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  1. Article ; Online: Substance P and pain chronicity.

    Zieglgänsberger, W

    Cell and tissue research

    2018  Volume 375, Issue 1, Page(s) 227–241

    Abstract: Substance P (SP) is a highly conserved member of the tachykinin peptide family that is widely expressed throughout the animal kingdom. The numerous members of the tachykinin peptide family are involved in a multitude of neuronal signaling pathways, ... ...

    Abstract Substance P (SP) is a highly conserved member of the tachykinin peptide family that is widely expressed throughout the animal kingdom. The numerous members of the tachykinin peptide family are involved in a multitude of neuronal signaling pathways, mediating sensations and emotional responses (Steinhoff et al. in Physiol Rev 94:265-301, 2014). In contrast to receptors for classical transmitters, such as glutamate (Parsons et al. in Handb Exp Pharmacol 249-303, 2005), only a minority of neurons in certain brain areas express neurokinin receptors (NKRs) (Mantyh in J Clin Psychiatry 63:6-10, 2002). SP is also expressed by a variety of non-neuronal cell types such as microglia, as well as immune cells (Mashaghi et al. in Cell Mol Life Sci 73:4249-4264, 2016). SP is an 11-amino acid neuropeptide that preferentially activates the neurokinin-1 receptor (NK1R). It transmits nociceptive signals via primary afferent fibers to spinal and brainstem second-order neurons (Cao et al. in Nature 392:390-394, 1998). Compounds that inhibit SP's action are being investigated as potential drugs to relieve pain. More recently, SP and NKR have gained attention for their role in complex psychiatric processes. It is a key goal in the field of pain research to understand mechanisms involved in the transition between acute pain and chronic pain. The influence of emotional and cognitive inputs and feedbacks from different brain areas makes pain not only a perception but an experience (Zieglgänsberger et al. in CNS Spectr 10:298-308, 2005; Trenkwaldner et al. Sleep Med 31:78-85, 2017). This review focuses on functional neuronal plasticity in spinal dorsal horn neurons as a major relay for nociceptive information.
    MeSH term(s) Animals ; Chronic Pain/metabolism ; Humans ; Memory ; Models, Biological ; Nerve Net/metabolism ; Nociception ; Substance P/metabolism
    Chemical Substances Substance P (33507-63-0)
    Language English
    Publishing date 2018-10-03
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 125067-x
    ISSN 1432-0878 ; 0302-766X
    ISSN (online) 1432-0878
    ISSN 0302-766X
    DOI 10.1007/s00441-018-2922-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Substance P and pain chronicity

    Zieglgänsberger, W

    Cell and tissue research. 2019 Jan., v. 375, no. 1

    2019  

    Abstract: Substance P (SP) is a highly conserved member of the tachykinin peptide family that is widely expressed throughout the animal kingdom. The numerous members of the tachykinin peptide family are involved in a multitude of neuronal signaling pathways, ... ...

    Abstract Substance P (SP) is a highly conserved member of the tachykinin peptide family that is widely expressed throughout the animal kingdom. The numerous members of the tachykinin peptide family are involved in a multitude of neuronal signaling pathways, mediating sensations and emotional responses (Steinhoff et al. in Physiol Rev 94:265–301, 2014). In contrast to receptors for classical transmitters, such as glutamate (Parsons et al. in Handb Exp Pharmacol 249–303, 2005), only a minority of neurons in certain brain areas express neurokinin receptors (NKRs) (Mantyh in J Clin Psychiatry 63:6–10, 2002). SP is also expressed by a variety of non-neuronal cell types such as microglia, as well as immune cells (Mashaghi et al. in Cell Mol Life Sci 73:4249–4264, 2016). SP is an 11-amino acid neuropeptide that preferentially activates the neurokinin-1 receptor (NK1R). It transmits nociceptive signals via primary afferent fibers to spinal and brainstem second-order neurons (Cao et al. in Nature 392:390–394, 1998). Compounds that inhibit SP’s action are being investigated as potential drugs to relieve pain. More recently, SP and NKR have gained attention for their role in complex psychiatric processes. It is a key goal in the field of pain research to understand mechanisms involved in the transition between acute pain and chronic pain. The influence of emotional and cognitive inputs and feedbacks from different brain areas makes pain not only a perception but an experience (Zieglgänsberger et al. in CNS Spectr 10:298–308, 2005; Trenkwaldner et al. Sleep Med 31:78–85, 2017). This review focuses on functional neuronal plasticity in spinal dorsal horn neurons as a major relay for nociceptive information.
    Keywords amino acids ; animals ; brain stem ; cognition ; drugs ; neuroglia ; neurons ; neuroplasticity ; pain ; receptors ; signal transduction ; sleep ; substance P
    Language English
    Dates of publication 2019-01
    Size p. 227-241.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    Note Review
    ZDB-ID 125067-x
    ISSN 1432-0878 ; 0302-766X
    ISSN (online) 1432-0878
    ISSN 0302-766X
    DOI 10.1007/s00441-018-2922-y
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Walter Zieglgänsberger.

    Zieglgänsberger, Walter

    Medical cannabis and cannabinoids

    2018  Volume 1, Issue 1, Page(s) 3

    Language English
    Publishing date 2018-06-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2908431-3
    ISSN 2504-3889 ; 2504-3889
    ISSN (online) 2504-3889
    ISSN 2504-3889
    DOI 10.1159/000489475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Walter Zieglgänsberger

    Zieglgänsberger, Walter

    Medical Cannabis and Cannabinoids

    2018  Volume 1, Issue 1, Page(s) 3–3

    Language English
    Publishing date 2018-06-12
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Interview ; This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
    ZDB-ID 2908431-3
    ISSN 2504-3889 ; 2504-3889
    ISSN (online) 2504-3889
    ISSN 2504-3889
    DOI 10.1159/000489475
    Database Karger publisher's database

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  5. Article ; Online: Seeing the site of treatment improves habitual pain but not cervical joint position sense immediately after manual therapy in chronic neck pain patients.

    Beinert, K / Lutz, B / Zieglgänsberger, W / Diers, M

    European journal of pain (London, England)

    2018  Volume 23, Issue 1, Page(s) 117–123

    Abstract: Background: Visual analgesia refers to the phenomena where people report decreased pain intensity when they see the painful or painfully stimulated body part. Alongside pain, sensorimotor impairment (i.e., disturbed proprioception) is also evident in ... ...

    Abstract Background: Visual analgesia refers to the phenomena where people report decreased pain intensity when they see the painful or painfully stimulated body part. Alongside pain, sensorimotor impairment (i.e., disturbed proprioception) is also evident in chronic pain. This study aims to investigate whether real-time visual feedback offers additional pain relief and proprioceptive improvement when used in combination with recommended therapies in neck pain patients who received manual therapy with or without real-time visual feedback.
    Methods: A total of 29 neck pain patients were recruited in an outpatient physical therapy practice. Patients were randomly allocated to receive manual therapy of the cervical spine with real-time visual feedback or to a control group where patients received manual therapy without real-time visual feedback. Habitual pain intensity, the pressure pain threshold at the zygapophyseal joint of C2-C3 and the superior angle of the scapulae and cervical proprioception were assessed before and immediately after the intervention by a blinded assessor.
    Results: A between-group comparison revealed a significant reduction in habitual pain in the real-time visual feedback group. No differences were found for the pressure pain threshold or proprioceptive performance.
    Conclusions: Real-time visual feedback combined with manual therapy enhanced the analgesic effect of manual therapy in neck pain patients, but had no positive effect on the pressure pain threshold and cervical joint position sense. The technical demands for integrating real-time visual feedback into daily practice to reduce habitual pain are low, have low costs and are easy to apply.
    Significance: Real-time visual feedback reduces habitual pain immediately after the intervention. Due to its easy integration, it may be an effective adjunct to recommended interventions (i.e., manual therapy) in patients with neck pain.
    MeSH term(s) Adult ; Chronic Pain/physiopathology ; Chronic Pain/therapy ; Feedback, Sensory ; Female ; Humans ; Male ; Middle Aged ; Musculoskeletal Manipulations ; Neck ; Neck Pain/physiopathology ; Neck Pain/therapy ; Pain Management ; Pain Measurement ; Pain Threshold ; Physical Therapy Modalities ; Proprioception ; Zygapophyseal Joint
    Language English
    Publishing date 2018-08-13
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1390424-3
    ISSN 1532-2149 ; 1090-3801
    ISSN (online) 1532-2149
    ISSN 1090-3801
    DOI 10.1002/ejp.1290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5194: Show issues Location:
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  6. Article: Gute Frage. Warum werden manche Schmerzen chronisch? Schätzungen zufolge leiden etwa zwölf Millionen Deutsche an länger anhaltenden oder wiederkehrenden schmerzen. Der Neurologe Walter Zieglgänsberger erklärt, welche Faktoren bei der Chronifizierung eine Rolle spielen.

    Zieglgänsberger, Walter

    Gehirn & Geist

    2016  Volume -, Issue 8, Page(s) 70

    Language German
    Document type Article
    ZDB-ID 2072879-7
    ISSN 1618-8519
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5667: Show issues Location:
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  7. Article ; Online: Visually induced analgesia during massage treatment in chronic back pain patients.

    Löffler, A / Trojan, J / Zieglgänsberger, W / Diers, M

    European journal of pain (London, England)

    2017  Volume 21, Issue 10, Page(s) 1623–1631

    Abstract: Background: Previous findings suggest that watching sites of experimental and chronic pain can exert an analgesic effect. Our present study investigates whether watching one's back during massage increases the analgesic effect of this treatment in ... ...

    Abstract Background: Previous findings suggest that watching sites of experimental and chronic pain can exert an analgesic effect. Our present study investigates whether watching one's back during massage increases the analgesic effect of this treatment in chronic back pain patients.
    Methods: Twenty patients with chronic back pain were treated with a conventional massage therapy. During this treatment, patients received a real-time video feedback of their own back. Watching a neutral object, a video of another person of the same sex being massaged, a picture of the own back, and keeping one's eyes closed were used as controls. These conditions were presented in randomized order on five separate days.
    Results: All conditions yielded significant decreases in habitual pain intensity. The effect of real-time video feedback of the own back on massage treatment was the strongest and differed significantly from the effect of watching a neutral object, but not from the other control conditions, which may have induced slight effects of their own.
    Conclusions: Repeated real-time video feedback may be useful during massage treatment of chronic pain.
    Significance: This study shows that inducing visual induced analgesia during massage treatment can be helpful in alleviating chronic pain.
    MeSH term(s) Adult ; Analgesia/methods ; Chronic Pain/therapy ; Feedback, Sensory ; Female ; Humans ; Low Back Pain/therapy ; Male ; Massage/methods ; Middle Aged ; Pain Measurement ; Treatment Outcome
    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1390424-3
    ISSN 1532-2149 ; 1090-3801
    ISSN (online) 1532-2149
    ISSN 1090-3801
    DOI 10.1002/ejp.1066
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  8. Article: Seeing the site of treatment improves habitual pain but not cervical joint position sense immediately after manual therapy in chronic neck pain patients

    Beinert, K. / Lutz, B. / Zieglgänsberger, W. / Diers, M.

    European Journal of Pain

    2019  Volume 23, Issue 1, Page(s) 117–123

    Abstract: Background: Visual analgesia refers to the phenomena where people report decreased pain intensity when they see the painful or painfully stimulated body part. Alongside pain, sensorimotor impairment (i.e., disturbed proprioception) is also evident in ... ...

    Title translation Das Sehen des Behandlungsortes verbessert die gewohnten Schmerzen, aber nicht die Position der Halswirbelsäule unmittelbar nach der manuellen Therapie bei chronischen Halsschmerzpatienten (DeepL)
    Abstract Background: Visual analgesia refers to the phenomena where people report decreased pain intensity when they see the painful or painfully stimulated body part. Alongside pain, sensorimotor impairment (i.e., disturbed proprioception) is also evident in chronic pain. This study aims to investigate whether real-time visual feedback offers additional pain relief and proprioceptive improvement when used in combination with recommended therapies in neck pain patients who received manual therapy with or without real-time visual feedback. Methods: A total of 29 neck pain patients were recruited in an outpatient physical therapy practice. Patients were randomly allocated to receive manual therapy of the cervical spine with real-time visual feedback or to a control group where patients received manual therapy without real-time visual feedback. Habitual pain intensity, the pressure pain threshold at the zygapophyseal joint of C2-C3 and the superior angle of the scapulae and cervical proprioception were assessed before and immediately after the intervention by a blinded assessor. Results: A between-group comparison revealed a significant reduction in habitual pain in the real-time visual feedback group. No differences were found for the pressure pain threshold or proprioceptive performance. Conclusions: Real-time visual feedback combined with manual therapy enhanced the analgesic effect of manual therapy in neck pain patients, but had no positive effect on the pressure pain threshold and cervical joint position sense. The technical demands for integrating real-time visual feedback into daily practice to reduce habitual pain are low, have low costs and are easy to apply. Significance: Real-time visual feedback reduces habitual pain immediately after the intervention. Due to its easy integration, it may be an effective adjunct to recommended interventions (i.e., manual therapy) in patients with neck pain.
    Keywords Chronic Pain ; Chronischer Schmerz ; Genick ; Neck (Anatomy) ; Pain Perception ; Physical Therapy ; Physiotherapie ; Proprioception ; Propriozeption ; Schmerzwahrnehmung ; Sensorische Rückmeldung ; Sensory Feedback ; Therapie ; Treatment ; Visual Perception ; Visuelle Wahrnehmung
    Language English
    Document type Article
    ZDB-ID 1390424-3
    ISSN 1532-2149 ; 1090-3801
    ISSN (online) 1532-2149
    ISSN 1090-3801
    DOI 10.1002/ejp.1290
    Database PSYNDEX

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  9. Article: Re-Learning: Eine Chance bei chronischen Schmerzen

    Zieglgänsberger, W.

    Orthopädie-Report

    2008  Volume 20, Issue Sonderheft, Page(s) 238

    Language German
    Document type Article
    ZDB-ID 1193742-7
    ISSN 0943-9536
    Database Current Contents Medicine

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  10. Article ; Online: Watching your pain site reduces pain intensity in chronic back pain patients.

    Diers, M / Löffler, A / Zieglgänsberger, W / Trojan, J

    European journal of pain (London, England)

    2016  Volume 20, Issue 4, Page(s) 581–585

    Abstract: Background: Chronic back pain (CBP) is a frequent debilitating and often treatment-resistant disorder. The awareness of one's own body seems to be essential in pain reduction through visual input. Visual feedback of the back reduces experimental pain ... ...

    Abstract Background: Chronic back pain (CBP) is a frequent debilitating and often treatment-resistant disorder. The awareness of one's own body seems to be essential in pain reduction through visual input. Visual feedback of the back reduces experimental pain perception in CBP at this site and watching the back during repeated lumbar spine movements reduces movement-evoked pain. In this study, we tested whether visual feedback alone can reduce habitual pain in CBP.
    Methods: In a within-subject design, 19 CBP patients participated in an online visual feedback condition, watching one's own back. This was compared to several control conditions, such as watching a neutral object (book), a video of another person of the same sex, a picture of the own back, and keeping one's eyes closed in randomized order on five separate days. In each experimental session, participants rated habitual pain intensity and unpleasantness before and after the experimental manipulation.
    Results: We present evidence that visual feedback by watching the site of chronic pain on a video screen alone is sufficient to reduce habitual chronic pain. No additional manipulation or movement was necessary.
    Conclusions: These results suggest that online video feedback may be helpful in alleviating chronic pain.
    MeSH term(s) Adult ; Back Pain/psychology ; Back Pain/therapy ; Chronic Pain/psychology ; Chronic Pain/therapy ; Feedback, Sensory ; Female ; Humans ; Lumbar Vertebrae ; Male ; Middle Aged ; Movement ; Pain Measurement ; Treatment Outcome
    Language English
    Publishing date 2016-04
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1390424-3
    ISSN 1532-2149 ; 1090-3801
    ISSN (online) 1532-2149
    ISSN 1090-3801
    DOI 10.1002/ejp.765
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