepatoblastoma remains obscure. Hepatoblastoma is closely related to genetic syndromes, hinting that hepatoblastoma is a genetic predisposition disease. However, no ... ...

    Abstract Hepatoblastoma is the most common malignant liver cancer in childhood. The etiology of hepatoblastoma remains obscure. Hepatoblastoma is closely related to genetic syndromes, hinting that hepatoblastoma is a genetic predisposition disease. However, no precise exposures or genetic events are reported to hepatoblastoma occurrence. During the past decade, significant advances have been made in the understanding of etiology leading to hepatoblastoma, and several important genetic events that appear to be important for the development and progression of this tumor have been identified. Advances in our understanding of the genetic changes that underlie hepatoblastoma may translate into better patient outcomes. Single nucleotide polymorphisms (SNPs) have been generally applied in the research of etiology's exploration, disease treatment, and prognosis assessment. Here, we reviewed and discussed the molecular epidemiology, especially SNPs progresses in hepatoblastoma, to provide references for future studies and promote the study of hepatoblastoma's etiology.
    Language English
    Publishing date 2021-07-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.690641
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Functions, mechanisms, and therapeutic implications of METTL14 in human cancer.

    Guan, Qian / Lin, Huiran / Miao, Lei / Guo, Huiqin / Chen, Yongping / Zhuo, Zhenjian / He, Jing

    Journal of hematology & oncology

    2022  Volume 15, Issue 1, Page(s) 13

    Abstract: RNA modification plays a crucial role in many biological functions, and its abnormal regulation is associated with the progression of cancer. Among them, ... ...

    Abstract RNA modification plays a crucial role in many biological functions, and its abnormal regulation is associated with the progression of cancer. Among them, N
    Language English
    Publishing date 2022-02-03
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2429631-4
    ISSN 1756-8722 ; 1756-8722
    ISSN (online) 1756-8722
    ISSN 1756-8722
    DOI 10.1186/s13045-022-01231-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: LncRNAs and CircRNAs in cancer.

    Yin, Xin / Lin, Huiran / Lin, Lei / Miao, Lei / He, Jing / Zhuo, Zhenjian

    MedComm

    2022  Volume 3, Issue 2, Page(s) e141

    Abstract: It is well known that noncoding RNAs (ncRNAs) cannot encode proteins, but they can play important regulatory roles in tumors by combining with proteins, RNAs, and DNAs. As more and more studies reveal the important roles and underlying mechanisms of long ...

    Abstract It is well known that noncoding RNAs (ncRNAs) cannot encode proteins, but they can play important regulatory roles in tumors by combining with proteins, RNAs, and DNAs. As more and more studies reveal the important roles and underlying mechanisms of long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in cancer, their huge application potential in cancer therapy cannot be ignored. For example, lncRNAs can be involved in tumor-related signal transduction pathways, cell cycle control, DNA damage, epigenetic regulation, and microRNA control. A group of studies confirmed that abnormal expression of lncRNAs can affect cancer progression. Furthermore, as covalently closed continuous circular ncRNAs, many recent studies have shown that circRNAs have regulatory effects and other important biological significances in cancer. Interestingly, circRNAs were found to have translational functions. This has greatly attracted people's attention to circRNAs research. In this review, we introduce the important roles of lncRNAs and circRNAs in some representative cancers, respectively. Furthermore, we focus on the biological functions and important clinical therapeutic implications of lnRNAs and circRNAs in neuroblastoma. Our review also focuses on providing rationale and relevant references for novel biomarkers for neuroblastoma diagnosis, prognosis, and treatment.
    Language English
    Publishing date 2022-05-12
    Publishing country China
    Document type Journal Article ; Review
    ISSN 2688-2663
    ISSN (online) 2688-2663
    DOI 10.1002/mco2.141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Association of ERCC1 and XPF polymorphisms with pediatric glioma susceptibility.

    Chen, Yongping / Liao, Yuxiang / Jia, Xingyu / Lin, Huiran / Miao, Lei / Yuan, Li / Huang, Xiaokai / Zhou, Jingying / Bian, Jun / Zhuo, Zhenjian

    Chinese medical journal

    2023  Volume 136, Issue 6, Page(s) 746–748

    MeSH term(s) Humans ; Child ; Polymorphism, Genetic ; Glioma/genetics ; Endonucleases/genetics ; DNA-Binding Proteins/genetics
    Chemical Substances Endonucleases (EC 3.1.-) ; ERCC1 protein, human (EC 3.1.-) ; DNA-Binding Proteins
    Language English
    Publishing date 2023-03-20
    Publishing country China
    Document type Journal Article
    ZDB-ID 127089-8
    ISSN 2542-5641 ; 0366-6999 ; 1002-0187
    ISSN (online) 2542-5641
    ISSN 0366-6999 ; 1002-0187
    DOI 10.1097/CM9.0000000000002126
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1207: Show issues Location:
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  10. Article: No Association Between

    Liao, Yuxiang / Yuan, Li / Zhang, Zhiping / Lin, Ao / Zhou, Jingying / Zhuo, Zhenjian / Zhao, Jie

    Pharmacogenomics and personalized medicine

    2021  Volume 14, Page(s) 109–115

    Abstract: Background: Central nervous system (CNS) tumor is a malignancy commonly seen occurring in childhood, worldwide. Fat mass and obesity-associated (FTO) enzyme, initially identified as an obesity-related protein, also functions as a susceptibility gene for ...

    Abstract Background: Central nervous system (CNS) tumor is a malignancy commonly seen occurring in childhood, worldwide. Fat mass and obesity-associated (FTO) enzyme, initially identified as an obesity-related protein, also functions as a susceptibility gene for cancers. However, predisposing effect of
    Methods: Herein, we genotyped 314 CNS tumor patients and 380 healthy controls samples from three hospitals to explore whether
    Results: We failed to detect significant associations between
    Conclusion: Our data indicated that
    Language English
    Publishing date 2021-01-19
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2508173-1
    ISSN 1178-7066
    ISSN 1178-7066
    DOI 10.2147/PGPM.S289345
    Database MEDical Literature Analysis and Retrieval System OnLINE

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