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  1. Article ; Online: Photothermal Fibrous Chitosan/Polydopamine Sponge for Intraoperative Hemostasis and Prevention of Tumor Recurrence in Hepatocellular Carcinoma Resection

    Lanxin Mu / Luhe Qi / Haitao Long / Jing Huang / Zibiao Zhong / Xiaowen Shi / Chaoji Chen / Qifa Ye

    Advanced Science, Vol 11, Iss 3, Pp n/a-n/a (2024)

    2024  

    Abstract: Abstract Hepatectomy, a surgical procedure for liver cancer, is often plagued by high recurrence rates worldwide. The recurrence of liver cancer is primarily attributed to microlesions in the liver, changes in the immune microenvironment, and circulating ...

    Abstract Abstract Hepatectomy, a surgical procedure for liver cancer, is often plagued by high recurrence rates worldwide. The recurrence of liver cancer is primarily attributed to microlesions in the liver, changes in the immune microenvironment, and circulating tumor cells in the bloodstream. To address this issue, a novel intervention method that combines intraoperative hemostasis with mild photothermal therapy is proposed, which has the potential to ablate microlesions and improve the immune microenvironment simultaneously. Specifically, the integrated strategy is realized based on the fibrous chitosan/polydopamine sponge (CPDS), which is constructed from shearing‐flow‐induced oriented hybrid chitosan fibers and subsequent self‐assembly of polydopamine. The CPDS demonstrates high elasticity, excellent water absorption, and photothermal conversion performance. The results confirm the efficient hemostatic properties of the fibrous CPDS in various bleeding models. Notably, in subcutaneous and orthotopic postoperative recurrence and metastasis models of hepatocellular carcinoma, the fibrous CPDS significantly inhibits local tumor recurrence and distant metastasis. Moreover, the combination with lenvatinib can substantially enhance the antitumor effect. This comprehensive treatment strategy offers new insights into hepatectomy of liver cancer, representing a promising approach for clinical management.
    Keywords hemostasis ; immunotherapy ; lenvatinib ; liver cancer recurrence ; photothermal therapy ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Roles of TRAFs in Ischemia-Reperfusion Injury

    Wei Zhou / Danni Lin / Zibiao Zhong / Qifa Ye

    Frontiers in Cell and Developmental Biology, Vol

    2020  Volume 8

    Abstract: Tumor necrosis factor receptor-associated factor (TRAF) proteins are a family of signaling molecules that function downstream of multiple receptor signaling pathways, and they play a pivotal role in the regulation of intracellular biological progresses. ... ...

    Abstract Tumor necrosis factor receptor-associated factor (TRAF) proteins are a family of signaling molecules that function downstream of multiple receptor signaling pathways, and they play a pivotal role in the regulation of intracellular biological progresses. These TRAF-dependent signaling pathways and physiological functions have been involved in the occurrence and progression of ischemia-reperfusion injury (IRI), which is a common pathophysiological process that occurs in a wide variety of clinical events, including ischemic shock, organ transplantation, and thrombolytic therapy, resulting in a poor prognosis and high mortality. IRI occurs in multiple organs, including liver, kidney, heart, lung, brain, intestine, and retina. In recent years, mounting compelling evidence has confirmed that the genetic alterations of TRAFs can cause subversive phenotype changes during IRI of those organs. In this review, based on current knowledge, we summarized and analyzed the regulatory effect of TRAFs on the IRI of various organs, providing clear direction and a firm theoretical basis for the development of treatment strategies to manipulate TRAF proteins or TRAF-dependent signaling pathways in IRI-related diseases.
    Keywords TRAFs ; ischemia-reperfusion injury ; hypoxia/reoxygenation ; inflammation ; ubiquitination ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: LINC00844 promotes proliferation and migration of hepatocellular carcinoma by regulating NDRG1 expression

    Wei Zhou / Kang Huang / Qiuyan Zhang / Shaojun Ye / Zibiao Zhong / Cheng Zeng / Guizhu Peng / Ling Li / Qifa Ye

    PeerJ, Vol 8, p e

    2020  Volume 8394

    Abstract: Background Aberrant expression of long noncoding RNAs are implicated in the pathogenesis of human malignancies. LINC00844 expression is dramatically downregulated in prostate cancer, and functional studies have revealed the association between the ... ...

    Abstract Background Aberrant expression of long noncoding RNAs are implicated in the pathogenesis of human malignancies. LINC00844 expression is dramatically downregulated in prostate cancer, and functional studies have revealed the association between the aberrant expression of LINC00844 and prostate cancer cell invasion and metastasis. However, the function and mechanism of action of LINC00844 in the pathogenesis of hepatocellular carcinoma (HCC) are poorly understood. Methods LINC00844 and N-Myc downstream-regulated 1 (NDRG1) expression in HCC tissues and cell lines was detected with real-time quantitative polymerase chain reaction (RT-qPCR) and western blot analysis. Correlations between LINC00844 expression level and clinicopathological features were investigated using the original data from The Cancer Genome Atlas (TCGA) database. HepG2 and HCCLM9 cell lines were transfected with Lv-LIN00844 virus to obtain LINC00844-overexpressing cell lines. Cell proliferation and cell invasion and migration were examined with the cell counting kit-8 (CCK-8) and transwell assay, respectively. Furthermore, the correlation between LINC00844 and NDRG1 expression was analysed using Pearson’s correlation analysis. Results LINC00844 expression was significantly downregulatedin HCC tissues and cell lines, and a statistical correlation was detected between low LINC00844 expression and sex (Female), advanced American Joint Committee on Cancer (AJCC) stage (III + IV), histological grade (G3 + G4), and vascular invasion (Micro and Macro). In vitro experiments showed that LINC00844 overexpression significantly repressed the proliferation, migration, and invasion of HCC cells. NDRG1 expression was higher in HCC tissues and LINC00844 could partly inhibit the expression of NDRG1.
    Keywords Hepatocellular carcinoma ; LINC00844 ; NDRG1 ; Proliferation ; Migration ; Invasion ; Medicine ; R ; Biology (General) ; QH301-705.5
    Subject code 616
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher PeerJ Inc.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: COVID-19 in the immunocompromised population

    Weijie Zhang / Fei Han / Xiongfei Wu / Zhendi Wang / Yanfeng Wang / Xiaojun Guo / Song Chen / Tao Qiu / Heng Li / Yafang Tu / Zibiao Zhong / Jiannan He / Bin Liu / Hui Zhang / Zhitao Cai / Long Zhang / Xia Lu / Lan Zhu / Dong Chen /
    Jiangqiao Zhou / Qiquan Sun / Zhishui Chen / Yuanyuan Ji

    Chinese Medical Journal, Vol 135, Iss 2, Pp 228-

    data from renal allograft recipients throughout full cycle of the outbreak in Hubei province, China

    2022  Volume 230

    Keywords Medicine ; R
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Wolters Kluwer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Homogeneous synthesis of quaternized chitin in NaOH/urea aqueous solution as a potential gene vector

    Peng, Na / Qifa Ye / Xiaoli Fan / Yanfeng Wang / Zehong Fang / Zhiping Xia / Zibiao Zhong / Ziye Ai

    Carbohydrate polymers. 2016 Oct. 05, v. 150

    2016  

    Abstract: Water-soluble quaternized chitins (QCs) were homogeneously synthesized by reacting chitin with (3-chloro-2-hydroxypropyl) trimethylammonium chloride (CHPTAC) in 8wt% NaOH/4wt% urea aqueous solutions. The chemical structure and solution properties of the ... ...

    Abstract Water-soluble quaternized chitins (QCs) were homogeneously synthesized by reacting chitin with (3-chloro-2-hydroxypropyl) trimethylammonium chloride (CHPTAC) in 8wt% NaOH/4wt% urea aqueous solutions. The chemical structure and solution properties of the quaternized chitins were characterized by 1H NMR, FT-IR, elemental analysis, dynamic light scattering (DLS) and zeta potential measurements. The results demonstrated that the water-soluble QCs, with a degree of substitution (DS) values of 0.27–0.54, could be obtained by varying the concentration of chitin, the molar ratio of CHPTAC to chitin unit, and the reaction time at room temperature (25°C). Two QCs (DS=0.36 and 0.54) were selected and studied as gene carriers. Agarose gel retardation assay revealed that both QCs could condense DNA efficiently when N/P ratio>3. The results of particle size and zeta potential indicated that both QCs had a good ability of condensing plasmid DNA into compact nanoparticles with the size of 100–200nm and zeta potential of +18 to +36mV. Compared to polyethylenimine (PEI, 25kDa), the QCs exhibited outstanding low cytotoxicity. Transfection efficiencies of the QCs/DNA complexes were measured using pGL-3 encoding luciferase as the foreign DNA, and the QCs/DNA complexes showed effective transfection efficiencies in 293T cells. These results revealed that the QCs prepared in NaOH/urea aqueous solutions could be used as promising non-viral gene carriers owing to their excellent characteristics.
    Keywords agarose ; ambient temperature ; aqueous solutions ; chemical structure ; chitin ; cytotoxicity ; Fourier transform infrared spectroscopy ; gel electrophoresis ; genes ; light scattering ; luciferase ; nanoparticles ; nuclear magnetic resonance spectroscopy ; particle size ; plasmids ; sodium hydroxide ; transfection ; urea ; zeta potential
    Language English
    Dates of publication 2016-1005
    Size p. 180-186.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1501516-6
    ISSN 1879-1344 ; 0144-8617
    ISSN (online) 1879-1344
    ISSN 0144-8617
    DOI 10.1016/j.carbpol.2016.04.110
    Database NAL-Catalogue (AGRICOLA)

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