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  1. AU="Zielinski, Kacper"
  2. AU="Reier, Louis Samuel"

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  1. Article: First In Vivo Applicational Data of Foam-Based Intrathoracic Chemotherapy (FBiTC) in a Swine Model.

    Khosrawipour, Carolina / Nicpoń, Jakub / Kiełbowicz, Zdzisław / Prządka, Przemysław / Liszka, Bartłomiej / Zielinski, Kacper / Khosrawipour, Veria / Li, Shiri / Lau, Hien / Kulas, Joanna / Diakun, Agata / Kielan, Wojciech / Mikolajczk-Martinez, Agata / Chabowski, Mariusz

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 17, Issue 1

    Abstract: Background: For decades, both intraperitoneal and pleural chemotherapy (IPC) have been delivered as a liquid solution. Recent studies suggest that foam carriers outperform liquid carriers for locoregional chemotherapy. For the first time, this study ... ...

    Abstract Background: For decades, both intraperitoneal and pleural chemotherapy (IPC) have been delivered as a liquid solution. Recent studies suggest that foam carriers outperform liquid carriers for locoregional chemotherapy. For the first time, this study aims to evaluate the feasibility, safety, and characteristics of foam-based intrathoracic chemotherapy (FBiTC) in an in vivo setting.
    Methods: In this study, contrast-enhanced FBiTC with doxorubicin was delivered via video-assisted thoracoscopy (VAT) in three swine under general anesthesia. Intraoperative and postoperative parameters, blood analyses, vital signs, and anesthesiologic data were collected. Additionally, an intraoperative computer tomography (CT) scan was performed, and histological tissue sections were collected and further analyzed using fluorescence microscopy.
    Results: FBiTC was delivered without major complications. End-tidal capnometry detected increased CO
    Discussion: Our preliminary results are encouraging and indicate that FBiTC is feasible. However, to consider a possible clinical application, further studies are required to investigate the pharmacologic, pharmacodynamic, and physical properties of FBiTC and to ensure the safety of the overall procedure regarding oxygenation levels and capnography parameters.
    Language English
    Publishing date 2023-12-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17010045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Safety, feasibility, and application of intraperitoneal gas-based hyperthermia beyond 43°C in the treatment of peritoneal metastasis: An

    Diakun, Agata / Khosrawipour, Tanja / Mikolajczyk-Martinez, Agata / Nicpoń, Jakub / Thelen, Simon / Kiełbowicz, Zdzisław / Prządka, Przemysław / Liszka, Bartłomiej / Kulas, Joanna / Zielinski, Kacper / Li, Shiri / Lau, Hien / Kielan, Wojciech / Khosrawipour, Veria

    Frontiers in oncology

    2022  Volume 12, Page(s) 953920

    Abstract: Background: 43°Celsius (C) is currently the highest temperature used in the treatment of peritoneal metastasis (PM). Despite sufficient data on water- based hyperthermic solutions in PM treatment, there is currently no information on gas-based ... ...

    Abstract Background: 43°Celsius (C) is currently the highest temperature used in the treatment of peritoneal metastasis (PM). Despite sufficient data on water- based hyperthermic solutions in PM treatment, there is currently no information on gas-based hyperthermia extending beyond 43°C. This study is the first to provide
    Methods: For this study, three swine were subjected to laparoscopy and subsequent gas-based intraperitoneal hyperthermia at 48°, 49° and 50°C under a high-flow air stream. Intraoperative data from multiple temperature sensors were analysed. Additionally, intraoperative anaesthesiologic and gasometrical data was analysed. Postoperatively, swine were monitored for one week and laboratory work-up was performed on postoperative days 1, 3 and 7.
    Results: During gas-based intraperitoneal hyperthermia, anesthesiologic parameters did not exhibit critical values. No intra- or postoperative complications were observed. Distinct temperature measurements on the skin, cystohepatic triangle and esophagus did not display any temperature increase. Postoperative laboratory workup did not show any changes in hemoglobin, white blood cell count, platelets, or kidney function.
    Discussion: Based on our data, there are no safety concerns for the application of gas-based hyperthermia between 48 - 50°C. In fact, no critical systemic temperature increase was observed. With respect to possible limitations, further
    Language English
    Publishing date 2022-10-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.953920
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The Onset of In-Vivo Dehydration in Gas -Based Intraperitoneal Hyperthermia and Its Cytotoxic Effects on Colon Cancer Cells.

    Diakun, Agata / Khosrawipour, Tanja / Mikolajczyk-Martinez, Agata / Nicpoń, Jakub / Kiełbowicz, Zdzisław / Prządka, Przemysław / Liszka, Bartłomiej / Kielan, Wojciech / Zielinski, Kacper / Migdal, Pawel / Lau, Hien / Li, Shiri / Khosrawipour, Veria

    Frontiers in oncology

    2022  Volume 12, Page(s) 927714

    Abstract: Background: Peritoneal metastasis (PM) is an ongoing challenge in surgical oncology. Current therapeutic options, including intravenous and intraperitoneal (i.p.) chemotherapies display limited clinical efficacy, resulting in an overall poor prognosis ... ...

    Abstract Background: Peritoneal metastasis (PM) is an ongoing challenge in surgical oncology. Current therapeutic options, including intravenous and intraperitoneal (i.p.) chemotherapies display limited clinical efficacy, resulting in an overall poor prognosis in affected patients. Combined hyperthermia and dehydration induced by a high-flow, gas-based i.p. hyperthermic procedure could be a novel approach in PM treatment. Our study is the first to evaluate the therapeutic potential of i.p. dehydration, hyperthermia, as well as the combination of both mechanisms in an
    Methods: For this study, three swine were subjected to diagnostic laparoscopy under a high-flow air stream at 48°, 49° and 50°Celsius (C). Hygrometry of the in- and outflow airstream was measured to calculate surface evaporation and i.p. dehydration. To analyze the effects of this concept,
    Results: According to our results, both dehydration and hyperthermia were cytotoxic to HT-29 cells. However, while dehydration reduced cell viability, hyperthermia did not. However, dehydration effects on cell viability were significantly increased when combined with hyperthermia (p<0.01).
    Conclusions: Changes to the physiological milieu of the peritoneal cavity could significantly reduce PM. Therefore, limited dehydration of the abdominal cavity might be a feasible, additional tool in PM treatment. Further studies are required to investigate dehydration effects and their applicability in PM management.
    Language English
    Publishing date 2022-06-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.927714
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Current meta-analysis does not support the possibility of COVID-19 reinfections.

    Arafkas, Mohamed / Khosrawipour, Tanja / Kocbach, Piotr / Zielinski, Kacper / Schubert, Justyna / Mikolajczyk, Agata / Celinska, Maria / Khosrawipour, Veria

    Journal of medical virology

    2020  Volume 93, Issue 3, Page(s) 1599–1604

    Abstract: Coronavirus disease 2019 (COVID-19) reinfections could be a major aggravating factor in this current pandemic, as this would further complicate potential vaccine development and help to maintain worldwide virus pockets. To investigate this critical ... ...

    Abstract Coronavirus disease 2019 (COVID-19) reinfections could be a major aggravating factor in this current pandemic, as this would further complicate potential vaccine development and help to maintain worldwide virus pockets. To investigate this critical question, we conducted a clinical meta-analysis including all available currently reported cases of potential COVID-19 reinfections. We searched for all peer-reviewed articles in the search engine of the National Center for Biotechnology Information. While there are over 30,000 publications on COVID-19, only about 15 specifically target the subject of COVID-19 reinfections. Available patient data in these reports was analyzed for age, gender, time of reported relapse after initial infection and persistent COVID-19 positive polymerase chain reaction (PCR) results. Following the first episode of infection, cases of clinical relapse are reported at 34 (mean) ± 10.5 days after full recovery. Patients with clinical relapse have persisting positive COVID-19 PCR testing results until 39 ± 9 days following initial positive testing. For patients without clinical relapse, positive testing was reported up to 54 ± 24 days. There were no reports of any clinical reinfections after a 70-day period following initial infection.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/pathology ; Female ; Humans ; Male ; Middle Aged ; Polymerase Chain Reaction ; Reinfection/epidemiology ; SARS-CoV-2 ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-09-27
    Publishing country United States
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26496
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article: Current meta-analysis does not support the possibility of COVID-19 reinfections

    Arafkas, Mohamed / Khosrawipour, Tanja / Kocbach, Piotr / Zielinski, Kacper / Schubert, Justyna / Mikolajczyk, Agata / Celinska, Maria / Khosrawipour, Veria

    J. med. virol

    Abstract: Coronavirus disease 2019 (COVID-19) reinfections could be a major aggravating factor in this current pandemic, as this would further complicate potential vaccine development and help to maintain worldwide virus pockets. To investigate this critical ... ...

    Abstract Coronavirus disease 2019 (COVID-19) reinfections could be a major aggravating factor in this current pandemic, as this would further complicate potential vaccine development and help to maintain worldwide virus pockets. To investigate this critical question, we conducted a clinical meta-analysis including all available currently reported cases of potential COVID-19 reinfections. We searched for all peer-reviewed articles in the search engine of the National Center for Biotechnology Information. While there are over 30,000 publications on COVID-19, only about 15 specifically target the subject of COVID-19 reinfections. Available patient data in these reports was analyzed for age, gender, time of reported relapse after initial infection and persistent COVID-19 positive polymerase chain reaction (PCR) results. Following the first episode of infection, cases of clinical relapse are reported at 34 (mean) ± 10.5 days after full recovery. Patients with clinical relapse have persisting positive COVID-19 PCR testing results until 39 ± 9 days following initial positive testing. For patients without clinical relapse, positive testing was reported up to 54 ± 24 days. There were no reports of any clinical reinfections after a 70-day period following initial infection.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #746415
    Database COVID19

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  6. Article ; Online: Current meta‐analysis does not support the possibility of COVID‐19 reinfections

    Arafkas, Mohamed / Khosrawipour, Tanja / Kocbach, Piotr / Zielinski, Kacper / Schubert, Justyna / Mikolajczyk, Agata / Celinska, Maria / Khosrawipour, Veria

    Journal of Medical Virology ; ISSN 0146-6615 1096-9071

    2020  

    Keywords Virology ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/jmv.26496
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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